SIMILAR PATTERNS OF AMINO ACIDS FOR 1S9P_A_DESA459

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		5 LEU A 268
LEU A 271
ALA A 274
VAL A 298
LEU A 328
 None
 1.05A 1s9pA-1e3hA:
undetectable		 1s9pA-1e3hA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6v DNA TRANSPOSITION
PROTEIN

(Escherichia
virus Mu) 		PF09077
(Phage-MuB_C) 		5 LEU A  53
LEU A  46
ALA A  45
LEU A  35
ILE A  21
 None
 1.13A 1s9pA-1f6vA:
undetectable		 1s9pA-1f6vA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7f HEAT SHOCK PROTEIN
33

(Escherichia
coli) 		PF01430
(HSP33) 		5 LEU A  47
LEU A  50
ALA A  53
LEU A  57
ILE A  33
 None
 1.08A 1s9pA-1i7fA:
undetectable		 1s9pA-1i7fA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im3 CYTOMEGALOVIRUS
PROTEIN US2

(Human
betaherpesvirus
5) 		PF05963
(Cytomega_US3) 		5 LEU D 131
LEU D 120
VAL D  89
LEU D 102
ILE D 129
 None
 1.12A 1s9pA-1im3D:
undetectable		 1s9pA-1im3D:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 533
LEU A 536
ALA A 540
GLU A 543
ILE A 514
 None
 0.70A 1s9pA-1itkA:
undetectable		 1s9pA-1itkA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		5 LEU A  75
ALA A  82
VAL A 119
TYR A 120
LEU A 191
 None
None
None
KCX  A  70 ( 3.7A)
None
 1.04A 1s9pA-1k38A:
undetectable		 1s9pA-1k38A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks9 2-DEHYDROPANTOATE
2-REDUCTASE

(Escherichia
coli) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A  68
MET A   1
VAL A 159
LEU A 152
ILE A  93
 None
 1.13A 1s9pA-1ks9A:
undetectable		 1s9pA-1ks9A:
23.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
ALA A 350
GLU A 353
LEU A 387
ARG A 394
HIS A 524
 EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
EST  A   1 (-3.8A)
 0.40A 1s9pA-1pcgA:
27.1		 1s9pA-1pcgA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		5 LEU A 265
LEU A 268
LEU A 460
TYR A 487
ILE A 197
 None
 1.11A 1s9pA-1q32A:
undetectable		 1s9pA-1q32A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 387
LEU A 386
LEU A 431
VAL A 365
LEU A 356
 None
 1.08A 1s9pA-1s5jA:
undetectable		 1s9pA-1s5jA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		5 LEU A 179
LEU A 176
LEU A 170
LEU A 141
ILE A 148
 None
 0.88A 1s9pA-1susA:
undetectable		 1s9pA-1susA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 ALA A 244
GLU A 243
LEU A 208
LEU A 198
ILE A 177
 None
 1.06A 1s9pA-1to3A:
undetectable		 1s9pA-1to3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF04045
(P34-Arc) 		5 LEU D 116
ALA D 122
GLU D 126
LEU D  84
ILE D  59
 None
 1.15A 1s9pA-1u2vD:
undetectable		 1s9pA-1u2vD:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end) 		5 LEU A 640
ALA A 463
MET A 311
LEU A 728
ILE A 595
 None
 1.02A 1s9pA-1um2A:
undetectable		 1s9pA-1um2A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Pyrobaculum
aerophilum) 		PF01791
(DeoC) 		5 ALA A  87
LEU A 104
VAL A 108
LEU A 185
ILE A 174
 None
 0.91A 1s9pA-1vcvA:
undetectable		 1s9pA-1vcvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		5 LEU A 328
LEU A 331
ALA A 335
ARG A 125
ILE A 247
 None
 1.06A 1s9pA-1wzzA:
undetectable		 1s9pA-1wzzA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 324
GLU A 331
MET A 362
LEU A 365
VAL A 369
ARG A 372
LEU A 401
HIS A 494
 None
 0.48A 1s9pA-1xb7A:
29.1		 1s9pA-1xb7A:
58.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp CHAPERONE PROTEIN
SYCN

(Yersinia pestis) 		no annotation 5 LEU B 103
LEU B 106
ALA B 109
LEU B 113
LEU B  15
 None
 1.15A 1s9pA-1xkpB:
undetectable		 1s9pA-1xkpB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k GTP-BINDING PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 103
LEU A  99
VAL A 131
TYR A  96
ILE A 116
 None
 1.14A 1s9pA-1z0kA:
undetectable		 1s9pA-1z0kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 LEU A 295
LEU A 337
LEU A 234
VAL A 238
ILE A 298
 None
 1.08A 1s9pA-2b0tA:
undetectable		 1s9pA-2b0tA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 470
ALA A 474
MET A 603
LEU A 507
VAL A 509
 None
 1.07A 1s9pA-2cvtA:
undetectable		 1s9pA-2cvtA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		5 LEU A 131
ALA A 135
LEU A  23
VAL A   7
LEU A  60
 None
 0.98A 1s9pA-2fekA:
undetectable		 1s9pA-2fekA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkp HYPOTHETICAL PROTEIN
NMB0488

(Neisseria
meningitidis) 		PF07262
(CdiI) 		5 LEU A  59
LEU A  56
GLU A  49
LEU A 143
ILE A 113
 None
 1.01A 1s9pA-2gkpA:
undetectable		 1s9pA-2gkpA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 LEU A 265
LEU A 268
ALA A 272
GLU A 275
MET A 306
LEU A 309
VAL A 313
ARG A 316
TYR A 326
LEU A 345
HIS A 434
ILE A 438
 None
OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
None
OHT  A 500 (-3.8A)
OHT  A 500 (-4.5A)
OHT  A 500 (-4.3A)
OHT  A 500 ( 4.7A)
None
 0.59A 1s9pA-2gpvA:
34.7		 1s9pA-2gpvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3j HYPOTHETICAL PROTEIN
PA4359

(Pseudomonas
aeruginosa) 		PF04023
(FeoA) 		5 LEU A  27
LEU A  32
ALA A  36
VAL A  52
LEU A  66
 None
 1.04A 1s9pA-2h3jA:
undetectable		 1s9pA-2h3jA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9c HYPOTHETICAL PROTEIN
RPA1889

(Rhodopseudomonas
palustris) 		PF09450
(DUF2019) 		5 LEU A  14
LEU A  17
GLU A  24
LEU A  40
LEU A   4
 None
 1.15A 1s9pA-2i9cA:
undetectable		 1s9pA-2i9cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls7 ASTROCYTIC
PHOSPHOPROTEIN
PEA-15

(Mus musculus) 		PF01335
(DED) 		5 LEU A  20
LEU A  23
ALA A  26
LEU A  49
ILE A  39
 None
 1.15A 1s9pA-2ls7A:
undetectable		 1s9pA-2ls7A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 LEU A  72
ALA A 131
GLU A 132
ARG A 143
LEU A 112
 None
 1.14A 1s9pA-2o7pA:
undetectable		 1s9pA-2o7pA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
ALA A 350
GLU A 353
LEU A 387
ARG A 394
HIS A 524
 EST  A 596 (-4.4A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 (-4.2A)
 0.60A 1s9pA-2ocfA:
28.2		 1s9pA-2ocfA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvq GLUTATHIONE
S-TRANSFERASE

(Ochrobactrum
anthropi) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  18
ALA A 194
GLU A 198
LEU A  12
LEU A  70
 None
 0.96A 1s9pA-2pvqA:
undetectable		 1s9pA-2pvqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  29
LEU A  32
ALA A  36
MET A  70
ARG A  80
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
 0.48A 1s9pA-2q3yA:
26.4		 1s9pA-2q3yA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		5 ALA A 242
LEU A 210
VAL A 239
HIS A 148
ILE A 190
 None
 1.13A 1s9pA-2w1vA:
undetectable		 1s9pA-2w1vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 179
ALA A 416
LEU A 502
VAL A 505
ILE A 160
 None
 0.95A 1s9pA-2wdwA:
undetectable		 1s9pA-2wdwA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 ALA A 510
LEU A 539
VAL A 541
LEU A 530
ILE A 658
 None
 1.09A 1s9pA-2xzoA:
undetectable		 1s9pA-2xzoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 150
ALA A 390
LEU A 476
VAL A 479
ILE A 131
 None
 0.92A 1s9pA-2y3sA:
undetectable		 1s9pA-2y3sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		5 LEU A 218
LEU A 224
ALA A 227
VAL A 276
LEU A 384
 None
 1.07A 1s9pA-3c87A:
undetectable		 1s9pA-3c87A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6r FLAVODOXIN

(Desulfovibrio
desulfuricans) 		PF00258
(Flavodoxin_1) 		5 LEU A  54
ALA A  19
LEU A  35
VAL A  33
ILE A 108
 None
 1.07A 1s9pA-3f6rA:
undetectable		 1s9pA-3f6rA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A   4
ALA A 119
GLU A 121
LEU A  92
ILE A  77
 None
 1.13A 1s9pA-3h2zA:
undetectable		 1s9pA-3h2zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		5 LEU C  80
ALA C  87
VAL C 124
TYR C 125
LEU C 196
 None
None
None
KCX  C  75 ( 3.6A)
None
 1.11A 1s9pA-3if6C:
undetectable		 1s9pA-3if6C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		5 LEU A 341
LEU A 344
ALA A 347
ARG A 298
LEU A 247
 None
 1.12A 1s9pA-3iv7A:
undetectable		 1s9pA-3iv7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kaq FLAVODOXIN

(Desulfovibrio
desulfuricans) 		PF00258
(Flavodoxin_1) 		5 LEU A  54
ALA A  19
LEU A  35
VAL A  33
ILE A 108
 None
 1.11A 1s9pA-3kaqA:
undetectable		 1s9pA-3kaqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A  62
ALA A 245
VAL A 268
LEU A 237
ILE A  95
 None
 1.15A 1s9pA-3kn1A:
undetectable		 1s9pA-3kn1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 LEU X  47
LEU X  50
ALA X  53
LEU X  57
ILE X  33
 None
 1.09A 1s9pA-3m7mX:
undetectable		 1s9pA-3m7mX:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		5 LEU A 726
LEU A 729
ALA A 733
LEU A 715
ILE A 748
 None
 1.05A 1s9pA-3mkqA:
undetectable		 1s9pA-3mkqA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncc PROLACTIN

(Homo sapiens) 		PF00103
(Hormone_1) 		5 LEU A  15
LEU A  18
ALA A  22
LEU A 126
ILE A 193
 None
 0.95A 1s9pA-3nccA:
undetectable		 1s9pA-3nccA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 ALA A 120
LEU A 142
TYR A 313
LEU A 151
ILE A 147
 None
 1.06A 1s9pA-3o75A:
undetectable		 1s9pA-3o75A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 562
LEU A 559
VAL A 855
TYR A 856
ILE A 600
 None
 1.05A 1s9pA-3p5pA:
2.1		 1s9pA-3p5pA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmo UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF04613
(LpxD) 		5 LEU A  92
LEU A  89
ALA A  87
LEU A  84
VAL A  79
 None
 1.15A 1s9pA-3pmoA:
undetectable		 1s9pA-3pmoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		5 LEU A  31
LEU A  74
VAL A 101
TYR A  71
ILE A  39
 None
 1.12A 1s9pA-3qvoA:
undetectable		 1s9pA-3qvoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 LEU A 134
ALA A  77
LEU A 126
LEU A 175
ILE A 167
 None
 1.14A 1s9pA-3r3sA:
undetectable		 1s9pA-3r3sA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		5 LEU A 265
LEU A 268
LEU A 460
TYR A 487
ILE A 197
 None
 1.09A 1s9pA-3sq7A:
undetectable		 1s9pA-3sq7A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 LEU A 273
LEU A 276
GLU A  94
VAL A 367
ILE A 399
 None
 1.13A 1s9pA-3srzA:
undetectable		 1s9pA-3srzA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uar GLUTATHIONE
S-TRANSFERASE

(Methylococcus
capsulatus) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  18
ALA A 195
GLU A 199
LEU A  12
LEU A  70
 None
 1.05A 1s9pA-3uarA:
undetectable		 1s9pA-3uarA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		5 LEU A  43
LEU A  40
ALA A  37
TYR A 237
LEU A 120
 None
 1.09A 1s9pA-3ufgA:
undetectable		 1s9pA-3ufgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]

(Saccharomyces
cerevisiae) 		PF05222
(AlaDh_PNT_N) 		5 ALA A  19
GLU A  11
LEU A  76
ARG A   9
LEU A 341
 None
 1.14A 1s9pA-3ugkA:
undetectable		 1s9pA-3ugkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		5 LEU A  71
LEU A  68
TYR A  76
LEU A 402
ILE A 429
 None
 0.77A 1s9pA-3wh7A:
undetectable		 1s9pA-3wh7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		5 LEU A 138
LEU A 141
ALA A 145
LEU A 182
TYR A 122
 None
 0.85A 1s9pA-3wiwA:
undetectable		 1s9pA-3wiwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		6 LEU A 309
LEU A  72
ALA A  70
LEU A 121
LEU A 239
ILE A 311
 None
 1.30A 1s9pA-3zfcA:
undetectable		 1s9pA-3zfcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ALA A 135
LEU A 139
VAL A 328
TYR A 204
LEU A 162
 PEG  A1335 (-3.9A)
None
None
None
None
 1.10A 1s9pA-4avcA:
undetectable		 1s9pA-4avcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		5 LEU A 700
LEU A 650
LEU A 645
LEU A 734
ILE A 698
 None
 1.09A 1s9pA-4blaA:
undetectable		 1s9pA-4blaA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A  68
LEU A  67
VAL A 344
HIS A  84
ILE A  83
 None
 1.03A 1s9pA-4c41A:
undetectable		 1s9pA-4c41A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 LEU A 130
VAL A 134
LEU A 152
HIS A 208
ILE A 211
 None
 1.10A 1s9pA-4conA:
undetectable		 1s9pA-4conA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 ALA A 680
LEU A 585
VAL A 610
LEU A 553
ILE A 699
 None
 1.12A 1s9pA-4fwgA:
undetectable		 1s9pA-4fwgA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA

(Thermotoga
maritima) 		no annotation 5 LEU D1051
LEU D1052
ALA D1054
VAL D1017
TYR D1012
 None
None
None
ADP  D1301 (-4.6A)
ADP  D1301 (-3.6A)
 1.13A 1s9pA-4hluD:
undetectable		 1s9pA-4hluD:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 446
LEU A 449
ALA A 452
VAL A 498
ILE A 417
 None
None
None
GOL  A 606 ( 4.1A)
None
 1.15A 1s9pA-4jgvA:
20.4		 1s9pA-4jgvA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 LEU A 481
LEU A 477
ALA A 475
MET A 440
LEU A 472
 None
 1.13A 1s9pA-4k0eA:
undetectable		 1s9pA-4k0eA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		5 LEU A 238
LEU A 257
VAL A 293
HIS A 217
ILE A 224
 None
 1.15A 1s9pA-4lg8A:
undetectable		 1s9pA-4lg8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		5 LEU A 801
LEU A 798
ALA A 794
LEU A 705
LEU A 101
 None
 1.07A 1s9pA-4mhcA:
undetectable		 1s9pA-4mhcA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		5 LEU A 801
LEU A 798
GLU A 791
LEU A 705
LEU A 101
 None
 0.96A 1s9pA-4mhcA:
undetectable		 1s9pA-4mhcA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 280
LEU A 283
ALA A 287
GLU A 290
MET A 321
LEU A 324
ARG A 331
 None
 0.48A 1s9pA-4n1yA:
28.2		 1s9pA-4n1yA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
 None
None
P5F  A1101 ( 3.7A)
None
None
 0.95A 1s9pA-4nmeA:
undetectable		 1s9pA-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		5 LEU A  13
LEU A 135
ALA A  98
LEU A 126
ILE A 183
 None
 1.01A 1s9pA-4pooA:
undetectable		 1s9pA-4pooA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 153
ALA A  22
LEU A 300
HIS A 215
ILE A 211
 None
 1.15A 1s9pA-4rpfA:
undetectable		 1s9pA-4rpfA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 ALA B 276
LEU B 280
VAL B 361
LEU B 437
ILE B 457
 None
 1.14A 1s9pA-4tx2B:
undetectable		 1s9pA-4tx2B:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uav HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN AT3G48420

(Arabidopsis
thaliana) 		PF13419
(HAD_2) 		5 LEU A 212
LEU A 213
ALA A 218
VAL A 194
ILE A 169
 None
 1.00A 1s9pA-4uavA:
undetectable		 1s9pA-4uavA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
LEU A 769
ALA A 773
MET A 807
LEU A 810
ARG A 817
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.7A)
 0.59A 1s9pA-4udbA:
25.5		 1s9pA-4udbA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Pseudomonas
aeruginosa) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B  61
ALA B  65
LEU B 176
LEU B  15
ILE B  99
 None
 1.15A 1s9pA-4wj3B:
undetectable		 1s9pA-4wj3B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		5 LEU A 585
ALA A 591
LEU A 595
LEU A 616
ILE A 631
 None
 1.15A 1s9pA-4yk6A:
undetectable		 1s9pA-4yk6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		6 ALA A 208
LEU A 261
VAL A 267
ARG A 216
HIS A 226
ILE A 192
 None
None
None
None
ACT  A 401 (-3.5A)
None
 1.14A 1s9pA-4yyfA:
undetectable		 1s9pA-4yyfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 244
ALA A 238
LEU A 186
ARG A 325
ILE A 167
 None
 1.07A 1s9pA-4zqgA:
undetectable		 1s9pA-4zqgA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apg TSR3

(Vulcanisaeta
distributa) 		PF04034
(Ribo_biogen_C) 		5 ALA A 118
LEU A  93
TYR A 153
LEU A 164
ILE A 145
 None
EEM  A1185 (-3.9A)
None
None
None
 1.01A 1s9pA-5apgA:
undetectable		 1s9pA-5apgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		5 LEU A 297
LEU A 407
ALA A 410
LEU A 323
ILE A 101
 None
 1.04A 1s9pA-5cbmA:
undetectable		 1s9pA-5cbmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGK

(Escherichia
coli) 		PF02626
(CT_A_B) 		5 LEU A 150
MET A  94
VAL A  44
LEU A 113
ILE A   4
 None
 1.12A 1s9pA-5dudA:
undetectable		 1s9pA-5dudA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		5 LEU A  33
LEU A  36
LEU A  50
LEU A  58
ILE A 151
 None
 0.86A 1s9pA-5e4vA:
undetectable		 1s9pA-5e4vA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 LEU A  10
LEU A  53
ALA A  25
VAL A  98
ILE A   6
 None
None
None
6OM  A 301 (-3.0A)
None
 1.10A 1s9pA-5hzgA:
undetectable		 1s9pA-5hzgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		6 LEU A 210
LEU A 213
ALA A 217
GLU A 220
LEU A 188
ILE A 183
 None
 1.40A 1s9pA-5k04A:
undetectable		 1s9pA-5k04A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Psychrobacter
arcticus) 		PF01634
(HisG) 		5 LEU E 110
ALA E  44
VAL E  67
LEU E  28
ILE E 112
 None
 1.11A 1s9pA-5m8hE:
undetectable		 1s9pA-5m8hE:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 766
LEU A 769
ALA A 773
MET A 807
ARG A 817
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
 0.56A 1s9pA-5mwpA:
26.9		 1s9pA-5mwpA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00583
(Acetyltransf_1) 		5 LEU B 131
ALA B 127
VAL B 121
TYR B 132
ILE B  96
 None
None
None
None
GOL  B 201 (-4.8A)
 1.09A 1s9pA-5nnpB:
undetectable		 1s9pA-5nnpB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 5 LEU A  75
LEU A  78
ALA A  81
VAL A 278
LEU A 197
 EDO  A 403 (-3.7A)
None
None
None
None
 1.05A 1s9pA-5o9wA:
undetectable		 1s9pA-5o9wA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 5 LEU A 103
LEU A 106
ALA A 110
LEU A  31
ILE A 123
 None
 1.02A 1s9pA-5obuA:
undetectable		 1s9pA-5obuA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obw CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 5 LEU A 103
LEU A 106
ALA A 110
LEU A  31
ILE A 123
 None
 1.06A 1s9pA-5obwA:
undetectable		 1s9pA-5obwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		6 LEU A 198
ALA A 191
GLU A 190
LEU A  74
LEU A 156
ILE A 163
 None
 1.34A 1s9pA-5tjrA:
undetectable		 1s9pA-5tjrA:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 302
MET A 336
LEU A 339
LEU A 380
ILE A 373
 EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
None
None
 1.11A 1s9pA-5toaA:
28.2		 1s9pA-5toaA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 298
ALA A 302
GLU A 305
MET A 336
LEU A 339
ARG A 346
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
EST  A 601 (-4.4A)
 0.40A 1s9pA-5toaA:
28.2		 1s9pA-5toaA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		6 LEU A 172
LEU A 175
ALA A 179
GLU A 182
LEU A 153
LEU A 114
 None
 1.33A 1s9pA-5uaiA:
undetectable		 1s9pA-5uaiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq0 STAGE 0 SPORULATION
PROTEIN

(Paenisporosarcina
sp. TG-14) 		no annotation 5 LEU B  15
ALA B   9
LEU B  53
VAL B   6
LEU B 115
 None
 1.03A 1s9pA-5wq0B:
undetectable		 1s9pA-5wq0B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 5 LEU A 345
LEU A 348
TYR A 329
LEU A 278
ILE A 356
 None
 1.06A 1s9pA-5x7uA:
undetectable		 1s9pA-5x7uA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 LEU A 258
LEU A 255
ALA A  84
VAL A  77
LEU A 231
 None
 1.12A 1s9pA-5ze4A:
undetectable		 1s9pA-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 5 LEU A 826
LEU A 829
ALA A 833
GLU A 836
ILE A 794
 None
 0.62A 1s9pA-6brsA:
undetectable		 1s9pA-6brsA:
14.10