SIMILAR PATTERNS OF AMINO ACIDS FOR 1RUL_L_ACTL611

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		4 LEU A 114
TRP A  33
ASN A 106
LEU A 102
 None
 1.49A 1rulH-2dutA:
0.6
1rulL-2dutA:
0.0		 1rulH-2dutA:
19.43
1rulL-2dutA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		4 LEU A 169
TRP A 166
LEU A 158
TRP A 152
 None
 1.36A 1rulH-2xa2A:
0.0
1rulL-2xa2A:
0.0		 1rulH-2xa2A:
19.71
1rulL-2xa2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi) 		PF01633
(Choline_kinase) 		4 LEU A  22
TRP A  28
ASN A  35
LEU A  54
 None
 1.37A 1rulH-3c5iA:
0.0
1rulL-3c5iA:
0.0		 1rulH-3c5iA:
18.52
1rulL-3c5iA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 LEU A 383
ASN A 294
LEU A 273
TRP A 243
 None
 1.50A 1rulH-3dhuA:
0.0
1rulL-3dhuA:
0.0		 1rulH-3dhuA:
20.05
1rulL-3dhuA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori) 		PF00155
(Aminotran_1_2) 		4 LEU A 170
TRP A 178
ASN A 191
LEU A 189
 EDO  A 377 (-4.1A)
None
None
None
 1.17A 1rulH-3ezsA:
0.0
1rulL-3ezsA:
0.0		 1rulH-3ezsA:
17.62
1rulL-3ezsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 LEU A 264
ASN A 238
LEU A 241
TRP A 226
 None
 1.47A 1rulH-3na8A:
0.0
1rulL-3na8A:
undetectable		 1rulH-3na8A:
20.94
1rulL-3na8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 334
TRP A 376
ASN A 369
LEU A 371
 None
 1.46A 1rulH-3o6nA:
0.0
1rulL-3o6nA:
0.0		 1rulH-3o6nA:
19.39
1rulL-3o6nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU B 334
TRP B 376
ASN B 369
LEU B 371
 None
 1.47A 1rulH-3ojaB:
undetectable
1rulL-3ojaB:
undetectable		 1rulH-3ojaB:
16.52
1rulL-3ojaB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 LEU A  16
TRP A  21
ASN A  13
LEU A 142
 None
 1.45A 1rulH-4lmvA:
undetectable
1rulL-4lmvA:
0.0		 1rulH-4lmvA:
18.32
1rulL-4lmvA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TRP H 103
ASN L  34
LEU L  36
TRP L  89
 None
 0.73A 1rulH-4pb0H:
25.6
1rulL-4pb0H:
15.5		 1rulH-4pb0H:
66.67
1rulL-4pb0H:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 LEU A 193
TRP A 197
LEU A 183
TRP A 175
 None
 1.22A 1rulH-4pj3A:
undetectable
1rulL-4pj3A:
undetectable		 1rulH-4pj3A:
10.36
1rulL-4pj3A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU A 175
TRP A 217
ASN A 210
LEU A 212
 None
 1.39A 1rulH-4xgoA:
undetectable
1rulL-4xgoA:
undetectable		 1rulH-4xgoA:
21.55
1rulL-4xgoA:
20.62