SIMILAR PATTERNS OF AMINO ACIDS FOR 1RU9_H_BEZH601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.34A 1ru9H-1db3A:
0.0
1ru9L-1db3A:
0.0		 1ru9H-1db3A:
19.95
1ru9L-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 ALA A 159
TYR A 109
LEU A 155
GLY A 154
GLY A  71
 None
 1.37A 1ru9H-1h7wA:
0.0
1ru9L-1h7wA:
0.0		 1ru9H-1h7wA:
13.21
1ru9L-1h7wA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		5 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.44A 1ru9H-1svcP:
2.3
1ru9L-1svcP:
2.4		 1ru9H-1svcP:
21.74
1ru9L-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhs HYPOTHETICAL UPF0131
PROTEIN YTFP

(Escherichia
coli) 		PF06094
(GGACT) 		5 ALA A  44
LEU A  35
GLY A 106
TRP A 108
GLY A  53
 None
 1.16A 1ru9H-1xhsA:
0.0
1ru9L-1xhsA:
0.0		 1ru9H-1xhsA:
19.82
1ru9L-1xhsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A 307
TYR A 367
LEU A 311
GLY A 312
GLY A 166
 None
 1.29A 1ru9H-1ysjA:
1.9
1ru9L-1ysjA:
1.6		 1ru9H-1ysjA:
17.06
1ru9L-1ysjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind)
PF08548
(Peptidase_M10_C) 		5 ALA A 128
TYR A 112
LEU A 129
GLY A 131
GLY A 108
 None
 1.23A 1ru9H-2agmA:
0.0
1ru9L-2agmA:
0.0		 1ru9H-2agmA:
20.66
1ru9L-2agmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 ALA A 959
TYR A 825
GLY A 818
GLY A 865
TYR A 821
 None
 1.12A 1ru9H-2fgeA:
1.1
1ru9L-2fgeA:
0.0		 1ru9H-2fgeA:
12.78
1ru9L-2fgeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 ALA A 112
ASN A 111
GLY A  43
PHE A  74
GLY A  47
 MLI  A   2 (-3.2A)
None
MLI  A   2 (-3.5A)
None
None
 1.48A 1ru9H-2ri6A:
0.0
1ru9L-2ri6A:
0.0		 1ru9H-2ri6A:
19.80
1ru9L-2ri6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 5 ALA A 521
LEU A 520
PHE A 209
GLY A 208
TYR A 207
 None
 1.49A 1ru9H-2wb7A:
4.7
1ru9L-2wb7A:
3.5		 1ru9H-2wb7A:
17.48
1ru9L-2wb7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 ALA A  62
ASN A  34
LEU A  73
GLY A  72
GLY A 121
 None
NAD  A 300 (-3.7A)
None
None
None
 1.18A 1ru9H-2ztuA:
undetectable
1ru9L-2ztuA:
undetectable		 1ru9H-2ztuA:
21.82
1ru9L-2ztuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		5 ALA A 249
ASN A 113
LEU A 254
GLY A 253
TYR A 107
 None
 1.12A 1ru9H-3e48A:
undetectable
1ru9L-3e48A:
undetectable		 1ru9H-3e48A:
18.95
1ru9L-3e48A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A 100
LEU A  99
GLY A 304
PHE A 125
GLY A 124
 None
 1.20A 1ru9H-3ec7A:
undetectable
1ru9L-3ec7A:
undetectable		 1ru9H-3ec7A:
22.47
1ru9L-3ec7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q TUBE

(Pseudomonas
aeruginosa) 		PF04985
(Phage_tube) 		5 ALA S 101
TYR S 132
GLY S  83
PHE S  81
GLY S 105
 None
 1.23A 1ru9H-3j9qS:
undetectable
1ru9L-3j9qS:
undetectable		 1ru9H-3j9qS:
20.43
1ru9L-3j9qS:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 ALA A 140
LEU A 136
GLY A 135
PHE A  78
GLY A 127
 None
 1.12A 1ru9H-3ju1A:
undetectable
1ru9L-3ju1A:
undetectable		 1ru9H-3ju1A:
20.82
1ru9L-3ju1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3leo LEUKOTRIENE C4
SYNTHASE

(Homo sapiens) 		PF01124
(MAPEG) 		5 ALA A  10
LEU A  14
GLY A  15
PHE A  63
GLY A  83
 PAM  A 215 (-3.7A)
PAM  A 215 (-3.9A)
None
None
None
 1.34A 1ru9H-3leoA:
undetectable
1ru9L-3leoA:
undetectable		 1ru9H-3leoA:
21.33
1ru9L-3leoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B) 		5 LEU A 218
GLY A 243
PHE A 244
TRP A 200
GLY A 215
 None
 1.02A 1ru9H-3mmlA:
1.5
1ru9L-3mmlA:
1.7		 1ru9H-3mmlA:
22.53
1ru9L-3mmlA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 ALA A  10
ASN A  11
LEU A   7
PHE A  45
GLY A  42
 None
 1.01A 1ru9H-3ndaA:
undetectable
1ru9L-3ndaA:
0.7		 1ru9H-3ndaA:
19.51
1ru9L-3ndaA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		5 ALA A 413
ASN A 414
LEU A 439
GLY A 422
GLY A 419
 None
 1.49A 1ru9H-3r31A:
undetectable
1ru9L-3r31A:
undetectable		 1ru9H-3r31A:
17.21
1ru9L-3r31A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 ALA A 330
TYR A 331
LEU A 329
PHE A 394
TYR A  39
 None
 1.45A 1ru9H-3ziuA:
undetectable
1ru9L-3ziuA:
undetectable		 1ru9H-3ziuA:
15.06
1ru9L-3ziuA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8u PUTATIVE
UNCHARACTERIZED
PROTEIN T8P19.180

(Arabidopsis
thaliana) 		PF03468
(XS) 		5 ALA A 203
TYR A 204
GLY A 197
PHE A 187
GLY A 133
 None
 1.16A 1ru9H-4e8uA:
undetectable
1ru9L-4e8uA:
undetectable		 1ru9H-4e8uA:
19.65
1ru9L-4e8uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		5 ALA A 469
ASN A 470
TYR A 206
PHE A 441
GLY A 497
 None
None
None
HEM  A 601 (-4.4A)
HEM  A 601 (-4.1A)
 1.46A 1ru9H-4ep6A:
undetectable
1ru9L-4ep6A:
undetectable		 1ru9H-4ep6A:
19.62
1ru9L-4ep6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A 100
LEU A  99
GLY A 305
PHE A 125
GLY A 124
 None
 1.28A 1ru9H-4l9rA:
undetectable
1ru9L-4l9rA:
undetectable		 1ru9H-4l9rA:
19.48
1ru9L-4l9rA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		5 ALA A 100
LEU A  99
GLY A 307
PHE A 125
GLY A 124
 None
 1.22A 1ru9H-4mioA:
undetectable
1ru9L-4mioA:
undetectable		 1ru9H-4mioA:
19.58
1ru9L-4mioA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ALA A 452
ASN A 298
LEU A 448
GLY A 438
PHE A 439
 None
 1.48A 1ru9H-4o7dA:
undetectable
1ru9L-4o7dA:
undetectable		 1ru9H-4o7dA:
19.75
1ru9L-4o7dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 LEU A 114
GLY A 113
PHE A  62
GLY A 105
TYR A 127
 None
 1.07A 1ru9H-4q1jA:
undetectable
1ru9L-4q1jA:
undetectable		 1ru9H-4q1jA:
22.30
1ru9L-4q1jA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 ALA A 346
ASN A 312
LEU A 345
GLY A 344
GLY A 293
 None
 1.23A 1ru9H-4r27A:
undetectable
1ru9L-4r27A:
undetectable		 1ru9H-4r27A:
18.45
1ru9L-4r27A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		5 ALA A 120
LEU A 201
GLY A 204
PHE A 123
GLY A 124
 None
 1.31A 1ru9H-4rasA:
undetectable
1ru9L-4rasA:
undetectable		 1ru9H-4rasA:
16.29
1ru9L-4rasA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		5 ALA A 376
ASN A 373
LEU A 375
GLY A 352
GLY A 348
 None
 1.43A 1ru9H-4ry1A:
undetectable
1ru9L-4ry1A:
undetectable		 1ru9H-4ry1A:
18.80
1ru9L-4ry1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		5 ALA A 197
LEU A 198
PHE A 325
TRP A 463
GLY A 324
 None
 1.48A 1ru9H-4uhiA:
undetectable
1ru9L-4uhiA:
undetectable		 1ru9H-4uhiA:
19.29
1ru9L-4uhiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		5 ALA A 250
GLY A 286
PHE A 285
GLY A 260
TYR A 261
 None
None
None
None
NAG  A 505 (-4.2A)
 1.42A 1ru9H-4wk4A:
undetectable
1ru9L-4wk4A:
undetectable		 1ru9H-4wk4A:
18.67
1ru9L-4wk4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 ALA A  75
ASN A 407
GLY A 388
PHE A 327
GLY A 330
 None
 1.23A 1ru9H-4xz8A:
undetectable
1ru9L-4xz8A:
undetectable		 1ru9H-4xz8A:
17.29
1ru9L-4xz8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 ALA A 133
TYR A 145
LEU A 130
GLY A 127
GLY A 121
 None
 1.25A 1ru9H-4zwnA:
undetectable
1ru9L-4zwnA:
undetectable		 1ru9H-4zwnA:
18.34
1ru9L-4zwnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 ALA A  70
TYR A  71
LEU A 105
GLY A  67
GLY A 110
 None
 1.32A 1ru9H-5df0A:
8.1
1ru9L-5df0A:
7.5		 1ru9H-5df0A:
17.60
1ru9L-5df0A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A 165
LEU A 410
GLY A 408
GLY A 403
TYR A 326
 None
 0.95A 1ru9H-5eb5A:
1.1
1ru9L-5eb5A:
undetectable		 1ru9H-5eb5A:
18.71
1ru9L-5eb5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		5 ASN A 266
LEU A 272
GLY A 279
GLY A 218
TYR A 213
 None
None
BR  A1634 (-4.4A)
None
None
 1.33A 1ru9H-5fqeA:
4.2
1ru9L-5fqeA:
4.7		 1ru9H-5fqeA:
17.64
1ru9L-5fqeA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ALA A 533
LEU A 574
GLY A 502
PHE A 342
GLY A 341
 None
 1.09A 1ru9H-5h3kA:
undetectable
1ru9L-5h3kA:
2.7		 1ru9H-5h3kA:
16.16
1ru9L-5h3kA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 219
LEU A 186
GLY A 187
PHE A 184
GLY A 404
 None
 1.49A 1ru9H-5hqlA:
undetectable
1ru9L-5hqlA:
undetectable		 1ru9H-5hqlA:
19.52
1ru9L-5hqlA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		5 ALA A  77
TYR A  51
LEU A  50
TRP A 487
GLY A  48
 None
 1.40A 1ru9H-5kjaA:
undetectable
1ru9L-5kjaA:
undetectable		 1ru9H-5kjaA:
17.87
1ru9L-5kjaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdq CHITOPORIN

(Vibrio harveyi) 		no annotation 5 ASN A 248
LEU A 325
GLY A 324
TRP A 216
GLY A 141
 None
 1.50A 1ru9H-5mdqA:
undetectable
1ru9L-5mdqA:
undetectable		 1ru9H-5mdqA:
undetectable
1ru9L-5mdqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 5 ALA A  15
LEU A 401
GLY A 357
PHE A 418
GLY A 419
 None
 1.42A 1ru9H-5ogzA:
undetectable
1ru9L-5ogzA:
undetectable		 1ru9H-5ogzA:
undetectable
1ru9L-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 ALA A 452
ASN A 298
LEU A 448
GLY A 438
PHE A 439
 None
 1.45A 1ru9H-5uqeA:
undetectable
1ru9L-5uqeA:
undetectable		 1ru9H-5uqeA:
18.58
1ru9L-5uqeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 5 ALA A 144
LEU A 141
GLY A 347
GLY A 316
TYR A 317
 None
 1.36A 1ru9H-5wmlA:
undetectable
1ru9L-5wmlA:
undetectable		 1ru9H-5wmlA:
undetectable
1ru9L-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D

(Escherichia
coli) 		PF00263
(Secretin)
PF03958
(Secretin_N) 		5 ALA A 366
LEU A 407
GLY A 398
PHE A 400
GLY A 405
 None
 1.43A 1ru9H-5wq7A:
undetectable
1ru9L-5wq7A:
undetectable		 1ru9H-5wq7A:
17.01
1ru9L-5wq7A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 5 ASN A 574
LEU A 604
GLY A 637
GLY A 649
TYR A 650
 None
 1.41A 1ru9H-5y31A:
undetectable
1ru9L-5y31A:
undetectable		 1ru9H-5y31A:
undetectable
1ru9L-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 5 ALA A 357
ASN A 266
TYR A 360
PHE A 313
GLY A 312
 None
None
None
MPD  A 704 (-4.2A)
None
 1.10A 1ru9H-5z0uA:
4.5
1ru9L-5z0uA:
6.3		 1ru9H-5z0uA:
undetectable
1ru9L-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z3r STEROID
DELTA-ISOMERASE

(Mycolicibacterium
neoaurum) 		no annotation 5 ALA A 136
ASN A 133
GLY A 113
PHE A 115
GLY A 130
 None
 1.42A 1ru9H-5z3rA:
undetectable
1ru9L-5z3rA:
undetectable		 1ru9H-5z3rA:
undetectable
1ru9L-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 ALA A 303
LEU A 237
GLY A 236
PHE A 206
GLY A 203
 None
 1.14A 1ru9H-5zb8A:
undetectable
1ru9L-5zb8A:
undetectable		 1ru9H-5zb8A:
undetectable
1ru9L-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 5 ALA B  26
TYR B 106
LEU B  27
GLY B  52
GLY B  30
 None
None
None
None
NAP  B 403 (-3.1A)
 1.29A 1ru9H-6gplB:
undetectable
1ru9L-6gplB:
undetectable		 1ru9H-6gplB:
undetectable
1ru9L-6gplB:
undetectable