SIMILAR PATTERNS OF AMINO ACIDS FOR 1RQJ_B_RISB903

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ARG A 126
GLN A 185
LYS A 214
THR A 215
 None
 1.00A 1rqjB-1fpsA:
25.4		 1rqjB-1fpsA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ASP A 117
ARG A 126
GLN A 185
THR A 215
 None
 0.81A 1rqjB-1fpsA:
25.4		 1rqjB-1fpsA:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		6 SER A  78
LEU A  79
ASP A  88
ARG A  93
GLN A 154
THR A 178
 None
 0.70A 1rqjB-1rtrA:
34.7		 1rqjB-1rtrA:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		6 SER A  78
LEU A  79
ASP A  88
ARG A  93
THR A 178
GLN A 215
 None
 0.88A 1rqjB-1rtrA:
34.7		 1rqjB-1rtrA:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.79A 1rqjB-1wy0A:
34.4		 1rqjB-1wy0A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.69A 1rqjB-1wy0A:
34.4		 1rqjB-1wy0A:
31.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 SER A  77
LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.76A 1rqjB-2azkA:
29.8		 1rqjB-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 SER A  77
LEU A  78
ASP A  81
THR A 161
GLN A 197
 None
 0.79A 1rqjB-2azkA:
29.8		 1rqjB-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 SER A  77
LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.69A 1rqjB-2azkA:
29.8		 1rqjB-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.71A 1rqjB-2dh4A:
23.1		 1rqjB-2dh4A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		7 SER A  76
ASP A  80
ASP A  84
GLN A 147
LYS A 174
THR A 175
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
None
 0.81A 1rqjB-2dh4A:
23.1		 1rqjB-2dh4A:
24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		6 SER A  70
LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 UNL  A 273 (-3.7A)
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 1rqjB-2ftzA:
31.6		 1rqjB-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		6 SER A  70
LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 UNL  A 273 (-3.7A)
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.51A 1rqjB-2ftzA:
31.6		 1rqjB-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 SER A  70
LEU A  71
THR A 164
GLN A 198
ASP A 201
 UNL  A 273 (-3.7A)
None
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
EDO  A 282 (-2.8A)
 0.89A 1rqjB-2ftzA:
31.6		 1rqjB-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 SER A 121
LEU A 122
ARG A 136
GLN A 198
THR A 222
 None
 0.98A 1rqjB-2h8oA:
35.6		 1rqjB-2h8oA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 SER A 121
LEU A 122
ASP A 131
ARG A 136
THR A 222
 None
 0.90A 1rqjB-2h8oA:
35.6		 1rqjB-2h8oA:
40.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		8 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.41A 1rqjB-2o1oA:
25.8		 1rqjB-2o1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
 None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
 0.74A 1rqjB-2q80A:
24.4		 1rqjB-2q80A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 SER A  60
LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
 GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
 1.24A 1rqjB-2q80A:
24.4		 1rqjB-2q80A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		9 SER A  60
LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
 GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
 0.71A 1rqjB-2q80A:
24.4		 1rqjB-2q80A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		7 SER A 103
LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 FPP  A1002 (-4.2A)
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.65A 1rqjB-3aq0A:
29.1		 1rqjB-3aq0A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.91A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		7 SER B  80
LEU B  81
ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.79A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		7 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.75A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		5 SER A  86
LEU A  87
ASP A  90
THR A 175
GLN A 212
 None
 0.92A 1rqjB-3ipiA:
28.1		 1rqjB-3ipiA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		5 SER A  86
LEU A  87
THR A 175
GLN A 212
ASP A 215
 None
 0.97A 1rqjB-3ipiA:
28.1		 1rqjB-3ipiA:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		6 SER A  90
LEU A  91
ASP A 100
ARG A 105
GLN A 168
THR A 193
 None
 0.93A 1rqjB-3lomA:
33.5		 1rqjB-3lomA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		7 SER A  77
LEU A  78
ASP A  87
ARG A  92
GLN A 153
LYS A 178
THR A 179
 None
 0.89A 1rqjB-3m0gA:
36.8		 1rqjB-3m0gA:
45.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 SER A  85
LEU A  86
ARG A 100
THR A 184
GLN A 221
ASP A 224
 None
GOL  A 310 ( 4.3A)
None
None
None
None
 0.91A 1rqjB-3m9uA:
34.3		 1rqjB-3m9uA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  89
ARG A 100
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
 0.77A 1rqjB-3m9uA:
34.3		 1rqjB-3m9uA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  89
LYS A 183
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
 0.97A 1rqjB-3m9uA:
34.3		 1rqjB-3m9uA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  95
ARG A 100
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
 0.46A 1rqjB-3m9uA:
34.3		 1rqjB-3m9uA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  95
LYS A 183
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
 0.72A 1rqjB-3m9uA:
34.3		 1rqjB-3m9uA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
LYS A 183
THR A 184
ASP A 224
 None
GOL  A 310 ( 4.3A)
None
None
None
 0.99A 1rqjB-3m9uA:
34.3		 1rqjB-3m9uA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  90
ASP A  93
ARG A 102
LYS A 179
THR A 180
GLN A 217
 None
 0.80A 1rqjB-3mzvA:
28.4		 1rqjB-3mzvA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 SER A 124
LEU A 125
ARG A 137
THR A 218
GLN A 255
 None
 0.97A 1rqjB-3nf2A:
31.5		 1rqjB-3nf2A:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		6 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
 None
 1.34A 1rqjB-3npkA:
31.5		 1rqjB-3npkA:
36.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		7 SER A  74
LEU A  75
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 None
 0.88A 1rqjB-3npkA:
31.5		 1rqjB-3npkA:
36.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		8 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 DMA  A 300 (-3.7A)
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.37A 1rqjB-3p41A:
36.2		 1rqjB-3p41A:
50.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 SER A  79
LEU A  80
LYS A 180
THR A 181
GLN A 219
 DMA  A 300 (-3.7A)
None
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.96A 1rqjB-3p41A:
36.2		 1rqjB-3p41A:
50.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		6 SER A  78
LEU A  79
ASP A  88
ARG A  93
GLN A 153
THR A 177
 None
 0.74A 1rqjB-3p8lA:
34.1		 1rqjB-3p8lA:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.95A 1rqjB-3pkoA:
26.9		 1rqjB-3pkoA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.89A 1rqjB-3pkoA:
26.9		 1rqjB-3pkoA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		11 SER A  88
LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
THR A 187
GLN A 225
ASP A 228
LYS A 242
 DMA  A 501 (-3.4A)
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
DMA  A 501 (-2.7A)
 0.39A 1rqjB-3q1oA:
35.1		 1rqjB-3q1oA:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 LEU A 105
ASP A 108
ARG A 117
GLN A 191
LYS A 215
LYS A 271
 None
MG  A 381 (-2.4A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
DMA  A 384 ( 2.8A)
 1.37A 1rqjB-3qqvA:
33.7		 1rqjB-3qqvA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
LYS A 215
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
 0.76A 1rqjB-3qqvA:
33.7		 1rqjB-3qqvA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		7 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
THR A 216
GLN A 254
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
 0.63A 1rqjB-3qqvA:
33.7		 1rqjB-3qqvA:
31.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		6 SER A  73
LEU A  74
ASP A  77
LYS A 162
THR A 163
GLN A 197
 None
 0.74A 1rqjB-3tc1A:
25.7		 1rqjB-3tc1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		6 SER A  73
LEU A  74
LYS A 162
THR A 163
GLN A 197
ASP A 200
 None
None
None
None
None
MG  A 500 (-2.9A)
 0.60A 1rqjB-3tc1A:
25.7		 1rqjB-3tc1A:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		6 SER A  84
LEU A  85
ASP A  94
ARG A  99
GLN A 162
THR A 186
 None
 0.89A 1rqjB-3ts7A:
36.5		 1rqjB-3ts7A:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		6 SER A  84
LEU A  85
ASP A  94
ARG A  99
LYS A 185
THR A 186
 None
 0.72A 1rqjB-3ts7A:
36.5		 1rqjB-3ts7A:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		5 SER A  87
LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 0.89A 1rqjB-3ucaA:
34.9		 1rqjB-3ucaA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		5 SER A  87
LEU A  88
ASP A  97
ARG A 102
THR A 188
 None
 0.54A 1rqjB-3ucaA:
34.9		 1rqjB-3ucaA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.01A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ARG A  93
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.72A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.93A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
ARG A  93
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.65A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.47A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		7 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.68A 1rqjB-3zouA:
36.1		 1rqjB-3zouA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		7 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.45A 1rqjB-3zouA:
36.1		 1rqjB-3zouA:
52.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.51A 1rqjB-4e1eA:
30.4		 1rqjB-4e1eA:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		6 SER A  79
LEU A  80
ASP A  83
ASP A  89
LYS A 178
THR A 179
 None
 0.70A 1rqjB-4f62A:
33.9		 1rqjB-4f62A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		6 SER A  79
LEU A  80
ASP A  83
GLN A 155
LYS A 178
THR A 179
 None
 0.92A 1rqjB-4f62A:
33.9		 1rqjB-4f62A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		7 SER A  82
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 GER  A 301 (-4.5A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.07A 1rqjB-4fp4A:
24.8		 1rqjB-4fp4A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		7 SER A  82
LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 GER  A 301 (-4.5A)
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 0.96A 1rqjB-4fp4A:
24.8		 1rqjB-4fp4A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.89A 1rqjB-4gp1A:
30.4		 1rqjB-4gp1A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 SER A  81
LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 0.87A 1rqjB-4gp1A:
30.4		 1rqjB-4gp1A:
31.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.95A 1rqjB-4jxyA:
28.5		 1rqjB-4jxyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.92A 1rqjB-4jxyA:
28.5		 1rqjB-4jxyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 1rqjB-4jzxA:
31.0		 1rqjB-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 1rqjB-4jzxA:
31.0		 1rqjB-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 LEU A  94
ASP A  97
ARG A 106
GLN A 165
THR A 195
 None
 0.72A 1rqjB-4kk2A:
25.4		 1rqjB-4kk2A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 LEU A  94
ASP A  97
ARG A 106
LYS A 194
THR A 195
 None
 0.92A 1rqjB-4kk2A:
25.4		 1rqjB-4kk2A:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		7 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
THR A 185
 None
 0.59A 1rqjB-4kkmA:
35.3		 1rqjB-4kkmA:
43.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		8 SER A  74
LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.88A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		8 SER A  74
LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.65A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		8 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.41A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		7 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-2.7A)
 0.70A 1rqjB-4llsA:
42.2		 1rqjB-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		10 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 1rqjB-4llsA:
42.2		 1rqjB-4llsA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
ASP A  88
LYS A 174
THR A 175
GLN A 211
 None
 0.91A 1rqjB-4lobA:
28.4		 1rqjB-4lobA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
 0.92A 1rqjB-4lobA:
28.4		 1rqjB-4lobA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.34A 1rqjB-4p0vA:
31.2		 1rqjB-4p0vA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		8 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.35A 1rqjB-4rxeA:
29.9		 1rqjB-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 ASP A 107
ARG A 112
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.93A 1rqjB-4rxeA:
29.9		 1rqjB-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
 0.61A 1rqjB-4rxeA:
29.9		 1rqjB-4rxeA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		6 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.78A 1rqjB-4wk5A:
31.8		 1rqjB-4wk5A:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.59A 1rqjB-5ahuB:
22.6		 1rqjB-5ahuB:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		8 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 160
LYS A 183
THR A 184
 None
 0.78A 1rqjB-5aypA:
34.0		 1rqjB-5aypA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 SER A  88
LEU A  89
ASP A  98
ARG A 103
THR A 193
 None
 0.70A 1rqjB-5e8hA:
34.8		 1rqjB-5e8hA:
41.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		6 SER A  87
LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
 None
 0.93A 1rqjB-5e8lA:
35.0		 1rqjB-5e8lA:
43.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 SER A  87
LEU A  88
ASP A  91
ASP A  97
THR A 193
 None
 0.92A 1rqjB-5e8lA:
35.0		 1rqjB-5e8lA:
43.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		5 SER A  84
LEU A  85
THR A 176
GLN A 216
ASP A 219
 None
 0.94A 1rqjB-5ernA:
20.2		 1rqjB-5ernA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.74A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.79A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 1.01A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		9 ASP A 126
ASP A 130
ARG A 135
GLN A 195
LYS A 243
THR A 244
GLN A 284
ASP A 287
LYS A 301
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
04M  A 401 ( 3.8A)
None
None
04M  A 401 ( 3.9A)
 0.78A 1rqjB-5hn7A:
28.1		 1rqjB-5hn7A:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 SER A  81
LEU A  82
ASP A  91
THR A 191
GLN A 228
 None
 0.90A 1rqjB-5xn6A:
35.3		 1rqjB-5xn6A:
44.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 9 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
THR A 245
GLN A 284
ASP A 287
LYS A 301
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
C6M  A 401 (-2.9A)
 0.42A 1rqjB-6b07A:
29.6		 1rqjB-6b07A:
13.04