SIMILAR PATTERNS OF AMINO ACIDS FOR 1RXC_D_URFD2021_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw1 TRIOSEPHOSPHATE
ISOMERASE

(Moritella
marina) 		PF00121
(TIM) 		4 GLY A 212
GLN A 210
MET A   7
ILE A 174
 PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
 0.93A 1rxcD-1aw1A:
undetectable		 1rxcD-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		4 GLY A 124
GLN A 148
ARG A 155
ILE A 122
 None
 1.03A 1rxcD-1czkA:
2.9		 1rxcD-1czkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 427
ILE A 423
VAL A 361
PRO A 349
 None
 1.07A 1rxcD-1ebdA:
undetectable		 1rxcD-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0y INTERLEUKIN-1
RECEPTOR, TYPE I

(Homo sapiens) 		PF07679
(I-set)
PF13895
(Ig_2) 		4 GLY R 121
GLN R 113
ILE R 165
VAL R 166
 None
 0.91A 1rxcD-1g0yR:
undetectable		 1rxcD-1g0yR:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 GLY A 232
MET A 384
ILE A 230
PRO A 236
 None
 1.01A 1rxcD-1iv8A:
undetectable		 1rxcD-1iv8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 1rxcD-1o4sA:
undetectable		 1rxcD-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 GLY C 301
MET C 293
ILE C 303
VAL C 304
 None
 0.94A 1rxcD-1oedC:
undetectable		 1rxcD-1oedC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  54
ILE A  60
VAL A  61
PRO A 122
 None
 1.03A 1rxcD-1pl8A:
2.4		 1rxcD-1pl8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 GLN A 406
ILE A 332
VAL A 328
PRO A 211
 None
 0.85A 1rxcD-1q50A:
2.8		 1rxcD-1q50A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu7 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN I

(Escherichia
coli) 		PF00015
(MCPsignal) 		4 GLY A 370
GLN A 374
ILE A 368
VAL A 367
 None
 1.08A 1rxcD-1qu7A:
undetectable		 1rxcD-1qu7A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 GLY A 207
GLN A  84
ARG A 306
ILE A 324
 None
 1.03A 1rxcD-1rdrA:
undetectable		 1rxcD-1rdrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 ARG A 224
MET A 474
ILE A 323
PRO A 168
 None
 0.92A 1rxcD-1sy7A:
undetectable		 1rxcD-1sy7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wol 122AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF05168
(HEPN) 		4 GLY A  44
GLN A  49
ILE A   8
VAL A   4
 None
 1.08A 1rxcD-1wolA:
undetectable		 1rxcD-1wolA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.05A 1rxcD-1wr8A:
undetectable		 1rxcD-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 GLY A 207
GLN A  84
ARG A 305
ILE A 323
 None
 0.96A 1rxcD-1xr6A:
undetectable		 1rxcD-1xr6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y25 PROBABLE THIOL
PEROXIDASE

(Mycobacterium
tuberculosis) 		PF08534
(Redoxin) 		4 GLY A  35
ARG A 108
ILE A  37
VAL A  36
 None
 1.04A 1rxcD-1y25A:
undetectable		 1rxcD-1y25A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0r POSSIBLE ADENYL
CYCLASE-ASSOCIATED
PROTEIN

(Cryptosporidium
parvum) 		PF08603
(CAP_C) 		4 GLY A 108
ILE A 128
VAL A 129
PRO A 130
 None
 0.99A 1rxcD-2b0rA:
undetectable		 1rxcD-2b0rA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13411
(MerR_1) 		4 GLY A  57
GLN A 192
VAL A  59
PRO A  90
 None
 1.02A 1rxcD-2dg6A:
undetectable		 1rxcD-2dg6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyy UPF0076 PROTEIN
PH0854

(Pyrococcus
horikoshii) 		PF01042
(Ribonuc_L-PSP) 		4 GLY A  45
ILE A  42
VAL A  43
PRO A  34
 None
 0.95A 1rxcD-2dyyA:
undetectable		 1rxcD-2dyyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		4 GLN A 111
ILE A  70
VAL A  73
PRO A  98
 None
 1.02A 1rxcD-2f6kA:
undetectable		 1rxcD-2f6kA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 GLY A 293
ILE A 240
VAL A 292
PRO A 303
 None
 1.00A 1rxcD-2gmhA:
undetectable		 1rxcD-2gmhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 GLY 1 390
GLN 1 267
ARG 1 489
ILE 1 507
 None
 1.00A 1rxcD-2ijd1:
undetectable		 1rxcD-2ijd1:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		4 GLY A  94
GLN A 283
ILE A  90
PRO A 155
 None
 1.00A 1rxcD-2iluA:
undetectable		 1rxcD-2iluA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF12401
(DUF3662) 		4 GLY A  29
ILE A  31
VAL A  32
PRO A  33
 None
 0.99A 1rxcD-2lc0A:
undetectable		 1rxcD-2lc0A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1

(Mus musculus) 		PF00595
(PDZ) 		4 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.94A 1rxcD-2mx6A:
undetectable		 1rxcD-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		4 GLY A 660
GLN A 643
ILE A 704
VAL A 661
 None
 1.01A 1rxcD-2oceA:
undetectable		 1rxcD-2oceA:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 GLY A1096
GLN A1166
ARG A1168
MET A1197
VAL A1221
 None
 0.77A 1rxcD-2oxfA:
43.8		 1rxcD-2oxfA:
97.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		4 GLY A1096
GLN A1166
ILE A1220
VAL A1221
 None
 0.71A 1rxcD-2oxfA:
43.8		 1rxcD-2oxfA:
97.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 GLY A  74
GLN A  71
ILE A  83
VAL A  78
 None
 1.03A 1rxcD-2pbiA:
undetectable		 1rxcD-2pbiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 GLY A 549
MET A 445
ILE A 440
VAL A 550
 None
 1.03A 1rxcD-2qqpA:
undetectable		 1rxcD-2qqpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC

(Thermotoga
maritima) 		PF01558
(POR) 		4 GLY A  19
MET A  26
ILE A  79
PRO A 137
 SO4  A 193 (-3.4A)
None
None
None
 1.07A 1rxcD-2raaA:
undetectable		 1rxcD-2raaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS) 		4 GLY A 199
GLN A 320
ILE A 312
VAL A 313
 AMP  A1324 ( 4.8A)
None
AMP  A1324 (-3.7A)
None
 1.04A 1rxcD-2uv7A:
undetectable		 1rxcD-2uv7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 GLY A 278
MET A 250
ILE A 359
VAL A 358
 None
 0.95A 1rxcD-2vr2A:
undetectable		 1rxcD-2vr2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 GLY A 564
ILE A 568
VAL A 569
PRO A 570
 None
 1.05A 1rxcD-2vycA:
undetectable		 1rxcD-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		4 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.91A 1rxcD-2wu8A:
undetectable		 1rxcD-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.94A 1rxcD-2xheA:
undetectable		 1rxcD-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 GLY A 123
ILE A 131
VAL A 126
PRO A 133
 None
 1.00A 1rxcD-2zm2A:
undetectable		 1rxcD-2zm2A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 GLY A 137
MET A 106
ILE A  80
VAL A 135
 None
 1.03A 1rxcD-3a1iA:
undetectable		 1rxcD-3a1iA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 GLY B  28
MET B  61
ILE B 190
VAL B  50
 FAD  B   1 ( 4.8A)
FAD  B   1 (-3.8A)
None
None
 0.99A 1rxcD-3adaB:
undetectable		 1rxcD-3adaB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus) 		PF01351
(RNase_HII)
PF11858
(DUF3378) 		4 GLY A 269
ILE A 271
VAL A 272
PRO A 265
 None
 1.08A 1rxcD-3asmA:
undetectable		 1rxcD-3asmA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		4 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.18A 1rxcD-3bjeA:
30.7		 1rxcD-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		4 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.01A 1rxcD-3epjA:
2.8		 1rxcD-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 GLY A 143
GLN A 217
ARG A 219
MET A 249
 BAU  A 400 (-3.3A)
BAU  A 400 (-3.1A)
BAU  A 400 (-3.0A)
BAU  A 400 (-3.8A)
 0.28A 1rxcD-3eufA:
26.7		 1rxcD-3eufA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 GLY A  56
GLN A  53
ILE A 170
VAL A 166
 None
 1.09A 1rxcD-3flbA:
3.6		 1rxcD-3flbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 237
MET A 209
ILE A 239
VAL A 240
 None
 0.94A 1rxcD-3gdoA:
undetectable		 1rxcD-3gdoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 355
ILE A 247
VAL A  87
PRO A 242
 None
 0.96A 1rxcD-3h5qA:
3.3		 1rxcD-3h5qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h95 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		PF00293
(NUDIX) 		4 GLY A 145
GLN A 143
ILE A 225
VAL A 146
 None
 0.97A 1rxcD-3h95A:
undetectable		 1rxcD-3h95A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 GLY A 226
MET A 382
ILE A 224
PRO A 230
 None
 1.00A 1rxcD-3hjeA:
undetectable		 1rxcD-3hjeA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 1rxcD-3kvyA:
26.9		 1rxcD-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odh OKRAI ENDONUCLEASE

(Oceanobacter
kriegii) 		PF02923
(BamHI) 		4 GLY A 118
ILE A  76
VAL A  74
PRO A  82
 None
 0.91A 1rxcD-3odhA:
undetectable		 1rxcD-3odhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oga NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Salmonella
enterica) 		PF00293
(NUDIX) 		4 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
None
BME  A 142 ( 4.7A)
None
 0.94A 1rxcD-3ogaA:
undetectable		 1rxcD-3ogaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5

(Saccharomyces
cerevisiae) 		PF00397
(WW)
PF00632
(HECT) 		4 GLY A 553
MET A 664
ILE A 688
VAL A 556
 None
 0.99A 1rxcD-3olmA:
undetectable		 1rxcD-3olmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 GLY A 149
GLN A 223
ARG A 225
MET A 255
 BAU  A 400 (-3.5A)
BAU  A 400 (-3.1A)
BAU  A 400 (-2.8A)
BAU  A 400 (-3.9A)
 0.23A 1rxcD-3p0fA:
26.6		 1rxcD-3p0fA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6l SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 GLY A 103
GLN A  37
ILE A 101
VAL A 102
 None
CIT  A 303 ( 3.9A)
None
None
 1.06A 1rxcD-3p6lA:
undetectable		 1rxcD-3p6lA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  52
GLN A  80
ARG A  88
ILE A 103
 None
 1.01A 1rxcD-3p94A:
4.7		 1rxcD-3p94A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 146
MET A 172
ILE A 143
PRO A 352
 None
 0.96A 1rxcD-3u37A:
undetectable		 1rxcD-3u37A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		4 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.07A 1rxcD-3uqeA:
undetectable		 1rxcD-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		4 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.86A 1rxcD-3wbnA:
undetectable		 1rxcD-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		4 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.00A 1rxcD-4c1lA:
undetectable		 1rxcD-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 295
GLN A 326
ILE A 300
VAL A 297
 None
 1.07A 1rxcD-4c2kA:
undetectable		 1rxcD-4c2kA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 GLY A 225
MET A 243
ILE A 134
VAL A 133
 None
 1.07A 1rxcD-4cgtA:
undetectable		 1rxcD-4cgtA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 GLN D 349
ILE D 275
VAL D 271
PRO D 161
 None
 0.90A 1rxcD-4em6D:
undetectable		 1rxcD-4em6D:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 GLY A 427
GLN A 431
VAL A 417
PRO A 447
 None
 0.94A 1rxcD-4fajA:
undetectable		 1rxcD-4fajA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 GLY A 100
GLN A 313
ILE A 110
VAL A 113
 None
 1.08A 1rxcD-4grsA:
undetectable		 1rxcD-4grsA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE

(Thermotoga
maritima) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.08A 1rxcD-4jxcA:
undetectable		 1rxcD-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.93A 1rxcD-4kg7A:
undetectable		 1rxcD-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 GLY A 438
ARG A 380
ILE A 440
PRO A 381
 None
 1.07A 1rxcD-4ksaA:
undetectable		 1rxcD-4ksaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM

(Caldanaerobacter
subterraneus) 		PF01891
(CbiM) 		4 GLY A 101
GLN A  94
MET A  54
ILE A   3
 None
 1.03A 1rxcD-4m5bA:
undetectable		 1rxcD-4m5bA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me8 SIGNAL PEPTIDASE I

(Enterococcus
faecalis) 		PF00717
(Peptidase_S24) 		4 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.93A 1rxcD-4me8A:
undetectable		 1rxcD-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 185
GLN A 190
VAL A 183
PRO A  86
 None
 1.08A 1rxcD-4mrqA:
undetectable		 1rxcD-4mrqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.00A 1rxcD-4nfyA:
2.1		 1rxcD-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 GLY A 270
MET A 276
ILE A 287
VAL A 288
 None
 0.78A 1rxcD-4qgsA:
undetectable		 1rxcD-4qgsA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		7 GLY A  93
GLN A 163
ARG A 165
MET A 194
ILE A 217
VAL A 218
PRO A 226
 None
None
None
GOL  A 303 (-3.5A)
None
None
None
 0.33A 1rxcD-4r2wA:
43.4		 1rxcD-4r2wA:
75.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		6 GLY A  94
GLN A 164
ARG A 166
MET A 195
ILE A 218
VAL A 219
 None
None
None
GOL  A 301 (-4.0A)
None
None
 0.68A 1rxcD-4r31A:
42.3		 1rxcD-4r31A:
66.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 GLY A 361
GLN A 397
ARG A 393
VAL A 365
 CL  A 505 (-3.5A)
None
None
None
 0.98A 1rxcD-4r6hA:
undetectable		 1rxcD-4r6hA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		4 GLN A 157
ILE A 198
VAL A 150
PRO A 151
 None
 1.08A 1rxcD-4rm4A:
undetectable		 1rxcD-4rm4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Desulfitobacterium
hafniense) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  60
GLN A  95
ARG A 103
ILE A 118
 None
 1.08A 1rxcD-4rshA:
undetectable		 1rxcD-4rshA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION FACTOR
CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C)
PF13072
(DUF3936) 		4 GLY A  37
MET J   6
ILE A  14
VAL A  38
 None
 1.03A 1rxcD-4u39A:
2.4		 1rxcD-4u39A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 339
MET A 332
ILE A 317
PRO A 150
 None
8ID  A 403 ( 4.7A)
None
None
 1.08A 1rxcD-4w6zA:
undetectable		 1rxcD-4w6zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		4 GLY A 207
GLN A  84
ARG A 307
ILE A 325
 None
 0.97A 1rxcD-4zpdA:
undetectable		 1rxcD-4zpdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		4 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.91A 1rxcD-4zxwA:
undetectable		 1rxcD-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14) 		PF17515
(CPV_Polyhedrin) 		4 GLY A 176
MET A 173
ILE A 115
VAL A 177
 None
 1.05A 1rxcD-5a96A:
undetectable		 1rxcD-5a96A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmt UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		no annotation 4 GLY A 207
MET A 213
ILE A 142
VAL A 205
 None
 1.08A 1rxcD-5bmtA:
undetectable		 1rxcD-5bmtA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF05108
(T7SS_ESX1_EccB) 		4 GLY A 366
ILE A 364
VAL A 180
PRO A 370
 None
 1.07A 1rxcD-5cyuA:
undetectable		 1rxcD-5cyuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 355
ILE A 247
VAL A  87
PRO A 242
 GLY  A 355 ( 0.0A)
ILE  A 247 ( 0.6A)
VAL  A  87 ( 0.6A)
PRO  A 242 ( 1.1A)
 0.94A 1rxcD-5ep8A:
3.2		 1rxcD-5ep8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 GLY A 355
GLN A 584
ILE A 263
VAL A 262
 None
 1.01A 1rxcD-5f7uA:
undetectable		 1rxcD-5f7uA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 GLY A 222
GLN A 248
ILE A 219
VAL A 218
 GOL  A 607 (-3.3A)
GOL  A 607 ( 4.1A)
None
None
 1.02A 1rxcD-5htkA:
undetectable		 1rxcD-5htkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2q SERINE/THREONINE-PRO
TEIN KINASE 40

(Homo sapiens) 		no annotation 4 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.95A 1rxcD-5l2qC:
undetectable		 1rxcD-5l2qC:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.26A 1rxcD-5lhvA:
43.7		 1rxcD-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofu FBP PROTEIN

(Leishmania
major) 		PF00316
(FBPase) 		4 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.88A 1rxcD-5ofuA:
undetectable		 1rxcD-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		4 GLY A 119
MET A  80
ILE A  30
VAL A  29
 None
 1.03A 1rxcD-5pepA:
undetectable		 1rxcD-5pepA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 GLY A 174
ILE A 178
VAL A 175
PRO A 429
 None
 1.04A 1rxcD-5uohA:
undetectable		 1rxcD-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 4 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.08A 1rxcD-5uz5G:
undetectable		 1rxcD-5uz5G:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		4 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.87A 1rxcD-5vatA:
2.2		 1rxcD-5vatA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 GLY A 509
ARG A 501
ILE A 140
VAL A 138
 None
 0.97A 1rxcD-5wzrA:
undetectable		 1rxcD-5wzrA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 4 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.85A 1rxcD-5xnzA:
undetectable		 1rxcD-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 GLY A 372
ARG A 459
VAL A 368
PRO A 389
 None
 1.02A 1rxcD-5yl7A:
undetectable		 1rxcD-5yl7A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 GLY A 915
GLN A 582
ILE A 563
PRO A 938
 NAG  A1914 ( 4.9A)
None
None
NAG  A1914 ( 4.6A)
 0.95A 1rxcD-6bfuA:
undetectable		 1rxcD-6bfuA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F

(Pyrococcus
furiosus) 		no annotation 4 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.05A 1rxcD-6cfwF:
undetectable		 1rxcD-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Klebsiella
pneumoniae) 		no annotation 4 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.94A 1rxcD-6dt3A:
undetectable		 1rxcD-6dt3A:
15.87