SIMILAR PATTERNS OF AMINO ACIDS FOR 1S1X_A_NVPA999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		4 LEU A  61
VAL A 264
GLY A 263
LEU A 179
 None
 1.03A 1s1xA-1bt4A:
undetectable		 1s1xA-1bt4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl3 PROTEIN
(PHOSPHORIBOSYLANTRA
NILATE ISOMERASE)

(Thermotoga
maritima) 		PF00697
(PRAI) 		4 LEU A 124
VAL A  57
TYR A  25
GLY A  27
 None
 0.93A 1s1xA-1dl3A:
undetectable		 1s1xA-1dl3A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		4 LEU A 159
VAL A  78
GLY A  46
LEU A  83
 None
 1.04A 1s1xA-1fztA:
undetectable		 1s1xA-1fztA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 574
TYR A 143
LEU A 151
TYR A 578
 None
 0.78A 1s1xA-1g8kA:
undetectable		 1s1xA-1g8kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 VAL A 331
TYR A 165
GLY A 330
TYR A 298
 None
None
None
FAD  A 579 (-4.4A)
 0.81A 1s1xA-1h81A:
0.0		 1s1xA-1h81A:
21.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 VAL A 106
TYR A 181
TYR A 188
GLY A 190
 None
 0.51A 1s1xA-1harA:
12.0		 1s1xA-1harA:
93.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 166
TYR A 213
GLY A 206
LEU A 272
 None
 0.95A 1s1xA-1kgpA:
undetectable		 1s1xA-1kgpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 LEU A 344
TYR A  94
GLY A  91
TYR A 348
 None
 1.03A 1s1xA-1krmA:
undetectable		 1s1xA-1krmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 LEU A 213
VAL A 134
GLY A 136
LEU A  27
 None
 0.90A 1s1xA-1lkdA:
undetectable		 1s1xA-1lkdA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 331
VAL A  17
GLY A  16
LEU A 301
 None
 0.97A 1s1xA-1mzjA:
0.0		 1s1xA-1mzjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LEU A 317
VAL A 295
GLY A 294
LEU A 360
 None
 0.94A 1s1xA-1qh4A:
3.2		 1s1xA-1qh4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LEU A 312
VAL A 290
GLY A 289
LEU A 355
 None
 0.93A 1s1xA-1qk1A:
2.7		 1s1xA-1qk1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 275
VAL A 262
TYR A 252
GLY A  32
 None
 0.99A 1s1xA-1tkcA:
undetectable		 1s1xA-1tkcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01135
(PCMT) 		4 LEU A  29
TYR A  83
GLY A  80
LEU A  45
 None
 0.96A 1s1xA-1vbfA:
undetectable		 1s1xA-1vbfA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.86A 1s1xA-1wzaA:
undetectable		 1s1xA-1wzaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		4 LEU A 192
GLY A  23
LEU A  16
TYR A 196
 None
 0.82A 1s1xA-1xcrA:
undetectable		 1s1xA-1xcrA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		4 LEU A  84
TYR A 109
LEU A 116
TYR A 418
 None
 1.01A 1s1xA-2bdeA:
undetectable		 1s1xA-2bdeA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 516
TYR A 478
GLY A 476
LEU A 450
 None
 1.00A 1s1xA-2bklA:
undetectable		 1s1xA-2bklA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL A 127
TYR A 123
GLY A 128
LEU A 193
 None
 0.94A 1s1xA-2d4wA:
4.2		 1s1xA-2d4wA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 LEU X 577
TYR X 513
GLY X 508
LEU X 451
 None
 0.88A 1s1xA-2epkX:
undetectable		 1s1xA-2epkX:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
VAL A 106
TYR A 181
TYR A 188
GLY A 190
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.57A 1s1xA-2hnzA:
35.7		 1s1xA-2hnzA:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 149
VAL A 123
GLY A 122
TYR A 144
 None
 0.92A 1s1xA-2ipcA:
undetectable		 1s1xA-2ipcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		4 LEU A 187
VAL A 200
GLY A 131
LEU A 214
 None
 0.98A 1s1xA-2jfnA:
undetectable		 1s1xA-2jfnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpt PUTATIVE SECRETED
PROTEIN

(Corynebacterium
glutamicum) 		PF04536
(TPM_phosphatase) 		4 LEU A 164
VAL A  79
GLY A 169
LEU A 117
 None
 1.03A 1s1xA-2kptA:
undetectable		 1s1xA-2kptA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 328
VAL A 375
GLY A 374
LEU A 324
 None
 1.03A 1s1xA-2nqlA:
undetectable		 1s1xA-2nqlA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 329
VAL A 376
GLY A 375
LEU A 325
 None
 0.98A 1s1xA-2ppgA:
undetectable		 1s1xA-2ppgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 LEU A 238
GLY A 243
LEU A 216
TYR A 235
 None
 0.96A 1s1xA-2pw6A:
undetectable		 1s1xA-2pw6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A 254
GLY A 362
LEU A 357
TYR A 256
 None
 0.93A 1s1xA-2qpmA:
2.1		 1s1xA-2qpmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 1.01A 1s1xA-2qtvB:
undetectable		 1s1xA-2qtvB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME

(Candida
albicans) 		PF09084
(NMT1) 		4 LEU A 124
VAL A 130
GLY A 129
LEU A 105
 None
 0.92A 1s1xA-2x7qA:
undetectable		 1s1xA-2x7qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 LEU A 669
TYR A 531
TYR A 678
GLY A 674
 None
 0.98A 1s1xA-2xaxA:
undetectable		 1s1xA-2xaxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y96 DUAL SPECIFICITY
PHOSPHATASE DUPD1

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A  76
VAL A  55
TYR A  63
GLY A  65
 None
SO4  A1208 (-4.1A)
None
None
 0.90A 1s1xA-2y96A:
undetectable		 1s1xA-2y96A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE

(Flavobacterium
frigidimaris) 		PF01370
(Epimerase) 		4 VAL A 165
TYR A 156
TYR A 157
TRP A 153
 None
None
None
PE8  A2002 (-4.8A)
 1.02A 1s1xA-2yy7A:
undetectable		 1s1xA-2yy7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		4 LEU A  90
VAL A 161
GLY A 158
LEU A  88
 None
 0.88A 1s1xA-2z9vA:
2.5		 1s1xA-2z9vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 LEU A 127
VAL A 152
LEU A  98
TYR A 126
 None
 0.87A 1s1xA-3bhwA:
undetectable		 1s1xA-3bhwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		4 LEU A  42
GLY A 260
LEU A 124
TYR A  48
 None
 0.77A 1s1xA-3bjxA:
undetectable		 1s1xA-3bjxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 LEU A  75
VAL A 274
GLY A 275
TYR A 107
 None
 0.86A 1s1xA-3c9fA:
undetectable		 1s1xA-3c9fA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 348
TYR A 186
GLY A 208
LEU A 178
 None
None
NAD  A 400 (-3.8A)
None
 1.03A 1s1xA-3cosA:
undetectable		 1s1xA-3cosA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 LEU A  77
VAL A  64
LEU A 115
TYR A  74
 None
 0.92A 1s1xA-3cs3A:
undetectable		 1s1xA-3cs3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7v O-SUCCINYLBENZOATE
SYNTHASE

(Thermosynechococcus
elongatus) 		PF13378
(MR_MLE_C) 		4 LEU A 162
GLY A 186
TRP A 135
LEU A 152
 None
 1.00A 1s1xA-3h7vA:
undetectable		 1s1xA-3h7vA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibs CONSERVED
HYPOTHETICAL PROTEIN
BATB

(Bacteroides
thetaiotaomicron) 		PF00092
(VWA) 		4 LEU A  12
VAL A 141
GLY A 140
LEU A  28
 None
 0.96A 1s1xA-3ibsA:
undetectable		 1s1xA-3ibsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		4 LEU A 544
TYR A 425
GLY A 419
LEU A 393
 None
 0.90A 1s1xA-3iukA:
undetectable		 1s1xA-3iukA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 4 LEU A 107
TYR A 374
GLY A 377
LEU A 157
 None
 0.86A 1s1xA-3j0hA:
undetectable		 1s1xA-3j0hA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm PRE-MRNA-SPLICING
FACTOR 6

(Saccharomyces
cerevisiae) 		PF06424
(PRP1_N) 		4 LEU G 828
TYR G 816
TRP G 844
LEU G 809
 None
 1.00A 1s1xA-3jcmG:
undetectable		 1s1xA-3jcmG:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 145
VAL A 119
GLY A 118
TYR A 140
 None
 1.04A 1s1xA-3juxA:
undetectable		 1s1xA-3juxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2d ABC-TYPE METAL ION
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Vibrio
vulnificus) 		PF03180
(Lipoprotein_9) 		4 LEU A 154
VAL A 131
GLY A 130
LEU A 196
 None
 0.95A 1s1xA-3k2dA:
undetectable		 1s1xA-3k2dA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		4 LEU A 298
VAL A 293
TYR A 284
GLY A 289
 None
 1.03A 1s1xA-3m4uA:
undetectable		 1s1xA-3m4uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 166
TYR A 213
GLY A 206
LEU A 272
 None
 0.99A 1s1xA-3mjoA:
undetectable		 1s1xA-3mjoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 LEU A  30
GLY A 153
LEU A 127
TYR A  26
 None
 0.98A 1s1xA-3oajA:
undetectable		 1s1xA-3oajA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 LEU A 138
VAL A 188
GLY A 185
LEU A 155
 None
 0.98A 1s1xA-3qfwA:
undetectable		 1s1xA-3qfwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2i EXOTOXIN 5

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 LEU A 231
TYR A 183
GLY A 185
LEU A 176
 None
 1.03A 1s1xA-3r2iA:
2.3		 1s1xA-3r2iA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLA

(Thermus
thermophilus) 		PF00025
(Arf) 		4 LEU A 124
TYR A  18
GLY A  98
LEU A 131
 None
 1.03A 1s1xA-3t12A:
undetectable		 1s1xA-3t12A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t20 CIS-ACONITATE PORIN
OPDH

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A 202
GLY A 174
LEU A 278
TYR A 206
 None
 0.76A 1s1xA-3t20A:
undetectable		 1s1xA-3t20A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii) 		PF00497
(SBP_bac_3) 		4 VAL A 230
TYR A 125
GLY A 231
TYR A  51
 None
None
None
ARG  A   1 (-3.6A)
 1.00A 1s1xA-3tqlA:
undetectable		 1s1xA-3tqlA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 LEU A 143
VAL A 127
GLY A 184
LEU A 199
 None
 0.88A 1s1xA-3uaiA:
2.0		 1s1xA-3uaiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU K 167
VAL K 178
GLY K 177
LEU K   4
 None
 0.92A 1s1xA-3wxrK:
undetectable		 1s1xA-3wxrK:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 1.01A 1s1xA-4bziB:
undetectable		 1s1xA-4bziB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		4 VAL A  58
TYR A 177
TYR A 174
GLY A 171
 None
 1.00A 1s1xA-4dr0A:
undetectable		 1s1xA-4dr0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 LEU A 886
GLY A 896
LEU A 853
TYR A 884
 None
 1.01A 1s1xA-4ecnA:
undetectable		 1s1xA-4ecnA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU A 405
GLY A 397
LEU A 460
TYR A 480
 None
 0.97A 1s1xA-4eqvA:
undetectable		 1s1xA-4eqvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 LEU A 241
GLY A 227
TRP A 253
LEU A  86
 None
 0.95A 1s1xA-4fajA:
undetectable		 1s1xA-4fajA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geq KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae) 		PF08286
(Spc24)
no annotation 		4 LEU A 210
TYR B 165
GLY B 169
LEU A 206
 None
 0.97A 1s1xA-4geqA:
undetectable		 1s1xA-4geqA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 LEU A 317
TYR A 308
GLY A 310
LEU A 303
 None
 0.95A 1s1xA-4gyoA:
undetectable		 1s1xA-4gyoA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS) 		4 LEU S 110
VAL S 144
GLY S 145
LEU S 114
 None
 0.84A 1s1xA-4hzuS:
undetectable		 1s1xA-4hzuS:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF00092
(VWA) 		4 LEU A  96
VAL A 225
GLY A 224
LEU A 112
 None
None
None
MLY  A 116 ( 4.5A)
 1.00A 1s1xA-4jduA:
2.0		 1s1xA-4jduA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		4 LEU A  69
VAL A 138
TYR A 135
GLY A 139
 GOL  A 301 ( 4.5A)
None
None
None
 1.03A 1s1xA-4jfcA:
undetectable		 1s1xA-4jfcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		4 LEU A 176
VAL A  39
TYR A  35
LEU A  67
 None
 1.02A 1s1xA-4jggA:
undetectable		 1s1xA-4jggA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxb INVASION-ASSOCIATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 LEU A  96
GLY A 109
LEU A 167
TYR A  91
 None
 0.90A 1s1xA-4jxbA:
undetectable		 1s1xA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN

(Pseudomonas
aeruginosa;
Vibrio cholerae) 		PF00437
(T2SSE)
PF05638
(T6SS_HCP) 		4 LEU A 370
VAL A 387
GLY A 386
LEU A 358
 None
 0.88A 1s1xA-4kssA:
undetectable		 1s1xA-4kssA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
LIGHT CHAIN OF E106
ANTIBODY (KAPPA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  89
TRP H  47
LEU H 100
TYR L  36
 None
 1.02A 1s1xA-4l5fL:
undetectable		 1s1xA-4l5fL:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 LEU A 233
GLY A 183
LEU A 176
TYR A 236
 None
 0.82A 1s1xA-4r3uA:
undetectable		 1s1xA-4r3uA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 LEU A 178
VAL A 208
GLY A 207
LEU A 107
 None
 1.04A 1s1xA-4yryA:
undetectable		 1s1xA-4yryA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 LEU A 205
TRP A 204
LEU A 290
TYR A 214
 None
 1.02A 1s1xA-4zhtA:
2.3		 1s1xA-4zhtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		4 LEU A 153
TYR A  58
GLY A  52
TYR A 154
 None
 0.69A 1s1xA-5a2oA:
undetectable		 1s1xA-5a2oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1

(Homo sapiens) 		no annotation 4 LEU A  50
VAL A  32
GLY A  29
TYR A  47
 None
 0.94A 1s1xA-5aj1A:
undetectable		 1s1xA-5aj1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwj SENSORY TRANSDUCTION
HISTIDINE KINASE,
PUTATIVE

(Borreliella
burgdorferi) 		PF00497
(SBP_bac_3) 		4 LEU A  97
VAL A  35
TYR A  88
GLY A  90
 None
 1.02A 1s1xA-5bwjA:
undetectable		 1s1xA-5bwjA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 VAL A 278
TYR A  12
GLY A  39
LEU A  56
 None
 1.03A 1s1xA-5bz3A:
undetectable		 1s1xA-5bz3A:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 VAL B 106
TYR B 181
TYR B 188
GLY B 190
 None
 0.39A 1s1xA-5c24B:
12.4		 1s1xA-5c24B:
96.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		4 LEU A 127
VAL A 103
TYR A 101
TYR A 124
 None
 0.87A 1s1xA-5c77A:
undetectable		 1s1xA-5c77A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 LEU A1884
VAL A1891
GLY A1890
LEU A1860
 None
 0.94A 1s1xA-5cslA:
2.1		 1s1xA-5cslA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgg UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 LEU A 224
VAL A 187
LEU A 148
TYR A 220
 None
 0.84A 1s1xA-5dggA:
undetectable		 1s1xA-5dggA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU B 124
VAL B 366
GLY B 367
TYR B 128
 None
 1.02A 1s1xA-5fwxB:
undetectable		 1s1xA-5fwxB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3b UNCHARACTERIZED
PROTEIN HI_1552

(Haemophilus
influenzae) 		PF04301
(DUF452) 		4 VAL A  70
TYR A  42
GLY A  67
LEU A  49
 None
 0.93A 1s1xA-5h3bA:
undetectable		 1s1xA-5h3bA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		4 VAL A 364
TYR A 361
GLY A 363
TYR A 408
 None
 0.90A 1s1xA-5i35A:
undetectable		 1s1xA-5i35A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		4 LEU A 771
VAL A 673
GLY A 788
LEU A 806
 None
 0.96A 1s1xA-5ijlA:
undetectable		 1s1xA-5ijlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 LEU A 435
GLY A 734
LEU A 760
TYR A 431
 None
 0.87A 1s1xA-5kufA:
undetectable		 1s1xA-5kufA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A  78
VAL A  39
GLY A 254
LEU A  47
 None
 1.01A 1s1xA-5l3sA:
undetectable		 1s1xA-5l3sA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 LEU A  36
VAL A  46
GLY A  45
LEU A 285
 None
 0.81A 1s1xA-5ll7A:
undetectable		 1s1xA-5ll7A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 LEU B 306
TYR B 318
TYR B 321
LEU B 295
 None
 0.92A 1s1xA-5nemB:
undetectable		 1s1xA-5nemB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 LEU B 439
VAL B 397
GLY B 444
TYR B 436
 None
 0.96A 1s1xA-5ofbB:
undetectable		 1s1xA-5ofbB:
9.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 VAL B 105
TYR B 180
TYR B 187
GLY B 189
 None
 0.28A 1s1xA-5ovnB:
11.1		 1s1xA-5ovnB:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcs KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae) 		PF08286
(Spc24)
no annotation 		4 LEU D 210
TYR C 165
GLY C 169
LEU D 206
 None
 0.97A 1s1xA-5tcsD:
undetectable		 1s1xA-5tcsD:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ua0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A  92
VAL A 113
TYR A 110
GLY A 114
 None
 0.98A 1s1xA-5ua0A:
undetectable		 1s1xA-5ua0A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 658
VAL A 692
GLY A 651
TRP A 646
 None
None
GLC  A 709 (-3.4A)
None
 0.89A 1s1xA-5ww1A:
undetectable		 1s1xA-5ww1A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 141
GLY A 144
LEU A  34
TYR A 129
 None
 0.92A 1s1xA-5xhxA:
undetectable		 1s1xA-5xhxA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S16,
PUTATIVE
40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE

(Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7)
PF00380
(Ribosomal_S9) 		4 LEU Q  41
TYR Q  76
GLY Q  70
LEU F  76
 None
None
U  21414 ( 3.2A)
C  21334 ( 3.7A)
 1.00A 1s1xA-5xyiQ:
undetectable		 1s1xA-5xyiQ:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 4 LEU I  27
VAL I  64
TYR I  66
LEU I  81
 None
 0.95A 1s1xA-6az1I:
undetectable		 1s1xA-6az1I:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 LEU A 537
VAL A 498
TYR A 282
GLY A 499
 None
 0.76A 1s1xA-6bfuA:
undetectable		 1s1xA-6bfuA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 LEU A 747
VAL A 621
GLY A 391
LEU A 743
 None
 0.97A 1s1xA-6fikA:
undetectable		 1s1xA-6fikA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fk6 RHODOPSIN

(Bos taurus) 		no annotation 4 LEU A  46
VAL A 300
GLY A  51
TYR A  43
 None
 0.97A 1s1xA-6fk6A:
undetectable		 1s1xA-6fk6A:
8.75