SIMILAR PATTERNS OF AMINO ACIDS FOR 1RS6_B_H4BB761_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 TRP A 673
PHE A 681
GLU A 649
VAL A 667
 None
 1.30A 1rs6A-1c4kA:
0.0
1rs6B-1c4kA:
0.0		 1rs6A-1c4kA:
19.09
1rs6B-1c4kA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 PHE A 501
GLU A 519
VAL A  41
TRP A 521
 None
 1.31A 1rs6A-1flgA:
undetectable
1rs6B-1flgA:
undetectable		 1rs6A-1flgA:
20.03
1rs6B-1flgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 PHE C 360
GLU C 353
MET C 291
VAL C 216
 None
 1.40A 1rs6A-1h2tC:
0.0
1rs6B-1h2tC:
0.0		 1rs6A-1h2tC:
19.51
1rs6B-1h2tC:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 GLU A 814
MET A 815
VAL A 707
TRP A 819
 None
 1.18A 1rs6A-1jqoA:
0.0
1rs6B-1jqoA:
0.0		 1rs6A-1jqoA:
18.24
1rs6B-1jqoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 TRP A  97
PHE A 131
GLU A  95
ARG A 130
 None
 1.41A 1rs6A-1kexA:
undetectable
1rs6B-1kexA:
undetectable		 1rs6A-1kexA:
16.83
1rs6B-1kexA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		4 PHE A 220
GLU A 222
ARG A 282
VAL A 226
 None
 1.29A 1rs6A-1kh2A:
undetectable
1rs6B-1kh2A:
0.0		 1rs6A-1kh2A:
22.65
1rs6B-1kh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 TRP A 558
PHE A 568
GLU A 566
VAL A 530
 None
 1.49A 1rs6A-1knbA:
undetectable
1rs6B-1knbA:
undetectable		 1rs6A-1knbA:
18.93
1rs6B-1knbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 TRP A 155
PHE A 156
GLU A 154
ARG A 340
 None
 1.36A 1rs6A-1l5jA:
undetectable
1rs6B-1l5jA:
0.0		 1rs6A-1l5jA:
19.23
1rs6B-1l5jA:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 MET A 336
ARG A 596
VAL A 677
TRP A 678
 H4B  A 760 ( 3.8A)
H4B  A 760 (-3.5A)
H4B  A 760 (-4.6A)
H4B  A 760 ( 3.6A)
 0.53A 1rs6A-1lzxA:
64.2
1rs6B-1lzxA:
62.8		 1rs6A-1lzxA:
100.00
1rs6B-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 TRP A 306
TRP A 676
PHE A 691
GLU A 694
 None
 0.10A 1rs6A-1lzxA:
64.2
1rs6B-1lzxA:
62.8		 1rs6A-1lzxA:
100.00
1rs6B-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  74
TRP A 445
PHE A 460
GLU A 463
 None
MPD  A 603 (-4.6A)
MPD  A 603 (-4.2A)
None
 0.14A 1rs6A-1m9qA:
59.7
1rs6B-1m9qA:
59.2		 1rs6A-1m9qA:
64.72
1rs6B-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 PHE D  35
GLU D 132
VAL D  28
TRP D  31
 None
 1.32A 1rs6A-1mhzD:
undetectable
1rs6B-1mhzD:
undetectable		 1rs6A-1mhzD:
20.89
1rs6B-1mhzD:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN

(Pseudomonas
aeruginosa) 		PF01475
(FUR) 		4 PHE A  79
GLU A  36
ARG A  69
VAL A  54
 None
 1.05A 1rs6A-1mzbA:
undetectable
1rs6B-1mzbA:
2.2		 1rs6A-1mzbA:
16.63
1rs6B-1mzbA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 TRP A 435
PHE A 432
MET A 440
VAL A 401
 None
 0.94A 1rs6A-1pduA:
undetectable
1rs6B-1pduA:
undetectable		 1rs6A-1pduA:
19.29
1rs6B-1pduA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 1rs6A-1qb4A:
undetectable
1rs6B-1qb4A:
3.8		 1rs6A-1qb4A:
19.19
1rs6B-1qb4A:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 TRP A  84
TRP A 455
PHE A 470
GLU A 473
 None
 0.25A 1rs6A-1qw5A:
57.9
1rs6B-1qw5A:
58.1		 1rs6A-1qw5A:
63.90
1rs6B-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfe HYPOTHETICAL PROTEIN
RV2991

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 TRP A  52
PHE A  73
GLU A  50
VAL A  20
 None
 1.39A 1rs6A-1rfeA:
undetectable
1rs6B-1rfeA:
undetectable		 1rs6A-1rfeA:
17.96
1rs6B-1rfeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 TRP A 277
PHE A 254
GLU A 250
VAL A 122
 None
 1.48A 1rs6A-1tkiA:
undetectable
1rs6B-1tkiA:
undetectable		 1rs6A-1tkiA:
20.28
1rs6B-1tkiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		4 PHE C 536
GLU C 542
MET C 541
VAL C 691
 None
 1.30A 1rs6A-1u0oC:
undetectable
1rs6B-1u0oC:
undetectable		 1rs6A-1u0oC:
21.14
1rs6B-1u0oC:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		4 TRP A 162
PHE A 265
GLU A 161
VAL A 221
 None
 1.46A 1rs6A-1vmkA:
undetectable
1rs6B-1vmkA:
undetectable		 1rs6A-1vmkA:
21.53
1rs6B-1vmkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.14A 1rs6A-1w8gA:
undetectable
1rs6B-1w8gA:
undetectable		 1rs6A-1w8gA:
20.28
1rs6B-1w8gA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 PHE B 163
GLU B  26
ARG B 156
VAL B 128
 None
 1.19A 1rs6A-1wqlB:
undetectable
1rs6B-1wqlB:
undetectable		 1rs6A-1wqlB:
19.79
1rs6B-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.25A 1rs6A-1y4jA:
undetectable
1rs6B-1y4jA:
undetectable		 1rs6A-1y4jA:
20.94
1rs6B-1y4jA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 PHE A 722
GLU A 693
ARG A 708
VAL A1424
 None
 1.05A 1rs6A-2b39A:
undetectable
1rs6B-2b39A:
2.4		 1rs6A-2b39A:
13.53
1rs6B-2b39A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 1rs6A-2b4xI:
undetectable
1rs6B-2b4xI:
undetectable		 1rs6A-2b4xI:
21.97
1rs6B-2b4xI:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 TRP B 788
GLU A 360
ARG A  62
VAL A 367
 None
 1.39A 1rs6A-2fjaB:
undetectable
1rs6B-2fjaB:
undetectable		 1rs6A-2fjaB:
18.53
1rs6B-2fjaB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggm CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A 162
GLU A 148
MET A 145
VAL A 157
 None
 1.32A 1rs6A-2ggmA:
undetectable
1rs6B-2ggmA:
undetectable		 1rs6A-2ggmA:
17.43
1rs6B-2ggmA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 PHE A  21
GLU A  17
ARG A 261
VAL A 443
 None
 1.29A 1rs6A-2glfA:
undetectable
1rs6B-2glfA:
undetectable		 1rs6A-2glfA:
20.87
1rs6B-2glfA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 PHE A 529
GLU A 534
MET A 537
TRP A 536
 None
 1.34A 1rs6A-2i0kA:
undetectable
1rs6B-2i0kA:
2.0		 1rs6A-2i0kA:
20.65
1rs6B-2i0kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obh CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A 162
GLU A 148
MET A 145
VAL A 157
 None
None
None
CA  A1001 ( 4.9A)
 1.35A 1rs6A-2obhA:
undetectable
1rs6B-2obhA:
undetectable		 1rs6A-2obhA:
17.13
1rs6B-2obhA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.09A 1rs6A-2v4jA:
undetectable
1rs6B-2v4jA:
undetectable		 1rs6A-2v4jA:
21.78
1rs6B-2v4jA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 TRP A 252
PHE A 254
GLU A 251
VAL A 245
 None
None
MRD  A1301 (-4.3A)
None
 1.43A 1rs6A-2vy0A:
undetectable
1rs6B-2vy0A:
undetectable		 1rs6A-2vy0A:
19.82
1rs6B-2vy0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1rs6A-2w4oA:
1.4
1rs6B-2w4oA:
undetectable		 1rs6A-2w4oA:
20.81
1rs6B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 PHE A  98
GLU A 108
ARG A 159
VAL A 164
 None
 1.47A 1rs6A-2xhyA:
undetectable
1rs6B-2xhyA:
undetectable		 1rs6A-2xhyA:
20.28
1rs6B-2xhyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 PHE A 309
GLU A 305
ARG A 211
VAL A 239
 None
 1.27A 1rs6A-2ywbA:
undetectable
1rs6B-2ywbA:
undetectable		 1rs6A-2ywbA:
21.54
1rs6B-2ywbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF13302
(Acetyltransf_3) 		4 TRP A  66
PHE A   4
GLU A   6
VAL A  64
 None
 1.37A 1rs6A-2z11A:
undetectable
1rs6B-2z11A:
undetectable		 1rs6A-2z11A:
17.58
1rs6B-2z11A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		4 TRP A 164
GLU A 206
ARG A 200
TRP A 234
 GLC  A 502 ( 3.8A)
GLC  A 503 ( 3.3A)
GLC  A 603 (-3.4A)
GLC  A 501 (-3.4A)
 1.40A 1rs6A-2z1kA:
undetectable
1rs6B-2z1kA:
undetectable		 1rs6A-2z1kA:
21.09
1rs6B-2z1kA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf8 COMPONENT OF
SODIUM-DRIVEN POLAR
FLAGELLAR MOTOR

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		4 TRP A  15
PHE A 137
GLU A  16
MET A  17
 None
 1.37A 1rs6A-2zf8A:
undetectable
1rs6B-2zf8A:
undetectable		 1rs6A-2zf8A:
20.92
1rs6B-2zf8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE

(Mycobacterium
gastri) 		PF00215
(OMPdecase) 		4 PHE A1074
GLU A1069
MET A1060
VAL A1106
 None
 1.28A 1rs6A-3ajxA:
undetectable
1rs6B-3ajxA:
undetectable		 1rs6A-3ajxA:
20.28
1rs6B-3ajxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
kodakarensis) 		PF05916
(Sld5) 		4 TRP B  30
PHE B  80
GLU B  28
VAL B  10
 None
 1.19A 1rs6A-3anwB:
undetectable
1rs6B-3anwB:
undetectable		 1rs6A-3anwB:
16.14
1rs6B-3anwB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT

(Cupriavidus
pinatubonensis) 		no annotation 4 TRP A 374
GLU A 372
VAL A 314
TRP A 293
 None
EDO  A 404 ( 3.8A)
None
None
 1.43A 1rs6A-3b7fA:
undetectable
1rs6B-3b7fA:
undetectable		 1rs6A-3b7fA:
20.87
1rs6B-3b7fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 PHE A 152
GLU A 205
ARG A 153
VAL A 211
 None
None
None
EDO  A 401 ( 4.2A)
 1.50A 1rs6A-3bjdA:
undetectable
1rs6B-3bjdA:
undetectable		 1rs6A-3bjdA:
21.60
1rs6B-3bjdA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2w TAR DNA-BINDING
PROTEIN 43

(Mus musculus) 		PF00076
(RRM_1) 		4 PHE A 211
GLU A 206
MET A 202
VAL A 220
 None
 0.99A 1rs6A-3d2wA:
undetectable
1rs6B-3d2wA:
undetectable		 1rs6A-3d2wA:
12.22
1rs6B-3d2wA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		4 TRP A  70
PHE A  88
GLU A  71
VAL A  16
 None
 1.49A 1rs6A-3ddlA:
undetectable
1rs6B-3ddlA:
undetectable		 1rs6A-3ddlA:
20.14
1rs6B-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 TRP A 349
PHE A 352
GLU A 350
VAL A 483
 None
 1.44A 1rs6A-3djaA:
undetectable
1rs6B-3djaA:
3.2		 1rs6A-3djaA:
21.19
1rs6B-3djaA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.19A 1rs6A-3e7gA:
56.7
1rs6B-3e7gA:
57.0		 1rs6A-3e7gA:
65.57
1rs6B-3e7gA:
65.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 TRP B  88
GLU A 380
ARG A  66
VAL A 387
 None
 1.31A 1rs6A-3gyxB:
undetectable
1rs6B-3gyxB:
undetectable		 1rs6A-3gyxB:
16.67
1rs6B-3gyxB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Prochlorococcus
marinus) 		PF12707
(DUF3804) 		4 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 1rs6A-3hzpA:
undetectable
1rs6B-3hzpA:
undetectable		 1rs6A-3hzpA:
13.98
1rs6B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri) 		PF14496
(NEL) 		4 TRP A 274
GLU A 314
VAL A 258
TRP A 261
 None
 1.30A 1rs6A-3l3pA:
undetectable
1rs6B-3l3pA:
3.3		 1rs6A-3l3pA:
20.65
1rs6B-3l3pA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 TRP A 257
PHE A 252
ARG A 269
VAL A 260
 None
 1.44A 1rs6A-3ma6A:
undetectable
1rs6B-3ma6A:
undetectable		 1rs6A-3ma6A:
21.55
1rs6B-3ma6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 TRP A1001
PHE A 946
GLU A 908
ARG A 944
 None
 1.46A 1rs6A-3n3kA:
undetectable
1rs6B-3n3kA:
undetectable		 1rs6A-3n3kA:
19.65
1rs6B-3n3kA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens) 		PF00173
(Cyt-b5) 		4 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
HEM  A 201 (-4.5A)
 1.49A 1rs6A-3nerA:
undetectable
1rs6B-3nerA:
undetectable		 1rs6A-3nerA:
14.93
1rs6B-3nerA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkz FLAGELLAR PROTEIN
FLIT

(Yersinia
enterocolitica) 		PF05400
(FliT) 		4 GLU A  37
MET A  38
ARG A  69
VAL A  44
 None
None
None
PG4  A 122 ( 4.2A)
 1.36A 1rs6A-3nkzA:
undetectable
1rs6B-3nkzA:
2.4		 1rs6A-3nkzA:
15.33
1rs6B-3nkzA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.28A 1rs6A-3or2A:
undetectable
1rs6B-3or2A:
undetectable		 1rs6A-3or2A:
21.83
1rs6B-3or2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 PHE A 121
GLU A 119
ARG A 175
VAL A  92
 None
 1.21A 1rs6A-3owcA:
undetectable
1rs6B-3owcA:
undetectable		 1rs6A-3owcA:
16.31
1rs6B-3owcA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		4 PHE A 165
GLU A  80
MET A  83
VAL A 187
 None
 1.47A 1rs6A-3p0lA:
undetectable
1rs6B-3p0lA:
undetectable		 1rs6A-3p0lA:
19.62
1rs6B-3p0lA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q63 MLL2253 PROTEIN

(Mesorhizobium
japonicum) 		PF08327
(AHSA1) 		4 PHE A 113
GLU A 109
MET A 108
TRP A 128
 None
 1.49A 1rs6A-3q63A:
undetectable
1rs6B-3q63A:
undetectable		 1rs6A-3q63A:
15.45
1rs6B-3q63A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 TRP A 146
PHE A 162
GLU A 187
VAL A 149
 None
 1.26A 1rs6A-3rjyA:
undetectable
1rs6B-3rjyA:
undetectable		 1rs6A-3rjyA:
21.27
1rs6B-3rjyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		4 TRP A 138
GLU A 155
VAL A 184
TRP A 156
 GOL  A 278 (-3.7A)
GOL  A 278 (-3.4A)
None
211  A 280 ( 4.7A)
 1.04A 1rs6A-3rq0A:
undetectable
1rs6B-3rq0A:
undetectable		 1rs6A-3rq0A:
20.78
1rs6B-3rq0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 PHE A 305
GLU A 265
VAL A 240
TRP A 239
 None
 1.43A 1rs6A-3ti8A:
undetectable
1rs6B-3ti8A:
undetectable		 1rs6A-3ti8A:
22.37
1rs6B-3ti8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 PHE B 953
GLU B 951
ARG B 924
VAL B 944
 None
 1.28A 1rs6A-3tixB:
undetectable
1rs6B-3tixB:
undetectable		 1rs6A-3tixB:
21.73
1rs6B-3tixB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa) 		PF02223
(Thymidylate_kin) 		4 PHE A 162
GLU A 156
ARG A 109
VAL A 166
 None
MG  A 213 (-3.2A)
None
None
 1.31A 1rs6A-3uxmA:
undetectable
1rs6B-3uxmA:
undetectable		 1rs6A-3uxmA:
20.29
1rs6B-3uxmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 TRP A 191
GLU A 486
MET A 434
VAL A 452
 None
 1.12A 1rs6A-4arcA:
undetectable
1rs6B-4arcA:
2.6		 1rs6A-4arcA:
18.53
1rs6B-4arcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		4 TRP C2314
PHE C2329
GLU C2310
VAL C2274
 None
 1.29A 1rs6A-4bgdC:
undetectable
1rs6B-4bgdC:
undetectable		 1rs6A-4bgdC:
20.63
1rs6B-4bgdC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 PHE A1118
GLU A1032
ARG A1065
VAL A1046
 None
 1.32A 1rs6A-4d8oA:
undetectable
1rs6B-4d8oA:
undetectable		 1rs6A-4d8oA:
19.77
1rs6B-4d8oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 TRP A 383
PHE A 370
ARG A 373
VAL A 412
 None
 1.49A 1rs6A-4fnqA:
undetectable
1rs6B-4fnqA:
undetectable		 1rs6A-4fnqA:
20.86
1rs6B-4fnqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 TRP A  62
PHE A  85
MET A 258
VAL A 265
 None
 1.32A 1rs6A-4g76A:
undetectable
1rs6B-4g76A:
undetectable		 1rs6A-4g76A:
19.91
1rs6B-4g76A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 TRP A 730
GLU A 412
ARG A 724
VAL A 442
 None
 1.12A 1rs6A-4iglA:
undetectable
1rs6B-4iglA:
undetectable		 1rs6A-4iglA:
14.88
1rs6B-4iglA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.28A 1rs6A-4j3qA:
undetectable
1rs6B-4j3qA:
undetectable		 1rs6A-4j3qA:
20.32
1rs6B-4j3qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 PHE A   7
GLU A  42
ARG A  29
VAL A  73
 None
None
None
FLC  A 300 (-4.1A)
 1.11A 1rs6A-4lmvA:
undetectable
1rs6B-4lmvA:
undetectable		 1rs6A-4lmvA:
21.00
1rs6B-4lmvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mln PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		4 PHE A  93
GLU A 183
MET A 180
VAL A   9
 None
 1.09A 1rs6A-4mlnA:
undetectable
1rs6B-4mlnA:
undetectable		 1rs6A-4mlnA:
16.12
1rs6B-4mlnA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		4 PHE A  93
GLU A 183
MET A 180
VAL A   9
 None
 1.15A 1rs6A-4n6wA:
undetectable
1rs6B-4n6wA:
undetectable		 1rs6A-4n6wA:
19.62
1rs6B-4n6wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		4 PHE A  68
GLU A 115
ARG A 125
VAL A  53
 None
 1.31A 1rs6A-4p2lA:
undetectable
1rs6B-4p2lA:
undetectable		 1rs6A-4p2lA:
21.43
1rs6B-4p2lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 TRP A 151
GLU A 168
VAL A 197
TRP A 169
 TRP  A 151 (-0.5A)
GLU  A 168 (-0.5A)
VAL  A 197 ( 0.6A)
TRP  A 169 ( 0.5A)
 1.05A 1rs6A-4w65A:
undetectable
1rs6B-4w65A:
undetectable		 1rs6A-4w65A:
20.65
1rs6B-4w65A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzf 1,3-BETA-GLUCANASE

(Mycobacterium
tuberculosis) 		PF00722
(Glyco_hydro_16) 		4 TRP A 156
GLU A 176
VAL A 205
TRP A 177
 EDO  A 402 (-4.1A)
EDO  A 402 (-3.5A)
None
None
 1.00A 1rs6A-4wzfA:
undetectable
1rs6B-4wzfA:
undetectable		 1rs6A-4wzfA:
20.86
1rs6B-4wzfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.27A 1rs6A-4x8dA:
undetectable
1rs6B-4x8dA:
2.6		 1rs6A-4x8dA:
19.80
1rs6B-4x8dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		4 TRP A 128
GLU A 148
VAL A 177
TRP A 149
 EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
None
EDO  A 308 (-3.6A)
 1.06A 1rs6A-4xdqA:
undetectable
1rs6B-4xdqA:
undetectable		 1rs6A-4xdqA:
21.18
1rs6B-4xdqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 264
GLU A 266
ARG A 276
VAL A 305
 None
 1.19A 1rs6A-4xj6A:
undetectable
1rs6B-4xj6A:
undetectable		 1rs6A-4xj6A:
21.11
1rs6B-4xj6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 TRP A 263
PHE A 264
GLU A 266
VAL A 305
 None
 1.08A 1rs6A-4xj6A:
undetectable
1rs6B-4xj6A:
undetectable		 1rs6A-4xj6A:
21.11
1rs6B-4xj6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		4 TRP A 147
GLU A 164
VAL A 193
TRP A 165
 None
 1.12A 1rs6A-4xxpA:
undetectable
1rs6B-4xxpA:
undetectable		 1rs6A-4xxpA:
17.55
1rs6B-4xxpA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 PHE A 277
GLU A 279
VAL A 288
TRP A 292
 None
 1.39A 1rs6A-4ylrA:
undetectable
1rs6B-4ylrA:
undetectable		 1rs6A-4ylrA:
22.86
1rs6B-4ylrA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 TRP A 732
GLU A 731
ARG A 505
VAL A 736
 None
 1.38A 1rs6A-5by3A:
undetectable
1rs6B-5by3A:
undetectable		 1rs6A-5by3A:
19.87
1rs6B-5by3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		4 TRP A 401
PHE A 397
GLU A 402
VAL B  28
 None
 1.47A 1rs6A-5c6gA:
3.6
1rs6B-5c6gA:
2.7		 1rs6A-5c6gA:
21.72
1rs6B-5c6gA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 GLU A 418
ARG A 316
VAL A 438
TRP A 439
 None
BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
 1.33A 1rs6A-5fjnA:
undetectable
1rs6B-5fjnA:
undetectable		 1rs6A-5fjnA:
23.52
1rs6B-5fjnA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 TRP A 311
TRP A 347
PHE A 290
GLU A 313
 None
 1.50A 1rs6A-5jseA:
undetectable
1rs6B-5jseA:
undetectable		 1rs6A-5jseA:
21.16
1rs6B-5jseA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TRP A  83
PHE A  61
GLU A  84
VAL A  92
 None
 1.31A 1rs6A-5kn8A:
undetectable
1rs6B-5kn8A:
undetectable		 1rs6A-5kn8A:
22.08
1rs6B-5kn8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.29A 1rs6A-5lb8A:
undetectable
1rs6B-5lb8A:
undetectable		 1rs6A-5lb8A:
20.27
1rs6B-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1rs6A-5m8tA:
undetectable
1rs6B-5m8tA:
undetectable		 1rs6A-5m8tA:
20.08
1rs6B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		4 TRP A 135
GLU A 144
ARG A 153
VAL A 192
 None
 1.40A 1rs6A-5nlaA:
undetectable
1rs6B-5nlaA:
undetectable		 1rs6A-5nlaA:
21.37
1rs6B-5nlaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		4 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.29A 1rs6A-5nyyA:
undetectable
1rs6B-5nyyA:
undetectable		 1rs6A-5nyyA:
21.71
1rs6B-5nyyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.32A 1rs6A-5or4A:
undetectable
1rs6B-5or4A:
undetectable		 1rs6A-5or4A:
10.39
1rs6B-5or4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 TRP A 465
GLU A 507
ARG A 501
TRP A 536
 None
 1.35A 1rs6A-5ot1A:
undetectable
1rs6B-5ot1A:
undetectable		 1rs6A-5ot1A:
14.43
1rs6B-5ot1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		4 TRP A 198
GLU A 207
VAL A 150
TRP A 206
 None
 1.17A 1rs6A-5ta9A:
undetectable
1rs6B-5ta9A:
undetectable		 1rs6A-5ta9A:
21.00
1rs6B-5ta9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgp SECRETED XWNT8
INHIBITOR SIZZLED

(Xenopus laevis) 		PF01392
(Fz) 		4 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.90A 1rs6A-5xgpA:
undetectable
1rs6B-5xgpA:
undetectable		 1rs6A-5xgpA:
19.72
1rs6B-5xgpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VH CHAIN OF 059-152
VL CHAIN OF 059-152

(Homo sapiens) 		no annotation 4 TRP H  49
MET H 105
VAL D  98
TRP D  91
 None
 1.16A 1rs6A-5xwdH:
undetectable
1rs6B-5xwdH:
undetectable		 1rs6A-5xwdH:
10.16
1rs6B-5xwdH:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 4 GLU A 322
ARG A 331
VAL A 317
TRP A 316
 None
None
UDP  A 501 ( 4.8A)
None
 1.33A 1rs6A-6bk1A:
undetectable
1rs6B-6bk1A:
undetectable		 1rs6A-6bk1A:
13.48
1rs6B-6bk1A:
13.48