SIMILAR PATTERNS OF AMINO ACIDS FOR 1RS7_B_ACTB861_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 GLY A 172
ILE A 171
GLN A 193
VAL A 199
 None
None
SO4  A  14 (-3.2A)
None
 0.84A 1rs7B-1dciA:
0.1		 1rs7B-1dciA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN

(Thermotoga
maritima) 		PF01975
(SurE) 		4 GLY A  10
ILE A  11
GLN A  12
SER A  66
 None
 0.76A 1rs7B-1j9lA:
0.0		 1rs7B-1j9lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 GLY A 472
ILE A 471
VAL A  49
SER A 467
 None
 1.05A 1rs7B-1jr1A:
0.0		 1rs7B-1jr1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.05A 1rs7B-1jroA:
undetectable		 1rs7B-1jroA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 265
GLN A 290
VAL A 268
SER A 167
 None
 1.10A 1rs7B-1jvbA:
undetectable		 1rs7B-1jvbA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		6 GLY A 417
ILE A 419
GLN A 420
TRP A 587
VAL A 649
SER A 657
 ACT  A 860 ( 3.9A)
None
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 3.9A)
 0.20A 1rs7B-1lzxA:
62.6		 1rs7B-1lzxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1110 (-3.2A)
PLP  A1110 (-4.5A)
None
PLP  A1110 ( 4.3A)
 1.08A 1rs7B-1m54A:
0.0		 1rs7B-1m54A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 186
ILE A 188
GLN A 189
TRP A 356
VAL A 418
 MPD  A 604 (-3.8A)
None
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
 0.25A 1rs7B-1m9qA:
59.3		 1rs7B-1m9qA:
64.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 ILE A 188
GLN A 189
TRP A 356
VAL A 418
SER A 426
 None
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 (-3.1A)
 0.81A 1rs7B-1m9qA:
59.3		 1rs7B-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 GLY L  84
ILE L  88
TRP L  86
VAL L  66
 None
 1.10A 1rs7B-1pssL:
1.3		 1rs7B-1pssL:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 GLY A 196
ILE A 198
GLN A 199
TRP A 366
 HEM  A 900 ( 4.1A)
None
None
HEM  A 900 ( 3.5A)
 0.34A 1rs7B-1qw5A:
57.9		 1rs7B-1qw5A:
63.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 ILE A 198
GLN A 199
TRP A 366
SER A 436
 None
None
HEM  A 900 ( 3.5A)
None
 0.77A 1rs7B-1qw5A:
57.9		 1rs7B-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLY A 215
ILE A 213
VAL A 222
SER A 210
 None
 1.04A 1rs7B-1s4eA:
undetectable		 1rs7B-1s4eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLY A 404
ILE A 405
GLN A 403
TRP A 165
 None
 1.02A 1rs7B-1w1kA:
undetectable		 1rs7B-1w1kA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 GLY A 153
GLN A 165
VAL A 125
SER A 146
 None
 1.08A 1rs7B-2a9vA:
undetectable		 1rs7B-2a9vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 0.93A 1rs7B-2aa4A:
undetectable		 1rs7B-2aa4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLY A 213
ILE A 211
VAL A 220
SER A 208
 None
 1.03A 1rs7B-2dejA:
undetectable		 1rs7B-2dejA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fne MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A2010
GLN A2008
VAL A2020
SER A2016
 None
 1.08A 1rs7B-2fneA:
undetectable		 1rs7B-2fneA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		4 ILE A  78
GLN A  95
VAL A  21
SER A  72
 None
None
OLA  A 130 ( 4.9A)
OLA  A 130 ( 3.8A)
 1.04A 1rs7B-2ftbA:
undetectable		 1rs7B-2ftbA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		4 GLY A 136
ILE A 163
VAL A   6
SER A 164
 None
 1.05A 1rs7B-2g5xA:
undetectable		 1rs7B-2g5xA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		4 GLY A  69
ILE A  67
VAL A  72
SER A  89
 MLY  A  68 ( 2.3A)
MLY  A  68 ( 3.9A)
None
None
 1.09A 1rs7B-2g9nA:
undetectable		 1rs7B-2g9nA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 GLY A  25
ILE A 265
GLN A  28
VAL A 312
 None
 1.05A 1rs7B-2livA:
undetectable		 1rs7B-2livA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		4 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 1.02A 1rs7B-2o4eA:
undetectable		 1rs7B-2o4eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 GLY X  51
ILE X  47
GLN X  50
VAL X  39
 None
 1.01A 1rs7B-2odtX:
undetectable		 1rs7B-2odtX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owa ARFGAP-LIKE FINGER
DOMAIN CONTAINING
PROTEIN

(Cryptosporidium
parvum) 		PF01412
(ArfGap) 		4 GLY A 125
ILE A 123
GLN A 127
VAL A 107
 None
 0.97A 1rs7B-2owaA:
undetectable		 1rs7B-2owaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		4 GLY A  22
ILE A  23
VAL A 196
SER A 232
 None
 1.04A 1rs7B-2qq5A:
undetectable		 1rs7B-2qq5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 GLY A 147
ILE A 146
GLN A 168
VAL A 174
 None
 0.83A 1rs7B-2vreA:
undetectable		 1rs7B-2vreA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLY A 716
ILE A 838
GLN A 771
VAL A 431
 None
 0.98A 1rs7B-2wanA:
undetectable		 1rs7B-2wanA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 GLY A 390
ILE A 389
VAL A 367
SER A 386
 None
 1.01A 1rs7B-2xpzA:
undetectable		 1rs7B-2xpzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 GLY A 409
ILE A 404
VAL A 337
SER A 412
 None
 0.97A 1rs7B-2y4oA:
undetectable		 1rs7B-2y4oA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLY A  44
ILE A 448
GLN A 446
VAL A  30
 None
 0.88A 1rs7B-3a3iA:
undetectable		 1rs7B-3a3iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 1.05A 1rs7B-3ak1A:
undetectable		 1rs7B-3ak1A:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLY A 202
ILE A 204
GLN A 205
TRP A 372
 HEM  A 901 ( 3.8A)
None
None
HEM  A 901 ( 3.7A)
 0.26A 1rs7B-3e7gA:
57.1		 1rs7B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 ILE A 204
GLN A 205
TRP A 372
SER A 442
 None
None
HEM  A 901 ( 3.7A)
None
 0.80A 1rs7B-3e7gA:
57.1		 1rs7B-3e7gA:
65.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 GLY A 163
ILE A 160
GLN A 164
VAL A  88
 None
 0.85A 1rs7B-3eqaA:
undetectable		 1rs7B-3eqaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLY A 355
ILE A 362
GLN A 354
VAL A 366
 None
 1.03A 1rs7B-3fefA:
undetectable		 1rs7B-3fefA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 GLY P 363
ILE P 344
GLN P 362
SER P 307
 CA  P 482 (-4.4A)
None
None
None
 0.93A 1rs7B-3hbuP:
undetectable		 1rs7B-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 GLY P 364
ILE P 344
GLN P 362
SER P 307
 CA  P 482 (-4.2A)
None
None
None
 1.05A 1rs7B-3hbuP:
undetectable		 1rs7B-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		4 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.08A 1rs7B-3krsA:
undetectable		 1rs7B-3krsA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY B 136
ILE B 138
GLN B 135
SER B 148
 SF4  B 585 ( 4.9A)
None
SRM  A 580 (-3.5A)
None
 1.02A 1rs7B-3mm5B:
undetectable		 1rs7B-3mm5B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 408
VAL A 502
 CL  A 691 (-3.5A)
None
None
None
 1.07A 1rs7B-3pvcA:
undetectable		 1rs7B-3pvcA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II

(Bacillus
anthracis) 		PF01116
(F_bP_aldolase) 		4 GLY A  21
ILE A  46
GLN A  22
VAL A 207
 None
None
13P  A 321 ( 4.8A)
None
 1.08A 1rs7B-3q94A:
undetectable		 1rs7B-3q94A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1x 2-OXO-3-DEOXYGALACTO
NATE KINASE

(Klebsiella
pneumoniae) 		PF05035
(DGOK) 		4 GLY A  65
ILE A 101
TRP A  10
VAL A  35
 None
 1.10A 1rs7B-3r1xA:
undetectable		 1rs7B-3r1xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 341
ILE A 339
VAL A  17
SER A 336
 None
 1.10A 1rs7B-3ue9A:
undetectable		 1rs7B-3ue9A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		4 GLY A 523
ILE A 526
VAL A 600
SER A 658
 None
 1.04A 1rs7B-3up3A:
undetectable		 1rs7B-3up3A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 GLY A 564
ILE A 578
TRP A 607
VAL A 600
 None
 0.82A 1rs7B-3va6A:
undetectable		 1rs7B-3va6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.93A 1rs7B-3vscA:
undetectable		 1rs7B-3vscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 GLY A 320
ILE A 354
GLN A 321
VAL A 109
 None
 0.92A 1rs7B-3vsvA:
undetectable		 1rs7B-3vsvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.00A 1rs7B-3wquA:
undetectable		 1rs7B-3wquA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.06A 1rs7B-3wt0A:
undetectable		 1rs7B-3wt0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj8 ZEBAVIDIN

(Danio rerio) 		PF01382
(Avidin) 		4 GLY A  88
ILE A  84
GLN A  90
SER A   4
 None
 1.09A 1rs7B-4bj8A:
undetectable		 1rs7B-4bj8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 GLY B 162
ILE B  93
GLN B  96
VAL B 123
 None
 1.06A 1rs7B-4ci2B:
undetectable		 1rs7B-4ci2B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLY X 220
ILE X 222
VAL X 275
SER X 249
 None
 0.90A 1rs7B-4crmX:
undetectable		 1rs7B-4crmX:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		4 GLY A 302
ILE A 449
VAL A 216
SER A 448
 None
 0.94A 1rs7B-4epsA:
undetectable		 1rs7B-4epsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 GLY A1087
ILE A1089
GLN A1085
VAL A1064
 None
 0.91A 1rs7B-4igiA:
undetectable		 1rs7B-4igiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jde PROTEIN F15E11.13

(Caenorhabditis
elegans) 		no annotation 4 GLY A  78
ILE A 106
VAL A  31
SER A 107
 None
 0.97A 1rs7B-4jdeA:
undetectable		 1rs7B-4jdeA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus) 		PF03051
(Peptidase_C1_2) 		4 GLY A 370
ILE A  54
TRP A 381
SER A  53
 None
 0.74A 1rs7B-4k7cA:
undetectable		 1rs7B-4k7cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.93A 1rs7B-4kpgA:
undetectable		 1rs7B-4kpgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.03A 1rs7B-4ktoA:
undetectable		 1rs7B-4ktoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 4 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 0.96A 1rs7B-4l27B:
undetectable		 1rs7B-4l27B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1p COPPER-SENSITIVE
OPERON REPRESSOR
(CSOR)

(Geobacillus
thermodenitrificans) 		PF02583
(Trns_repr_metal) 		4 GLY A  35
ILE A  33
GLN A  36
VAL A  40
 None
 1.10A 1rs7B-4m1pA:
undetectable		 1rs7B-4m1pA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.92A 1rs7B-4m1zA:
undetectable		 1rs7B-4m1zA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 246
ILE A 243
VAL A   5
SER A 321
 None
 1.00A 1rs7B-4m9dA:
undetectable		 1rs7B-4m9dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)

(Agrobacterium
fabrum) 		PF04069
(OpuAC) 		4 GLY A 204
GLN A 258
VAL A 199
SER A 209
 None
 1.07A 1rs7B-4ne4A:
undetectable		 1rs7B-4ne4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx9 FLAGELLIN

(Pseudomonas
aeruginosa) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		4 GLY A 295
ILE A 290
VAL A 302
SER A  95
 None
 1.01A 1rs7B-4nx9A:
undetectable		 1rs7B-4nx9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 GLY A  89
ILE A  87
VAL A 143
SER A 118
 None
 1.09A 1rs7B-4ofwA:
undetectable		 1rs7B-4ofwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 GLY A 282
ILE A 280
VAL A 336
SER A 311
 None
 1.04A 1rs7B-4ofwA:
undetectable		 1rs7B-4ofwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkw MUSCLE-RELATED
COILED-COIL PROTEIN

(Danio rerio) 		PF15237
(PTRF_SDPR) 		4 GLY A  37
ILE A  35
GLN A  39
SER A  32
 None
 0.77A 1rs7B-4qkwA:
undetectable		 1rs7B-4qkwA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		4 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.02A 1rs7B-4r8uB:
undetectable		 1rs7B-4r8uB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		4 GLY A  93
ILE A  91
GLN A  95
VAL A  72
 None
 0.81A 1rs7B-4ryaA:
undetectable		 1rs7B-4ryaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II

(Staphylococcus
aureus) 		PF01116
(F_bP_aldolase) 		4 GLY A  21
ILE A  46
GLN A  22
VAL A 207
 None
 1.07A 1rs7B-4to8A:
undetectable		 1rs7B-4to8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 GLY B 170
ILE B 168
GLN B 171
VAL B 175
 None
 1.05A 1rs7B-4wvmB:
undetectable		 1rs7B-4wvmB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 ILE A 258
GLN A 262
VAL A 252
SER A 256
 None
 1.09A 1rs7B-4xgjA:
undetectable		 1rs7B-4xgjA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 GLY A 185
ILE A 184
VAL A 166
SER A 180
 None
None
None
78M  A 505 (-4.3A)
 1.05A 1rs7B-4xniA:
undetectable		 1rs7B-4xniA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 GLY A 145
ILE A 142
GLN A 146
VAL A 278
 None
 0.96A 1rs7B-4z0nA:
undetectable		 1rs7B-4z0nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		4 GLY A 304
ILE A 411
TRP A 299
SER A 412
 None
 0.98A 1rs7B-4zg8A:
undetectable		 1rs7B-4zg8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 307
ILE A 308
VAL A 347
SER A 410
 None
 1.09A 1rs7B-4zohA:
undetectable		 1rs7B-4zohA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 GLY A  59
ILE A 168
VAL A  55
SER A 137
 None
 1.10A 1rs7B-4zxlA:
undetectable		 1rs7B-4zxlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e44 FNR REGULATOR

(Aliivibrio
fischeri) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLY A 153
ILE A 151
GLN A 155
SER A 148
 MPD  A 302 (-4.0A)
None
None
None
 0.81A 1rs7B-5e44A:
undetectable		 1rs7B-5e44A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)

(Plasmodium
falciparum) 		no annotation 4 GLY A 166
ILE A 164
VAL A 130
SER A 162
 None
 1.10A 1rs7B-5ewpA:
undetectable		 1rs7B-5ewpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hou CELLULAR TUMOR
ANTIGEN
P53,CREB-BINDING
PROTEIN FUSION
PROTEIN

(Homo sapiens;
Mus musculus) 		PF02135
(zf-TAZ)
PF08563
(P53_TAD) 		4 ILE A1050
GLN A3356
VAL A3390
SER A3410
 None
 1.08A 1rs7B-5houA:
undetectable		 1rs7B-5houA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 GLY Z 161
ILE Z  92
GLN Z  95
VAL Z 122
 None
 1.05A 1rs7B-5hxbZ:
undetectable		 1rs7B-5hxbZ:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 GLY A 131
ILE A 128
GLN A 132
VAL A 181
 None
 0.92A 1rs7B-5ig2A:
undetectable		 1rs7B-5ig2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1g PLECTIN

(Homo sapiens) 		no annotation 4 GLY A1124
ILE A1122
GLN A1126
SER A1119
 None
 0.81A 1rs7B-5j1gA:
undetectable		 1rs7B-5j1gA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1i PLECTIN

(Homo sapiens) 		no annotation 4 GLY A1124
ILE A1122
GLN A1126
SER A1119
 None
 0.85A 1rs7B-5j1iA:
undetectable		 1rs7B-5j1iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		4 GLY A 455
ILE A 451
GLN A 454
SER A  23
 None
None
None
FAD  A 601 (-2.7A)
 0.88A 1rs7B-5j7xA:
undetectable		 1rs7B-5j7xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLY A 349
ILE A 252
TRP A 339
VAL A 298
 None
 0.96A 1rs7B-5jouA:
undetectable		 1rs7B-5jouA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 GLY A 272
ILE A 270
GLN A 273
VAL A 372
 None
 1.07A 1rs7B-5karA:
undetectable		 1rs7B-5karA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.90A 1rs7B-5kf7A:
undetectable		 1rs7B-5kf7A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 1.01A 1rs7B-5l1xB:
undetectable		 1rs7B-5l1xB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1002 (-3.6A)
PLP  A1002 (-4.7A)
None
PLP  A1002 (-3.7A)
 0.98A 1rs7B-5mmsA:
undetectable		 1rs7B-5mmsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L6

(Mycolicibacterium
smegmatis) 		PF00347
(Ribosomal_L6) 		4 GLY G   5
ILE G   4
GLN G   7
VAL G   9
 None
A  A2973 ( 4.5A)
None
None
 1.03A 1rs7B-5o60G:
undetectable		 1rs7B-5o60G:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 GLY A 479
ILE A 478
VAL A  55
SER A 474
 None
 1.07A 1rs7B-5tc3A:
undetectable		 1rs7B-5tc3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		4 GLY A  29
GLN A  30
VAL A  32
SER A 105
 None
 1.03A 1rs7B-5vf4A:
undetectable		 1rs7B-5vf4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		4 GLY A 265
ILE A 263
VAL A  34
SER A  51
 None
 1.06A 1rs7B-5x6sA:
undetectable		 1rs7B-5x6sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 GLY A 164
ILE A 168
VAL A 156
SER A 124
 None
 1.10A 1rs7B-5xjhA:
undetectable		 1rs7B-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 GLY A 242
ILE A 243
VAL A 150
SER A   7
 None
 1.04A 1rs7B-5xn8A:
undetectable		 1rs7B-5xn8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 GLY B 309
ILE B 311
GLN B 362
VAL B 573
 None
 0.89A 1rs7B-6f0kB:
undetectable		 1rs7B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 GLY A 163
ILE A 160
GLN A 164
VAL A  88
 None
 0.95A 1rs7B-6frvA:
undetectable		 1rs7B-6frvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 4 GLY A  77
ILE A  74
GLN A  78
VAL A  19
 None
 0.87A 1rs7B-6fwhA:
undetectable		 1rs7B-6fwhA:
undetectable