SIMILAR PATTERNS OF AMINO ACIDS FOR 1RTS_A_D16A309
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1am5 | PEPSIN (Gadus morhua) |
PF00026(Asp) | 4 | ASP A 303GLY A 302PHE A 301TYR A 14 | None | 0.79A | 1rtsA-1am5A:0.0 | 1rtsA-1am5A:22.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bsf | THYMIDYLATE SYNTHASEA (Bacillussubtilis) |
PF00303(Thymidylat_synt) | 4 | ASP A 184GLY A 188PHE A 191TYR A 224 | None | 0.35A | 1rtsA-1bsfA:31.1 | 1rtsA-1bsfA:35.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ci7 | PROTEIN (THYMIDYLATESYNTHASE) (Pneumocystiscarinii) |
PF00303(Thymidylat_synt) | 7 | PHE A 58ILE A 86ASP A 202LEU A 205GLY A 206PHE A 209TYR A 242 | CB3 A 768 (-3.6A)CB3 A 768 (-3.6A)CB3 A 768 ( 3.6A)CB3 A 768 ( 4.4A)UMP A 767 (-3.7A)CB3 A 768 (-3.6A)CB3 A 768 ( 4.7A) | 0.64A | 1rtsA-1ci7A:41.0 | 1rtsA-1ci7A:58.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g60 | ADENINE-SPECIFICMETHYLTRANSFERASEMBOIIA (Moraxella bovis) |
PF01555(N6_N4_Mtase) | 4 | TRP A 96LEU A 86PHE A 93TYR A 54 | None | 0.71A | 1rtsA-1g60A:0.0 | 1rtsA-1g60A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxl | CHROMOSOMESEGREGATION SMCPROTEIN (Thermotogamaritima) |
PF06470(SMC_hinge) | 4 | ILE A 524LEU A 609GLY A 610PHE A 614 | None | 0.83A | 1rtsA-1gxlA:0.0 | 1rtsA-1gxlA:22.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvy | THYMIDYLATE SYNTHASE (Homo sapiens) |
PF00303(Thymidylat_synt) | 6 | ILE A 108TRP A 109ASP A 218LEU A 221GLY A 222TYR A 258 | D16 A 414 (-3.7A)D16 A 414 (-3.7A)D16 A 414 ( 3.6A)D16 A 414 (-4.0A)D16 A 414 (-3.3A)UMP A 314 ( 4.4A) | 0.60A | 1rtsA-1hvyA:45.1 | 1rtsA-1hvyA:92.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvy | THYMIDYLATE SYNTHASE (Homo sapiens) |
PF00303(Thymidylat_synt) | 7 | PHE A 80ILE A 108ASP A 218LEU A 221GLY A 222PHE A 225TYR A 258 | D16 A 414 (-3.7A)D16 A 414 (-3.7A)D16 A 414 ( 3.6A)D16 A 414 (-4.0A)D16 A 414 (-3.3A)D16 A 414 (-3.6A)UMP A 314 ( 4.4A) | 0.50A | 1rtsA-1hvyA:45.1 | 1rtsA-1hvyA:92.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | ASP A 300LEU A 303GLY A 299PHE A 298TYR A 17 | None | 1.16A | 1rtsA-1izeA:0.0 | 1rtsA-1izeA:21.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j3j | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00303(Thymidylat_synt) | 4 | ASP C 513LEU C 516GLY C 517TYR C 553 | UMP C 611 (-4.9A)NoneUMP C 611 (-3.5A)UMP C 611 (-4.9A) | 0.63A | 1rtsA-1j3jC:40.4 | 1rtsA-1j3jC:50.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j3j | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00303(Thymidylat_synt) | 4 | ILE C 403ASP C 513GLY C 517TYR C 553 | NoneUMP C 611 (-4.9A)UMP C 611 (-3.5A)UMP C 611 (-4.9A) | 0.54A | 1rtsA-1j3jC:40.4 | 1rtsA-1j3jC:50.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqs | SLY1 PROTEIN (Saccharomycescerevisiae) |
PF00995(Sec1) | 4 | PHE A 238ILE A 213LEU A 231GLY A 232 | None | 0.61A | 1rtsA-1mqsA:undetectable | 1rtsA-1mqsA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1omo | ALANINEDEHYDROGENASE (Archaeoglobusfulgidus) |
PF02423(OCD_Mu_crystall) | 4 | PHE A 288ILE A 268ASP A 277GLY A 278 | PHE A 288 ( 1.3A)ILE A 268 ( 0.3A)ASP A 277 ( 0.5A)GLY A 278 ( 0.0A) | 0.86A | 1rtsA-1omoA:undetectable | 1rtsA-1omoA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdn | PROTEIN(N-ETHYLMALEIMIDESENSITIVE FUSIONPROTEIN (NSF)) (Cricetulusgriseus) |
PF02359(CDC48_N)PF02933(CDC48_2) | 4 | PHE A 140LEU A 147GLY A 146PHE A 145 | None | 0.73A | 1rtsA-1qdnA:undetectable | 1rtsA-1qdnA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rtr | GERANYLTRANSTRANSFERASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 4 | ILE A 45LEU A 210GLY A 211PHE A 214 | None | 0.55A | 1rtsA-1rtrA:undetectable | 1rtsA-1rtrA:23.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tis | THYMIDYLATE SYNTHASE (Escherichiavirus T4) |
PF00303(Thymidylat_synt) | 4 | ASP A 179GLY A 183PHE A 186TYR A 219 | None | 0.60A | 1rtsA-1tisA:30.5 | 1rtsA-1tisA:41.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tis | THYMIDYLATE SYNTHASE (Escherichiavirus T4) |
PF00303(Thymidylat_synt) | 4 | ASP A 179LEU A 182GLY A 183TYR A 219 | None | 0.59A | 1rtsA-1tisA:30.5 | 1rtsA-1tisA:41.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zi7 | KES1 PROTEIN (Saccharomycescerevisiae) |
PF01237(Oxysterol_BP) | 4 | PHE A 246ILE A 231GLY A 217PHE A 233 | None | 0.77A | 1rtsA-1zi7A:undetectable | 1rtsA-1zi7A:22.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 5 | ILE A 100ASP A 219LEU A 222GLY A 223TYR A 259 | CB3 A2351 (-3.6A)CB3 A2351 ( 3.6A)CB3 A2351 (-4.1A)CB3 A2351 ( 3.2A)CB3 A2351 ( 4.3A) | 0.70A | 1rtsA-2aazA:undetectable | 1rtsA-2aazA:59.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 5 | ILE A 100LEU A 222GLY A 223PHE A 226TYR A 259 | CB3 A2351 (-3.6A)CB3 A2351 (-4.1A)CB3 A2351 ( 3.2A)CB3 A2351 (-3.8A)CB3 A2351 ( 4.3A) | 1.07A | 1rtsA-2aazA:undetectable | 1rtsA-2aazA:59.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 4 | ILE A 100TRP A 101ASP A 219GLY A 223 | CB3 A2351 (-3.6A)CB3 A2351 (-3.7A)CB3 A2351 ( 3.6A)CB3 A2351 ( 3.2A) | 0.80A | 1rtsA-2aazA:undetectable | 1rtsA-2aazA:59.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 4 | PHE A 72ILE A 100ASP A 219TYR A 259 | CB3 A2351 (-3.9A)CB3 A2351 (-3.6A)CB3 A2351 ( 3.6A)CB3 A2351 ( 4.3A) | 0.65A | 1rtsA-2aazA:undetectable | 1rtsA-2aazA:59.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amy | PHOSPHOMANNOMUTASE 2 (Homo sapiens) |
PF03332(PMM) | 4 | ILE A 240ASP A 209GLY A 208PHE A 207 | None | 0.85A | 1rtsA-2amyA:undetectable | 1rtsA-2amyA:22.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | PHE A 288ASP A 426LEU A 429GLY A 430PHE A 433TYR A 466 | NoneNoneNone DU A 611 (-3.5A)None DU A 611 (-4.6A) | 0.77A | 1rtsA-2h2qA:40.2 | 1rtsA-2h2qA:38.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | PHE A 288ILE A 316ASP A 426GLY A 430PHE A 433TYR A 466 | NoneNoneNone DU A 611 (-3.5A)None DU A 611 (-4.6A) | 0.53A | 1rtsA-2h2qA:40.2 | 1rtsA-2h2qA:38.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j1q | ARGININE KINASE (Trypanosomacruzi) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 4 | TRP A 221ASP A 192LEU A 195GLY A 191 | None | 0.77A | 1rtsA-2j1qA:undetectable | 1rtsA-2j1qA:21.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ILE A 315ASP A 426LEU A 429GLY A 430TYR A 466 | CB3 A 604 ( 3.7A)CB3 A 604 ( 3.9A)CB3 A 604 ( 4.4A)CB3 A 604 ( 3.4A)UMP A 603 ( 4.3A) | 0.68A | 1rtsA-2oipA:41.4 | 1rtsA-2oipA:35.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ILE A 315TRP A 316ASP A 426TYR A 466 | CB3 A 604 ( 3.7A)CB3 A 604 ( 4.4A)CB3 A 604 ( 3.9A)UMP A 603 ( 4.3A) | 0.76A | 1rtsA-2oipA:41.4 | 1rtsA-2oipA:35.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqz | GLYOXALASE FAMILYPROTEIN, PUTATIVE (Bacillusanthracis) |
PF00903(Glyoxalase) | 4 | PHE A 75ILE A 116ASP A 97PHE A 118 | None | 0.82A | 1rtsA-2qqzA:undetectable | 1rtsA-2qqzA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qty | POLY(ADP-RIBOSE)GLYCOHYDROLASE ARH3 (Mus musculus) |
PF03747(ADP_ribosyl_GH) | 4 | PHE A 195ILE A 265LEU A 237GLY A 234 | None | 0.54A | 1rtsA-2qtyA:undetectable | 1rtsA-2qtyA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ra8 | UNCHARACTERIZEDPROTEIN Q64V53_BACFR (Bacteroidesfragilis) |
PF05406(WGR) | 4 | PHE A 138LEU A 144GLY A 143PHE A 141 | None | 0.84A | 1rtsA-2ra8A:undetectable | 1rtsA-2ra8A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 4 | ASP A 300GLY A 299PHE A 298TYR A 17 | None | 0.74A | 1rtsA-2wedA:undetectable | 1rtsA-2wedA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wf7 | BETA-PHOSPHOGLUCOMUTASE (Lactococcuslactis) |
PF13419(HAD_2) | 4 | PHE A 7ILE A 96GLY A 11TYR A 19 | NoneNone MG A1220 ( 4.5A)None | 0.83A | 1rtsA-2wf7A:undetectable | 1rtsA-2wf7A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wmc | EUKARYOTICTRANSLATIONINITIATION FACTOR 4E (Pisum sativum) |
PF01652(IF4E) | 4 | ILE A 179ASP A 161GLY A 160PHE A 157 | None | 0.71A | 1rtsA-2wmcA:undetectable | 1rtsA-2wmcA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo7 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASECYCLOPHILIN-TYPE (Toxoplasmagondii) |
PF00160(Pro_isomerase) | 4 | ILE A 121ASP A 144LEU A 143GLY A 142 | None | 0.76A | 1rtsA-3bo7A:undetectable | 1rtsA-3bo7A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dlj | BETA-ALA-HISDIPEPTIDASE (Homo sapiens) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | PHE A 473ILE A 442GLY A 466PHE A 470 | None | 0.85A | 1rtsA-3dljA:undetectable | 1rtsA-3dljA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 5 | ASP A 304LEU A 307GLY A 303PHE A 302TYR A 14 | None | 1.14A | 1rtsA-3emyA:undetectable | 1rtsA-3emyA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3evr | MYOSIN LIGHT CHAINKINASE, GREENFLUORESCENT PROTEIN,CALMODULIN-1 CHIMERA (Aequoreavictoria;Rattusnorvegicus) |
PF01353(GFP)PF13499(EF-hand_7) | 4 | ILE A 256ASP A 287GLY A 262PHE A 258 | None | 0.83A | 1rtsA-3evrA:undetectable | 1rtsA-3evrA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3heb | RESPONSE REGULATORRECEIVER DOMAINPROTEIN (CHEY) (Rhodospirillumrubrum) |
PF00072(Response_reg) | 4 | ILE A 10LEU A 135GLY A 136PHE A 139 | None | 0.66A | 1rtsA-3hebA:undetectable | 1rtsA-3hebA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ij3 | CYTOSOLAMINOPEPTIDASE (Coxiellaburnetii) |
PF00883(Peptidase_M17) | 4 | PHE A 424ILE A 331GLY A 225PHE A 333 | None | 0.76A | 1rtsA-3ij3A:undetectable | 1rtsA-3ij3A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivr | PUTATIVELONG-CHAIN-FATTY-ACID COA LIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding) | 4 | PHE A 359TRP A 363ASP A 162GLY A 163 | NoneGOL A 1 (-4.1A)NoneNone | 0.77A | 1rtsA-3ivrA:undetectable | 1rtsA-3ivrA:21.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ix6 | THYMIDYLATE SYNTHASE (Brucellamelitensis) |
PF00303(Thymidylat_synt) | 4 | ASP A 169LEU A 172GLY A 173TYR A 209 | None | 0.78A | 1rtsA-3ix6A:33.7 | 1rtsA-3ix6A:41.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j97 | VESICLE-FUSINGATPASE (Cricetulusgriseus) |
PF00004(AAA)PF02359(CDC48_N)PF02933(CDC48_2) | 4 | PHE A 140LEU A 147GLY A 146PHE A 145 | None | 0.68A | 1rtsA-3j97A:undetectable | 1rtsA-3j97A:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9t | PUTATIVE PEPTIDASE (Clostridiumacetobutylicum) |
PF09940(DUF2172)PF16221(HTH_47)PF16254(DUF4910) | 4 | PHE A 221ILE A 48GLY A 169PHE A 223 | NoneMRD A 441 ( 4.8A)NoneNone | 0.86A | 1rtsA-3k9tA:undetectable | 1rtsA-3k9tA:21.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kgb | THYMIDYLATE SYNTHASE1/2 (Encephalitozooncuniculi) |
PF00303(Thymidylat_synt) | 5 | PHE A 60LEU A 200GLY A 201PHE A 204TYR A 237 | None | 0.76A | 1rtsA-3kgbA:36.9 | 1rtsA-3kgbA:57.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ASP A 416LEU A 419GLY A 420TYR A 456 | None | 0.67A | 1rtsA-3kjrA:41.3 | 1rtsA-3kjrA:34.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3osr | MALTOSE-BINDINGPERIPLASMICPROTEIN,GREENFLUORESCENT PROTEIN (Aequoreavictoria;Escherichiacoli) |
PF01353(GFP)PF01547(SBP_bac_1) | 4 | ILE A 510ASP A 541GLY A 516PHE A 512 | None | 0.82A | 1rtsA-3osrA:undetectable | 1rtsA-3osrA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psh | PROTEIN HI_1472 (Haemophilusinfluenzae) |
PF01497(Peripla_BP_2) | 4 | PHE A 172ILE A 168ASP A 179GLY A 178 | None | 0.74A | 1rtsA-3pshA:undetectable | 1rtsA-3pshA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3thn | EXONUCLEASE,PUTATIVE (Thermotogamaritima) |
PF00149(Metallophos) | 4 | ILE A 230ASP A 14GLY A 233PHE A 220 | None MN A 360 (-3.4A)NoneNone | 0.76A | 1rtsA-3thnA:undetectable | 1rtsA-3thnA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tho | EXONUCLEASE,PUTATIVE (Thermotogamaritima) |
PF00149(Metallophos) | 4 | ILE B 230ASP B 14GLY B 233PHE B 220 | None MN B 1 (-3.7A)NoneNone | 0.73A | 1rtsA-3thoB:undetectable | 1rtsA-3thoB:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ASP A 513LEU A 516GLY A 517TYR A 553 | UMP A 611 (-4.9A)NoneUMP A 611 (-3.3A)UMP A 611 (-4.5A) | 0.68A | 1rtsA-3um6A:40.6 | 1rtsA-3um6A:28.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ILE A 403ASP A 513GLY A 517TYR A 553 | NoneUMP A 611 (-4.9A)UMP A 611 (-3.3A)UMP A 611 (-4.5A) | 0.56A | 1rtsA-3um6A:40.6 | 1rtsA-3um6A:28.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v8h | THYMIDYLATE SYNTHASE (Burkholderiathailandensis) |
PF00303(Thymidylat_synt) | 5 | ASP A 217LEU A 220GLY A 221PHE A 224TYR A 257 | NoneNoneNoneNoneCIT A 400 (-4.5A) | 0.82A | 1rtsA-3v8hA:34.6 | 1rtsA-3v8hA:34.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va6 | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 4 | ILE A 344ASP A 644GLY A 645PHE A 646 | None | 0.67A | 1rtsA-3va6A:undetectable | 1rtsA-3va6A:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjo | OCTAPRENYLDIPHOSPHATE SYNTHASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 4 | ILE A 47LEU A 203GLY A 204PHE A 207 | NoneNoneNoneIPE A 402 (-4.5A) | 0.63A | 1rtsA-3wjoA:undetectable | 1rtsA-3wjoA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aee | ALPHA AMYLASE,CATALYTIC REGION (Staphylothermusmarinus) |
PF00128(Alpha-amylase) | 4 | ILE A 447LEU A 472GLY A 470TYR A 489 | None | 0.80A | 1rtsA-4aeeA:undetectable | 1rtsA-4aeeA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 4 | ILE A1098ASP A1129GLY A1104PHE A1100 | None | 0.86A | 1rtsA-4anjA:undetectable | 1rtsA-4anjA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhl | ARGININE KINASE (Litopenaeusvannamei) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 4 | TRP A 221ASP A 192LEU A 195GLY A 191 | None | 0.76A | 1rtsA-4bhlA:undetectable | 1rtsA-4bhlA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cv7 | VIRULENCE ASSOCIATEDPROTEIN VAPB (Rhodococcushoagii) |
PF05526(R_equi_Vir) | 4 | PHE A 149ILE A 160GLY A 171PHE A 162 | None | 0.82A | 1rtsA-4cv7A:undetectable | 1rtsA-4cv7A:16.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 4 | ASP A 224GLY A 228PHE A 231TYR A 264 | NoneUMP A 501 ( 4.0A)NoneUMP A 501 (-4.2A) | 0.43A | 1rtsA-4dq1A:34.3 | 1rtsA-4dq1A:46.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 4 | ASP A 224LEU A 227GLY A 228TYR A 264 | NoneNoneUMP A 501 ( 4.0A)UMP A 501 (-4.2A) | 0.77A | 1rtsA-4dq1A:34.3 | 1rtsA-4dq1A:46.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 4 | ILE A 84ASP A 224PHE A 231TYR A 264 | NoneNoneNoneUMP A 501 (-4.2A) | 0.59A | 1rtsA-4dq1A:34.3 | 1rtsA-4dq1A:46.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fn5 | ELONGATION FACTOR G1 (Pseudomonasaeruginosa) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 4 | PHE A 522ILE A 560LEU A 574GLY A 576 | None | 0.86A | 1rtsA-4fn5A:undetectable | 1rtsA-4fn5A:18.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fog | THYMIDYLATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00303(Thymidylat_synt) | 4 | ILE A 79ASP A 169GLY A 173TYR A 209 | C2F A 302 (-3.3A)C2F A 302 ( 3.9A)C2F A 302 (-3.2A)C2F A 302 ( 4.6A) | 0.56A | 1rtsA-4fogA:36.6 | 1rtsA-4fogA:47.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h0u | THYMIDYLATE SYNTHASE (Corynebacteriumglutamicum) |
PF00303(Thymidylat_synt) | 4 | ASP A 172LEU A 175GLY A 176TYR A 212 | NoneNoneUMP A 301 (-3.6A)UMP A 301 (-4.5A) | 0.74A | 1rtsA-4h0uA:35.4 | 1rtsA-4h0uA:46.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1x | PHOSPHATE-BINDINGPROTEIN PSTS 2 (Streptococcuspneumoniae) |
PF12849(PBP_like_2) | 4 | ILE A 212LEU A 143GLY A 144PHE A 147 | None | 0.39A | 1rtsA-4h1xA:undetectable | 1rtsA-4h1xA:20.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqq | THYMIDYLATE SYNTHASE (Caenorhabditiselegans) |
PF00303(Thymidylat_synt) | 6 | ILE A 110ASP A 220LEU A 223GLY A 224PHE A 227TYR A 260 | D16 A 402 (-4.0A)D16 A 402 ( 4.0A)D16 A 402 (-3.7A)D16 A 402 ( 3.1A)D16 A 402 (-3.2A)D16 A 402 ( 4.2A) | 0.24A | 1rtsA-4iqqA:42.7 | 1rtsA-4iqqA:63.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5q | O-ACETYL-ADP-RIBOSEDEACETYLASE 1 (Homo sapiens) |
PF01661(Macro) | 4 | PHE A 48ILE A 78LEU A 58GLY A 54 | None | 0.61A | 1rtsA-4j5qA:undetectable | 1rtsA-4j5qA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k46 | ADENYLATE KINASE (Photobacteriumprofundum) |
PF00406(ADK)PF05191(ADK_lid) | 4 | PHE A 196ILE A 107GLY A 7PHE A 109 | None | 0.66A | 1rtsA-4k46A:undetectable | 1rtsA-4k46A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6l | CYTOLETHALDISTENDING TOXINSUBUNIT B HOMOLOG (Salmonellaenterica) |
PF03372(Exo_endo_phos) | 4 | ILE F 124ASP F 131LEU F 151GLY F 150 | None | 0.75A | 1rtsA-4k6lF:undetectable | 1rtsA-4k6lF:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgc | BILE ACID-COENZYME ALIGASE ([Clostridium]scindens) |
PF00501(AMP-binding) | 4 | PHE A 237ILE A 202GLY A 212TYR A 317 | None | 0.71A | 1rtsA-4lgcA:undetectable | 1rtsA-4lgcA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf7 | ARGININE KINASE (Anthopleurajaponica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 4 | TRP A 225ASP A 196LEU A 199GLY A 195 | None | 0.81A | 1rtsA-4rf7A:undetectable | 1rtsA-4rf7A:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjz | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (SUGAR) (Agrobacteriumfabrum) |
PF01547(SBP_bac_1) | 4 | ILE A 88GLY A 136PHE A 102TYR A 120 | None | 0.72A | 1rtsA-4rjzA:undetectable | 1rtsA-4rjzA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uar | PROTEIN CBBY (Rhodobactersphaeroides) |
PF13419(HAD_2) | 4 | PHE A 214ASP A 224LEU A 223GLY A 222 | None | 0.80A | 1rtsA-4uarA:undetectable | 1rtsA-4uarA:21.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xsc | THYMIDYLATE SYNTHASE (Humanalphaherpesvirus3) |
PF00303(Thymidylat_synt) | 4 | ASP A 206LEU A 209GLY A 210TYR A 246 | NoneNoneBVP A1001 (-3.4A)BVP A1001 (-4.5A) | 0.71A | 1rtsA-4xscA:40.9 | 1rtsA-4xscA:65.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xsc | THYMIDYLATE SYNTHASE (Humanalphaherpesvirus3) |
PF00303(Thymidylat_synt) | 6 | PHE A 68ILE A 96ASP A 206GLY A 210PHE A 213TYR A 246 | None1PE A1002 (-4.6A)NoneBVP A1001 (-3.4A)1PE A1002 (-3.8A)BVP A1001 (-4.5A) | 0.48A | 1rtsA-4xscA:40.9 | 1rtsA-4xscA:65.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y2w | ALANINE RACEMASE 1 (Caldanaerobactersubterraneus) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 4 | PHE A 363ILE A 338ASP A 289GLY A 290 | None | 0.82A | 1rtsA-4y2wA:undetectable | 1rtsA-4y2wA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aeo | R. EQUI VAPG PROTEIN (Rhodococcushoagii) |
PF05526(R_equi_Vir) | 4 | PHE A 103ILE A 114GLY A 125PHE A 116 | None | 0.82A | 1rtsA-5aeoA:undetectable | 1rtsA-5aeoA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5anr | PROBABLEATP-DEPENDENT RNAHELICASE DDX6 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | PHE B 377ILE B 400GLY B 383PHE B 380 | None | 0.86A | 1rtsA-5anrB:undetectable | 1rtsA-5anrB:20.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5by6 | THYMIDYLATE SYNTHASE (Trichinellaspiralis) |
PF00303(Thymidylat_synt) | 4 | ASP A 212LEU A 215GLY A 216TYR A 252 | NoneNoneUMP A 401 (-3.5A)UMP A 401 (-4.6A) | 0.72A | 1rtsA-5by6A:43.1 | 1rtsA-5by6A:62.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5by6 | THYMIDYLATE SYNTHASE (Trichinellaspiralis) |
PF00303(Thymidylat_synt) | 5 | PHE A 74ASP A 212GLY A 216PHE A 219TYR A 252 | NoneNoneUMP A 401 (-3.5A)DTT A 402 ( 4.1A)UMP A 401 (-4.6A) | 0.41A | 1rtsA-5by6A:43.1 | 1rtsA-5by6A:62.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5by6 | THYMIDYLATE SYNTHASE (Trichinellaspiralis) |
PF00303(Thymidylat_synt) | 5 | PHE A 74ILE A 102ASP A 212PHE A 219TYR A 252 | NoneDTT A 402 ( 4.3A)NoneDTT A 402 ( 4.1A)UMP A 401 (-4.6A) | 0.36A | 1rtsA-5by6A:43.1 | 1rtsA-5by6A:62.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eip | YTHDOMAIN-CONTAININGPROTEIN MMI1 (Schizosaccharomycespombe) |
PF04146(YTH) | 4 | PHE A 393ILE A 432GLY A 405PHE A 395 | None | 0.81A | 1rtsA-5eipA:undetectable | 1rtsA-5eipA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f4l | ENVELOPEGLYCOPROTEIN GP120OF HIV-1 CLADE C (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 4 | PHE A 468ILE A 359GLY A 393PHE A 361 | None | 0.73A | 1rtsA-5f4lA:undetectable | 1rtsA-5f4lA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6j | ENVELOPEGLYCOPROTEIN GP120OF HIV-1 CLADE C (Humanimmunodeficiencyvirus 1) |
no annotation | 4 | PHE G 468ILE G 359GLY G 393PHE G 361 | None | 0.66A | 1rtsA-5f6jG:undetectable | 1rtsA-5f6jG:18.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 6 | PHE A 104ILE A 132ASP A 242GLY A 246PHE A 249TYR A 282 | D16 A 401 (-3.6A)D16 A 401 ( 4.0A)D16 A 401 ( 4.0A)D16 A 401 ( 3.2A)D16 A 401 (-3.4A)UMP A 402 (-4.5A) | 0.26A | 1rtsA-5h3aA:43.7 | 1rtsA-5h3aA:70.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8a | YTHDOMAIN-CONTAININGPROTEIN MMI1 (Schizosaccharomycespombe) |
PF04146(YTH) | 4 | PHE A 393ILE A 432GLY A 405PHE A 395 | None | 0.80A | 1rtsA-5h8aA:undetectable | 1rtsA-5h8aA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | ASP A 307LEU A 310GLY A 306PHE A 305TYR A 17 | None | 1.15A | 1rtsA-5hctA:undetectable | 1rtsA-5hctA:19.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j7w | THYMIDYLATE SYNTHASE (Enterococcusfaecalis) |
PF00303(Thymidylat_synt) | 4 | ASP A 220LEU A 223GLY A 224TYR A 260 | None | 0.77A | 1rtsA-5j7wA:33.8 | 1rtsA-5j7wA:47.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j7w | THYMIDYLATE SYNTHASE (Enterococcusfaecalis) |
PF00303(Thymidylat_synt) | 4 | LEU A 223GLY A 224PHE A 227TYR A 260 | None | 0.80A | 1rtsA-5j7wA:33.8 | 1rtsA-5j7wA:47.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5min | QUINOPROTEIN GLUCOSEDEHYDROGENASE B (Acinetobactercalcoaceticus) |
no annotation | 4 | ILE A 94LEU A 149GLY A 81PHE A 82 | None | 0.75A | 1rtsA-5minA:undetectable | 1rtsA-5minA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | ASP A 307LEU A 310GLY A 306PHE A 305TYR A 17 | None | 1.14A | 1rtsA-5p60A:undetectable | 1rtsA-5p60A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy5 | NEURONAL PASDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
PF00010(HLH)PF00989(PAS)PF08447(PAS_3) | 4 | ILE B 271ASP B 147GLY B 148PHE B 149 | None | 0.78A | 1rtsA-5sy5B:undetectable | 1rtsA-5sy5B:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy7 | NEURONAL PASDOMAIN-CONTAININGPROTEIN 3 (Mus musculus) |
PF00010(HLH)PF00989(PAS)PF08447(PAS_3) | 4 | ILE B 291ASP B 164GLY B 165PHE B 166 | None | 0.66A | 1rtsA-5sy7B:undetectable | 1rtsA-5sy7B:21.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | ILE A 402TRP A 403ASP A 513LEU A 516GLY A 517PHE A 520TYR A 553 | CB3 A 703 (-3.4A)CB3 A 703 (-4.1A)CB3 A 703 ( 3.8A)CB3 A 703 (-3.7A)CB3 A 703 ( 3.0A)CB3 A 703 (-3.8A)UMP A 701 (-4.4A) | 0.57A | 1rtsA-5t0lA:42.4 | 1rtsA-5t0lA:34.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | PHE A 374ILE A 402ASP A 513LEU A 516GLY A 517PHE A 520TYR A 553 | NoneCB3 A 703 (-3.4A)CB3 A 703 ( 3.8A)CB3 A 703 (-3.7A)CB3 A 703 ( 3.0A)CB3 A 703 (-3.8A)UMP A 701 (-4.4A) | 0.44A | 1rtsA-5t0lA:42.4 | 1rtsA-5t0lA:34.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6auj | THYMIDYLATE SYNTHASE (Elizabethkingiaanophelis) |
PF00303(Thymidylat_synt) | 4 | ASP A 177GLY A 181PHE A 184TYR A 217 | NonePGE A 301 ( 4.0A)PGE A 301 (-3.7A)None | 0.42A | 1rtsA-6aujA:34.2 | 1rtsA-6aujA:49.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6auj | THYMIDYLATE SYNTHASE (Elizabethkingiaanophelis) |
PF00303(Thymidylat_synt) | 4 | ILE A 87ASP A 177PHE A 184TYR A 217 | PGE A 301 ( 4.2A)NonePGE A 301 (-3.7A)None | 0.52A | 1rtsA-6aujA:34.2 | 1rtsA-6aujA:49.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cdz | THYMIDYLATE SYNTHASE (Escherichiacoli) |
no annotation | 6 | ILE A 79ASP A 169LEU A 172GLY A 173PHE A 176TYR A 209 | CB3 A 701 (-3.9A)CB3 A 701 ( 3.6A)CB3 A 701 (-3.5A)CB3 A 701 (-3.3A)CB3 A 701 (-3.8A)UMP A 702 ( 4.2A) | 0.46A | 1rtsA-6cdzA:36.7 | 1rtsA-6cdzA:39.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ekt | P-47 PROTEIN (Clostridiumbotulinum) |
no annotation | 4 | PHE A 166ILE A 111GLY A 132PHE A 131 | None | 0.78A | 1rtsA-6ektA:undetectable | 1rtsA-6ektA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fwf | NITRIC-OXIDEREDUCTASE (Neisseriameningitidis) |
no annotation | 4 | ILE A 21LEU A 540GLY A 538PHE A 559 | None | 0.85A | 1rtsA-6fwfA:undetectable | 1rtsA-6fwfA:17.70 |