SIMILAR PATTERNS OF AMINO ACIDS FOR 1RMT_C_ADNC1503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoa T-FIMBRIN

(Homo sapiens) 		PF00307
(CH) 		4 PHE A 369
LEU A 341
GLY A 348
ASP A 345
 PHE  A 369 ( 1.3A)
LEU  A 341 ( 0.6A)
GLY  A 348 ( 0.0A)
ASP  A 345 ( 0.6A)
 1.02A 1rmtC-1aoaA:
undetectable		 1rmtC-1aoaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		4 PHE A 145
LEU A 154
TRP A 153
GLY A 109
 None
 0.91A 1rmtC-1escA:
2.1		 1rmtC-1escA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewx TRYPAREDOXIN I

(Crithidia
fasciculata) 		PF13905
(Thioredoxin_8) 		4 PHE A  33
LEU A   8
GLY A   3
ASP A   5
 None
None
ACE  A   1 (-4.2A)
None
 0.96A 1rmtC-1ewxA:
undetectable		 1rmtC-1ewxA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 513
TYR A 139
LEU A 143
TRP A 142
 None
 0.90A 1rmtC-1h0hA:
undetectable		 1rmtC-1h0hA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 ASP A  66
TYR A 324
LEU A 320
GLY A  68
 None
 0.89A 1rmtC-1i6qA:
undetectable		 1rmtC-1i6qA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iou YKT6P

(Saccharomyces
cerevisiae) 		PF13774
(Longin) 		4 ASP A 112
TYR A 101
LEU A  19
GLY A  12
 None
 0.93A 1rmtC-1iouA:
undetectable		 1rmtC-1iouA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j77 HEMO

(Neisseria
meningitidis) 		PF01126
(Heme_oxygenase) 		4 ASP A  87
LEU A  46
GLY A  89
TYR A 133
 None
 0.90A 1rmtC-1j77A:
undetectable		 1rmtC-1j77A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 TYR A 317
LEU A 313
GLY A 267
ASP A 309
 None
None
None
NA  A 522 (-2.4A)
 1.02A 1rmtC-1jedA:
2.2		 1rmtC-1jedA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		4 ASP A 230
TYR A 252
LEU A 254
GLY A 258
 None
 0.89A 1rmtC-1jjfA:
undetectable		 1rmtC-1jjfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9o ALASERPIN

(Manduca sexta) 		PF00079
(Serpin) 		4 PHE I 379
LEU I 100
GLY I 182
ASP I  99
 None
 0.98A 1rmtC-1k9oI:
undetectable		 1rmtC-1k9oI:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 ASP A 306
PHE A 278
GLY A 309
TYR A 305
 None
 0.92A 1rmtC-1kxhA:
undetectable		 1rmtC-1kxhA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ASP A 510
TYR A 570
GLY A 512
ASP A 516
 None
 0.83A 1rmtC-1ldjA:
undetectable		 1rmtC-1ldjA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ASP A 566
TYR A 574
LEU A 598
GLY A 570
 None
 0.86A 1rmtC-1lf9A:
undetectable		 1rmtC-1lf9A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE H 199
LEU H 130
GLY H 133
ASP H 132
 None
 0.94A 1rmtC-1o5fH:
undetectable		 1rmtC-1o5fH:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ASP A 155
PHE A 159
GLY A 147
ASP A 136
 None
 0.99A 1rmtC-1r47A:
undetectable		 1rmtC-1r47A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		4 PHE A  66
LEU A  53
GLY A  11
ASP A 108
 None
 0.96A 1rmtC-1tz6A:
3.1		 1rmtC-1tz6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy9 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Mus musculus) 		no annotation 4 PHE A  50
TYR A 103
LEU A 107
GLY A 112
 None
 1.02A 1rmtC-1wy9A:
undetectable		 1rmtC-1wy9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 PHE A  96
TYR B 612
LEU B 608
GLY B 591
 None
 0.94A 1rmtC-2amcA:
undetectable		 1rmtC-2amcA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 150
GLY A  79
ASP A  75
TYR A  94
 None
 0.87A 1rmtC-2bi0A:
undetectable		 1rmtC-2bi0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 ASP A 221
TYR A  92
LEU A 215
GLY A 218
 None
 0.94A 1rmtC-2c0yA:
undetectable		 1rmtC-2c0yA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hf7 CLASS B ACID
PHOSPHATASE

(Escherichia
coli) 		PF03767
(Acid_phosphat_B) 		8 ASP A  46
PHE A  56
TYR A  70
LEU A  71
TRP A  77
GLY A 113
ASP A 145
TYR A 193
 AF3  A 800 ( 3.7A)
None
None
None
None
AF3  A 800 (-3.5A)
None
None
 0.26A 1rmtC-2hf7A:
36.8		 1rmtC-2hf7A:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hf7 CLASS B ACID
PHOSPHATASE

(Escherichia
coli) 		PF03767
(Acid_phosphat_B) 		5 TYR A  70
LEU A  71
TRP A  77
GLY A 144
ASP A 145
 None
 1.17A 1rmtC-2hf7A:
36.8		 1rmtC-2hf7A:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 TYR A 112
LEU A  70
GLY A  75
ASP A  71
 None
 0.98A 1rmtC-2ibdA:
undetectable		 1rmtC-2ibdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nda MID-CELL-ANCHORED
PROTEIN Z

(Streptococcus
pneumoniae) 		no annotation 4 TYR A 113
LEU A 111
GLY A 104
ASP A 109
 None
 1.03A 1rmtC-2ndaA:
undetectable		 1rmtC-2ndaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq1 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2) 		4 TYR A 180
GLY A 187
ASP A 186
TYR A 211
 None
 0.97A 1rmtC-2oq1A:
undetectable		 1rmtC-2oq1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ASP A 489
LEU A 462
TRP A 465
GLY A 493
 None
 0.87A 1rmtC-2p6rA:
undetectable		 1rmtC-2p6rA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbh PROCATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 PHE A   5
TRP A  11
GLY A 168
ASP A  40
 None
 1.00A 1rmtC-2pbhA:
undetectable		 1rmtC-2pbhA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
10) 		PF00500
(Late_protein_L1) 		4 PHE A  70
LEU A  41
GLY A 105
ASP A 367
 None
 0.96A 1rmtC-2r5kA:
undetectable		 1rmtC-2r5kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 PHE A 156
LEU A  71
GLY A 124
ASP A  99
 None
 0.99A 1rmtC-2w8zA:
4.3		 1rmtC-2w8zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 PHE A 236
LEU A 156
GLY A 107
ASP A 211
 None
 1.00A 1rmtC-2wgyA:
undetectable		 1rmtC-2wgyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 ASP A 533
LEU A 370
GLY A 531
ASP A 530
 None
None
None
CA  A1001 (-2.9A)
 0.92A 1rmtC-2ww8A:
3.1		 1rmtC-2ww8A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 TYR A 127
LEU A 123
GLY A 115
ASP A 119
 None
 1.03A 1rmtC-2xpiA:
undetectable		 1rmtC-2xpiA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		4 PHE B 241
LEU B 236
GLY B 229
ASP B 232
 None
 0.97A 1rmtC-2y9yB:
undetectable		 1rmtC-2y9yB:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 TYR A 321
GLY A 500
ASP A 502
TYR A 269
 None
 0.99A 1rmtC-2z23A:
undetectable		 1rmtC-2z23A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 ASP A 171
PHE A 175
GLY A 163
ASP A 142
 None
 0.90A 1rmtC-3a21A:
undetectable		 1rmtC-3a21A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 146
PHE A  83
LEU A 368
GLY A 390
 None
 1.00A 1rmtC-3d46A:
undetectable		 1rmtC-3d46A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		4 ASP A 161
GLY A 165
ASP A 164
TYR A 162
 None
 1.02A 1rmtC-3e8sA:
2.8		 1rmtC-3e8sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezz DUAL SPECIFICITY
PROTEIN PHOSPHATASE
4

(Homo sapiens) 		PF00782
(DSPc) 		4 ASP A 218
TYR A 242
LEU A 225
GLY A 221
 None
 0.96A 1rmtC-3ezzA:
undetectable		 1rmtC-3ezzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		4 PHE A 333
LEU A 271
GLY A 277
ASP A 278
 None
 1.01A 1rmtC-3fnrA:
undetectable		 1rmtC-3fnrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		4 PHE A 269
LEU A 275
GLY A 231
TYR A 138
 None
 0.90A 1rmtC-3h2iA:
undetectable		 1rmtC-3h2iA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 LEU 3 602
TRP 3 322
GLY 3 636
TYR 3 567
 None
 0.87A 1rmtC-3i9v3:
2.6		 1rmtC-3i9v3:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		4 PHE G  58
TYR G  35
LEU G  36
GLY G  42
 CLA  G 602 ( 4.9A)
None
CLA  G 602 (-4.1A)
CLA  G 602 (-4.4A)
 1.01A 1rmtC-3jcuG:
undetectable		 1rmtC-3jcuG:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 PHE A 270
LEU A 226
GLY A  49
ASP A 223
 None
 0.85A 1rmtC-3kkjA:
undetectable		 1rmtC-3kkjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472

(Streptococcus
mutans) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 PHE A 295
LEU A 304
GLY A 261
ASP A 200
 None
 0.99A 1rmtC-3ldgA:
2.2		 1rmtC-3ldgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		4 PHE A 159
TYR A 204
LEU A 208
GLY A 213
 None
 0.93A 1rmtC-3ntvA:
4.3		 1rmtC-3ntvA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oeb S-LAYER ASSOCIATED
MULTIDOMAIN
ENDOGLUCANASE

(Caldanaerobius
polysaccharolyticus) 		PF02018
(CBM_4_9) 		4 PHE A  10
LEU A  14
GLY A  48
ASP A  19
 None
 0.84A 1rmtC-3oebA:
undetectable		 1rmtC-3oebA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 PHE A 640
TYR A 144
GLY A 186
ASP A 190
 None
 0.98A 1rmtC-3s5kA:
undetectable		 1rmtC-3s5kA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 PHE A 357
LEU A 285
GLY A 288
ASP A 287
 None
 1.02A 1rmtC-3t2nA:
undetectable		 1rmtC-3t2nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		4 PHE A  22
LEU A 123
GLY A  91
ASP A 119
 None
None
AMP  A 500 (-3.2A)
None
 1.00A 1rmtC-3tlzA:
undetectable		 1rmtC-3tlzA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 ASP A 132
TYR A 187
LEU A 191
GLY A 134
 None
 0.90A 1rmtC-3vohA:
undetectable		 1rmtC-3vohA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Coprinopsis
cinerea) 		no annotation 4 PHE A 177
LEU A 190
TRP A 165
GLY A 156
 None
 0.99A 1rmtC-3w9aA:
undetectable		 1rmtC-3w9aA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdq BETA-MANNANASE

(Symbiotic
protist of
Reticulitermes
speratus) 		PF02156
(Glyco_hydro_26) 		4 TYR A 308
LEU A  54
GLY A  57
ASP A  58
 None
 1.01A 1rmtC-3wdqA:
undetectable		 1rmtC-3wdqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 PHE A 269
TYR A 205
LEU A 208
GLY A 217
 None
 0.86A 1rmtC-4b52A:
undetectable		 1rmtC-4b52A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 TYR A 852
LEU A 856
GLY A 860
ASP A 859
 None
 0.99A 1rmtC-4c3zA:
undetectable		 1rmtC-4c3zA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 ASP A 441
PHE A 445
TYR A 168
LEU A 167
ASP A 163
 None
 1.37A 1rmtC-4c7gA:
undetectable		 1rmtC-4c7gA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A   7
TRP A   9
GLY A  12
ASP A  10
 MLY  A   8 ( 4.0A)
MLY  A   8 ( 4.7A)
None
None
 0.95A 1rmtC-4f6eA:
undetectable		 1rmtC-4f6eA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h79 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Thermobifida
fusca) 		PF09485
(CRISPR_Cse2) 		4 ASP A  64
PHE A  18
GLY A  60
TYR A  68
 None
 0.83A 1rmtC-4h79A:
undetectable		 1rmtC-4h79A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila) 		PF02614
(UxaC) 		4 PHE A 380
TYR A  46
GLY A  39
TYR A 376
 None
GOL  A 503 (-4.4A)
None
None
 0.92A 1rmtC-4i6vA:
undetectable		 1rmtC-4i6vA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipb UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF11396
(PepSY_like) 		4 PHE A  93
TYR A 135
LEU A 133
GLY A 123
 None
 0.80A 1rmtC-4ipbA:
undetectable		 1rmtC-4ipbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l83 UBE2I2 PROTEIN

(Brugia malayi) 		PF00179
(UQ_con) 		4 ASP A  67
PHE A  40
LEU A  10
GLY A   4
 None
 0.93A 1rmtC-4l83A:
undetectable		 1rmtC-4l83A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7s BTRN

(Bacillus
circulans) 		PF13186
(SPASM) 		4 PHE A  59
LEU A  71
GLY A  76
ASP A  72
 None
 0.96A 1rmtC-4m7sA:
2.4		 1rmtC-4m7sA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		4 ASP A 228
PHE A 232
GLY A 220
ASP A 209
 None
 0.98A 1rmtC-4nzjA:
undetectable		 1rmtC-4nzjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ASP A 228
PHE A 232
GLY A 220
ASP A 209
 None
 0.99A 1rmtC-4ogzA:
undetectable		 1rmtC-4ogzA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		4 ASP A  65
TYR A 291
GLY A 260
ASP A 259
 CA  A 409 (-3.0A)
None
None
None
 0.86A 1rmtC-4ovyA:
10.3		 1rmtC-4ovyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pui SUFE-LIKE PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01722
(BolA) 		4 ASP A 302
PHE A 325
LEU A 358
GLY A 321
 None
 0.98A 1rmtC-4puiA:
undetectable		 1rmtC-4puiA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO

(Escherichia
coli) 		PF02624
(YcaO) 		4 ASP A 143
TYR A 573
LEU A  91
GLY A 147
 None
 0.99A 1rmtC-4q85A:
undetectable		 1rmtC-4q85A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 TYR U 195
LEU U 212
GLY U 191
ASP U 214
 None
 1.02A 1rmtC-4qtiU:
undetectable		 1rmtC-4qtiU:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 ASP A1784
TYR A1792
LEU A1788
ASP A1781
 None
 0.77A 1rmtC-4r04A:
undetectable		 1rmtC-4r04A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5w TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		4 ASP B 176
PHE B 149
LEU B 223
GLY B 182
 None
 1.02A 1rmtC-4u5wB:
undetectable		 1rmtC-4u5wB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8l ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		4 TYR A 515
LEU A 511
GLY A 497
ASP A 507
 None
None
None
CA  A1101 (-2.2A)
 0.91A 1rmtC-4w8lA:
undetectable		 1rmtC-4w8lA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASP A 401
TYR A 670
LEU A 723
GLY A 406
 None
 1.02A 1rmtC-4wz9A:
undetectable		 1rmtC-4wz9A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		4 PHE A 269
TYR A 254
LEU A 225
GLY A 110
 None
EDO  A 304 (-4.6A)
None
None
 0.99A 1rmtC-4x00A:
undetectable		 1rmtC-4x00A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 LEU A 149
TRP A 148
GLY A 153
ASP A 154
 None
 1.00A 1rmtC-4yzgA:
undetectable		 1rmtC-4yzgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z45 ODORANT-BINDING
PROTEIN NRIBOBP3

(Nasonovia
ribisnigri) 		PF01395
(PBP_GOBP) 		4 PHE A   5
TRP A  71
GLY A  66
TYR A  13
 None
 0.86A 1rmtC-4z45A:
undetectable		 1rmtC-4z45A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 PHE A  60
TYR A 492
LEU A 491
GLY A 322
 None
GOL  A 602 ( 4.0A)
None
None
 1.01A 1rmtC-5ddsA:
2.4		 1rmtC-5ddsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		4 ASP A  42
LEU A 232
GLY A  40
ASP A  39
 None
 1.02A 1rmtC-5dk6A:
undetectable		 1rmtC-5dk6A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		4 ASP A  49
TYR A  59
LEU A  58
GLY A  52
 None
 1.01A 1rmtC-5e57A:
undetectable		 1rmtC-5e57A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egl ACYL COA HYDROLASE

(Staphylococcus
aureus) 		PF03061
(4HBT) 		4 ASP A  26
TYR A  80
LEU A  78
ASP A  76
 None
 1.02A 1rmtC-5eglA:
undetectable		 1rmtC-5eglA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		4 PHE A 197
TYR A 217
LEU A 221
ASP A 225
 None
 0.89A 1rmtC-5frsA:
undetectable		 1rmtC-5frsA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		4 PHE A  83
LEU A  97
GLY A 102
ASP A 101
 None
 0.93A 1rmtC-5heiA:
undetectable		 1rmtC-5heiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED

(Oryza sativa) 		PF03514
(GRAS) 		4 TYR A 445
LEU A 412
GLY A 320
TYR A 283
 None
 1.02A 1rmtC-5hyzA:
2.9		 1rmtC-5hyzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 ASP A 623
GLY A 380
ASP A 606
TYR A 609
 None
 0.97A 1rmtC-5i08A:
undetectable		 1rmtC-5i08A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l37 MSM0273

(Mycolicibacterium
smegmatis) 		PF03319
(EutN_CcmL) 		4 PHE A  62
LEU A  72
GLY A  22
ASP A  40
 None
 0.90A 1rmtC-5l37A:
undetectable		 1rmtC-5l37A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE BETA
SUBUNIT
ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF08882
(Acetone_carb_G) 		4 PHE C   7
LEU C 104
GLY A 259
ASP A 258
 None
 0.99A 1rmtC-5l9wC:
undetectable		 1rmtC-5l9wC:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 TYR A 134
LEU A 139
GLY A  75
ASP A  74
 None
 0.94A 1rmtC-5l9wA:
undetectable		 1rmtC-5l9wA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 4 PHE B  40
LEU B 155
TRP B 215
GLY B  44
 None
 0.97A 1rmtC-5lhsB:
undetectable		 1rmtC-5lhsB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 PHE A1110
TRP A1141
ASP A1127
TYR A1109
 None
 0.94A 1rmtC-5lkiA:
undetectable		 1rmtC-5lkiA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ln4 PH 6 ANTIGEN,PH 6
ANTIGEN

(Yersinia pestis) 		no annotation 4 PHE A 110
LEU A  67
TRP A  81
GLY A  54
 None
 0.87A 1rmtC-5ln4A:
undetectable		 1rmtC-5ln4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo7 FIMBRIAL PROTEIN
MYFA,FIMBRIAL
PROTEIN MYFA

(Yersinia
enterocolitica) 		no annotation 4 PHE A 113
LEU A  73
TRP A  85
GLY A  60
 None
 0.87A 1rmtC-5lo7A:
undetectable		 1rmtC-5lo7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ASP A  26
LEU A  34
TRP A 131
GLY A  30
 None
 0.98A 1rmtC-5macA:
undetectable		 1rmtC-5macA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 PHE G  92
TYR G  69
LEU G  70
GLY G  76
 CLA  G 602 (-4.5A)
None
CLA  G 602 (-4.1A)
CLA  G 602 (-4.8A)
 0.93A 1rmtC-5mdxG:
undetectable		 1rmtC-5mdxG:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 PHE T3557
LEU T3645
GLY T3707
TYR T3560
 None
 1.03A 1rmtC-5ojsT:
undetectable		 1rmtC-5ojsT:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01493
(GXGXG) 		4 PHE C 218
TYR B 224
LEU B 223
GLY C 247
 None
 0.80A 1rmtC-5t5iC:
undetectable		 1rmtC-5t5iC:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 PHE A 119
LEU A  57
GLY A 246
TYR A 121
 NAP  A 501 (-4.5A)
None
None
ZBZ  A 249 ( 4.0A)
 0.84A 1rmtC-5ucdA:
3.9		 1rmtC-5ucdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft 26S PROTEASOME
REGULATORY SUBUNIT 8

(Homo sapiens) 		no annotation 4 ASP C 119
LEU C 116
GLY C  70
TYR C 121
 None
 0.98A 1rmtC-5vftC:
undetectable		 1rmtC-5vftC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9c MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		no annotation 4 PHE A  74
LEU A  42
GLY A 109
ASP A 370
 None
 0.88A 1rmtC-5y9cA:
undetectable		 1rmtC-5y9cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 4 PHE Y  54
TYR Y  31
LEU Y  32
GLY Y  38
 CLA  Y 602 (-4.7A)
None
CLA  Y 602 (-4.0A)
CLA  Y 602 (-4.5A)
 1.00A 1rmtC-5zjiY:
undetectable		 1rmtC-5zjiY:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASP A1196
TYR A1220
LEU A1203
GLY A1199
 None
 0.94A 1rmtC-6apxA:
undetectable		 1rmtC-6apxA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 ASP A 256
PHE A 343
TYR A 350
LEU A 244
 EDO  A 610 (-3.3A)
None
None
None
 0.92A 1rmtC-6cc2A:
undetectable		 1rmtC-6cc2A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 4 ASP A 416
PHE A 444
TYR A 477
GLY A 463
 None
 0.99A 1rmtC-6eomA:
undetectable		 1rmtC-6eomA:
13.74