SIMILAR PATTERNS OF AMINO ACIDS FOR 1S8F_A_BEZA1502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 HIS A 632
ILE A 659
GLN A 655
PHE A 628
 None
 1.27A 1s8fA-3v5qA:
0.0
1s8fB-3v5qA:
0.0		 1s8fA-3v5qA:
21.38
1s8fB-3v5qA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 HIS A 273
ILE A 290
GLN A 336
PHE A 280
 None
 1.24A 1s8fA-4lg8A:
0.0
1s8fB-4lg8A:
0.0		 1s8fA-4lg8A:
20.12
1s8fB-4lg8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 HIS A 330
ILE A 229
GLN A 195
PHE A 227
 None
 1.23A 1s8fA-4xoxA:
0.0
1s8fB-4xoxA:
0.0		 1s8fA-4xoxA:
16.75
1s8fB-4xoxA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 HIS B 251
ILE B 217
GLN B 235
PHE B 222
 None
 1.44A 1s8fA-5m5xB:
0.0
1s8fB-5m5xB:
0.0		 1s8fA-5m5xB:
10.12
1s8fB-5m5xB:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 4 HIS A 257
ILE A  38
GLN A 278
PHE A 304
 None
 1.50A 1s8fA-5yu1A:
2.4
1s8fB-5yu1A:
0.0		 1s8fA-5yu1A:
undetectable
1s8fB-5yu1A:
undetectable