SIMILAR PATTERNS OF AMINO ACIDS FOR 1RV7_B_AB1B1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 ALA A 184
VAL A  48
LEU A 319
THR A 326
ALA A 323
 None
 1.11A 1rv7A-1a59A:
0.0
1rv7B-1a59A:
0.0		 1rv7A-1a59A:
13.90
1rv7B-1a59A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A 659
THR A 691
PRO A 692
PRO A 861
ALA A 864
 None
None
None
None
MCN  A 914 ( 3.8A)
 1.18A 1rv7A-1dgjA:
0.0
1rv7B-1dgjA:
0.0		 1rv7A-1dgjA:
8.70
1rv7B-1dgjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		5 ALA B 158
ILE B 145
VAL B 160
THR B 151
ALA B 152
 None
 1.03A 1rv7A-1ekbB:
0.0
1rv7B-1ekbB:
0.0		 1rv7A-1ekbB:
24.84
1rv7B-1ekbB:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 286
THR A 177
VAL A 288
LEU A 279
VAL A 259
 None
NAD  A 375 (-3.6A)
NAD  A 375 (-4.4A)
None
None
 1.14A 1rv7A-1f8fA:
0.0
1rv7B-1f8fA:
0.0		 1rv7A-1f8fA:
15.72
1rv7B-1f8fA:
15.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  28
PRO A  81
LEU A  23
THR A  80
PRO A  81
 A79  A 800 (-3.2A)
A79  A 800 ( 3.4A)
A79  A 800 ( 3.8A)
None
A79  A 800 ( 3.9A)
 0.92A 1rv7A-1hvcA:
12.4
1rv7B-1hvcA:
12.7		 1rv7A-1hvcA:
43.35
1rv7B-1hvcA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		5 THR A 140
PRO A 141
THR A  69
ALA A 108
VAL A 103
 None
KPL  A 265 (-4.5A)
None
None
None
 0.96A 1rv7A-1m3uA:
0.0
1rv7B-1m3uA:
0.0		 1rv7A-1m3uA:
17.80
1rv7B-1m3uA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A

(Escherichia
coli) 		PF02861
(Clp_N) 		5 ALA A  91
LEU A  30
THR A  81
PRO A  80
VAL A  27
 None
 1.11A 1rv7A-1mbxA:
undetectable
1rv7B-1mbxA:
undetectable		 1rv7A-1mbxA:
20.71
1rv7B-1mbxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 ALA A 147
ILE A 168
PRO A 159
LEU A  94
VAL A  90
 None
 1.06A 1rv7A-1ocmA:
0.0
1rv7B-1ocmA:
0.0		 1rv7A-1ocmA:
13.79
1rv7B-1ocmA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srv PROTEIN (GROEL
(HSP60 CLASS))

(Thermus
thermophilus) 		PF00118
(Cpn60_TCP1) 		5 ALA A 251
VAL A 254
LEU A 289
THR A 296
ALA A 293
 None
 1.13A 1rv7A-1srvA:
undetectable
1rv7B-1srvA:
0.0		 1rv7A-1srvA:
17.69
1rv7B-1srvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5z MAJOR NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Aliivibrio
fischeri) 		PF00881
(Nitroreductase) 		5 ALA A 155
PRO A   4
LEU A  32
ALA A  35
VAL A  31
 None
 1.13A 1rv7A-1v5zA:
0.0
1rv7B-1v5zA:
undetectable		 1rv7A-1v5zA:
16.98
1rv7B-1v5zA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A 314
THR A 325
PRO A 324
ALA A 234
VAL A 236
 None
 1.18A 1rv7A-1v9lA:
undetectable
1rv7B-1v9lA:
undetectable		 1rv7A-1v9lA:
14.73
1rv7B-1v9lA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 ALA A 237
ILE A 180
THR A 155
PRO A 156
ALA A 199
 None
 0.82A 1rv7A-1z1wA:
undetectable
1rv7B-1z1wA:
undetectable		 1rv7A-1z1wA:
8.98
1rv7B-1z1wA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 ALA B 368
ILE B 501
VAL B 434
LEU B 379
THR B 496
 None
 1.18A 1rv7A-2afhB:
undetectable
1rv7B-2afhB:
undetectable		 1rv7A-2afhB:
12.60
1rv7B-2afhB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahn THAUMATIN-LIKE
PROTEIN

(Prunus avium) 		PF00314
(Thaumatin) 		5 ALA A  53
ILE A   3
VAL A  13
LEU A  90
VAL A 106
 None
 1.07A 1rv7A-2ahnA:
undetectable
1rv7B-2ahnA:
undetectable		 1rv7A-2ahnA:
16.96
1rv7B-2ahnA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 ALA A 107
ILE A 236
THR A 178
PRO A 177
ALA A 311
 None
 1.15A 1rv7A-2bbvA:
undetectable
1rv7B-2bbvA:
undetectable		 1rv7A-2bbvA:
15.28
1rv7B-2bbvA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		5 ALA A 317
VAL A 277
LEU A 353
PRO A  64
VAL A 358
 None
 1.13A 1rv7A-2bvtA:
undetectable
1rv7B-2bvtA:
undetectable		 1rv7A-2bvtA:
12.64
1rv7B-2bvtA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		5 ALA A  12
ILE A 125
VAL A  58
LEU A  31
VAL A  27
 None
 1.18A 1rv7A-2csuA:
undetectable
1rv7B-2csuA:
undetectable		 1rv7A-2csuA:
13.25
1rv7B-2csuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 THR A 384
VAL A 347
LEU A 484
ALA A 486
VAL A 483
 None
 1.16A 1rv7A-2fonA:
undetectable
1rv7B-2fonA:
undetectable		 1rv7A-2fonA:
8.78
1rv7B-2fonA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 ALA A 457
ILE A 615
THR A 648
PRO A 647
LEU A 550
 None
 1.19A 1rv7A-2iuuA:
undetectable
1rv7B-2iuuA:
undetectable		 1rv7A-2iuuA:
12.74
1rv7B-2iuuA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jar 5'(3')-DEOXYRIBONUCL
EOTIDASE

(Mus musculus) 		PF06941
(NT5C) 		5 ASN A 150
ILE A 163
THR A 137
PRO A 158
LEU A 173
 None
 1.19A 1rv7A-2jarA:
undetectable
1rv7B-2jarA:
undetectable		 1rv7A-2jarA:
20.61
1rv7B-2jarA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 ASN A  71
VAL A  76
LEU A  37
ALA A  50
VAL A  48
 None
 1.17A 1rv7A-2jjfA:
undetectable
1rv7B-2jjfA:
undetectable		 1rv7A-2jjfA:
13.24
1rv7B-2jjfA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m46 ARSENATE REDUCTASE,
PUTATIVE

(Staphylococcus
aureus) 		PF03960
(ArsC) 		5 ILE A   2
THR A  36
PRO A  37
VAL A  92
THR A 115
 None
 1.14A 1rv7A-2m46A:
undetectable
1rv7B-2m46A:
undetectable		 1rv7A-2m46A:
18.62
1rv7B-2m46A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		5 ALA A1204
ILE A1197
VAL A1111
ALA A1224
VAL A1216
 None
 1.09A 1rv7A-2p3vA:
undetectable
1rv7B-2p3vA:
undetectable		 1rv7A-2p3vA:
17.32
1rv7B-2p3vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		5 ALA A 197
ILE A 151
LEU A 162
ALA A 160
VAL A 193
 None
 1.07A 1rv7A-2qr6A:
undetectable
1rv7B-2qr6A:
undetectable		 1rv7A-2qr6A:
13.77
1rv7B-2qr6A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6i UNCHARACTERIZED
PROTEIN ATU1473

(Agrobacterium
fabrum) 		PF07542
(ATP12) 		6 ALA A 207
ILE A 115
VAL A 145
LEU A 254
THR A 194
ALA A 191
 None
 1.32A 1rv7A-2r6iA:
undetectable
1rv7B-2r6iA:
undetectable		 1rv7A-2r6iA:
15.98
1rv7B-2r6iA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ILE A 144
THR A 121
PRO A 141
ALA A 140
VAL A 137
 None
 1.14A 1rv7A-2uuuA:
undetectable
1rv7B-2uuuA:
undetectable		 1rv7A-2uuuA:
12.18
1rv7B-2uuuA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		5 ALA A  86
PRO A 136
LEU A  17
ALA A  20
VAL A  16
 None
 1.07A 1rv7A-2v8jA:
undetectable
1rv7B-2v8jA:
undetectable		 1rv7A-2v8jA:
10.37
1rv7B-2v8jA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1

(Homo sapiens) 		PF09770
(PAT1) 		5 ALA A 721
ILE A 691
VAL A 717
LEU A 680
VAL A 679
 None
 0.91A 1rv7A-2xesA:
undetectable
1rv7B-2xesA:
undetectable		 1rv7A-2xesA:
14.57
1rv7B-2xesA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV

(Pseudomonas
putida) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 ALA A  26
ILE A  17
VAL A  43
LEU A  74
VAL A  63
 None
 1.18A 1rv7A-2xroA:
undetectable
1rv7B-2xroA:
undetectable		 1rv7A-2xroA:
17.89
1rv7B-2xroA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7l AGGLUTININ-LIKE ALS9
PROTEIN

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		5 ILE A 173
THR A  28
PRO A  29
VAL A  22
LEU A 272
 None
 1.19A 1rv7A-2y7lA:
undetectable
1rv7B-2y7lA:
undetectable		 1rv7A-2y7lA:
16.61
1rv7B-2y7lA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Escherichia
coli) 		PF13360
(PQQ_2) 		5 THR B 145
VAL B 181
LEU D 270
ALA D 260
VAL D 258
 None
 1.17A 1rv7A-2ymsB:
undetectable
1rv7B-2ymsB:
undetectable		 1rv7A-2ymsB:
21.78
1rv7B-2ymsB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 313
ILE A   7
THR A  39
LEU A 290
VAL A 286
 FAD  A1601 (-3.6A)
None
FAD  A1601 (-3.5A)
None
None
 1.14A 1rv7A-2yquA:
undetectable
1rv7B-2yquA:
undetectable		 1rv7A-2yquA:
13.57
1rv7B-2yquA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ILE A  93
THR A 204
VAL A 193
THR A  41
PRO A  42
 None
 1.12A 1rv7A-3bsfA:
undetectable
1rv7B-3bsfA:
undetectable		 1rv7A-3bsfA:
17.72
1rv7B-3bsfA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		5 ALA A 171
VAL A 203
PRO A  17
ALA A  16
VAL A  14
 None
None
FMN  A 370 (-4.4A)
FMN  A 370 (-3.5A)
None
 1.12A 1rv7A-3bw2A:
undetectable
1rv7B-3bw2A:
undetectable		 1rv7A-3bw2A:
14.48
1rv7B-3bw2A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR

(Saccharomyces
cerevisiae) 		PF00996
(GDI) 		5 ILE G  85
PRO G 243
VAL G 108
ALA G 346
VAL G 348
 None
 1.19A 1rv7A-3cpiG:
undetectable
1rv7B-3cpiG:
undetectable		 1rv7A-3cpiG:
12.67
1rv7B-3cpiG:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr5 PUTATIVE
O-METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13578
(Methyltransf_24) 		5 LEU A  69
THR A  64
PRO A  65
ALA A  66
VAL A  70
 None
 1.00A 1rv7A-3dr5A:
undetectable
1rv7B-3dr5A:
undetectable		 1rv7A-3dr5A:
15.74
1rv7B-3dr5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A 657
THR A 689
PRO A 690
PRO A 861
ALA A 864
 None
None
None
None
PCD  A 921 ( 3.7A)
 1.10A 1rv7A-3fahA:
undetectable
1rv7B-3fahA:
undetectable		 1rv7A-3fahA:
8.12
1rv7B-3fahA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 ALA A 135
THR A  14
LEU A 123
ALA A 187
VAL A 185
 None
 0.98A 1rv7A-3hdjA:
undetectable
1rv7B-3hdjA:
undetectable		 1rv7A-3hdjA:
17.23
1rv7B-3hdjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 ALA A 267
ILE A 222
LEU A 235
THR A 206
ALA A 246
 None
 1.19A 1rv7A-3ifqA:
undetectable
1rv7B-3ifqA:
undetectable		 1rv7A-3ifqA:
13.95
1rv7B-3ifqA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ira CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03190
(Thioredox_DsbH) 		5 ASN A  38
LEU A 153
PRO A 116
ALA A 156
VAL A 152
 None
 1.16A 1rv7A-3iraA:
undetectable
1rv7B-3iraA:
undetectable		 1rv7A-3iraA:
21.02
1rv7B-3iraA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3s ALTRONATE HYDROLASE

(Shigella
flexneri) 		PF08666
(SAF) 		5 ALA A  71
VAL A  32
THR A  80
ALA A  65
VAL A  55
 None
 1.14A 1rv7A-3k3sA:
undetectable
1rv7B-3k3sA:
undetectable		 1rv7A-3k3sA:
22.31
1rv7B-3k3sA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 ALA A  19
THR A 150
VAL A 144
LEU A  33
VAL A  31
 None
 1.19A 1rv7A-3k96A:
undetectable
1rv7B-3k96A:
undetectable		 1rv7A-3k96A:
17.25
1rv7B-3k96A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 ALA A 123
ILE A 287
VAL A 117
LEU A 207
ALA A 205
 None
 1.15A 1rv7A-3l44A:
undetectable
1rv7B-3l44A:
undetectable		 1rv7A-3l44A:
14.91
1rv7B-3l44A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 ALA A 205
PRO A 263
LEU A 153
THR A 121
VAL A 154
 None
None
None
LLP  A 270 ( 3.5A)
None
 1.18A 1rv7A-3l44A:
undetectable
1rv7B-3l44A:
undetectable		 1rv7A-3l44A:
14.91
1rv7B-3l44A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 ALA A 229
VAL A 226
LEU A 284
ALA A 287
VAL A 283
 None
 1.00A 1rv7A-3pl2A:
undetectable
1rv7B-3pl2A:
undetectable		 1rv7A-3pl2A:
13.88
1rv7B-3pl2A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 ALA A 336
LEU A 417
THR A 360
ALA A 420
VAL A 416
 None
 1.10A 1rv7A-3pplA:
undetectable
1rv7B-3pplA:
undetectable		 1rv7A-3pplA:
11.40
1rv7B-3pplA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		5 ALA A 283
ILE A  49
PRO A 252
VAL A 225
ALA A 183
 None
 1.19A 1rv7A-3qhyA:
undetectable
1rv7B-3qhyA:
undetectable		 1rv7A-3qhyA:
16.67
1rv7B-3qhyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ASN A   3
VAL A 151
THR A 213
ALA A 185
VAL A 181
 None
 1.20A 1rv7A-3r44A:
undetectable
1rv7B-3r44A:
undetectable		 1rv7A-3r44A:
10.44
1rv7B-3r44A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 ALA A 181
ILE A  84
THR A 116
VAL A 161
ALA A 231
 None
 1.17A 1rv7A-3rwbA:
undetectable
1rv7B-3rwbA:
undetectable		 1rv7A-3rwbA:
17.92
1rv7B-3rwbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 ALA A 312
VAL A 308
LEU A 328
ALA A 350
VAL A 352
 None
 1.11A 1rv7A-3slkA:
undetectable
1rv7B-3slkA:
undetectable		 1rv7A-3slkA:
8.78
1rv7B-3slkA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		5 ALA A 243
ILE A 235
VAL A 251
LEU A 314
ALA A 310
 None
 1.12A 1rv7A-3sweA:
undetectable
1rv7B-3sweA:
undetectable		 1rv7A-3sweA:
14.25
1rv7B-3sweA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 ALA A 191
ILE A 412
VAL A 200
THR A 275
ALA A 276
 None
 1.14A 1rv7A-3t05A:
undetectable
1rv7B-3t05A:
undetectable		 1rv7A-3t05A:
11.11
1rv7B-3t05A:
11.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ILE A  50
LEU A  23
THR A  80
ALA A  82
VAL A  84
 017  A 201 (-3.3A)
SO4  A 101 (-4.2A)
None
SO4  A 101 (-3.5A)
None
 1.17A 1rv7A-3t3cA:
16.9
1rv7B-3t3cA:
17.1		 1rv7A-3t3cA:
76.77
1rv7B-3t3cA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
THR A  80
PRO A  81
ALA A  82
VAL A  84
 SO4  A 101 (-4.2A)
None
None
SO4  A 101 (-3.5A)
None
 0.64A 1rv7A-3t3cA:
16.9
1rv7B-3t3cA:
17.1		 1rv7A-3t3cA:
76.77
1rv7B-3t3cA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 169
THR A  44
VAL A 296
ALA A 102
VAL A  98
 None
 1.17A 1rv7A-3t6sA:
undetectable
1rv7B-3t6sA:
undetectable		 1rv7A-3t6sA:
13.73
1rv7B-3t6sA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF00562
(RNA_pol_Rpb2_6) 		5 ALA B 861
ILE B 870
VAL B 857
ALA B 875
VAL B 877
 None
 1.15A 1rv7A-3tbiB:
undetectable
1rv7B-3tbiB:
undetectable		 1rv7A-3tbiB:
16.67
1rv7B-3tbiB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 ALA A  35
ILE A  44
THR A 114
PRO A 115
ALA A 116
 None
None
None
None
PHE  A 400 (-3.6A)
 1.13A 1rv7A-3td9A:
undetectable
1rv7B-3td9A:
undetectable		 1rv7A-3td9A:
17.54
1rv7B-3td9A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus) 		PF00506
(Flu_NP) 		5 ASN A  91
ILE A 108
THR A 367
PRO A 368
ALA A 366
 None
 1.19A 1rv7A-3tj0A:
undetectable
1rv7B-3tj0A:
undetectable		 1rv7A-3tj0A:
12.50
1rv7B-3tj0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A 293
VAL A 297
LEU A 365
ALA A 401
VAL A 399
 None
 1.21A 1rv7A-3tv2A:
undetectable
1rv7B-3tv2A:
undetectable		 1rv7A-3tv2A:
12.75
1rv7B-3tv2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 ALA A 914
ILE A 883
LEU A 907
ALA A 920
VAL A 923
 None
 1.19A 1rv7A-3u6nA:
undetectable
1rv7B-3u6nA:
undetectable		 1rv7A-3u6nA:
9.54
1rv7B-3u6nA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 ILE A 708
VAL A 742
LEU A 719
ALA A 714
VAL A 796
 None
 1.03A 1rv7A-3u6nA:
undetectable
1rv7B-3u6nA:
undetectable		 1rv7A-3u6nA:
9.54
1rv7B-3u6nA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 ILE A 332
VAL A 472
LEU A 446
ALA A 408
VAL A 443
 None
 1.05A 1rv7A-3vfdA:
undetectable
1rv7B-3vfdA:
undetectable		 1rv7A-3vfdA:
16.77
1rv7B-3vfdA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		5 ASN A 902
ALA A 903
VAL A 728
ALA A 879
VAL A 877
 None
 1.17A 1rv7A-4cvuA:
undetectable
1rv7B-4cvuA:
undetectable		 1rv7A-4cvuA:
7.22
1rv7B-4cvuA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		5 ASN A 902
ALA A 903
VAL A 728
PRO A 862
ALA A 879
 None
 1.17A 1rv7A-4cvuA:
undetectable
1rv7B-4cvuA:
undetectable		 1rv7A-4cvuA:
7.22
1rv7B-4cvuA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsj CAPSID PROTEIN BETA

(Flock House
virus) 		PF01829
(Peptidase_A6) 		5 ALA A 107
ILE A 236
THR A 178
PRO A 177
ALA A 311
 None
 1.12A 1rv7A-4fsjA:
undetectable
1rv7B-4fsjA:
undetectable		 1rv7A-4fsjA:
14.57
1rv7B-4fsjA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fte CAPSID PROTEIN ALPHA

(Flock House
virus) 		PF01829
(Peptidase_A6) 		5 ALA A 107
ILE A 236
THR A 178
PRO A 177
ALA A 311
 None
 1.14A 1rv7A-4fteA:
undetectable
1rv7B-4fteA:
undetectable		 1rv7A-4fteA:
11.47
1rv7B-4fteA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 329
ILE A  76
THR A 270
THR A  43
VAL A  10
 None
 1.13A 1rv7A-4h5iA:
undetectable
1rv7B-4h5iA:
undetectable		 1rv7A-4h5iA:
13.94
1rv7B-4h5iA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 ALA N  28
LEU N  89
THR N  73
ALA N  70
VAL N  88
 None
 1.20A 1rv7A-4heaN:
undetectable
1rv7B-4heaN:
undetectable		 1rv7A-4heaN:
13.18
1rv7B-4heaN:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 ASN A  79
ALA A  82
ILE A  48
THR A  39
ALA A  45
 None
 1.02A 1rv7A-4i6mA:
undetectable
1rv7B-4i6mA:
undetectable		 1rv7A-4i6mA:
12.00
1rv7B-4i6mA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 ILE A 244
VAL A 308
PRO A 261
ALA A 294
VAL A 300
 None
 1.19A 1rv7A-4ljsA:
undetectable
1rv7B-4ljsA:
undetectable		 1rv7A-4ljsA:
14.51
1rv7B-4ljsA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 ALA A 126
VAL A 114
LEU A 158
PRO A 151
VAL A 159
 None
 1.19A 1rv7A-4lk5A:
undetectable
1rv7B-4lk5A:
undetectable		 1rv7A-4lk5A:
13.84
1rv7B-4lk5A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE

(Campylobacter
jejuni) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ALA A 141
THR A   8
PRO A   9
VAL A 121
VAL A 180
 None
 1.06A 1rv7A-4n3oA:
undetectable
1rv7B-4n3oA:
undetectable		 1rv7A-4n3oA:
14.85
1rv7B-4n3oA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		5 ALA A 214
ILE A 185
VAL A 221
THR A 190
ALA A  93
 None
 0.98A 1rv7A-4o2iA:
undetectable
1rv7B-4o2iA:
undetectable		 1rv7A-4o2iA:
15.99
1rv7B-4o2iA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		5 ILE A  29
VAL A 145
LEU A  77
ALA A  80
VAL A  76
 None
 1.21A 1rv7A-4o8mA:
undetectable
1rv7B-4o8mA:
undetectable		 1rv7A-4o8mA:
13.99
1rv7B-4o8mA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		5 ALA A 497
ILE A 520
VAL A 467
LEU A 505
VAL A 508
 None
 1.16A 1rv7A-4onqA:
undetectable
1rv7B-4onqA:
undetectable		 1rv7A-4onqA:
15.85
1rv7B-4onqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxx CINDOXIN

(Citrobacter
braakii) 		PF00258
(Flavodoxin_1) 		6 ALA A  18
ILE A 144
VAL A  33
LEU A  92
THR A 122
ALA A 123
 None
None
None
FMN  A 200 ( 4.3A)
None
None
 1.24A 1rv7A-4oxxA:
undetectable
1rv7B-4oxxA:
undetectable		 1rv7A-4oxxA:
20.25
1rv7B-4oxxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 ILE A 278
VAL A 247
PRO A 292
ALA A 291
VAL A 289
 None
FAD  A 501 (-4.1A)
None
None
None
 1.10A 1rv7A-4repA:
undetectable
1rv7B-4repA:
undetectable		 1rv7A-4repA:
11.78
1rv7B-4repA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		5 ALA A 168
ILE A 189
PRO A 180
LEU A 109
VAL A 105
 None
 1.06A 1rv7A-4wj3A:
undetectable
1rv7B-4wj3A:
undetectable		 1rv7A-4wj3A:
13.84
1rv7B-4wj3A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgx FAD:PROTEIN FMN
TRANSFERASE

(Escherichia
coli) 		PF02424
(ApbE) 		5 ILE A 308
VAL A 298
LEU A 327
ALA A 224
VAL A 226
 None
 0.93A 1rv7A-4xgxA:
undetectable
1rv7B-4xgxA:
undetectable		 1rv7A-4xgxA:
16.72
1rv7B-4xgxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb8 PCURE2P6

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A  76
ILE A  23
VAL A  71
THR A 166
ALA A 168
 None
 1.18A 1rv7A-4zb8A:
undetectable
1rv7B-4zb8A:
undetectable		 1rv7A-4zb8A:
17.94
1rv7B-4zb8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 ILE A 399
PRO A 525
VAL A 320
LEU A 355
ALA A 382
 None
 1.16A 1rv7A-4zdkA:
undetectable
1rv7B-4zdkA:
undetectable		 1rv7A-4zdkA:
10.75
1rv7B-4zdkA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		5 ASN A 193
ALA A 227
LEU A 231
THR A 252
ALA A 261
 None
 1.17A 1rv7A-4zm4A:
undetectable
1rv7B-4zm4A:
undetectable		 1rv7A-4zm4A:
18.80
1rv7B-4zm4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aws SH3-CONTAINING
GRB2-LIKE PROTEIN
3-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF10291
(muHD) 		5 ALA A 821
ILE A 583
VAL A 789
LEU A 798
ALA A 680
 None
 1.19A 1rv7A-5awsA:
undetectable
1rv7B-5awsA:
undetectable		 1rv7A-5awsA:
15.22
1rv7B-5awsA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		5 THR A 108
VAL A 274
PRO A  51
ALA A  52
VAL A  54
 None
 1.12A 1rv7A-5cb2A:
undetectable
1rv7B-5cb2A:
undetectable		 1rv7A-5cb2A:
10.20
1rv7B-5cb2A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdj RUBISCO LARGE
SUBUNIT-BINDING
PROTEIN SUBUNIT
ALPHA, CHLOROPLASTIC

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		5 ALA A 251
VAL A 254
LEU A 289
THR A 296
ALA A 293
 None
 1.16A 1rv7A-5cdjA:
undetectable
1rv7B-5cdjA:
undetectable		 1rv7A-5cdjA:
21.14
1rv7B-5cdjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		6 ASN A 173
ILE A 167
VAL A 200
LEU A 182
ALA A 185
VAL A 181
 None
 1.44A 1rv7A-5evjA:
undetectable
1rv7B-5evjA:
undetectable		 1rv7A-5evjA:
13.98
1rv7B-5evjA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghc SMALL
UBIQUITIN-RELATED
MODIFIER 2

(Homo sapiens) 		PF11976
(Rad60-SLD) 		5 ILE A  34
THR A  12
THR A  72
PRO A  73
ALA A  74
 ALY  A  33 ( 3.8A)
None
None
None
None
 1.12A 1rv7A-5ghcA:
undetectable
1rv7B-5ghcA:
undetectable		 1rv7A-5ghcA:
19.13
1rv7B-5ghcA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD

(Escherichia
coli) 		PF09481
(CRISPR_Cse1)
PF09704
(Cas_Cas5d) 		5 ASN A 131
THR J 106
VAL A 130
PRO A 156
ALA A 155
 None
None
A  L   5 ( 4.8A)
None
None
 1.19A 1rv7A-5h9fA:
undetectable
1rv7B-5h9fA:
undetectable		 1rv7A-5h9fA:
12.33
1rv7B-5h9fA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASN A 460
ILE A 447
PRO A 438
VAL A 435
ALA A 494
 None
 1.20A 1rv7A-5i1wA:
undetectable
1rv7B-5i1wA:
undetectable		 1rv7A-5i1wA:
11.18
1rv7B-5i1wA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 ASN A 182
ALA A 216
LEU A 220
THR A 241
ALA A 250
 None
 1.20A 1rv7A-5i92A:
undetectable
1rv7B-5i92A:
undetectable		 1rv7A-5i92A:
13.22
1rv7B-5i92A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 ALA A4338
VAL A4150
LEU A4429
THR A4426
ALA A4427
 None
 1.01A 1rv7A-5iicA:
undetectable
1rv7B-5iicA:
undetectable		 1rv7A-5iicA:
11.29
1rv7B-5iicA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASN A 435
ILE A 512
THR A 546
LEU A 440
VAL A 443
 None
None
SO4  A 702 (-3.3A)
None
None
 1.07A 1rv7A-5jznA:
undetectable
1rv7B-5jznA:
undetectable		 1rv7A-5jznA:
16.79
1rv7B-5jznA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5moy BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ALA A1194
ILE A1161
VAL A1214
THR A1158
VAL A1125
 None
 1.18A 1rv7A-5moyA:
undetectable
1rv7B-5moyA:
undetectable		 1rv7A-5moyA:
12.02
1rv7B-5moyA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqj U6 SNRNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF09749
(HVSL) 		5 ALA A 235
ILE A 179
PRO A 191
THR A 244
VAL A 116
 None
 1.04A 1rv7A-5uqjA:
undetectable
1rv7B-5uqjA:
undetectable		 1rv7A-5uqjA:
17.73
1rv7B-5uqjA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10) 		no annotation 5 ALA A 189
ILE A 141
VAL A 175
LEU A  85
PRO A  25
 None
 0.77A 1rv7A-5uytA:
undetectable
1rv7B-5uytA:
undetectable		 1rv7A-5uytA:
12.92
1rv7B-5uytA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF10418
(DHODB_Fe-S_bind)
PF14691
(Fer4_20) 		5 ILE A 226
THR B  48
PRO B  49
THR A 232
ALA A 415
 None
FAD  B 301 (-3.4A)
None
None
None
 0.91A 1rv7A-5vj7A:
undetectable
1rv7B-5vj7A:
undetectable		 1rv7A-5vj7A:
13.56
1rv7B-5vj7A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE A 214
VAL A 183
LEU A 255
ALA A 258
VAL A 254
 None
 1.09A 1rv7A-5wy4A:
undetectable
1rv7B-5wy4A:
undetectable		 1rv7A-5wy4A:
18.00
1rv7B-5wy4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9k DARP14 - SUBUNIT A
WITH DARPIN

(synthetic
construct) 		no annotation 5 ALA A 287
THR A 298
VAL A 289
LEU A 250
VAL A 246
 None
 1.21A 1rv7A-6c9kA:
undetectable
1rv7B-6c9kA:
undetectable		 1rv7A-6c9kA:
21.43
1rv7B-6c9kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 ALA A 293
THR A 304
VAL A 295
LEU A 256
VAL A 252
 None
 1.18A 1rv7A-6f5eA:
undetectable
1rv7B-6f5eA:
undetectable		 1rv7A-6f5eA:
22.34
1rv7B-6f5eA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 5 ALA L 464
ILE L 329
THR L 251
ALA L  93
VAL L  96
 None
 1.15A 1rv7A-6g2jL:
undetectable
1rv7B-6g2jL:
undetectable		 1rv7A-6g2jL:
16.04
1rv7B-6g2jL:
16.04