SIMILAR PATTERNS OF AMINO ACIDS FOR 1RQP_C_SAMC500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfv MONOCLONAL ANTIBODY
FV4155
MONOCLONAL ANTIBODY
FV4155

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 ASP H 107
ASN H 100
SER L  61
ALA H 102
 None
 1.14A 1rqpA-1cfvH:
undetectable		 1rqpA-1cfvH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		4 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
 1.00A 1rqpA-1hylA:
undetectable		 1rqpA-1hylA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 ASN A 416
SER A 397
ARG A 405
ALA A 277
 None
 1.03A 1rqpA-1i5pA:
undetectable		 1rqpA-1i5pA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id1 PUTATIVE POTASSIUM
CHANNEL PROTEIN

(Escherichia
coli) 		PF02254
(TrkA_N) 		4 ASP A  84
ASN A  87
SER A 126
ALA A  79
 None
 1.02A 1rqpA-1id1A:
undetectable		 1rqpA-1id1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		4 ASP H 102
PHE H  94
SER H 195
ALA H 104
 None
 1.14A 1rqpA-1kigH:
undetectable		 1rqpA-1kigH:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		PF01144
(CoA_trans)
PF01144
(CoA_trans) 		4 ASP A 100
ASN A  72
PHE A  87
SER B 121
 None
 1.15A 1rqpA-1poiA:
undetectable		 1rqpA-1poiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qso HPA2 HISTONE
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		4 ASP A  92
ASN A  74
PHE A  49
ALA A  58
 None
 1.01A 1rqpA-1qsoA:
undetectable		 1rqpA-1qsoA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		4 ASP A 230
PHE A 213
SER A  59
ALA A 298
 None
 1.08A 1rqpA-1r76A:
undetectable		 1rqpA-1r76A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		4 PHE B 186
PHE B  42
SER B 107
ARG B 137
 None
 1.08A 1rqpA-1uliB:
undetectable		 1rqpA-1uliB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 PHE A 412
ASN A 409
SER A 404
ALA A 227
 None
 1.18A 1rqpA-1v8bA:
3.4		 1rqpA-1v8bA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 PHE A  39
PHE A 310
SER A 147
ARG A 151
 None
 1.10A 1rqpA-1wu7A:
undetectable		 1rqpA-1wu7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		5 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
 None
 1.11A 1rqpA-1wu8A:
26.8		 1rqpA-1wu8A:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 ASN A   6
SER A  89
ARG A 153
ALA A   8
 None
 1.16A 1rqpA-1wx4A:
undetectable		 1rqpA-1wx4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpw LOC51668 PROTEIN

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 PHE A 125
PHE A  45
SER A  20
ALA A 121
 None
 1.15A 1rqpA-1xpwA:
undetectable		 1rqpA-1xpwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		4 PHE A 214
PHE A  23
SER A 249
ARG A 328
 ACT  A 803 (-4.5A)
None
None
SO4  A 801 (-3.4A)
 0.70A 1rqpA-1y1pA:
undetectable		 1rqpA-1y1pA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 ASN A  96
PHE A 218
SER A 116
ALA A 209
 None
 0.94A 1rqpA-1y3tA:
undetectable		 1rqpA-1y3tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a77 IMMUNOGLOBULIN HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H 109
TRP H  47
SER H  59
ALA H  97
 None
 1.19A 1rqpA-2a77H:
undetectable		 1rqpA-2a77H:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		4 ASP A 149
TRP A 137
PHE A 266
SER A 208
 None
 0.97A 1rqpA-2b2iA:
undetectable		 1rqpA-2b2iA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		4 ASP A 435
ASN A 406
SER A 460
ALA A 377
 None
 1.03A 1rqpA-2bexA:
undetectable		 1rqpA-2bexA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
 0.15A 1rqpA-2c4tA:
47.1		 1rqpA-2c4tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 429
PHE A 312
ARG A 269
ALA A 529
 None
None
AMP  A1563 (-3.4A)
None
 1.14A 1rqpA-2cfmA:
undetectable		 1rqpA-2cfmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		5 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
 None
 0.98A 1rqpA-2cw5A:
23.2		 1rqpA-2cw5A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis) 		PF00089
(Trypsin) 		4 ASP A  56
PHE A  52
SER A 137
ALA A  58
 None
 0.88A 1rqpA-2ea3A:
undetectable		 1rqpA-2ea3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
DT8  A 700 ( 3.9A)
None
 1.00A 1rqpA-2ei8A:
undetectable		 1rqpA-2ei8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		4 ASP A 179
PHE A 181
ASN A 183
SER A 236
 None
 0.75A 1rqpA-2f4nA:
22.9		 1rqpA-2f4nA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		4 ASP A 134
PHE A 130
SER A  65
ARG A 403
 None
 1.17A 1rqpA-2gjmA:
undetectable		 1rqpA-2gjmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ASP A 219
PHE A 429
SER A 157
ARG A 158
 None
 1.03A 1rqpA-2hgsA:
undetectable		 1rqpA-2hgsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		4 PHE A 299
PHE A 301
SER A  38
ARG A 149
 None
 1.00A 1rqpA-2hkeA:
undetectable		 1rqpA-2hkeA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 PHE A 462
PHE A 814
SER A 468
ALA A 812
 None
 1.17A 1rqpA-2ivfA:
undetectable		 1rqpA-2ivfA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		4 PHE A 324
ASN A 326
TRP A 321
SER A 318
 None
 1.08A 1rqpA-2j04A:
undetectable		 1rqpA-2j04A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 ASP A 541
PHE A 524
SER A 659
ALA A 543
 None
 0.95A 1rqpA-2odpA:
undetectable		 1rqpA-2odpA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba) 		PF00089
(Trypsin) 		4 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
AES  A9001 (-2.5A)
None
 0.95A 1rqpA-2ouaA:
undetectable		 1rqpA-2ouaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASP A 302
SER A  94
ARG A 154
ALA A 322
 FAD  A 701 (-2.8A)
FAD  A 701 ( 3.8A)
FAD  A 701 (-4.8A)
FAD  A 701 (-3.5A)
 1.02A 1rqpA-2panA:
undetectable		 1rqpA-2panA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		6 ASP A 183
PHE A 186
ASN A 188
TRP A 190
PHE A 228
SER A 242
 PEG  A 402 (-2.9A)
None
None
None
None
PEG  A 402 (-3.3A)
 0.80A 1rqpA-2q6kA:
31.6		 1rqpA-2q6kA:
38.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		4 ASP A 198
PHE A 137
ARG A 224
ALA A 136
 None
 1.15A 1rqpA-2qkdA:
undetectable		 1rqpA-2qkdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		4 ASN A 729
SER A 688
ARG A 722
ALA A 731
 None
 1.11A 1rqpA-2yhaA:
undetectable		 1rqpA-2yhaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		6 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
 None
 0.86A 1rqpA-2zbvA:
30.6		 1rqpA-2zbvA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 106
PHE A  98
SER A 209
ALA A 108
 None
None
11N  A   1 (-3.3A)
None
 1.04A 1rqpA-2zecA:
undetectable		 1rqpA-2zecA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ASP A 376
PHE A 393
ARG A 361
ALA A 390
 None
 1.20A 1rqpA-2zygA:
undetectable		 1rqpA-2zygA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 ASP A 519
PHE A 400
SER A 404
ALA A 517
 None
 1.18A 1rqpA-3c2uA:
undetectable		 1rqpA-3c2uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 PHE A 367
ASN A 453
PHE A 347
SER A 449
 None
 1.03A 1rqpA-3ecqA:
undetectable		 1rqpA-3ecqA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PHE A 439
PHE A 466
ARG A 429
ALA A  70
 None
 1.13A 1rqpA-3eh2A:
3.2		 1rqpA-3eh2A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ASP A 467
PHE A  73
ASN A  78
ALA A  77
 None
 1.14A 1rqpA-3ehmA:
undetectable		 1rqpA-3ehmA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 PHE A 211
ASN A 271
TRP A 202
ALA A 259
 None
 1.16A 1rqpA-3eqaA:
undetectable		 1rqpA-3eqaA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 PHE A 318
ASN A 354
SER A 386
ALA A 322
 None
 1.09A 1rqpA-3gcwA:
2.8		 1rqpA-3gcwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 283
ASN A 137
SER A 279
ALA A 135
 None
 0.89A 1rqpA-3gyrA:
undetectable		 1rqpA-3gyrA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbd CLASS IV CHITINASE
CHIA4-PA2

(Picea abies) 		PF00182
(Glyco_hydro_19) 		4 ASN A 109
PHE A 207
SER A 229
ALA A 105
 None
 1.14A 1rqpA-3hbdA:
undetectable		 1rqpA-3hbdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A 170
PHE A 174
SER A 165
ALA A 210
 None
 0.93A 1rqpA-3hjrA:
3.9		 1rqpA-3hjrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 ASP A 321
ASN A  36
ARG A 283
ALA A 127
 None
 1.06A 1rqpA-3j4uA:
undetectable		 1rqpA-3j4uA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		4 PHE A 366
ASN A 101
SER A 122
ARG A 154
 None
 1.17A 1rqpA-3ldfA:
undetectable		 1rqpA-3ldfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ASP A 394
SER A  42
ARG A  61
ALA A  71
 None
 1.04A 1rqpA-3lmkA:
2.7		 1rqpA-3lmkA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0c THYMIDYLATE SYNTHASE
THYX

(Thermotoga
maritima) 		PF02511
(Thy1) 		4 ASP A  20
PHE A  57
ARG A  42
ALA A  23
 None
 1.13A 1rqpA-3n0cA:
undetectable		 1rqpA-3n0cA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 ASP A 464
ASN A 467
ARG A 414
ALA A 469
 None
 1.17A 1rqpA-3nzqA:
undetectable		 1rqpA-3nzqA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella) 		no annotation 4 ASP A 148
ASN A 145
PHE A  50
SER A 272
 None
 1.05A 1rqpA-3ocdA:
undetectable		 1rqpA-3ocdA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASN A 421
PHE A 465
SER A 426
ALA A 448
 None
 0.87A 1rqpA-3pocA:
undetectable		 1rqpA-3pocA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 ASP A1551
ASN A1548
SER A1521
ARG A1553
 None
 0.97A 1rqpA-3pvlA:
undetectable		 1rqpA-3pvlA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 280
ASN A 558
PHE A 282
SER A 565
 None
 1.09A 1rqpA-3sunA:
undetectable		 1rqpA-3sunA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		4 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
SO4  A 304 (-2.8A)
None
 0.89A 1rqpA-3ureA:
undetectable		 1rqpA-3ureA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ASN C 667
PHE C 669
SER C 432
ARG C 427
 None
 1.13A 1rqpA-3v64C:
undetectable		 1rqpA-3v64C:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pyogenes) 		PF09704
(Cas_Cas5d) 		5 PHE A 101
ASN A  55
PHE A  99
SER A 126
ARG A 132
 None
 1.15A 1rqpA-3vzhA:
undetectable		 1rqpA-3vzhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 4 ASP A 253
PHE A 218
SER A 318
ALA A 217
 None
 0.80A 1rqpA-4cmrA:
undetectable		 1rqpA-4cmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 ASP D  51
PHE D  38
PHE D  31
SER D 427
 None
 1.19A 1rqpA-4em6D:
undetectable		 1rqpA-4em6D:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc9 UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		no annotation 4 PHE B 527
SER B 540
ARG B 541
ALA B 532
 None
 1.12A 1rqpA-4fc9B:
undetectable		 1rqpA-4fc9B:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE

(Cupriavidus
pinatubonensis) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 PHE A 374
PHE A 333
ARG A 367
ALA A 301
 None
 1.14A 1rqpA-4g5eA:
undetectable		 1rqpA-4g5eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		4 ASP A 122
PHE A  76
ARG A 166
ALA A 108
 None
 0.81A 1rqpA-4ijmA:
undetectable		 1rqpA-4ijmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP E 534
PHE E 526
SER E 645
ALA E 536
 None
 1.10A 1rqpA-4iw4E:
undetectable		 1rqpA-4iw4E:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 ASP A 308
ASN A 311
SER A 349
ALA A 303
 None
 1.10A 1rqpA-4j9vA:
undetectable		 1rqpA-4j9vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt1 ACCELERATED-CELL-DEA
TH 11

(Arabidopsis
thaliana) 		PF08718
(GLTP) 		4 PHE A  36
PHE A  17
SER A  44
ALA A  16
 None
 0.90A 1rqpA-4nt1A:
undetectable		 1rqpA-4nt1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 PHE B 318
ASN B 354
SER B 386
ALA B 322
 None
 1.17A 1rqpA-4ov6B:
5.6		 1rqpA-4ov6B:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyi HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 PHE A  45
PHE A  63
ARG A  53
ALA A  39
 None
 0.88A 1rqpA-4qyiA:
undetectable		 1rqpA-4qyiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
3KM  A 900 (-3.6A)
None
 1.12A 1rqpA-4r0iA:
undetectable		 1rqpA-4r0iA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0j UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF09704
(Cas_Cas5d) 		5 PHE A 103
ASN A  57
PHE A 101
SER A 128
ARG A 134
 None
None
None
SO4  A 303 ( 4.7A)
SO4  A 303 (-4.1A)
 1.22A 1rqpA-4r0jA:
undetectable		 1rqpA-4r0jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 ASP A 546
PHE A 290
PHE A 529
ALA A 541
 None
 1.13A 1rqpA-4uw2A:
undetectable		 1rqpA-4uw2A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(uncultured
bacterium;
Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		4 PHE A  49
SER A  33
ARG A  62
ALA A  92
 None
 1.19A 1rqpA-4xzwA:
undetectable		 1rqpA-4xzwA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 PHE A 367
ASN A 453
PHE A 347
SER A 449
 None
 1.12A 1rqpA-5a55A:
undetectable		 1rqpA-5a55A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 ASP A 186
TRP A 173
PHE A 309
SER A 249
 None
 1.19A 1rqpA-5aexA:
undetectable		 1rqpA-5aexA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c00 MDBA PROTEIN

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		4 ASP A 125
ASN A 122
PHE A 201
ALA A 205
 None
 1.14A 1rqpA-5c00A:
undetectable		 1rqpA-5c00A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 PHE B 649
PHE B 680
SER B 595
ALA B 651
 None
 1.10A 1rqpA-5cxcB:
undetectable		 1rqpA-5cxcB:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 ASP A 659
PHE A 612
SER A 398
ALA A 657
 None
 1.06A 1rqpA-5f7uA:
undetectable		 1rqpA-5f7uA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 PHE A 101
SER A  85
ARG A 114
ALA A 141
 None
 1.19A 1rqpA-5fipA:
undetectable		 1rqpA-5fipA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT

(Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 PHE A 150
SER A 168
ARG A 115
ALA A 219
 None
 1.02A 1rqpA-5g5gA:
undetectable		 1rqpA-5g5gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 ASP A  74
PHE A  88
SER A 339
ALA A  77
 None
GOL  A 403 ( 3.7A)
None
None
 1.14A 1rqpA-5gllA:
undetectable		 1rqpA-5gllA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7t CLASS IV CHITINASE

(Cryptomeria
japonica) 		no annotation 4 ASN A  62
PHE A 161
SER A 183
ALA A  58
 None
 1.13A 1rqpA-5h7tA:
undetectable		 1rqpA-5h7tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		4 ASP A 290
PHE A 374
ARG A 320
ALA A 296
 None
None
SO4  A 506 ( 3.4A)
None
 1.02A 1rqpA-5huqA:
undetectable		 1rqpA-5huqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp5 GALECTIN-5

(Rattus
norvegicus) 		PF00337
(Gal-bind_lectin) 		4 PHE A  44
PHE A  62
ARG A  95
ALA A  41
 None
 0.98A 1rqpA-5jp5A:
undetectable		 1rqpA-5jp5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PHE B 705
PHE B 732
ARG B 695
ALA B 336
 None
 1.16A 1rqpA-5kyuB:
2.6		 1rqpA-5kyuB:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
None
1DA  A 301 (-3.0A)
 0.64A 1rqpA-5lmzA:
43.0		 1rqpA-5lmzA:
87.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 ASP A  63
PHE A  59
SER A 144
ALA A  65
 None
 0.90A 1rqpA-5mrrA:
undetectable		 1rqpA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyx HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ASP H 111
PHE H 112
SER H  33
ALA H  98
 None
 1.18A 1rqpA-5nyxH:
undetectable		 1rqpA-5nyxH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL

(Homo sapiens) 		PF00297
(Ribosomal_L3) 		4 PHE e 234
PHE e 204
ARG e 190
ALA e 236
 None
 1.00A 1rqpA-5oole:
undetectable		 1rqpA-5oole:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 ASP A  10
SER A  14
ARG A  15
ALA A 111
 None
 1.08A 1rqpA-5td7A:
undetectable		 1rqpA-5td7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5

(Ricinus
communis) 		PF00856
(SET) 		4 PHE A 246
SER A 315
ARG A 356
ALA A 183
 None
SAH  A 401 (-3.9A)
None
None
 1.19A 1rqpA-5vbcA:
undetectable		 1rqpA-5vbcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 PHE A 318
ASN A 354
SER A 386
ALA A 322
 None
 1.09A 1rqpA-5vlhA:
5.4		 1rqpA-5vlhA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 PHE A 267
ASN A 296
SER A 174
ALA A 265
 PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
 1.01A 1rqpA-5w7dA:
undetectable		 1rqpA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 PHE A  95
SER A 113
ARG A  59
ALA A 149
 None
 1.16A 1rqpA-5y6qA:
undetectable		 1rqpA-5y6qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 ASN A2161
SER A2168
ARG A2169
ALA A2160
 None
 1.13A 1rqpA-6b3rA:
undetectable		 1rqpA-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 4 ASP B 102
PHE B  94
SER B 195
ALA B 104
 None
None
SO4  B 304 ( 2.5A)
None
 1.06A 1rqpA-6b74B:
undetectable		 1rqpA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2

(Danio rerio) 		no annotation 4 ASP A 154
PHE A 131
SER A 127
ARG A 125
 None
 1.01A 1rqpA-6d21A:
undetectable		 1rqpA-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 4 ASN A 618
SER A 693
ARG A 706
ALA A 660
 None
 0.97A 1rqpA-6ej2A:
undetectable		 1rqpA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 PHE A 211
ASN A 271
TRP A 202
ALA A 259
 None
 1.14A 1rqpA-6frvA:
undetectable		 1rqpA-6frvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.44A 1rqpC-1biyA:
2.2		 1rqpC-1biyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		5 LEU A 936
SER A 958
THR A 977
PHE A1010
SER A 992
 None
 1.41A 1rqpC-1hq0A:
0.0		 1rqpC-1hq0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.50A 1rqpC-1i6qA:
1.1		 1rqpC-1i6qA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 LEU A 640
ASP A 638
SER A 639
TYR A 587
PHE A 590
 None
 1.46A 1rqpC-1kv9A:
undetectable		 1rqpC-1kv9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.47A 1rqpC-1n76A:
0.4		 1rqpC-1n76A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.39A 1rqpC-1qjmA:
0.0		 1rqpC-1qjmA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		5 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
 None
 1.26A 1rqpC-1y7iA:
3.2		 1rqpC-1y7iA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
SA8  A1299 (-2.6A)
 0.12A 1rqpC-2c4tA:
46.4		 1rqpC-2c4tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.33A 1rqpC-4hscX:
0.0		 1rqpC-4hscX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA

(Escherichia
coli) 		PF02917
(Pertussis_S1) 		5 LEU A  77
SER A  12
THR A 137
TYR A 138
PHE A  73
 None
 1.48A 1rqpC-4z9cA:
undetectable		 1rqpC-4z9cA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.38A 1rqpC-5jwzA:
undetectable		 1rqpC-5jwzA:
17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
None
 0.25A 1rqpC-5lmzA:
42.8		 1rqpC-5lmzA:
87.33