SIMILAR PATTERNS OF AMINO ACIDS FOR 1S8F_B_BEZB1503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 VAL A 192
GLU A 195
LEU A 196
PHE A 261
 None
 1.14A 1s8fB-1bh6A:
0.9		 1s8fB-1bh6A:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 VAL A 192
GLU A 195
LEU A 196
PHE A 261
 None
 1.10A 1s8fB-1c3lA:
2.9		 1s8fB-1c3lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1d PROTEIN (CAPSID
PROTEIN)

(Rous sarcoma
virus) 		PF00607
(Gag_p24) 		5 VAL A  40
THR A  36
LEU A 137
ARG A 141
PHE A 140
 None
 1.43A 1s8fB-1d1dA:
undetectable		 1s8fB-1d1dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		4 VAL A  19
GLU A  24
LEU A  22
ARG A  58
 None
 1.10A 1s8fB-1ek6A:
5.5		 1s8fB-1ek6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		4 GLU A  93
LEU A  91
ARG A 232
PHE A 233
 None
 1.06A 1s8fB-1f8rA:
undetectable		 1s8fB-1f8rA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A  41
THR A  29
ARG A  84
PHE A  87
 None
 0.95A 1s8fB-1gg4A:
1.7		 1s8fB-1gg4A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  61
GLU A  23
LEU A  21
ARG A  29
 None
 1.05A 1s8fB-1h2bA:
2.5		 1s8fB-1h2bA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 VAL A 106
THR A 107
LEU A  35
ARG A  41
 None
 1.01A 1s8fB-1idjA:
undetectable		 1s8fB-1idjA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq6 (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Aeromonas
caviae) 		PF01575
(MaoC_dehydratas) 		4 VAL A  99
THR A 100
GLU A 127
LEU A 111
 None
 1.14A 1s8fB-1iq6A:
undetectable		 1s8fB-1iq6A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME

(Methanothermobacter
thermautotrophicus) 		PF00730
(HhH-GPD) 		4 VAL A  53
GLU A  42
LEU A  44
ARG A  46
 None
 1.11A 1s8fB-1keaA:
undetectable		 1s8fB-1keaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 VAL A 226
THR A 249
GLU A 235
LEU A 238
 None
 1.05A 1s8fB-1nvtA:
0.9		 1s8fB-1nvtA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 VAL A  14
THR A  13
GLU A   9
ARG A 231
 None
 1.12A 1s8fB-1rxmA:
undetectable		 1s8fB-1rxmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		4 GLU A  93
LEU A  91
ARG A 232
PHE A 233
 None
 1.01A 1s8fB-1tdkA:
undetectable		 1s8fB-1tdkA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		4 VAL A 255
GLU A 176
LEU A 171
PHE A 172
 None
 1.11A 1s8fB-1wiwA:
undetectable		 1s8fB-1wiwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		4 VAL A 255
LEU A 171
ARG A 173
PHE A 172
 None
 1.11A 1s8fB-1wiwA:
undetectable		 1s8fB-1wiwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		4 VAL A  63
GLU A 133
LEU A 126
PHE A 125
 None
NI  A 200 ( 4.1A)
None
None
 1.12A 1s8fB-1ws0A:
undetectable		 1s8fB-1ws0A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL A  77
THR A  74
GLU A 115
LEU A  88
 None
 1.03A 1s8fB-1wz9A:
undetectable		 1s8fB-1wz9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 253
THR A 252
GLU A 349
LEU A 341
 None
 1.13A 1s8fB-1xfcA:
undetectable		 1s8fB-1xfcA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		4 VAL A 118
THR A 119
LEU A 211
PHE A 215
 None
None
None
ACY  A 801 (-3.6A)
 1.09A 1s8fB-1z72A:
undetectable		 1s8fB-1z72A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		4 VAL A  76
THR A  86
LEU A 279
PHE A 278
 None
 0.92A 1s8fB-1zupA:
undetectable		 1s8fB-1zupA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		4 VAL A 106
GLU A 104
LEU A 130
PHE A 103
 None
 1.12A 1s8fB-2avnA:
undetectable		 1s8fB-2avnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw0 MENKES
COPPER-TRANSPORTING
ATPASE

(Homo sapiens) 		PF00403
(HMA) 		4 VAL A  45
THR A   5
LEU A  57
ARG A  58
 None
 1.07A 1s8fB-2aw0A:
undetectable		 1s8fB-2aw0A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azo MUTH

(Escherichia
coli) 		PF02976
(MutH) 		4 VAL A 106
THR A 107
GLU A 109
ARG A 114
 None
 1.13A 1s8fB-2azoA:
undetectable		 1s8fB-2azoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 222
GLU A 224
LEU A 226
PHE A 187
 None
 0.84A 1s8fB-2ebaA:
undetectable		 1s8fB-2ebaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f06 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 4 VAL A 130
GLU A 127
LEU A 125
PHE A  89
 None
 1.00A 1s8fB-2f06A:
undetectable		 1s8fB-2f06A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm4 PYRUVATE, PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers) 		4 VAL A 448
THR A 447
LEU A 429
ARG A 428
 None
 0.99A 1s8fB-2fm4A:
undetectable		 1s8fB-2fm4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz4 HYPOTHETICAL PROTEIN
ATU1052

(Agrobacterium
fabrum) 		no annotation 4 VAL A  56
THR A  55
LEU A  38
ARG A  40
 None
 0.91A 1s8fB-2gz4A:
undetectable		 1s8fB-2gz4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 VAL A 411
GLU A 406
ARG A 402
PHE A 399
 None
 0.78A 1s8fB-2hivA:
undetectable		 1s8fB-2hivA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 232
THR A 231
GLU A 238
LEU A 233
 None
None
GSH  A3001 (-3.8A)
None
 1.04A 1s8fB-2hqmA:
undetectable		 1s8fB-2hqmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 VAL A 169
THR A 166
LEU A 132
PHE A 129
 None
 1.03A 1s8fB-2ifyA:
2.2		 1s8fB-2ifyA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		4 VAL A 287
GLU A 265
LEU A 263
PHE A 259
 None
 1.12A 1s8fB-2iqtA:
undetectable		 1s8fB-2iqtA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 VAL A 279
GLU A 257
LEU A 254
ARG A 262
 None
 0.91A 1s8fB-2ivdA:
1.9		 1s8fB-2ivdA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxp PUTATIVE LIPOPROTEIN
B

(Nitrosomonas
europaea) 		PF04390
(LptE) 		4 GLU A  62
LEU A  79
ARG A  64
PHE A  77
 None
 1.09A 1s8fB-2jxpA:
undetectable		 1s8fB-2jxpA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5y PUTATIVE TUBERCULIN
RELATED PEPTIDE

(Mycobacterium
tuberculosis) 		PF13399
(LytR_C) 		4 VAL A  94
THR A  97
LEU A  56
ARG A  51
 None
 0.98A 1s8fB-2m5yA:
undetectable		 1s8fB-2m5yA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oee UPF0342 PROTEIN YHEA

(Bacillus
subtilis) 		PF06133
(Com_YlbF) 		4 VAL A  77
GLU A  90
ARG A  46
PHE A  45
 None
 1.07A 1s8fB-2oeeA:
undetectable		 1s8fB-2oeeA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 VAL A 177
THR A 176
LEU A 351
ARG A 347
 None
 0.94A 1s8fB-2p82A:
undetectable		 1s8fB-2p82A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		4 VAL A 154
THR A 153
GLU A 149
LEU A 137
 None
 1.13A 1s8fB-2pxxA:
undetectable		 1s8fB-2pxxA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		4 VAL A 594
THR A 595
GLU A 575
LEU A 609
 None
 0.99A 1s8fB-2qsfA:
undetectable		 1s8fB-2qsfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 154
THR A 153
LEU A 255
PHE A 149
 None
 1.02A 1s8fB-2rsvA:
undetectable		 1s8fB-2rsvA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 VAL A  83
THR A  80
LEU A 481
PHE A 484
 None
 1.10A 1s8fB-2vl8A:
undetectable		 1s8fB-2vl8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 VAL A  31
THR A  79
LEU A 234
ARG A 232
 None
 0.98A 1s8fB-2w3pA:
2.1		 1s8fB-2w3pA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 VAL C  80
THR C  77
LEU C 105
PHE C 106
 None
 0.99A 1s8fB-2wy0C:
undetectable		 1s8fB-2wy0C:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 VAL A 613
LEU A 553
ARG A 558
PHE A 556
 None
 1.09A 1s8fB-2zufA:
undetectable		 1s8fB-2zufA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 VAL B 101
THR B 102
GLU B 131
LEU B  91
 None
 1.03A 1s8fB-3bxwB:
undetectable		 1s8fB-3bxwB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		4 VAL A 146
THR A 117
LEU A 186
ARG A 184
 None
 0.82A 1s8fB-3da8A:
undetectable		 1s8fB-3da8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkt MARITIMACIN

(Thermotoga
maritima) 		PF04454
(Linocin_M18) 		4 VAL A 257
GLU A 261
ARG A 140
PHE A 137
 None
 1.08A 1s8fB-3dktA:
undetectable		 1s8fB-3dktA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A  12
LEU A 157
ARG A 155
PHE A 154
 None
 1.10A 1s8fB-3dljA:
3.0		 1s8fB-3dljA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 VAL A  28
THR A  29
GLU A  41
LEU A 106
 None
 0.97A 1s8fB-3e97A:
undetectable		 1s8fB-3e97A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bacteroides
fragilis) 		PF13407
(Peripla_BP_4) 		4 VAL A 303
THR A 302
GLU A 300
LEU A 298
 None
 0.98A 1s8fB-3gbvA:
2.2		 1s8fB-3gbvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 VAL A 250
THR A 249
GLU A 242
LEU A 251
 None
 1.08A 1s8fB-3gcfA:
undetectable		 1s8fB-3gcfA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 GLU A 199
LEU A 197
ARG A 195
PHE A 174
 BTB  A 344 (-4.0A)
None
SO4  A 342 ( 3.3A)
None
 1.14A 1s8fB-3gr8A:
2.1		 1s8fB-3gr8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		4 VAL A 174
GLU A 127
LEU A 134
PHE A 135
 None
 1.04A 1s8fB-3hjlA:
undetectable		 1s8fB-3hjlA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG

(Homo sapiens) 		PF03932
(CutC) 		4 VAL A 142
THR A 143
GLU A  50
LEU A 114
 None
 1.07A 1s8fB-3iwpA:
undetectable		 1s8fB-3iwpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 VAL B 417
THR B 132
GLU B 400
LEU B 402
 None
 1.12A 1s8fB-3kdjB:
undetectable		 1s8fB-3kdjB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 VAL A 222
LEU A  71
ARG A  69
PHE A  70
 None
 1.06A 1s8fB-3lkzA:
undetectable		 1s8fB-3lkzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 762
THR A 761
LEU A 723
ARG A 724
 None
 1.14A 1s8fB-3lzbA:
undetectable		 1s8fB-3lzbA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 VAL A 238
THR A 239
LEU A 263
ARG A 243
 None
 0.92A 1s8fB-3muoA:
undetectable		 1s8fB-3muoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 VAL A 312
THR A 289
GLU A 138
LEU A 292
 None
 1.07A 1s8fB-3muuA:
undetectable		 1s8fB-3muuA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og5 OUTER MEMBRANE
PROTEIN ASSEMBLY
COMPLEX, YAET
PROTEIN

(Escherichia
coli) 		PF07244
(POTRA) 		4 VAL A 412
LEU A 377
ARG A 346
PHE A 347
 None
 1.08A 1s8fB-3og5A:
undetectable		 1s8fB-3og5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 794
THR A 793
LEU A 755
ARG A 756
 None
 1.14A 1s8fB-3pp0A:
undetectable		 1s8fB-3pp0A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 VAL A 131
LEU A 221
ARG A 222
PHE A 225
 None
None
GOL  A 311 (-4.2A)
None
 0.94A 1s8fB-3pvtA:
undetectable		 1s8fB-3pvtA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6b OUTER MEMBRANE
PROTEIN ASSEMBLY
COMPLEX, YAET
PROTEIN

(Escherichia
coli) 		PF07244
(POTRA) 		4 VAL A 412
LEU A 377
ARG A 346
PHE A 347
 None
 1.12A 1s8fB-3q6bA:
undetectable		 1s8fB-3q6bA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		4 VAL A 147
THR A 144
LEU A 158
PHE A 160
 NA  A 287 ( 4.0A)
ZYC  A 245 (-3.8A)
None
None
 0.99A 1s8fB-3qm1A:
4.8		 1s8fB-3qm1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 THR A 128
GLU A 133
LEU A 131
ARG A 130
 None
 1.05A 1s8fB-3t2nA:
undetectable		 1s8fB-3t2nA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpu 42F3 BETA

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B  14
THR B  15
GLU B 112
LEU B 114
 None
 1.13A 1s8fB-3tpuB:
undetectable		 1s8fB-3tpuB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		4 VAL A 267
THR A 322
GLU A 327
LEU A 331
 None
 1.07A 1s8fB-3tw0A:
2.8		 1s8fB-3tw0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 VAL A 107
THR A 108
LEU A 143
ARG A 142
 None
 1.06A 1s8fB-3w6qA:
undetectable		 1s8fB-3w6qA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 VAL A 122
GLU A 138
LEU A  57
ARG A  58
 None
 1.06A 1s8fB-4ah6A:
undetectable		 1s8fB-4ah6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bit CEREBRAL DOPAMINE
NEUROTROPHIC FACTOR

(Homo sapiens) 		PF10208
(Armet) 		4 VAL A  73
THR A  74
GLU A  38
LEU A  59
 None
 1.11A 1s8fB-4bitA:
undetectable		 1s8fB-4bitA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 VAL A 581
GLU A 586
LEU A 584
ARG A 621
 None
 1.08A 1s8fB-4bzkA:
undetectable		 1s8fB-4bzkA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 VAL A 358
GLU A 374
LEU A 372
ARG A 370
 None
 1.13A 1s8fB-4d3yA:
undetectable		 1s8fB-4d3yA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  42
LEU A   6
ARG A 393
PHE A 394
 None
 1.04A 1s8fB-4dx3A:
undetectable		 1s8fB-4dx3A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 VAL C 201
THR C 202
GLU C 230
LEU C 224
 None
 0.96A 1s8fB-4gnxC:
undetectable		 1s8fB-4gnxC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 VAL B 449
THR B 440
GLU B 455
LEU B 453
 None
 1.11A 1s8fB-4iglB:
undetectable		 1s8fB-4iglB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 VAL A 152
LEU A 161
ARG A 165
PHE A 164
 None
 1.05A 1s8fB-4jb7A:
undetectable		 1s8fB-4jb7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		4 GLU A 213
LEU A 211
ARG A 209
PHE A 188
 None
 1.13A 1s8fB-4jipA:
undetectable		 1s8fB-4jipA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		4 VAL A 484
GLU A 507
LEU A 509
ARG A 511
 None
 1.00A 1s8fB-4k35A:
undetectable		 1s8fB-4k35A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8f TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Rhodospirillum
rubrum) 		no annotation 4 VAL A  47
GLU A  86
LEU A  52
ARG A  51
 None
 1.14A 1s8fB-4k8fA:
undetectable		 1s8fB-4k8fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 VAL A 300
THR A 301
GLU A 492
LEU A 274
ARG A 272
 None
 1.47A 1s8fB-4l4iA:
undetectable		 1s8fB-4l4iA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH

(Lechevalieria
aerocolonigenes) 		PF04820
(Trp_halogenase) 		4 VAL A 269
GLU A 522
LEU A 524
ARG A 525
 None
 1.10A 1s8fB-4lu6A:
1.6		 1s8fB-4lu6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnu TRANSCRIPTION FACTOR
A, MITOCHONDRIAL

(Homo sapiens) 		PF00505
(HMG_box)
PF09011
(HMG_box_2) 		4 VAL A 185
THR A 184
GLU A 180
LEU A 182
 None
 1.11A 1s8fB-4nnuA:
undetectable		 1s8fB-4nnuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		4 VAL A4149
THR A4150
LEU A4155
ARG A4179
 None
None
None
CL  A4404 (-4.0A)
 0.99A 1s8fB-4o2wA:
undetectable		 1s8fB-4o2wA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 VAL A1949
THR A1940
GLU A1955
LEU A1953
 None
 1.12A 1s8fB-4o9xA:
undetectable		 1s8fB-4o9xA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A 119
THR A 120
LEU A 115
ARG A 116
 None
 1.09A 1s8fB-4rvwA:
undetectable		 1s8fB-4rvwA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 VAL A 160
GLU A 176
LEU A 187
PHE A 191
 None
 1.04A 1s8fB-4uwqA:
undetectable		 1s8fB-4uwqA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		4 VAL A 502
THR A 503
GLU A 505
LEU A 410
 None
 1.13A 1s8fB-4ux8A:
undetectable		 1s8fB-4ux8A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN BL28M,
MRPL28

(Sus scrofa) 		PF00830
(Ribosomal_L28) 		4 VAL 1 125
THR 1 124
LEU 1 114
ARG 1 122
 None
 1.09A 1s8fB-4v191:
undetectable		 1s8fB-4v191:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 VAL A 180
THR A 179
GLU A 182
PHE A 160
 None
 1.07A 1s8fB-4yycA:
1.9		 1s8fB-4yycA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 VAL A 258
THR A 244
GLU A 260
LEU A 302
 None
 1.13A 1s8fB-4zoyA:
undetectable		 1s8fB-4zoyA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 VAL A1352
GLU A1308
LEU A1310
ARG A1312
 None
 1.12A 1s8fB-5f3yA:
undetectable		 1s8fB-5f3yA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 VAL A  75
LEU A  66
ARG A  64
PHE A  67
 None
 1.13A 1s8fB-5ljoA:
undetectable		 1s8fB-5ljoA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 4 VAL A 262
THR A 265
GLU A  35
LEU A  32
 None
 1.03A 1s8fB-5m41A:
undetectable		 1s8fB-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrg TAR DNA-BINDING
PROTEIN 43

(Homo sapiens) 		no annotation 4 VAL A  19
THR A  20
LEU A  83
ARG A  56
 None
 1.10A 1s8fB-5mrgA:
undetectable		 1s8fB-5mrgA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		4 VAL A 505
THR A 504
LEU A 531
ARG A 533
 None
 0.94A 1s8fB-5nv6A:
undetectable		 1s8fB-5nv6A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 4 GLU B 208
LEU B 228
ARG B 227
PHE B 229
 None
 1.10A 1s8fB-5op0B:
undetectable		 1s8fB-5op0B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 GLU A  93
LEU A  91
ARG A 232
PHE A 233
 None
 1.04A 1s8fB-5ts5A:
undetectable		 1s8fB-5ts5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 4 GLU A 112
LEU A 110
ARG A 251
PHE A 252
 None
 0.97A 1s8fB-5z2gA:
2.2		 1s8fB-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 247
THR A 246
GLU A 275
LEU A 269
 None
 1.11A 1s8fB-6aooA:
4.5		 1s8fB-6aooA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 VAL A  89
LEU A  92
ARG A 243
PHE A 180
 None
 1.10A 1s8fB-6b92A:
undetectable		 1s8fB-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1

(Homo sapiens;
Gallus gallus) 		no annotation
no annotation 		4 VAL A1101
THR A1102
LEU A1053
PHE B  58
 None
 1.08A 1s8fB-6c7yA:
undetectable		 1s8fB-6c7yA:
undetectable