SIMILAR PATTERNS OF AMINO ACIDS FOR 1RLB_F_REAF177

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9a PROTEIN
(PARVALBUMIN)

(Cyprinus carpio) 		PF13499
(EF-hand_7) 		5 PHE A  30
LEU A  35
ALA A  48
ALA A  46
VAL A  33
 None
 1.10A 1rlbF-1b9aA:
undetectable		 1rlbF-1b9aA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 LEU A 238
ALA A 224
VAL A 277
LEU A 307
MET A 270
 None
 1.16A 1rlbF-1epxA:
undetectable		 1rlbF-1epxA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF00102
(Y_phosphatase)
PF03545
(YopE) 		5 LEU S 218
ALA S 175
VAL S 231
LEU S 234
LEU S 280
 None
 1.16A 1rlbF-1g4uS:
1.0		 1rlbF-1g4uS:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ALA A 395
VAL A  43
LEU A  48
LEU A 237
GLN A 240
 None
 1.14A 1rlbF-1hwwA:
0.0		 1rlbF-1hwwA:
10.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		10 PHE A  36
LEU A  37
ALA A  55
ALA A  57
VAL A  61
LEU A  63
MET A  73
MET A  88
LEU A  97
GLN A  98
 None
RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
None
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
 0.65A 1rlbF-1iiuA:
30.5		 1rlbF-1iiuA:
80.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		10 PHE A  36
LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
 None
RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
 0.54A 1rlbF-1iiuA:
30.5		 1rlbF-1iiuA:
80.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A 391
VAL A 373
LEU A 377
MET A  70
LEU A  65
 None
None
None
CPR  A 631 ( 3.8A)
None
 1.16A 1rlbF-1jcnA:
0.1		 1rlbF-1jcnA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		5 LEU A 170
ALA A  59
ALA A  10
VAL A 201
LEU A 204
 None
 1.17A 1rlbF-1ka0A:
0.3		 1rlbF-1ka0A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x37 ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF05362
(Lon_C) 		5 ALA A  68
ALA A  66
LEU A  17
LEU A  33
GLN A  32
 None
 1.15A 1rlbF-1x37A:
undetectable		 1rlbF-1x37A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 ALA A 357
ALA A 182
LEU A 208
LEU A 188
GLN A 189
 None
AGS  A1600 (-4.5A)
None
None
None
 1.13A 1rlbF-1xpoA:
0.0		 1rlbF-1xpoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 744
ALA A 721
ALA A 719
LEU A 712
GLN A 711
 None
None
None
None
BHM  A   1 (-2.2A)
 1.07A 1rlbF-2ax9A:
undetectable		 1rlbF-2ax9A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 PHE A 137
ALA A 202
VAL A 163
LEU A 166
LEU A 195
 None
 1.13A 1rlbF-2bxyA:
0.0		 1rlbF-2bxyA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		6 LEU A  94
ALA A 175
VAL A  98
LEU A 101
MET A 333
LEU A 118
 None
 1.13A 1rlbF-2c6xA:
undetectable		 1rlbF-2c6xA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 LEU A  97
ALA A 158
ALA A 156
VAL A  96
LEU A  80
 None
 1.06A 1rlbF-2g7lA:
undetectable		 1rlbF-2g7lA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hes YDR267CP

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU X  27
ALA X 313
VAL X  39
LEU X  48
LEU X  10
 None
 1.05A 1rlbF-2hesX:
undetectable		 1rlbF-2hesX:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.04A 1rlbF-2i7xA:
undetectable		 1rlbF-2i7xA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 LEU A  43
ALA A 276
ALA A  61
VAL A   5
LEU A  57
 None
 1.01A 1rlbF-2jh3A:
undetectable		 1rlbF-2jh3A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 PHE A 155
LEU A 160
VAL A 199
LEU A 279
LEU A 306
 None
 1.15A 1rlbF-2o3cA:
undetectable		 1rlbF-2o3cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 LEU A 299
ALA A 274
ALA A 272
VAL A 335
LEU A 339
 None
 1.17A 1rlbF-2obmA:
undetectable		 1rlbF-2obmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 PHE A 105
ALA A 269
ALA A 273
VAL A 107
LEU A 101
 None
 1.13A 1rlbF-2oryA:
undetectable		 1rlbF-2oryA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pau 5'-DEOXYNUCLEOTIDASE
YFBR

(Escherichia
coli) 		PF13023
(HD_3) 		5 LEU A  13
ALA A  38
VAL A  73
LEU A  74
TYR A  67
 None
 1.11A 1rlbF-2pauA:
undetectable		 1rlbF-2pauA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		5 LEU A 158
ALA A 177
VAL A 161
LEU A 117
LEU A  65
 None
 1.17A 1rlbF-2pxxA:
undetectable		 1rlbF-2pxxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		5 LEU B  50
ALA B 223
ALA B 206
VAL B  46
LEU B 196
 None
 1.13A 1rlbF-2q2eB:
undetectable		 1rlbF-2q2eB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxg CG6181-PA, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 LEU A1244
VAL A1247
LEU A1239
LEU A1275
GLN A1277
 None
 1.17A 1rlbF-2vxgA:
undetectable		 1rlbF-2vxgA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  55
ALA A  57
VAL A  61
LEU A  63
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
 0.82A 1rlbF-2wq9A:
30.5		 1rlbF-2wq9A:
92.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 172
ALA A 147
VAL A 176
LEU A 180
LEU A 207
 None
 1.14A 1rlbF-2xaxA:
undetectable		 1rlbF-2xaxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 VAL A 237
LEU A 210
MET A 227
LEU A 198
GLN A 202
 None
 1.11A 1rlbF-2yv2A:
undetectable		 1rlbF-2yv2A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 298
ALA A 247
VAL A 229
TYR A 254
LEU A 213
 None
 1.00A 1rlbF-2yxzA:
undetectable		 1rlbF-2yxzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		5 LEU A 133
ALA A  65
VAL A 129
LEU A 125
LEU A  49
 None
 1.18A 1rlbF-3bkwA:
undetectable		 1rlbF-3bkwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 111
ALA A  55
ALA A  51
VAL A  97
LEU A  94
 None
 1.17A 1rlbF-3c8tA:
undetectable		 1rlbF-3c8tA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  36
LEU A  37
ALA A  55
ALA A  57
MET A  73
TYR A  90
GLN A  98
 2T1  A 184 (-3.7A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
 0.99A 1rlbF-3fmzA:
29.4		 1rlbF-3fmzA:
92.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  36
LEU A  37
ALA A  55
ALA A  57
MET A  88
TYR A  90
GLN A  98
 2T1  A 184 (-3.7A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
 0.72A 1rlbF-3fmzA:
29.4		 1rlbF-3fmzA:
92.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  36
LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  88
 2T1  A 184 (-3.7A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.1A)
 0.83A 1rlbF-3fmzA:
29.4		 1rlbF-3fmzA:
92.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  36
LEU A  37
ALA A  57
VAL A  61
LEU A  63
 2T1  A 184 (-3.7A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
None
None
 0.94A 1rlbF-3fmzA:
29.4		 1rlbF-3fmzA:
92.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		5 VAL A  67
LEU A  71
TYR A   7
LEU A 320
GLN A   5
 None
 1.05A 1rlbF-3gc2A:
undetectable		 1rlbF-3gc2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  32
VAL A 210
LEU A 230
TYR A  35
LEU A 181
 None
 1.15A 1rlbF-3hf9A:
undetectable		 1rlbF-3hf9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj9 OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		PF00881
(Nitroreductase) 		5 LEU A 138
ALA A  71
VAL A  97
LEU A  99
LEU A  64
 None
 0.85A 1rlbF-3hj9A:
undetectable		 1rlbF-3hj9A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		5 LEU A 173
ALA A 183
VAL A 161
LEU A 165
LEU A 190
 None
 1.04A 1rlbF-3i44A:
undetectable		 1rlbF-3i44A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im7 CARDIAC CA2+ RELEASE
CHANNEL

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		5 PHE A  67
LEU A  22
ALA A 205
VAL A 214
LEU A  14
 None
 1.09A 1rlbF-3im7A:
undetectable		 1rlbF-3im7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN

(Bordetella
parapertussis) 		PF00571
(CBS) 		5 LEU A 161
ALA A 149
ALA A 173
VAL A 191
LEU A 192
 None
 1.19A 1rlbF-3jtfA:
undetectable		 1rlbF-3jtfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfr PUTATIVE METAL ION
TRANSPORTER

(Pseudomonas
syringae group
genomosp. 3) 		PF00571
(CBS) 		5 LEU A 149
ALA A 137
ALA A 161
VAL A 179
LEU A 180
 None
 1.19A 1rlbF-3lfrA:
undetectable		 1rlbF-3lfrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Aeromonas
salmonicida) 		PF00072
(Response_reg) 		5 LEU A  51
ALA A  23
VAL A  76
LEU A  96
LEU A 117
 None
 1.01A 1rlbF-3lufA:
undetectable		 1rlbF-3lufA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 PHE A 360
LEU A  92
ALA A 422
VAL A 363
LEU A 366
 None
 1.18A 1rlbF-3ncyA:
undetectable		 1rlbF-3ncyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 262
ALA A 286
VAL A 297
LEU A 329
MET A 283
 None
 1.10A 1rlbF-3o04A:
undetectable		 1rlbF-3o04A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o44 HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		5 ALA A 678
VAL A 610
LEU A 608
LEU A 662
GLN A 672
 None
 1.14A 1rlbF-3o44A:
undetectable		 1rlbF-3o44A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 LEU A 204
ALA A 111
VAL A 181
LEU A 178
LEU A  48
 None
 1.06A 1rlbF-3o7qA:
undetectable		 1rlbF-3o7qA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		6 LEU A 205
ALA A 236
ALA A 211
VAL A 204
LEU A 177
LEU A 124
 None
 1.47A 1rlbF-3pwzA:
undetectable		 1rlbF-3pwzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 LEU A 499
ALA A 495
VAL A 981
LEU A1056
LEU A 944
 None
 1.14A 1rlbF-3u6nA:
undetectable		 1rlbF-3u6nA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ALA A 140
ALA A 138
VAL A 147
LEU A 149
LEU A 131
 None
 1.10A 1rlbF-3vabA:
undetectable		 1rlbF-3vabA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.09A 1rlbF-3whlA:
undetectable		 1rlbF-3whlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 LEU A  41
ALA A 238
ALA A 233
LEU A 202
LEU A 227
 None
 0.98A 1rlbF-3zrpA:
undetectable		 1rlbF-3zrpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		5 LEU A 339
ALA A  57
VAL A 336
LEU A 103
LEU A 290
 None
 1.11A 1rlbF-4a6uA:
undetectable		 1rlbF-4a6uA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		5 LEU B 357
ALA B 502
ALA B 497
VAL B 360
LEU B 366
 P6G  B1546 ( 4.1A)
None
P6G  B1546 (-4.3A)
None
None
 1.05A 1rlbF-4bwcB:
undetectable		 1rlbF-4bwcB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  35
ALA A  43
ALA A  39
VAL A  23
LEU A 218
 None
 1.11A 1rlbF-4d4gA:
undetectable		 1rlbF-4d4gA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		6 ALA A 341
ALA A 343
VAL A 347
LEU A 322
MET A 331
TYR A 134
 None
 0.91A 1rlbF-4efiA:
undetectable		 1rlbF-4efiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		6 LEU A 345
ALA A 341
VAL A 347
LEU A 322
MET A 331
TYR A 134
 None
 1.26A 1rlbF-4efiA:
undetectable		 1rlbF-4efiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 517
ALA A 545
ALA A 583
VAL A 499
LEU A 600
 None
None
SLA  A 801 ( 4.2A)
None
None
 1.16A 1rlbF-4fwgA:
undetectable		 1rlbF-4fwgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 PHE A 142
LEU A 152
ALA A 340
ALA A  99
VAL A 148
 None
 1.07A 1rlbF-4g6cA:
undetectable		 1rlbF-4g6cA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN

(Dyadobacter
fermentans) 		PF00501
(AMP-binding) 		5 LEU A 147
ALA A 139
VAL A 150
LEU A 152
GLN A 130
 None
None
None
None
EDO  A 413 ( 4.5A)
 1.07A 1rlbF-4gs5A:
undetectable		 1rlbF-4gs5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		5 LEU A 138
ALA A 157
VAL A 118
LEU A  79
MET A 209
 None
 1.10A 1rlbF-4gwnA:
undetectable		 1rlbF-4gwnA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		5 LEU A 332
ALA A 264
ALA A 337
VAL A 328
LEU A 319
 None
 1.07A 1rlbF-4jndA:
undetectable		 1rlbF-4jndA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqo ORNITHINE
CARBAMOYLTRANSFERASE

(Vibrio
vulnificus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 163
ALA A 161
VAL A 257
LEU A 262
GLN A 264
 None
None
None
PEG  A 404 (-4.9A)
None
 1.17A 1rlbF-4jqoA:
undetectable		 1rlbF-4jqoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 133
ALA A 149
ALA A 145
VAL A 264
LEU A 102
 None
 1.08A 1rlbF-4lcbA:
undetectable		 1rlbF-4lcbA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		5 LEU A 286
ALA A  77
VAL A 299
LEU A  87
GLN A  88
 None
 1.12A 1rlbF-4lcmA:
undetectable		 1rlbF-4lcmA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 139
ALA A 155
ALA A 151
VAL A 270
LEU A 108
 None
 1.16A 1rlbF-4lgmA:
undetectable		 1rlbF-4lgmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE

(Amycolatopsis
mediterranei) 		PF14765
(PS-DH) 		5 LEU A  88
ALA A 101
VAL A  58
LEU A  47
LEU A  20
 None
 0.99A 1rlbF-4ln9A:
undetectable		 1rlbF-4ln9A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 LEU A 504
VAL A 533
LEU A 556
MET A 519
LEU A 544
 None
 1.14A 1rlbF-4oj5A:
undetectable		 1rlbF-4oj5A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 493
ALA A 515
VAL A 496
LEU A 691
LEU A 481
 None
 1.14A 1rlbF-4oqjA:
undetectable		 1rlbF-4oqjA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF08759
(GT-D) 		5 LEU A 200
ALA A 176
VAL A 146
LEU A 144
TYR A 180
 UDP  A 301 (-4.5A)
UDP  A 301 (-3.3A)
None
None
None
 1.16A 1rlbF-4phsA:
undetectable		 1rlbF-4phsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		5 PHE A 100
LEU A 138
ALA A 166
VAL A 140
LEU A 155
 None
 0.98A 1rlbF-4pooA:
undetectable		 1rlbF-4pooA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		5 ALA A 134
ALA A 136
VAL A  72
LEU A  75
LEU A 156
 None
 1.13A 1rlbF-4r42A:
undetectable		 1rlbF-4r42A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 LEU D 247
ALA D 116
ALA D 259
VAL D 242
LEU D 207
 None
 1.17A 1rlbF-4s1vD:
undetectable		 1rlbF-4s1vD:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 LEU A 137
ALA A 388
VAL A 141
LEU A 144
LEU A 167
 None
 0.99A 1rlbF-4tvmA:
undetectable		 1rlbF-4tvmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 LEU A  78
ALA A  94
VAL A  99
LEU A 101
LEU A  88
 None
 1.10A 1rlbF-4x2rA:
undetectable		 1rlbF-4x2rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 PHE A 783
LEU A 786
VAL A 828
LEU A 824
LEU A 716
 None
 1.18A 1rlbF-4xqkA:
undetectable		 1rlbF-4xqkA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		5 LEU A  12
ALA A 227
VAL A  16
TYR A 279
GLN A 275
 None
None
None
C  D  17 ( 4.3A)
G  D  19 ( 3.6A)
 1.02A 1rlbF-4ycoA:
undetectable		 1rlbF-4ycoA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 146
LEU A 141
ALA A 107
VAL A 164
LEU A 189
 None
 1.12A 1rlbF-4z61A:
undetectable		 1rlbF-4z61A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A1031
ALA A1053
VAL A1034
LEU A1166
LEU A1019
 None
 1.13A 1rlbF-4zdnA:
undetectable		 1rlbF-4zdnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF13406
(SLT_2) 		5 LEU A 260
ALA A 269
VAL A 285
LEU A 293
LEU A 316
 None
 1.09A 1rlbF-5ao8A:
undetectable		 1rlbF-5ao8A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5q MEMBRANE THIOL
PROTEASE

(Chlamydia
trachomatis) 		PF02902
(Peptidase_C48) 		5 LEU B 242
ALA B 212
VAL B 281
LEU B 288
LEU B 315
 None
 1.14A 1rlbF-5b5qB:
undetectable		 1rlbF-5b5qB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab) 		5 PHE B 383
LEU B 343
ALA B 328
LEU B 351
LEU B 321
 None
 1.19A 1rlbF-5bn4B:
undetectable		 1rlbF-5bn4B:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnl IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Pyrococcus
furiosus) 		PF00475
(IGPD) 		5 LEU A 119
ALA A  87
VAL A 123
LEU A 126
LEU A 155
 None
 1.07A 1rlbF-5dnlA:
undetectable		 1rlbF-5dnlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.05A 1rlbF-5eqtA:
undetectable		 1rlbF-5eqtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		5 LEU A 407
ALA A 257
VAL A 419
LEU A 421
LEU A 261
 None
 1.14A 1rlbF-5fulA:
undetectable		 1rlbF-5fulA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 PHE A 144
LEU A 151
ALA A  97
LEU A 202
LEU A 192
 None
 1.00A 1rlbF-5gvaA:
undetectable		 1rlbF-5gvaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Yersinia pestis) 		PF04390
(LptE) 		5 ALA B 144
VAL B  88
LEU B  55
LEU B 139
GLN B 138
 None
 1.17A 1rlbF-5ixmB:
undetectable		 1rlbF-5ixmB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3e THYMOCYTE NUCLEAR
PROTEIN 1

(Homo sapiens) 		PF01878
(EVE) 		5 PHE A 213
LEU A 217
VAL A 216
LEU A 178
MET A 169
 None
 1.15A 1rlbF-5j3eA:
undetectable		 1rlbF-5j3eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 PHE A1112
LEU A1080
ALA A1136
ALA A1134
LEU A1096
 None
 1.17A 1rlbF-5lpyA:
undetectable		 1rlbF-5lpyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 PHE A1112
LEU A1080
ALA A1136
ALA A1134
LEU A1096
 None
 1.18A 1rlbF-5lpzA:
undetectable		 1rlbF-5lpzA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		5 LEU C 463
ALA C 368
VAL C 466
LEU C 330
LEU C 312
 None
 1.01A 1rlbF-5nd7C:
undetectable		 1rlbF-5nd7C:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		5 ALA A 189
ALA A 187
VAL A 353
LEU A 351
LEU A 311
 None
 1.18A 1rlbF-5oe5A:
undetectable		 1rlbF-5oe5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 PHE f 601
ALA f 536
ALA f 569
LEU f 589
MET f 570
 None
 1.15A 1rlbF-5t0hf:
undetectable		 1rlbF-5t0hf:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 LEU A 615
ALA A 625
VAL A 603
LEU A 607
LEU A 632
 None
 0.96A 1rlbF-5ux5A:
undetectable		 1rlbF-5ux5A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		5 ALA A 119
ALA A 115
LEU A 286
TYR A 236
LEU A  93
 None
None
EDO  A 604 (-4.3A)
None
None
 1.13A 1rlbF-5vnxA:
undetectable		 1rlbF-5vnxA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vug UNCHARACTERIZED
PROTEIN RV2277C

(Mycobacterium
tuberculosis) 		PF03009
(GDPD) 		5 LEU A  53
ALA A  31
ALA A  15
VAL A  43
LEU A 123
 None
 1.16A 1rlbF-5vugA:
undetectable		 1rlbF-5vugA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 PHE B 380
LEU B 383
ALA B 410
ALA B 394
LEU B 218
 None
 1.15A 1rlbF-5y58B:
undetectable		 1rlbF-5y58B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9v RYANODINE RECEPTOR 1

(Plutella
xylostella) 		no annotation 6 PHE A  65
LEU A  25
ALA A 189
VAL A 198
LEU A  17
LEU A 146
 None
 1.39A 1rlbF-5y9vA:
undetectable		 1rlbF-5y9vA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhc PSEUDOPODIUM-ENRICHE
D ATYPICAL KINASE 1

(Homo sapiens) 		no annotation 5 LEU A1519
ALA A1642
VAL A1471
LEU A1524
LEU A1496
 None
 1.14A 1rlbF-6bhcA:
undetectable		 1rlbF-6bhcA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 LEU A 360
ALA A 337
TYR A 335
LEU A 302
GLN A 319
 None
 1.13A 1rlbF-6byxA:
undetectable		 1rlbF-6byxA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3

(Homo sapiens) 		no annotation 5 LEU A 591
ALA A 538
ALA A 557
VAL A 607
LEU A 579
 None
 1.08A 1rlbF-6cvzA:
undetectable		 1rlbF-6cvzA:
13.79