SIMILAR PATTERNS OF AMINO ACIDS FOR 1RUA_L_ACTL611

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of5 MRNA EXPORT FACTOR
MEX67

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 289
TRP A 292
LEU A 465
TRP A 449
 None
 1.35A 1ruaH-1of5A:
undetectable
1ruaL-1of5A:
0.0		 1ruaH-1of5A:
21.99
1ruaL-1of5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		4 LEU A 114
TRP A  33
ASN A 106
LEU A 102
 None
 1.49A 1ruaH-2dutA:
0.0
1ruaL-2dutA:
0.0		 1ruaH-2dutA:
19.43
1ruaL-2dutA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		4 LEU A 169
TRP A 166
LEU A 158
TRP A 152
 None
 1.41A 1ruaH-2xa2A:
0.0
1ruaL-2xa2A:
undetectable		 1ruaH-2xa2A:
19.71
1ruaL-2xa2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A 839
ASN A 708
LEU A 809
TRP A 685
 None
 1.49A 1ruaH-2xzlA:
0.0
1ruaL-2xzlA:
0.0		 1ruaH-2xzlA:
14.76
1ruaL-2xzlA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi) 		PF01633
(Choline_kinase) 		4 LEU A  22
TRP A  28
ASN A  35
LEU A  54
 None
 1.36A 1ruaH-3c5iA:
0.0
1ruaL-3c5iA:
0.0		 1ruaH-3c5iA:
18.52
1ruaL-3c5iA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori) 		PF00155
(Aminotran_1_2) 		4 LEU A 170
TRP A 178
ASN A 191
LEU A 189
 EDO  A 377 (-4.1A)
None
None
None
 1.09A 1ruaH-3ezsA:
0.0
1ruaL-3ezsA:
0.0		 1ruaH-3ezsA:
17.62
1ruaL-3ezsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 LEU A 264
ASN A 238
LEU A 241
TRP A 226
 None
 1.46A 1ruaH-3na8A:
0.0
1ruaL-3na8A:
undetectable		 1ruaH-3na8A:
20.94
1ruaL-3na8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 334
TRP A 376
ASN A 369
LEU A 371
 None
 1.49A 1ruaH-3o6nA:
0.0
1ruaL-3o6nA:
0.0		 1ruaH-3o6nA:
19.39
1ruaL-3o6nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00002
(7tm_2)
PF07361
(Cytochrom_B562) 		4 LEU A1010
TRP A1007
ASN A1006
LEU A1003
 None
 1.48A 1ruaH-4l6rA:
undetectable
1ruaL-4l6rA:
undetectable		 1ruaH-4l6rA:
19.86
1ruaL-4l6rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 LEU A  16
TRP A  21
ASN A  13
LEU A 142
 None
 1.41A 1ruaH-4lmvA:
undetectable
1ruaL-4lmvA:
0.0		 1ruaH-4lmvA:
18.32
1ruaL-4lmvA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TRP H 103
ASN L  34
LEU L  36
TRP L  89
 None
 0.71A 1ruaH-4pb0H:
25.6
1ruaL-4pb0H:
15.5		 1ruaH-4pb0H:
66.67
1ruaL-4pb0H:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 LEU A 193
TRP A 197
LEU A 183
TRP A 175
 None
 1.24A 1ruaH-4pj3A:
undetectable
1ruaL-4pj3A:
undetectable		 1ruaH-4pj3A:
10.36
1ruaL-4pj3A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU A 175
TRP A 217
ASN A 210
LEU A 212
 None
 1.42A 1ruaH-4xgoA:
undetectable
1ruaL-4xgoA:
undetectable		 1ruaH-4xgoA:
21.55
1ruaL-4xgoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 356
ASN A 195
LEU A 199
TRP A 187
 None
 1.26A 1ruaH-4xpzA:
undetectable
1ruaL-4xpzA:
undetectable		 1ruaH-4xpzA:
21.14
1ruaL-4xpzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 LEU A -92
TRP A -95
ASN A -96
LEU A -99
 None
 1.49A 1ruaH-6cc4A:
undetectable
1ruaL-6cc4A:
undetectable		 1ruaH-6cc4A:
undetectable
1ruaL-6cc4A:
undetectable