SIMILAR PATTERNS OF AMINO ACIDS FOR 1RXC_C_URFC2081

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw1 TRIOSEPHOSPHATE
ISOMERASE


(Moritella
marina)
PF00121
(TIM)
4 GLY A 212
GLN A 210
MET A   7
ILE A 174
PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
0.95A 1rxcC-1aw1A:
undetectable
1rxcC-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0y INTERLEUKIN-1
RECEPTOR, TYPE I


(Homo sapiens)
PF07679
(I-set)
PF13895
(Ig_2)
4 GLY R 121
GLN R 113
ILE R 165
VAL R 166
None
0.86A 1rxcC-1g0yR:
undetectable
1rxcC-1g0yR:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE


(Thermotoga
maritima)
PF00155
(Aminotran_1_2)
4 GLY A 244
MET A 238
ILE A 267
VAL A  94
None
0.93A 1rxcC-1o4sA:
undetectable
1rxcC-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN


(Torpedo
marmorata)
PF02932
(Neur_chan_memb)
4 GLY C 301
MET C 293
ILE C 303
VAL C 304
None
0.88A 1rxcC-1oedC:
undetectable
1rxcC-1oedC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2


(Synechocystis
sp. PCC 6803)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
4 GLY A 341
MET A  47
ILE A 339
PRO A 288
None
1.06A 1rxcC-1ofeA:
undetectable
1rxcC-1ofeA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
4 GLY A 344
ILE A  39
VAL A 378
PRO A 379
None
1.00A 1rxcC-1p49A:
undetectable
1rxcC-1p49A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Leishmania
mexicana)
PF00342
(PGI)
4 GLN A 406
ILE A 332
VAL A 328
PRO A 211
None
0.90A 1rxcC-1q50A:
2.6
1rxcC-1q50A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE


(Enterovirus C)
PF00680
(RdRP_1)
4 GLY A 207
GLN A  84
ARG A 306
ILE A 324
None
1.05A 1rxcC-1rdrA:
undetectable
1rxcC-1rdrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa)
PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel)
4 ARG A 224
MET A 474
ILE A 323
PRO A 168
None
0.95A 1rxcC-1sy7A:
undetectable
1rxcC-1sy7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 GLY A 214
ARG A  88
ILE A 216
VAL A 217
FUM  A1311 ( 4.8A)
FUM  A1311 (-4.0A)
None
None
0.88A 1rxcC-1uxiA:
undetectable
1rxcC-1uxiA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE


(Pyrococcus
horikoshii)
PF08282
(Hydrolase_3)
4 GLY A 176
GLN A 196
ILE A   8
VAL A 175
None
1.01A 1rxcC-1wr8A:
3.4
1rxcC-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN


(Yersinia pestis)
PF07201
(HrpJ)
PF09059
(TyeA)
4 GLY C  10
GLN A 220
ILE C  12
VAL C  13
None
0.93A 1rxcC-1xl3C:
undetectable
1rxcC-1xl3C:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A)
PF00680
(RdRP_1)
4 GLY A 207
GLN A  84
ARG A 305
ILE A 323
None
0.99A 1rxcC-1xr6A:
undetectable
1rxcC-1xr6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0r POSSIBLE ADENYL
CYCLASE-ASSOCIATED
PROTEIN


(Cryptosporidium
parvum)
PF08603
(CAP_C)
4 GLY A 108
ILE A 128
VAL A 129
PRO A 130
None
1.02A 1rxcC-2b0rA:
undetectable
1rxcC-2b0rA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF13411
(MerR_1)
4 GLY A  57
GLN A 192
VAL A  59
PRO A  90
None
0.98A 1rxcC-2dg6A:
undetectable
1rxcC-2dg6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyy UPF0076 PROTEIN
PH0854


(Pyrococcus
horikoshii)
PF01042
(Ribonuc_L-PSP)
4 GLY A  45
ILE A  42
VAL A  43
PRO A  34
None
0.84A 1rxcC-2dyyA:
undetectable
1rxcC-2dyyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE


(Lactobacillus
plantarum)
PF04909
(Amidohydro_2)
4 GLN A 111
ILE A  70
VAL A  73
PRO A  98
None
1.05A 1rxcC-2f6kA:
undetectable
1rxcC-2f6kA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
4 GLY A 293
ILE A 240
VAL A 292
PRO A 303
None
0.99A 1rxcC-2gmhA:
undetectable
1rxcC-2gmhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis)
PF00496
(SBP_bac_5)
4 GLY A 588
GLN A 253
VAL A 585
PRO A 278
None
1.05A 1rxcC-2grvA:
undetectable
1rxcC-2grvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 GLY A 231
ARG A 100
ILE A 233
VAL A 234
None
CIT  A2001 (-3.9A)
None
None
0.97A 1rxcC-2hjrA:
undetectable
1rxcC-2hjrA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE


(Enterovirus C)
PF00548
(Peptidase_C3)
PF00680
(RdRP_1)
4 GLY 1 390
GLN 1 267
ARG 1 489
ILE 1 507
None
1.03A 1rxcC-2ijd1:
undetectable
1rxcC-2ijd1:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A


(Escherichia
coli)
PF00171
(Aldedh)
4 GLY A  94
GLN A 283
ILE A  90
PRO A 155
None
0.96A 1rxcC-2iluA:
2.0
1rxcC-2iluA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8


(Mycobacterium
tuberculosis)
PF12401
(DUF3662)
4 GLY A  29
ILE A  31
VAL A  32
PRO A  33
None
0.94A 1rxcC-2lc0A:
undetectable
1rxcC-2lc0A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT


(Lactobacillus
plantarum)
PF00890
(FAD_binding_2)
4 GLY A  29
GLN A  49
ILE A 107
VAL A 108
None
1.05A 1rxcC-2lfcA:
undetectable
1rxcC-2lfcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1


(Mus musculus)
PF00595
(PDZ)
4 GLY A 281
MET A 284
ILE A 266
VAL A 267
None
1.00A 1rxcC-2mx6A:
undetectable
1rxcC-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201


(Pseudomonas
aeruginosa)
PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF)
4 GLY A 660
GLN A 643
ILE A 704
VAL A 661
None
0.98A 1rxcC-2oceA:
undetectable
1rxcC-2oceA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofq TRAO

(IncN plasmid
R46)
PF03524
(CagX)
4 GLY A 263
ILE A 255
VAL A 262
PRO A 197
None
1.06A 1rxcC-2ofqA:
undetectable
1rxcC-2ofqA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxf URIDINE
PHOSPHORYLASE


(Salmonella
enterica)
PF01048
(PNP_UDP_1)
5 GLY A1096
GLN A1166
ARG A1168
ILE A1220
VAL A1221
None
0.86A 1rxcC-2oxfA:
43.3
1rxcC-2oxfA:
97.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxf URIDINE
PHOSPHORYLASE


(Salmonella
enterica)
PF01048
(PNP_UDP_1)
5 GLY A1096
GLN A1166
ARG A1168
MET A1197
VAL A1221
None
0.65A 1rxcC-2oxfA:
43.3
1rxcC-2oxfA:
97.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus)
PF03566
(Peptidase_A21)
4 GLY A 549
MET A 445
ILE A 440
VAL A 550
None
1.03A 1rxcC-2qqpA:
undetectable
1rxcC-2qqpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC


(Thermotoga
maritima)
PF01558
(POR)
4 GLY A  19
MET A  26
ILE A  79
PRO A 137
SO4  A 193 (-3.4A)
None
None
None
1.06A 1rxcC-2raaA:
undetectable
1rxcC-2raaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00571
(CBS)
4 GLY A 199
GLN A 320
ILE A 312
VAL A 313
AMP  A1324 ( 4.8A)
None
AMP  A1324 (-3.7A)
None
1.04A 1rxcC-2uv7A:
undetectable
1rxcC-2uv7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE


(Escherichia
coli)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
4 GLY A 564
ILE A 568
VAL A 569
PRO A 570
None
1.06A 1rxcC-2vycA:
undetectable
1rxcC-2vycA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Mycobacterium
tuberculosis)
PF00342
(PGI)
4 GLN A 353
ILE A 279
VAL A 275
PRO A 164
None
0.91A 1rxcC-2wu8A:
undetectable
1rxcC-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis)
PF00995
(Sec1)
4 GLN A 199
ARG A 500
ILE A 211
VAL A 206
None
0.96A 1rxcC-2xheA:
undetectable
1rxcC-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE


(Flavobacterium
sp.)
PF00144
(Beta-lactamase)
4 GLY A 123
ILE A 131
VAL A 126
PRO A 133
None
1.02A 1rxcC-2zm2A:
undetectable
1rxcC-2zm2A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE


(Trypanosoma
brucei)
PF01048
(PNP_UDP_1)
4 GLY A 142
GLN A 246
ARG A 248
MET A 285
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
0.33A 1rxcC-3bjeA:
5.7
1rxcC-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE


(Toxoplasma
gondii)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 GLY A 237
ARG A 109
ILE A 239
VAL A 240
None
OXQ  A 708 (-4.0A)
None
None
0.92A 1rxcC-3czmA:
undetectable
1rxcC-3czmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE


(Saccharomyces
cerevisiae)
PF01715
(IPPT)
4 GLY A 110
GLN A  49
MET A  74
ILE A  19
None
1.00A 1rxcC-3epjA:
2.7
1rxcC-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1


(Homo sapiens)
PF01048
(PNP_UDP_1)
4 GLY A 143
GLN A 217
ARG A 219
MET A 249
BAU  A 400 (-3.3A)
BAU  A 400 (-3.1A)
BAU  A 400 (-3.0A)
BAU  A 400 (-3.8A)
0.40A 1rxcC-3eufA:
25.9
1rxcC-3eufA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA


(Bacillus
subtilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLY A 237
MET A 209
ILE A 239
VAL A 240
None
0.97A 1rxcC-3gdoA:
undetectable
1rxcC-3gdoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE


(Staphylococcus
aureus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
4 GLY A 355
ILE A 247
VAL A  87
PRO A 242
None
0.99A 1rxcC-3h5qA:
3.4
1rxcC-3h5qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h95 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6


(Homo sapiens)
PF00293
(NUDIX)
4 GLY A 145
GLN A 143
ILE A 225
VAL A 146
None
0.95A 1rxcC-3h95A:
undetectable
1rxcC-3h95A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvy URIDINE
PHOSPHORYLASE


(Bos taurus)
PF01048
(PNP_UDP_1)
4 GLY A 142
GLN A 216
ARG A 218
MET A 248
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
0.41A 1rxcC-3kvyA:
25.9
1rxcC-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n77 NUCLEOSIDE
TRIPHOSPHATASE NUDI


(Salmonella
enterica)
PF00293
(NUDIX)
4 GLY A  37
ARG A  52
ILE A   6
VAL A   7
None
1.00A 1rxcC-3n77A:
undetectable
1rxcC-3n77A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF05721
(PhyH)
4 GLY A  37
GLN A 258
ILE A  39
VAL A  40
None
1.07A 1rxcC-3obzA:
undetectable
1rxcC-3obzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odh OKRAI ENDONUCLEASE

(Oceanobacter
kriegii)
PF02923
(BamHI)
4 GLY A 118
ILE A  76
VAL A  74
PRO A  82
None
0.85A 1rxcC-3odhA:
undetectable
1rxcC-3odhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oga NUCLEOSIDE
TRIPHOSPHATASE NUDI


(Salmonella
enterica)
PF00293
(NUDIX)
4 GLY A  37
ARG A  52
ILE A   6
VAL A   7
None
None
BME  A 142 ( 4.7A)
None
0.79A 1rxcC-3ogaA:
undetectable
1rxcC-3ogaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5


(Saccharomyces
cerevisiae)
PF00397
(WW)
PF00632
(HECT)
4 GLY A 553
MET A 664
ILE A 688
VAL A 556
None
1.04A 1rxcC-3olmA:
undetectable
1rxcC-3olmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE


(Toxoplasma
gondii)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 GLY A 237
ARG A 109
ILE A 239
VAL A 240
None
OXQ  A 702 (-3.9A)
None
None
0.92A 1rxcC-3om9A:
undetectable
1rxcC-3om9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2


(Homo sapiens)
PF01048
(PNP_UDP_1)
4 GLY A 149
GLN A 223
ARG A 225
MET A 255
BAU  A 400 (-3.5A)
BAU  A 400 (-3.1A)
BAU  A 400 (-2.8A)
BAU  A 400 (-3.9A)
0.33A 1rxcC-3p0fA:
25.8
1rxcC-3p0fA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6l SUGAR PHOSPHATE
ISOMERASE/EPIMERASE


(Parabacteroides
distasonis)
PF01261
(AP_endonuc_2)
4 GLY A 103
GLN A  37
ILE A 101
VAL A 102
None
CIT  A 303 ( 3.9A)
None
None
0.99A 1rxcC-3p6lA:
undetectable
1rxcC-3p6lA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Clostridium
beijerinckii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A 368
MET A  97
ILE A 362
PRO A 352
None
1.03A 1rxcC-3s47A:
undetectable
1rxcC-3s47A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A


(Butyrivibrio
proteoclasticus)
PF13472
(Lipase_GDSL_2)
4 GLY A 146
MET A 172
ILE A 143
PRO A 352
None
0.91A 1rxcC-3u37A:
2.8
1rxcC-3u37A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF01554
(MatE)
4 GLY A 108
MET A 115
ILE A 150
VAL A 151
None
None
OLC  A 505 ( 4.4A)
None
0.90A 1rxcC-3wbnA:
undetectable
1rxcC-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zth STU0660

(Streptococcus
thermophilus)
PF16813
(Cas_St_Csn2)
4 GLY A  25
MET A 304
ILE A 256
VAL A  24
None
1.05A 1rxcC-3zthA:
undetectable
1rxcC-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE


(Pyrococcus
furiosus)
PF00793
(DAHP_synth_1)
4 GLY A  29
GLN A 242
ILE A  39
VAL A  42
None
1.06A 1rxcC-4c1lA:
undetectable
1rxcC-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eew LARGE PROLINE-RICH
PROTEIN BAG6


(Homo sapiens)
PF00240
(ubiquitin)
4 GLY A  34
GLN A  73
ILE A  32
VAL A  33
None
1.05A 1rxcC-4eewA:
undetectable
1rxcC-4eewA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Brucella
melitensis)
no annotation 4 GLN D 349
ILE D 275
VAL D 271
PRO D 161
None
0.90A 1rxcC-4em6D:
undetectable
1rxcC-4em6D:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Borreliella
burgdorferi)
PF00300
(His_Phos_1)
4 GLY A 234
GLN A  50
ILE A 215
PRO A 216
None
1.05A 1rxcC-4embA:
undetectable
1rxcC-4embA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis)
PF00496
(SBP_bac_5)
4 GLY A 427
GLN A 431
VAL A 417
PRO A 447
None
1.03A 1rxcC-4fajA:
undetectable
1rxcC-4fajA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE


(Thermotoga
maritima)
PF04055
(Radical_SAM)
PF06968
(BATS)
4 GLY A 226
MET A 271
ILE A 265
VAL A 225
None
1.05A 1rxcC-4jxcA:
undetectable
1rxcC-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
4 GLY A 291
GLN A 375
VAL A 287
PRO A 308
None
0.98A 1rxcC-4kg7A:
2.7
1rxcC-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE


(Rhodopseudomonas
palustris)
PF05292
(MCD)
PF17408
(MCD_N)
4 GLY A 438
ARG A 380
ILE A 440
PRO A 381
None
1.04A 1rxcC-4ksaA:
undetectable
1rxcC-4ksaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY


(Thermococcus
kodakarensis)
PF00375
(SDF)
4 GLY A 102
GLN A 244
ILE A 104
VAL A 105
None
1.00A 1rxcC-4ky0A:
undetectable
1rxcC-4ky0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me8 SIGNAL PEPTIDASE I

(Enterococcus
faecalis)
PF00717
(Peptidase_S24)
4 GLY A 163
ILE A  60
VAL A 164
PRO A  54
None
0.81A 1rxcC-4me8A:
undetectable
1rxcC-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE


(Entamoeba
histolytica)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 GLY A 210
MET A 230
ILE A 184
VAL A 183
None
0.99A 1rxcC-4nfyA:
undetectable
1rxcC-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB


(Cupriavidus
necator)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 MET A 158
ILE A 292
VAL A 328
PRO A 294
None
1.06A 1rxcC-4nzsA:
undetectable
1rxcC-4nzsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Chromohalobacter
salexigens)
PF03480
(DctP)
4 GLY A 103
MET A 179
ILE A 105
VAL A 106
None
BDP  A 401 (-3.5A)
None
None
0.98A 1rxcC-4p1lA:
undetectable
1rxcC-4p1lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plf LACTATE
DEHYDROGENASE


(Apicomplexa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 GLY A 230
ARG A  99
ILE A 232
VAL A 233
None
PYR  A 402 (-3.8A)
None
None
0.98A 1rxcC-4plfA:
undetectable
1rxcC-4plfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD


(Escherichia
coli)
PF00465
(Fe-ADH)
4 GLY A 270
MET A 276
ILE A 287
VAL A 288
None
0.84A 1rxcC-4qgsA:
undetectable
1rxcC-4qgsA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r2w URIDINE
PHOSPHORYLASE


(Shewanella
oneidensis)
PF01048
(PNP_UDP_1)
7 GLY A  93
GLN A 163
ARG A 165
MET A 194
ILE A 217
VAL A 218
PRO A 226
None
None
None
GOL  A 303 (-3.5A)
None
None
None
0.44A 1rxcC-4r2wA:
43.4
1rxcC-4r2wA:
75.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r31 URIDINE
PHOSPHORYLASE


(Actinobacillus
succinogenes)
PF01048
(PNP_UDP_1)
6 GLY A  94
GLN A 164
ARG A 166
MET A 195
ILE A 218
VAL A 219
None
None
None
GOL  A 301 (-4.0A)
None
None
0.62A 1rxcC-4r31A:
22.6
1rxcC-4r31A:
66.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION FACTOR
CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
PF13072
(DUF3936)
4 GLY A  37
MET J   6
ILE A  14
VAL A  38
None
0.98A 1rxcC-4u39A:
undetectable
1rxcC-4u39A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v14 MUTATOR MUTT PROTEIN

(Vibrio cholerae)
PF00293
(NUDIX)
4 GLY A  38
ARG A  53
ILE A   6
VAL A   7
None
0.92A 1rxcC-4v14A:
undetectable
1rxcC-4v14A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1


(Azotobacter
vinelandii)
PF00142
(Fer4_NifH)
4 GLY E 167
ILE E 168
VAL E 169
PRO E 256
None
1.03A 1rxcC-4wzbE:
undetectable
1rxcC-4wzbE:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum)
PF00202
(Aminotran_3)
4 GLY A 407
ARG A 438
ILE A  58
VAL A 408
None
1.03A 1rxcC-4zm4A:
undetectable
1rxcC-4zm4A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE


(Enterovirus B)
PF00680
(RdRP_1)
4 GLY A 207
GLN A  84
ARG A 307
ILE A 325
None
1.00A 1rxcC-4zpdA:
undetectable
1rxcC-4zpdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14)
PF17515
(CPV_Polyhedrin)
4 GLY A 176
MET A 173
ILE A 115
VAL A 177
None
1.03A 1rxcC-5a96A:
undetectable
1rxcC-5a96A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmt UNCHARACTERIZED
PROTEIN


(Parabacteroides
merdae)
no annotation 4 GLY A 207
MET A 213
ILE A 142
VAL A 205
None
1.00A 1rxcC-5bmtA:
undetectable
1rxcC-5bmtA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE


(Bacillus
subtilis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
4 GLY A 355
ILE A 247
VAL A  87
PRO A 242
GLY  A 355 ( 0.0A)
ILE  A 247 ( 0.6A)
VAL  A  87 ( 0.6A)
PRO  A 242 ( 1.1A)
0.95A 1rxcC-5ep8A:
3.4
1rxcC-5ep8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE


(Pyrococcus
horikoshii)
PF00004
(AAA)
5 GLY A 110
GLN A 114
MET A 156
ILE A 285
PRO A 277
None
None
None
ADP  A 401 (-4.2A)
None
1.46A 1rxcC-5eqtA:
undetectable
1rxcC-5eqtA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 GLY A 355
GLN A 584
ILE A 263
VAL A 262
None
0.97A 1rxcC-5f7uA:
undetectable
1rxcC-5f7uA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2


(Homo sapiens)
PF00300
(His_Phos_1)
PF01591
(6PF2K)
4 GLY A 222
GLN A 248
ILE A 219
VAL A 218
GOL  A 607 (-3.3A)
GOL  A 607 ( 4.1A)
None
None
0.99A 1rxcC-5htkA:
undetectable
1rxcC-5htkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48


(Homo sapiens)
PF00400
(WD40)
PF11816
(DUF3337)
4 GLY B  32
ARG B  55
MET B 428
VAL B  33
None
1.04A 1rxcC-5k1bB:
undetectable
1rxcC-5k1bB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2q SERINE/THREONINE-PRO
TEIN KINASE 40


(Homo sapiens)
no annotation 4 GLY C  86
ILE C  49
VAL C  46
PRO C  45
None
1.02A 1rxcC-5l2qC:
undetectable
1rxcC-5l2qC:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhv URIDINE
PHOSPHORYLASE


(Vibrio cholerae)
PF01048
(PNP_UDP_1)
5 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
0.29A 1rxcC-5lhvA:
42.9
1rxcC-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT


(Xanthobacter
autotrophicus)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
4 GLY B 143
ARG B 138
ILE B  97
VAL B  98
None
0.87A 1rxcC-5m45B:
2.3
1rxcC-5m45B:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofu FBP PROTEIN

(Leishmania
major)
PF00316
(FBPase)
4 GLY A 304
ARG A 335
ILE A 306
VAL A 300
None
0.97A 1rxcC-5ofuA:
undetectable
1rxcC-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
4 GLY T1681
ARG T1731
ILE T1678
VAL T1677
None
1.06A 1rxcC-5ojsT:
undetectable
1rxcC-5ojsT:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa)
PF00026
(Asp)
4 GLY A 119
MET A  80
ILE A  30
VAL A  29
None
1.06A 1rxcC-5pepA:
undetectable
1rxcC-5pepA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN


(Thermoactinomyces
vulgaris)
PF00668
(Condensation)
4 GLY A1132
GLN A 913
ILE A1130
VAL A1131
None
1.05A 1rxcC-5t3eA:
undetectable
1rxcC-5t3eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis)
PF00561
(Abhydrolase_1)
4 GLY A 174
ILE A 178
VAL A 175
PRO A 429
None
1.04A 1rxcC-5uohA:
undetectable
1rxcC-5uohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Bifidobacterium
bifidum)
PF11308
(Glyco_hydro_129)
4 GLY A 509
ARG A 501
ILE A 140
VAL A 138
None
0.92A 1rxcC-5wzrA:
undetectable
1rxcC-5wzrA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus)
no annotation 4 GLY A 374
ILE A 376
VAL A 377
PRO A 437
None
0.77A 1rxcC-5xnzA:
undetectable
1rxcC-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15)
no annotation 4 GLY A 915
GLN A 582
ILE A 563
PRO A 938
NAG  A1914 ( 4.9A)
None
None
NAG  A1914 ( 4.6A)
1.04A 1rxcC-6bfuA:
undetectable
1rxcC-6bfuA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C


(Flavobacterium
johnsoniae)
no annotation 4 GLY C 312
GLN C 358
ILE C 310
VAL C 311
None
1.06A 1rxcC-6btmC:
undetectable
1rxcC-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum)
no annotation 4 GLY A 284
GLN A 312
ILE A 345
VAL A 344
None
0.99A 1rxcC-6cddA:
undetectable
1rxcC-6cddA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI


(Klebsiella
pneumoniae)
no annotation 4 GLY A  37
ARG A  52
ILE A   6
VAL A   7
None
0.82A 1rxcC-6dt3A:
undetectable
1rxcC-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyu BACTERIORHODOPSIN

(Candidatus
Nanosalina sp.
J07AB43)
no annotation 4 GLY A 118
GLN A 122
ILE A 116
VAL A 115
RET  A 301 (-3.1A)
None
None
RET  A 301 ( 4.2A)
1.06A 1rxcC-6eyuA:
undetectable
1rxcC-6eyuA:
12.97