SIMILAR PATTERNS OF AMINO ACIDS FOR 1RU9_H_ACTH611

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 ASN A 170
LEU A 215
TRP A 210
PHE A  41
 DCM  A 300 (-3.9A)
None
None
None
 1.20A 1ru9H-1b5dA:
undetectable
1ru9L-1b5dA:
undetectable		 1ru9H-1b5dA:
20.82
1ru9L-1b5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3u TRANSCRIPTION
INITIATION FACTOR
IIF, BETA SUBUNIT
TRANSCRIPTION
INITIATION FACTOR
IIF, ALPHA SUBUNIT

(Homo sapiens;
Homo sapiens) 		PF02270
(TFIIF_beta)
PF05793
(TFIIF_alpha) 		4 LEU B 100
LEU A 106
TRP B  42
PHE B  39
 None
 1.46A 1ru9H-1f3uB:
undetectable
1ru9L-1f3uB:
undetectable		 1ru9H-1f3uB:
21.00
1ru9L-1f3uB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7o GLUTAREDOXIN 2

(Escherichia
coli) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  13
ASN A 181
LEU A 210
PHE A 110
 None
 1.27A 1ru9H-1g7oA:
undetectable
1ru9L-1g7oA:
undetectable		 1ru9H-1g7oA:
20.49
1ru9L-1g7oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		4 ASN A 176
LEU A  93
TRP A 171
PHE A 167
 None
 0.94A 1ru9H-1jdzA:
undetectable
1ru9L-1jdzA:
undetectable		 1ru9H-1jdzA:
22.18
1ru9L-1jdzA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 590
ASN A 584
LEU A 627
PHE A 647
 None
 1.25A 1ru9H-1ji6A:
undetectable
1ru9L-1ji6A:
0.0		 1ru9H-1ji6A:
15.93
1ru9L-1ji6A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 521
TRP A 993
LEU A1167
PHE A1313
 None
 0.79A 1ru9H-1n5xA:
undetectable
1ru9L-1n5xA:
0.0		 1ru9H-1n5xA:
10.71
1ru9L-1n5xA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 LEU A 305
TRP A 298
LEU A 254
PHE A 336
 None
 1.37A 1ru9H-1nowA:
undetectable
1ru9L-1nowA:
undetectable		 1ru9H-1nowA:
17.95
1ru9L-1nowA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF00115
(COX1)
PF00510
(COX3) 		4 LEU C  92
LEU A 205
TRP A 229
PHE A 225
 None
 1.23A 1ru9H-1qleC:
undetectable
1ru9L-1qleC:
undetectable		 1ru9H-1qleC:
20.57
1ru9L-1qleC:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qma NUCLEAR TRANSPORT
FACTOR 2

(Rattus
norvegicus) 		PF02136
(NTF2) 		4 LEU A  39
TRP A  41
LEU A  59
PHE A  22
 None
 1.10A 1ru9H-1qmaA:
undetectable
1ru9L-1qmaA:
undetectable		 1ru9H-1qmaA:
16.74
1ru9L-1qmaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK

(Escherichia
coli) 		PF04107
(GCS2) 		4 LEU A 314
TRP A 263
LEU A 264
PHE A 270
 None
 1.26A 1ru9H-1r8gA:
undetectable
1ru9L-1r8gA:
undetectable		 1ru9H-1r8gA:
20.32
1ru9L-1r8gA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 LEU A 314
TRP A 263
LEU A 264
PHE A 270
 None
 1.27A 1ru9H-1tt4A:
undetectable
1ru9L-1tt4A:
undetectable		 1ru9H-1tt4A:
17.63
1ru9L-1tt4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf1 KIAA1526 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A  96
ASN A  74
LEU A  89
PHE A  78
 None
 1.42A 1ru9H-1uf1A:
undetectable
1ru9L-1uf1A:
undetectable		 1ru9H-1uf1A:
21.05
1ru9L-1uf1A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 A CHAIN
EMS16 B CHAIN

(Echis
multisquamatus;
Echis
multisquamatus) 		PF00059
(Lectin_C)
PF00059
(Lectin_C) 		4 TRP A 116
LEU A  72
TRP B  76
PHE B  84
 None
 1.28A 1ru9H-1ukmA:
undetectable
1ru9L-1ukmA:
undetectable		 1ru9H-1ukmA:
19.10
1ru9L-1ukmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		4 LEU A 303
LEU A 416
TRP A 414
PHE A 381
 None
 1.43A 1ru9H-1upsA:
undetectable
1ru9L-1upsA:
undetectable		 1ru9H-1upsA:
19.44
1ru9L-1upsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 134
LEU A 161
TRP A 159
PHE A 191
 None
 1.42A 1ru9H-1vpkA:
undetectable
1ru9L-1vpkA:
undetectable		 1ru9H-1vpkA:
18.65
1ru9L-1vpkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 4 LEU A 104
TRP A 135
LEU A 145
PHE A  88
 None
 1.47A 1ru9H-1wwlA:
undetectable
1ru9L-1wwlA:
undetectable		 1ru9H-1wwlA:
22.15
1ru9L-1wwlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		4 LEU A 125
ASN A 170
LEU A 171
PHE A 321
 None
 1.07A 1ru9H-1y9uA:
undetectable
1ru9L-1y9uA:
undetectable		 1ru9H-1y9uA:
20.68
1ru9L-1y9uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo2 NUCLEAR TRANSPORT
FACTOR 2

(Cryptosporidium
parvum) 		PF02136
(NTF2) 		4 LEU A  42
TRP A  44
LEU A  62
PHE A  25
 None
 0.91A 1ru9H-1zo2A:
undetectable
1ru9L-1zo2A:
undetectable		 1ru9H-1zo2A:
18.64
1ru9L-1zo2A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zx5 MANNOSEPHOSPHATE
ISOMERASE, PUTATIVE

(Archaeoglobus
fulgidus) 		PF01238
(PMI_typeI) 		4 TRP A 200
ASN A 196
LEU A 145
PHE A 152
 None
ACY  A 505 (-3.5A)
None
None
 1.32A 1ru9H-1zx5A:
undetectable
1ru9L-1zx5A:
undetectable		 1ru9H-1zx5A:
20.50
1ru9L-1zx5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 LEU A 278
TRP A 276
LEU A 437
PHE A 426
 None
 1.45A 1ru9H-2ffuA:
undetectable
1ru9L-2ffuA:
undetectable		 1ru9H-2ffuA:
15.98
1ru9L-2ffuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		4 LEU A  64
TRP A  62
LEU A  86
PHE A  97
 None
 1.39A 1ru9H-2frxA:
undetectable
1ru9L-2frxA:
undetectable		 1ru9H-2frxA:
18.85
1ru9L-2frxA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8y MALATE/L-LACTATE
DEHYDROGENASES

(Escherichia
coli) 		PF02615
(Ldh_2) 		4 LEU A 330
TRP A 335
LEU A 359
PHE A  15
 None
 1.39A 1ru9H-2g8yA:
undetectable
1ru9L-2g8yA:
undetectable		 1ru9H-2g8yA:
20.00
1ru9L-2g8yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj3 NITROGEN FIXATION
REGULATORY PROTEIN

(Azotobacter
vinelandii) 		PF00989
(PAS) 		4 LEU A 114
ASN A 102
LEU A  73
PHE A  54
 FAD  A 500 (-4.3A)
FAD  A 500 (-3.0A)
FAD  A 500 (-4.2A)
None
 1.45A 1ru9H-2gj3A:
undetectable
1ru9L-2gj3A:
undetectable		 1ru9H-2gj3A:
20.54
1ru9L-2gj3A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 4 LEU I 273
TRP I 266
LEU I 221
PHE I 304
 None
 1.28A 1ru9H-2gk1I:
undetectable
1ru9L-2gk1I:
undetectable		 1ru9H-2gk1I:
17.80
1ru9L-2gk1I:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 LEU M 305
TRP M 298
LEU M 254
PHE N 336
 None
 1.28A 1ru9H-2gk1M:
undetectable
1ru9L-2gk1M:
undetectable		 1ru9H-2gk1M:
21.43
1ru9L-2gk1M:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyn UPF0368 PROTEIN
YPL225W

(Saccharomyces
cerevisiae) 		PF04669
(Polysacc_synt_4) 		4 LEU A  34
ASN A 134
LEU A  44
PHE A 126
 None
 1.15A 1ru9H-2jynA:
undetectable
1ru9L-2jynA:
undetectable		 1ru9H-2jynA:
17.52
1ru9L-2jynA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		4 LEU A 322
TRP A   5
LEU A  85
PHE A 314
 None
 1.16A 1ru9H-2pgsA:
undetectable
1ru9L-2pgsA:
undetectable		 1ru9H-2pgsA:
17.72
1ru9L-2pgsA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 TRP A  98
ASN A 135
LEU A 131
PHE A 121
 None
 1.44A 1ru9H-2q01A:
undetectable
1ru9L-2q01A:
undetectable		 1ru9H-2q01A:
19.34
1ru9L-2q01A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		4 LEU A1243
TRP A1262
LEU A1315
PHE A1338
 None
 1.26A 1ru9H-2ri8A:
undetectable
1ru9L-2ri8A:
undetectable		 1ru9H-2ri8A:
17.52
1ru9L-2ri8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1n PROTEIN KIN HOMOLOG

(Homo sapiens) 		PF10357
(Kin17_mid) 		4 LEU A  66
TRP A  63
LEU A  73
PHE A  23
 None
 1.44A 1ru9H-2v1nA:
undetectable
1ru9L-2v1nA:
undetectable		 1ru9H-2v1nA:
16.13
1ru9L-2v1nA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TRP A 297
ASN A 291
LEU A 158
PHE A 316
 None
 1.11A 1ru9H-2w2iA:
undetectable
1ru9L-2w2iA:
undetectable		 1ru9H-2w2iA:
19.67
1ru9L-2w2iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		4 LEU A 169
TRP A 166
LEU A 158
TRP A 152
 None
 1.31A 1ru9H-2xa2A:
undetectable
1ru9L-2xa2A:
undetectable		 1ru9H-2xa2A:
19.71
1ru9L-2xa2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 LEU A 609
TRP A 574
LEU A 642
PHE A 646
 None
 1.13A 1ru9H-2yheA:
undetectable
1ru9L-2yheA:
undetectable		 1ru9H-2yheA:
15.73
1ru9L-2yheA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 TRP A 273
ASN A 298
LEU A 252
PHE A 294
 None
 1.32A 1ru9H-2z01A:
undetectable
1ru9L-2z01A:
undetectable		 1ru9H-2z01A:
18.93
1ru9L-2z01A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi) 		PF01633
(Choline_kinase) 		4 LEU A  22
TRP A  28
ASN A  35
LEU A  54
 None
 1.36A 1ru9H-3c5iA:
undetectable
1ru9L-3c5iA:
undetectable		 1ru9H-3c5iA:
18.52
1ru9L-3c5iA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 TRP A 708
ASN A 694
LEU A 691
PHE A 605
 None
 1.47A 1ru9H-3cmmA:
undetectable
1ru9L-3cmmA:
undetectable		 1ru9H-3cmmA:
13.11
1ru9L-3cmmA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 LEU A 348
TRP A 338
LEU A 374
PHE A 312
 None
 1.07A 1ru9H-3cvrA:
undetectable
1ru9L-3cvrA:
undetectable		 1ru9H-3cvrA:
17.88
1ru9L-3cvrA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori) 		PF00155
(Aminotran_1_2) 		4 LEU A 170
TRP A 178
ASN A 191
LEU A 189
 EDO  A 377 (-4.1A)
None
None
None
 1.18A 1ru9H-3ezsA:
undetectable
1ru9L-3ezsA:
undetectable		 1ru9H-3ezsA:
17.62
1ru9L-3ezsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		4 TRP A  74
ASN A  82
LEU A  81
PHE A 154
 None
 1.47A 1ru9H-3g0iA:
undetectable
1ru9L-3g0iA:
undetectable		 1ru9H-3g0iA:
21.00
1ru9L-3g0iA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8m EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF00536
(SAM_1) 		4 LEU A 952
TRP A 931
LEU A 932
PHE A 944
 LEU  A 952 ( 0.5A)
TRP  A 931 ( 0.5A)
LEU  A 932 ( 0.6A)
PHE  A 944 ( 1.4A)
 1.30A 1ru9H-3h8mA:
undetectable
1ru9L-3h8mA:
undetectable		 1ru9H-3h8mA:
14.41
1ru9L-3h8mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9k ADP-RIBOSYL CYCLASE

(Aplysia
californica) 		PF02267
(Rib_hydrolayse) 		4 LEU A 106
LEU A   7
TRP A 111
PHE A  45
 None
 1.14A 1ru9H-3i9kA:
undetectable
1ru9L-3i9kA:
undetectable		 1ru9H-3i9kA:
19.08
1ru9L-3i9kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 LEU A 541
TRP A 597
LEU A 480
PHE A 581
 None
 1.45A 1ru9H-3j04A:
undetectable
1ru9L-3j04A:
undetectable		 1ru9H-3j04A:
13.10
1ru9L-3j04A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri) 		PF14496
(NEL) 		4 LEU A 313
TRP A 274
LEU A 254
PHE A 327
 None
 1.31A 1ru9H-3l3pA:
undetectable
1ru9L-3l3pA:
undetectable		 1ru9H-3l3pA:
21.43
1ru9L-3l3pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		4 LEU A 207
ASN A 267
LEU A 266
PHE A 239
 None
 1.36A 1ru9H-3m5wA:
undetectable
1ru9L-3m5wA:
undetectable		 1ru9H-3m5wA:
22.08
1ru9L-3m5wA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 LEU A 264
ASN A 238
LEU A 241
TRP A 226
 None
 1.42A 1ru9H-3na8A:
undetectable
1ru9L-3na8A:
undetectable		 1ru9H-3na8A:
20.94
1ru9L-3na8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 334
TRP A 376
ASN A 369
LEU A 371
 None
 1.41A 1ru9H-3o6nA:
undetectable
1ru9L-3o6nA:
undetectable		 1ru9H-3o6nA:
19.39
1ru9L-3o6nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU B 334
TRP B 376
ASN B 369
LEU B 371
 None
 1.44A 1ru9H-3ojaB:
undetectable
1ru9L-3ojaB:
undetectable		 1ru9H-3ojaB:
16.52
1ru9L-3ojaB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9) 		4 LEU A  37
TRP A  50
LEU A 185
PHE A 169
 None
 1.47A 1ru9H-3p6bA:
undetectable
1ru9L-3p6bA:
2.0		 1ru9H-3p6bA:
19.92
1ru9L-3p6bA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pay PUTATIVE ADHESIN

(Bacteroides
ovatus) 		PF08842
(Mfa2) 		4 LEU A 293
LEU A 269
TRP A 299
PHE A 176
 None
 1.15A 1ru9H-3payA:
2.8
1ru9L-3payA:
1.1		 1ru9H-3payA:
22.46
1ru9L-3payA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		4 TRP A 199
ASN A   9
LEU A 196
PHE A   7
 None
 1.09A 1ru9H-3pg5A:
undetectable
1ru9L-3pg5A:
undetectable		 1ru9H-3pg5A:
21.29
1ru9L-3pg5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 TRP A 214
ASN A 175
LEU A 178
PHE A 285
 None
 1.16A 1ru9H-3q3cA:
undetectable
1ru9L-3q3cA:
undetectable		 1ru9H-3q3cA:
20.93
1ru9L-3q3cA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 LEU B 727
LEU B 757
TRP B 789
PHE B 790
 None
 1.44A 1ru9H-3s4wB:
undetectable
1ru9L-3s4wB:
undetectable		 1ru9H-3s4wB:
10.28
1ru9L-3s4wB:
10.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 TRP A 111
ASN A 171
LEU A 173
PHE A 235
 None
 0.68A 1ru9H-3umtA:
19.7
1ru9L-3umtA:
20.4		 1ru9H-3umtA:
31.82
1ru9L-3umtA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 LEU A  79
TRP A  47
LEU A 211
PHE A 184
 None
 1.48A 1ru9H-3uyqA:
undetectable
1ru9L-3uyqA:
undetectable		 1ru9H-3uyqA:
26.15
1ru9L-3uyqA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vac CFA/I FIMBRIAL
SUBUNIT E

(Escherichia
coli) 		PF07434
(CblD) 		4 LEU A 285
TRP A 327
LEU A 250
PHE A 353
 None
 1.46A 1ru9H-3vacA:
3.9
1ru9L-3vacA:
4.1		 1ru9H-3vacA:
21.18
1ru9L-3vacA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whd C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D

(Homo sapiens) 		PF00059
(Lectin_C) 		4 TRP A 194
LEU A 145
TRP A 154
PHE A 162
 None
 1.45A 1ru9H-3whdA:
undetectable
1ru9L-3whdA:
undetectable		 1ru9H-3whdA:
19.64
1ru9L-3whdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ww0 PROTEIN HIKESHI

(Homo sapiens) 		PF05603
(DUF775) 		4 LEU B 188
TRP B 195
LEU B 193
PHE B 138
 None
 1.31A 1ru9H-3ww0B:
2.6
1ru9L-3ww0B:
undetectable		 1ru9H-3ww0B:
26.32
1ru9L-3ww0B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ASN A 468
LEU A 463
TRP A 434
PHE A 459
 None
 1.32A 1ru9H-4bfrA:
undetectable
1ru9L-4bfrA:
3.1		 1ru9H-4bfrA:
12.85
1ru9L-4bfrA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 LEU A 164
LEU A 206
TRP A 100
PHE A 196
 COA  A 320 ( 4.7A)
None
None
None
 1.32A 1ru9H-4bqnA:
undetectable
1ru9L-4bqnA:
undetectable		 1ru9H-4bqnA:
18.75
1ru9L-4bqnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 LEU C 141
TRP C 153
LEU C 115
PHE C 124
 None
 1.34A 1ru9H-4bujC:
undetectable
1ru9L-4bujC:
undetectable		 1ru9H-4bujC:
18.83
1ru9L-4bujC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 ASN A 375
LEU A 376
TRP A  92
PHE A 318
 None
 1.22A 1ru9H-4dshA:
undetectable
1ru9L-4dshA:
undetectable		 1ru9H-4dshA:
19.46
1ru9L-4dshA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		4 LEU A 239
ASN A 243
LEU A 246
PHE A  15
 None
 1.01A 1ru9H-4dteA:
undetectable
1ru9L-4dteA:
undetectable		 1ru9H-4dteA:
19.72
1ru9L-4dteA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		4 LEU A  32
TRP A  28
LEU A  76
PHE A  53
 None
 1.47A 1ru9H-4eelA:
undetectable
1ru9L-4eelA:
undetectable		 1ru9H-4eelA:
20.22
1ru9L-4eelA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		4 LEU A  83
ASN A  11
LEU A  10
PHE A   8
 None
 1.44A 1ru9H-4eswA:
undetectable
1ru9L-4eswA:
undetectable		 1ru9H-4eswA:
19.40
1ru9L-4eswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5

(Saccharomyces
cerevisiae) 		PF09084
(NMT1) 		4 LEU A  83
ASN A  11
LEU A  10
PHE A   8
 None
 1.42A 1ru9H-4h65A:
undetectable
1ru9L-4h65A:
undetectable		 1ru9H-4h65A:
22.16
1ru9L-4h65A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		4 TRP A 505
ASN A 498
LEU A 502
PHE A 427
 None
 1.45A 1ru9H-4k35A:
undetectable
1ru9L-4k35A:
undetectable		 1ru9H-4k35A:
14.79
1ru9L-4k35A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TRP A 938
ASN A 900
LEU A 939
PHE A 706
 None
 1.43A 1ru9H-4kxbA:
2.3
1ru9L-4kxbA:
undetectable		 1ru9H-4kxbA:
14.53
1ru9L-4kxbA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00002
(7tm_2)
PF07361
(Cytochrom_B562) 		4 TRP A1007
ASN A1006
LEU A1003
PHE A1065
 None
 1.42A 1ru9H-4l6rA:
undetectable
1ru9L-4l6rA:
undetectable		 1ru9H-4l6rA:
19.86
1ru9L-4l6rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 LEU A  16
TRP A  21
ASN A  13
LEU A 142
 None
 1.46A 1ru9H-4lmvA:
undetectable
1ru9L-4lmvA:
undetectable		 1ru9H-4lmvA:
18.32
1ru9L-4lmvA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU E 249
TRP E 281
LEU E 301
PHE E 232
 None
 1.44A 1ru9H-4md8E:
undetectable
1ru9L-4md8E:
undetectable		 1ru9H-4md8E:
19.70
1ru9L-4md8E:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 TRP H 103
ASN L  34
LEU L  36
TRP L  89
PHE L  98
 None
 0.73A 1ru9H-4pb0H:
25.6
1ru9L-4pb0H:
15.5		 1ru9H-4pb0H:
66.67
1ru9L-4pb0H:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A 535
TRP A 591
LEU A 474
PHE A 575
 None
 1.47A 1ru9H-4pd3A:
undetectable
1ru9L-4pd3A:
undetectable		 1ru9H-4pd3A:
11.20
1ru9L-4pd3A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 LEU A 193
TRP A 197
LEU A 183
TRP A 175
 None
 1.21A 1ru9H-4pj3A:
undetectable
1ru9L-4pj3A:
undetectable		 1ru9H-4pj3A:
10.36
1ru9L-4pj3A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B 260
TRP B 259
LEU B 301
PHE B 316
 None
 1.18A 1ru9H-4r0mB:
undetectable
1ru9L-4r0mB:
undetectable		 1ru9H-4r0mB:
16.46
1ru9L-4r0mB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 LEU A 187
TRP A 127
LEU A 121
PHE A 207
 None
 1.45A 1ru9H-4rxlA:
undetectable
1ru9L-4rxlA:
undetectable		 1ru9H-4rxlA:
23.88
1ru9L-4rxlA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU A 175
TRP A 217
ASN A 210
LEU A 212
 None
 1.35A 1ru9H-4xgoA:
undetectable
1ru9L-4xgoA:
undetectable		 1ru9H-4xgoA:
21.55
1ru9L-4xgoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS

(Influenza A
virus) 		no annotation 4 LEU D  61
TRP D  69
LEU D  70
PHE D 118
 None
 1.15A 1ru9H-4xnqD:
undetectable
1ru9L-4xnqD:
undetectable		 1ru9H-4xnqD:
19.92
1ru9L-4xnqD:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 356
ASN A 195
LEU A 199
TRP A 187
 None
 1.22A 1ru9H-4xpzA:
undetectable
1ru9L-4xpzA:
undetectable		 1ru9H-4xpzA:
21.14
1ru9L-4xpzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 520
TRP A 993
LEU A1167
PHE A1312
 None
 0.74A 1ru9H-4yswA:
undetectable
1ru9L-4yswA:
undetectable		 1ru9H-4yswA:
11.02
1ru9L-4yswA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 LEU A 132
ASN A 214
LEU A 275
TRP A 210
 ON3  A2000 ( 4.7A)
None
None
ON3  A2000 (-4.2A)
 1.14A 1ru9H-4z36A:
undetectable
1ru9L-4z36A:
undetectable		 1ru9H-4z36A:
17.75
1ru9L-4z36A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrv MINCLE CRD

(Bos taurus) 		PF00059
(Lectin_C) 		4 TRP A 191
LEU A 140
TRP A 149
PHE A 157
 None
 1.37A 1ru9H-4zrvA:
undetectable
1ru9L-4zrvA:
undetectable		 1ru9H-4zrvA:
18.67
1ru9L-4zrvA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 LEU A 224
ASN A 199
LEU A 217
PHE A 205
 None
 1.45A 1ru9H-5aeeA:
undetectable
1ru9L-5aeeA:
undetectable		 1ru9H-5aeeA:
15.05
1ru9L-5aeeA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 528
TRP A1002
LEU A1176
PHE A1319
 None
 0.80A 1ru9H-5epgA:
undetectable
1ru9L-5epgA:
undetectable		 1ru9H-5epgA:
10.33
1ru9L-5epgA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 LEU A 361
LEU A 303
TRP A 296
PHE A 293
 None
 1.19A 1ru9H-5f15A:
undetectable
1ru9L-5f15A:
undetectable		 1ru9H-5f15A:
17.47
1ru9L-5f15A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0m HNH ENDONUCLEASE

(Geobacillus
virus E2) 		PF01844
(HNH) 		4 LEU A 110
LEU A  97
TRP A  61
PHE A  55
 None
 1.30A 1ru9H-5h0mA:
undetectable
1ru9L-5h0mA:
undetectable		 1ru9H-5h0mA:
19.28
1ru9L-5h0mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1q INNEXIN-6

(Caenorhabditis
elegans) 		PF00876
(Innexin) 		4 LEU A  26
TRP A 126
LEU A 137
PHE A 340
 None
 0.78A 1ru9H-5h1qA:
undetectable
1ru9L-5h1qA:
undetectable		 1ru9H-5h1qA:
18.80
1ru9L-5h1qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A 554
TRP A 610
LEU A 493
PHE A 594
 None
 1.44A 1ru9H-5i4eA:
undetectable
1ru9L-5i4eA:
undetectable		 1ru9H-5i4eA:
11.90
1ru9L-5i4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		4 LEU A 678
TRP A 599
LEU A 650
PHE A 521
 None
 1.40A 1ru9H-5idoA:
undetectable
1ru9L-5idoA:
undetectable		 1ru9H-5idoA:
17.13
1ru9L-5idoA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 4 TRP B 215
ASN B 154
LEU B 155
PHE B  40
 None
 1.47A 1ru9H-5lhsB:
undetectable
1ru9L-5lhsB:
undetectable		 1ru9H-5lhsB:
22.18
1ru9L-5lhsB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 LEU A 341
TRP A 338
LEU A 558
PHE A 520
 None
 1.36A 1ru9H-5m3hA:
undetectable
1ru9L-5m3hA:
undetectable		 1ru9H-5m3hA:
13.83
1ru9L-5m3hA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 249
TRP A 281
LEU A 301
PHE A 232
 None
 1.41A 1ru9H-5movA:
undetectable
1ru9L-5movA:
undetectable		 1ru9H-5movA:
20.30
1ru9L-5movA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		4 LEU 1 806
LEU 1 757
TRP 1 916
PHE 1 914
 None
 1.30A 1ru9H-5mz61:
undetectable
1ru9L-5mz61:
undetectable		 1ru9H-5mz61:
10.85
1ru9L-5mz61:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		no annotation 4 LEU A 278
TRP A 276
LEU A 437
PHE A 426
 None
 1.43A 1ru9H-5ndfA:
undetectable
1ru9L-5ndfA:
undetectable		 1ru9H-5ndfA:
16.20
1ru9L-5ndfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 TRP A 742
LEU A 738
TRP A 736
PHE A 732
 None
 1.05A 1ru9H-5svcA:
undetectable
1ru9L-5svcA:
undetectable		 1ru9H-5svcA:
13.73
1ru9L-5svcA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TRP A 657
ASN A 553
LEU A 554
PHE A 460
 GIF  A 901 ( 4.4A)
None
None
None
 1.06A 1ru9H-5t9gA:
5.8
1ru9L-5t9gA:
5.1		 1ru9H-5t9gA:
12.13
1ru9L-5t9gA:
14.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
FV FRAGMENT (MAB4D1)
HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 TRP E 104
ASN F  39
LEU F  41
PHE F 103
 None
 0.62A 1ru9H-5tbdE:
18.9
1ru9L-5tbdE:
16.1		 1ru9H-5tbdE:
31.09
1ru9L-5tbdE:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 4 LEU A 422
TRP A 425
LEU A 355
PHE A 373
 None
 1.38A 1ru9H-5vehA:
undetectable
1ru9L-5vehA:
undetectable		 1ru9H-5vehA:
19.52
1ru9L-5vehA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 4 LEU A 533
TRP A 593
LEU A 475
PHE A 577
 None
 1.48A 1ru9H-5w1aA:
undetectable
1ru9L-5w1aA:
undetectable		 1ru9H-5w1aA:
undetectable
1ru9L-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 TRP A -95
ASN A -96
LEU A -99
PHE A -37
 None
 1.38A 1ru9H-6cc4A:
undetectable
1ru9L-6cc4A:
undetectable		 1ru9H-6cc4A:
undetectable
1ru9L-6cc4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 LEU X 172
TRP X 175
LEU X 216
PHE X 220
 None
 1.45A 1ru9H-6elqX:
undetectable
1ru9L-6elqX:
undetectable		 1ru9H-6elqX:
undetectable
1ru9L-6elqX:
undetectable