SIMILAR PATTERNS OF AMINO ACIDS FOR 1RS7_A_ACTA860_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 GLY A 187
ILE A 186
VAL A 197
SER A 206
 TZP  A2005 ( 3.9A)
ICP  A2001 ( 3.7A)
None
ICP  A2001 ( 4.1A)
 1.23A 1rs7A-1g67A:
0.0		 1rs7A-1g67A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 GLY A 472
ILE A 471
VAL A  49
SER A 467
 None
 1.18A 1rs7A-1jr1A:
0.0		 1rs7A-1jr1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.06A 1rs7A-1jroA:
undetectable		 1rs7A-1jroA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 GLY A 417
ILE A 419
TRP A 587
VAL A 649
SER A 657
 ACT  A 860 ( 3.9A)
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 3.9A)
 0.18A 1rs7A-1lzxA:
64.0		 1rs7A-1lzxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1110 (-3.2A)
PLP  A1110 (-4.5A)
None
PLP  A1110 ( 4.3A)
 1.02A 1rs7A-1m54A:
0.0		 1rs7A-1m54A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 186
ILE A 188
TRP A 356
VAL A 418
SER A 426
 MPD  A 604 (-3.8A)
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 (-3.1A)
 0.65A 1rs7A-1m9qA:
59.7		 1rs7A-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 GLY L  84
ILE L  88
TRP L  86
VAL L  66
 None
 1.10A 1rs7A-1pssL:
undetectable		 1rs7A-1pssL:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		4 GLY A 174
ILE A 107
TRP A 189
VAL A 163
 None
 1.17A 1rs7A-1pvtA:
0.0		 1rs7A-1pvtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.05A 1rs7A-1q8yA:
0.0		 1rs7A-1q8yA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 GLY A 196
ILE A 198
TRP A 366
SER A 436
 HEM  A 900 ( 4.1A)
None
HEM  A 900 ( 3.5A)
None
 0.65A 1rs7A-1qw5A:
57.9		 1rs7A-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		4 GLY A  11
ILE A 130
VAL A  36
SER A 128
 None
 1.14A 1rs7A-1tz6A:
undetectable		 1rs7A-1tz6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 GLY A 242
ILE A 206
TRP A 145
VAL A 141
 None
 1.17A 1rs7A-1uznA:
undetectable		 1rs7A-1uznA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3f HEMOLYTIC LECTIN
FROM LAETIPORUS
SULPHUREUS

(Laetiporus
sulphureus) 		PF03318
(ETX_MTX2) 		4 GLY A 300
ILE A 275
VAL A 220
SER A 302
 None
 1.24A 1rs7A-1w3fA:
undetectable		 1rs7A-1w3fA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wi4 SYNTAXIN BINDING
PROTEIN 4

(Mus musculus) 		PF00595
(PDZ) 		4 GLY A  28
ILE A  86
TRP A  97
VAL A  21
 None
 1.26A 1rs7A-1wi4A:
undetectable		 1rs7A-1wi4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.00A 1rs7A-1yt8A:
undetectable		 1rs7A-1yt8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 0.98A 1rs7A-2aa4A:
undetectable		 1rs7A-2aa4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		4 GLY A  69
ILE A  67
VAL A  72
SER A  89
 MLY  A  68 ( 2.3A)
MLY  A  68 ( 3.9A)
None
None
 1.17A 1rs7A-2g9nA:
undetectable		 1rs7A-2g9nA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		4 GLY A  69
ILE A  67
VAL A 210
SER A  89
 MLY  A  68 ( 2.3A)
MLY  A  68 ( 3.9A)
None
None
 1.21A 1rs7A-2g9nA:
undetectable		 1rs7A-2g9nA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		4 GLY A  58
ILE A  60
VAL A 424
SER A  91
 None
 1.20A 1rs7A-2gwnA:
undetectable		 1rs7A-2gwnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		4 GLY A 180
ILE A 181
VAL A 157
SER A 212
 None
 1.23A 1rs7A-2hp3A:
undetectable		 1rs7A-2hp3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		4 GLY A  69
ILE A  68
VAL A  75
SER A  42
 None
 1.25A 1rs7A-2nqoA:
undetectable		 1rs7A-2nqoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		4 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.93A 1rs7A-2o4eA:
undetectable		 1rs7A-2o4eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME C1

(Rhodobacter
sphaeroides) 		PF02167
(Cytochrom_C1) 		4 GLY B 127
ILE B 131
VAL B   9
SER B 212
 None
HEM  B 301 ( 4.3A)
None
None
 1.09A 1rs7A-2qjpB:
undetectable		 1rs7A-2qjpB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		4 GLY A  22
ILE A  23
VAL A 196
SER A 232
 None
 0.97A 1rs7A-2qq5A:
undetectable		 1rs7A-2qq5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 1.07A 1rs7A-2v9iA:
undetectable		 1rs7A-2v9iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1n O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00041
(fn3)
PF00963
(Cohesin) 		4 GLY A 945
ILE A 947
TRP A 934
VAL A 917
 None
 1.11A 1rs7A-2w1nA:
undetectable		 1rs7A-2w1nA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoy RBAM17540

(Bacillus
amyloliquefaciens) 		PF03067
(LPMO_10) 		4 GLY A 185
ILE A  31
VAL A  67
SER A  36
 None
 1.16A 1rs7A-2yoyA:
undetectable		 1rs7A-2yoyA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 1.00A 1rs7A-3ak1A:
undetectable		 1rs7A-3ak1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 GLY A 468
ILE A 459
TRP A 467
VAL A 463
 None
 1.14A 1rs7A-3b9tA:
undetectable		 1rs7A-3b9tA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLY A 202
ILE A 204
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.66A 1rs7A-3e7gA:
57.0		 1rs7A-3e7gA:
65.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 GLY A 275
ILE A 250
VAL A 292
SER A 254
 None
 1.17A 1rs7A-3eafA:
undetectable		 1rs7A-3eafA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		4 GLY A  54
ILE A  56
VAL A 371
SER A  91
 None
 1.13A 1rs7A-3egjA:
undetectable		 1rs7A-3egjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 GLY P 320
ILE P 248
VAL P 338
SER P 294
 None
 1.24A 1rs7A-3hbuP:
undetectable		 1rs7A-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 GLY 1 234
ILE 1 230
TRP 1 237
SER 1  60
 None
 1.26A 1rs7A-3i9v1:
undetectable		 1rs7A-3i9v1:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		4 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.14A 1rs7A-3krsA:
undetectable		 1rs7A-3krsA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nym UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		no annotation 4 GLY A  15
ILE A  12
TRP A  40
VAL A  27
 None
MLY  A   8 ( 3.9A)
MLY  A  39 ( 4.1A)
None
 1.26A 1rs7A-3nymA:
undetectable		 1rs7A-3nymA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oev PROTEASOME COMPONENT
C1

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 GLY F  75
ILE F  67
VAL F  46
SER F 213
 None
 1.24A 1rs7A-3oevF:
undetectable		 1rs7A-3oevF:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		4 GLY A  51
ILE A  55
TRP A 132
VAL A 136
 None
 1.20A 1rs7A-3p1uA:
undetectable		 1rs7A-3p1uA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1x 2-OXO-3-DEOXYGALACTO
NATE KINASE

(Klebsiella
pneumoniae) 		PF05035
(DGOK) 		4 GLY A  65
ILE A 101
TRP A  10
VAL A  35
 None
 1.11A 1rs7A-3r1xA:
undetectable		 1rs7A-3r1xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF07228
(SpoIIE) 		4 GLY A 135
ILE A 136
VAL A  47
SER A 132
 None
 1.20A 1rs7A-3rnrA:
undetectable		 1rs7A-3rnrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		4 GLY A 190
ILE A 189
VAL A 263
SER A 249
 None
 1.14A 1rs7A-3rucA:
undetectable		 1rs7A-3rucA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		4 GLY A 174
ILE A 176
VAL A 169
SER A 154
 None
 1.25A 1rs7A-3s55A:
undetectable		 1rs7A-3s55A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6d PHOTOSYNTHETIC
REACTION CENTER
M-SUBUNIT

(Blastochloris
viridis) 		PF00124
(Photo_RC) 		4 GLY M 125
TRP M 128
VAL M 131
SER M  54
 LDA  M 705 ( 3.7A)
None
BPB  M 402 ( 4.7A)
SO4  M 325 (-2.9A)
 1.25A 1rs7A-3t6dM:
undetectable		 1rs7A-3t6dM:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 GLY A 564
ILE A 578
TRP A 607
VAL A 600
 None
 0.84A 1rs7A-3va6A:
undetectable		 1rs7A-3va6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A  99
ILE A 235
TRP A  73
VAL A  76
 None
 1.18A 1rs7A-3vb9A:
undetectable		 1rs7A-3vb9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.81A 1rs7A-3vscA:
undetectable		 1rs7A-3vscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 GLY A 182
ILE A 186
VAL A 249
SER A  87
 None
 1.10A 1rs7A-4av6A:
undetectable		 1rs7A-4av6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		4 GLY A 106
ILE A 179
VAL A 176
SER A  47
 None
 1.19A 1rs7A-4c41A:
undetectable		 1rs7A-4c41A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLY X 220
ILE X 222
VAL X 275
SER X 249
 None
 0.98A 1rs7A-4crmX:
undetectable		 1rs7A-4crmX:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		4 GLY A 302
ILE A 449
VAL A 216
SER A 448
 None
 1.00A 1rs7A-4epsA:
undetectable		 1rs7A-4epsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 GLY C 187
ILE C 185
TRP C 195
VAL C 260
 None
 1.12A 1rs7A-4gnxC:
undetectable		 1rs7A-4gnxC:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j73 COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY A 115
ILE A 100
TRP A 124
VAL A 112
 None
 1.19A 1rs7A-4j73A:
undetectable		 1rs7A-4j73A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jde PROTEIN F15E11.13

(Caenorhabditis
elegans) 		no annotation 4 GLY A  78
ILE A 106
VAL A  31
SER A 107
 None
 1.02A 1rs7A-4jdeA:
undetectable		 1rs7A-4jdeA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus) 		PF03051
(Peptidase_C1_2) 		4 GLY A 370
ILE A  54
TRP A 381
SER A  53
 None
 0.83A 1rs7A-4k7cA:
undetectable		 1rs7A-4k7cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.96A 1rs7A-4kpgA:
undetectable		 1rs7A-4kpgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		4 GLY A  21
ILE A  23
VAL A 121
SER A  68
 None
 1.08A 1rs7A-4kq6A:
undetectable		 1rs7A-4kq6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.07A 1rs7A-4ktoA:
undetectable		 1rs7A-4ktoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 4 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 0.88A 1rs7A-4l27B:
undetectable		 1rs7A-4l27B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.94A 1rs7A-4m1zA:
undetectable		 1rs7A-4m1zA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 245
ILE A 243
VAL A   5
SER A 321
 None
 1.03A 1rs7A-4m9dA:
undetectable		 1rs7A-4m9dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 246
ILE A 243
VAL A   5
SER A 321
 None
 1.00A 1rs7A-4m9dA:
undetectable		 1rs7A-4m9dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		4 GLY A 546
ILE A 547
VAL A 620
SER A 634
 None
 1.00A 1rs7A-4mhcA:
undetectable		 1rs7A-4mhcA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Plesiocystis
pacifica) 		PF13561
(adh_short_C2) 		4 GLY A 176
ILE A 178
VAL A 171
SER A 156
 None
 1.26A 1rs7A-4nbwA:
undetectable		 1rs7A-4nbwA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 GLY A  89
ILE A  87
VAL A 143
SER A 118
 None
 0.98A 1rs7A-4ofwA:
undetectable		 1rs7A-4ofwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 GLY A 282
ILE A 280
VAL A 336
SER A 311
 None
 0.90A 1rs7A-4ofwA:
undetectable		 1rs7A-4ofwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 GLY A 260
ILE A 532
TRP A 264
VAL A 206
 None
 1.25A 1rs7A-4q6kA:
undetectable		 1rs7A-4q6kA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		4 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.00A 1rs7A-4r8uB:
undetectable		 1rs7A-4r8uB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		4 GLY A 158
ILE A 159
VAL A 173
SER A 132
 None
None
None
PRO  A 501 (-2.6A)
 1.16A 1rs7A-4rdcA:
undetectable		 1rs7A-4rdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 GLY A 239
ILE A 426
VAL A 256
SER A 218
 None
 1.25A 1rs7A-4xhjA:
undetectable		 1rs7A-4xhjA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 GLY A 506
ILE A 505
VAL A 486
SER A 528
 None
 1.25A 1rs7A-5aeeA:
undetectable		 1rs7A-5aeeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		4 GLY A 140
ILE A  54
TRP A  57
SER A  85
 None
None
GOL  A 407 ( 4.1A)
None
 1.21A 1rs7A-5d6oA:
undetectable		 1rs7A-5d6oA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE
PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ)
PF03170
(BcsB) 		4 GLY A  43
ILE A  45
VAL B 585
SER A  48
 None
 1.14A 1rs7A-5ej1A:
undetectable		 1rs7A-5ej1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		4 GLY A 413
ILE A 412
VAL A  24
SER A 409
 None
 1.11A 1rs7A-5esoA:
undetectable		 1rs7A-5esoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)

(Plasmodium
falciparum) 		no annotation 4 GLY A 166
ILE A 164
VAL A 130
SER A 162
 None
 1.14A 1rs7A-5ewpA:
undetectable		 1rs7A-5ewpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 GLY A  70
ILE A  71
VAL A  23
SER A 164
 None
None
PPV  A1339 (-4.0A)
PPV  A1339 (-3.2A)
 1.15A 1rs7A-5fo1A:
undetectable		 1rs7A-5fo1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzp TRIOSEPHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00121
(TIM) 		4 GLY A 228
ILE A 221
VAL A 212
SER A 246
 None
EDO  A 305 (-4.8A)
None
None
 1.24A 1rs7A-5gzpA:
undetectable		 1rs7A-5gzpA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmu PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

([Eubacterium]
rectale) 		PF01522
(Polysacc_deac_1) 		4 GLY A 401
ILE A 402
VAL A 494
SER A 395
 OCS  A 399 ( 4.2A)
OCS  A 399 ( 3.6A)
None
None
 1.20A 1rs7A-5jmuA:
undetectable		 1rs7A-5jmuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLY A 349
ILE A 252
TRP A 339
VAL A 298
 None
 0.96A 1rs7A-5jouA:
undetectable		 1rs7A-5jouA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.88A 1rs7A-5kf7A:
undetectable		 1rs7A-5kf7A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 0.95A 1rs7A-5l1xB:
undetectable		 1rs7A-5l1xB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 4 GLY B 277
ILE B 279
VAL B 149
SER B  40
 None
 1.00A 1rs7A-5l22B:
undetectable		 1rs7A-5l22B:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2v CHITIN-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF03067
(LPMO_10) 		4 GLY A 145
ILE A   4
VAL A  32
SER A   9
 None
 1.21A 1rs7A-5l2vA:
undetectable		 1rs7A-5l2vA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		4 GLY A 510
ILE A 542
VAL A 490
SER A 572
 None
 1.18A 1rs7A-5m60A:
undetectable		 1rs7A-5m60A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1002 (-3.6A)
PLP  A1002 (-4.7A)
None
PLP  A1002 (-3.7A)
 0.90A 1rs7A-5mmsA:
undetectable		 1rs7A-5mmsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 4 GLY A 250
ILE A 214
TRP A 153
VAL A 149
 None
 1.21A 1rs7A-5ovkA:
undetectable		 1rs7A-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovl 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 4 GLY A 250
ILE A 214
TRP A 153
VAL A 149
 None
 1.23A 1rs7A-5ovlA:
undetectable		 1rs7A-5ovlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 1.08A 1rs7A-5supA:
undetectable		 1rs7A-5supA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 1.08A 1rs7A-5suqA:
undetectable		 1rs7A-5suqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 GLY A 479
ILE A 478
VAL A  55
SER A 474
 None
 1.21A 1rs7A-5tc3A:
undetectable		 1rs7A-5tc3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0y HYDROPHOBIN

(Serpula
lacrymans) 		no annotation 4 GLY A  53
ILE A  54
VAL A  12
SER A  60
 None
 1.07A 1rs7A-5w0yA:
undetectable		 1rs7A-5w0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb0 FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		no annotation 4 GLY F 393
ILE F 399
VAL F 424
SER F 391
 None
 1.20A 1rs7A-5wb0F:
undetectable		 1rs7A-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 ILE B 304
TRP B 302
VAL B 277
SER B 378
 None
 1.23A 1rs7A-5x2oB:
undetectable		 1rs7A-5x2oB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		4 GLY A 265
ILE A 263
VAL A  34
SER A  51
 None
 1.17A 1rs7A-5x6sA:
undetectable		 1rs7A-5x6sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 GLY A 164
ILE A 168
VAL A 156
SER A 124
 None
 1.09A 1rs7A-5xjhA:
undetectable		 1rs7A-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 GLY A 242
ILE A 243
VAL A 150
SER A   7
 None
 1.06A 1rs7A-5xn8A:
undetectable		 1rs7A-5xn8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxa NON-STRUCTURAL
PROTEIN 1

(Yellow fever
virus) 		no annotation 4 GLY A  78
ILE A  76
VAL A  91
SER A  75
 None
 1.24A 1rs7A-5yxaA:
undetectable		 1rs7A-5yxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 GLY A 137
ILE A 141
VAL A 129
SER A  97
 None
 1.10A 1rs7A-6aneA:
undetectable		 1rs7A-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Legionella
pneumophila) 		no annotation 4 GLY A 114
ILE A 130
VAL A  45
SER A 148
 None
None
None
EDO  A 302 (-3.8A)
 1.20A 1rs7A-6cktA:
undetectable		 1rs7A-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 GLY B 309
ILE B 311
VAL B 573
SER B 291
 None
 1.09A 1rs7A-6f0kB:
undetectable		 1rs7A-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 4 GLY A 353
ILE A 288
VAL A 340
SER A 326
 None
 1.24A 1rs7A-6gu8A:
undetectable		 1rs7A-6gu8A:
undetectable