SIMILAR PATTERNS OF AMINO ACIDS FOR 1RLB_E_REAE176

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aep APOLIPOPHORIN III

(Locusta
migratoria) 		no annotation 5 LEU A  81
ALA A 133
ALA A 137
VAL A 108
LEU A  14
 None
 1.31A 1rlbE-1aepA:
undetectable		 1rlbE-1aepA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b33 ALLOPHYCOCYANIN,
ALPHA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 ALA A 127
ALA A 131
MET A 132
LEU A  88
PHE A  58
 None
 1.34A 1rlbE-1b33A:
undetectable		 1rlbE-1b33A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbt FOOT-AND-MOUTH
DISEASE VIRUS
(SUBUNIT VP1)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ALA 1  93
ALA 1 167
VAL 1 173
LEU 1  86
ASP 1  99
 None
 1.20A 1rlbE-1bbt1:
0.0		 1rlbE-1bbt1:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 5 ALA P 265
MET P 262
LEU P 217
GLN P 300
ASP P 303
 None
 1.34A 1rlbE-1cf2P:
0.1		 1rlbE-1cf2P:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		5 LEU A  16
ALA A  46
ALA A  48
VAL A  20
PHE A  12
 None
 1.27A 1rlbE-1f0xA:
undetectable		 1rlbE-1f0xA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  94
ALA C 149
ALA C 134
VAL C  87
ASP C 115
 None
None
None
None
FAD  C1922 (-2.9A)
 1.17A 1rlbE-1ffvC:
0.0		 1rlbE-1ffvC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 359
ALA A 299
VAL A 358
LEU A 272
ASP A 467
 None
None
None
ZN  A 601 ( 4.7A)
None
 1.21A 1rlbE-1gytA:
undetectable		 1rlbE-1gytA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		5 LEU A 117
ALA A 180
VAL A 113
LEU A 173
PHE A  82
 None
 1.25A 1rlbE-1i5pA:
undetectable		 1rlbE-1i5pA:
14.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		9 LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  73
LEU A  97
GLN A  98
ASP A 102
PHE A 135
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
None
RTL  A 176 ( 4.2A)
 0.62A 1rlbE-1iiuA:
30.8		 1rlbE-1iiuA:
80.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		5 ALA A 110
ALA A 112
VAL A 133
LEU A 119
ASP A  80
 None
 1.12A 1rlbE-1lbuA:
0.0		 1rlbE-1lbuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 239
ALA A 205
VAL A 241
LEU A 212
GLN A 214
 None
 1.20A 1rlbE-1mnsA:
0.0		 1rlbE-1mnsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 LEU A 667
ALA A 723
VAL A 663
LEU A 681
GLN A 719
 None
 1.22A 1rlbE-1oxjA:
undetectable		 1rlbE-1oxjA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU B 334
ALA B 361
ALA B 359
VAL B 339
PHE B  96
 None
 1.30A 1rlbE-1t3qB:
undetectable		 1rlbE-1t3qB:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 171
ALA A 135
VAL A 154
LEU A 142
ASP A 291
 None
 1.26A 1rlbE-1tt7A:
undetectable		 1rlbE-1tt7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc7 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF13899
(Thioredoxin_7) 		5 LEU A  81
ALA A  68
VAL A  86
LEU A  93
GLN A  76
 None
 1.30A 1rlbE-1uc7A:
undetectable		 1rlbE-1uc7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		5 LEU A  43
ALA A  17
VAL A  49
GLN A 294
ASP A 286
 FAD  A 400 (-4.1A)
None
FAD  A 400 (-3.5A)
FAD  A 400 (-3.8A)
FAD  A 400 ( 2.8A)
 1.00A 1rlbE-1vdcA:
undetectable		 1rlbE-1vdcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 LEU A 170
ALA A 134
VAL A 153
LEU A 141
ASP A 290
 None
 1.13A 1rlbE-1xa0A:
undetectable		 1rlbE-1xa0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A 480
ALA A 516
VAL A 491
LEU A 448
PHE A 412
 None
 1.19A 1rlbE-1y9gA:
undetectable		 1rlbE-1y9gA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		5 LEU A  82
ALA A 204
VAL A  33
LEU A 125
ASP A 134
 None
 1.32A 1rlbE-1yw6A:
1.8		 1rlbE-1yw6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 744
ALA A 721
ALA A 719
LEU A 712
GLN A 711
 None
None
None
None
BHM  A   1 (-2.2A)
 1.07A 1rlbE-2ax9A:
undetectable		 1rlbE-2ax9A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		5 ALA A 254
VAL A  95
MET A 255
LEU A  31
ASP A 248
 None
None
None
None
CA  A 302 (-3.0A)
 1.20A 1rlbE-2b30A:
undetectable		 1rlbE-2b30A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A  20
ALA A  43
VAL A  56
LEU A 102
PHE A  22
 None
 1.32A 1rlbE-2d3tA:
undetectable		 1rlbE-2d3tA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		5 LEU A  60
ALA A  67
ALA A  98
VAL A  88
PHE A  41
 None
 1.18A 1rlbE-2deoA:
undetectable		 1rlbE-2deoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A  86
ALA A 220
ALA A 256
LEU A   5
PHE A 282
 None
 1.10A 1rlbE-2ffhA:
undetectable		 1rlbE-2ffhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnu AMINOTRANSFERASE

(Helicobacter
pylori) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A  45
ALA A  56
ALA A 192
VAL A  47
ASP A 129
 None
PMP  A 901 (-3.3A)
None
None
None
 1.11A 1rlbE-2fnuA:
undetectable		 1rlbE-2fnuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A  64
ALA A 125
VAL A  62
LEU A 178
PHE A  32
 None
 1.15A 1rlbE-2hxsA:
undetectable		 1rlbE-2hxsA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		5 LEU A 201
ALA A 221
VAL A 230
GLN A 250
PHE A 176
 None
 1.02A 1rlbE-2jg2A:
undetectable		 1rlbE-2jg2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		5 LEU A 201
ALA A 221
VAL A 230
LEU A 252
PHE A 176
 None
 1.27A 1rlbE-2jg2A:
undetectable		 1rlbE-2jg2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 LEU A  43
ALA A 276
ALA A  61
VAL A   5
LEU A  57
 None
 1.15A 1rlbE-2jh3A:
undetectable		 1rlbE-2jh3A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kx7 SENSOR-LIKE
HISTIDINE KINASE
YOJN

(Escherichia
coli) 		PF16359
(RcsD_ABL) 		5 LEU A 736
ALA A 774
ALA A 778
VAL A 696
LEU A 691
 None
 1.05A 1rlbE-2kx7A:
undetectable		 1rlbE-2kx7A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		5 ALA A 243
ALA A 245
LEU A 470
GLN A 472
GLN A 238
 None
 1.32A 1rlbE-2q01A:
undetectable		 1rlbE-2q01A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		5 LEU A  53
ALA A  22
VAL A  59
GLN A 301
ASP A 293
 FAD  A 400 (-4.0A)
None
FAD  A 400 ( 3.8A)
FAD  A 400 (-4.1A)
FAD  A 400 (-3.0A)
 0.94A 1rlbE-2whdA:
undetectable		 1rlbE-2whdA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  73
LEU A  97
GLN A  98
ASP A 102
GLN A 117
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
OLA  A1179 ( 4.9A)
None
None
None
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 0.79A 1rlbE-2wq9A:
31.1		 1rlbE-2wq9A:
92.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		5 ALA A 983
ALA A 905
LEU A 927
GLN A 926
ASP A 827
 None
 1.19A 1rlbE-2y3aA:
undetectable		 1rlbE-2y3aA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		5 LEU A 143
ALA A 191
VAL A 146
GLN A 155
GLN A 128
 None
 1.22A 1rlbE-2yg6A:
undetectable		 1rlbE-2yg6A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkp CYCLOPHILIN

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		5 LEU A  26
ALA A 113
VAL A  24
LEU A  37
PHE A  63
 None
 1.27A 1rlbE-3bkpA:
undetectable		 1rlbE-3bkpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 LEU A 336
ALA A 214
VAL A 296
GLN A 208
PHE A 338
 None
 1.33A 1rlbE-3c0kA:
undetectable		 1rlbE-3c0kA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE

(Mycolicibacterium
smegmatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 351
ALA A  48
ALA A  46
LEU A 332
PHE A 272
 None
 1.29A 1rlbE-3dg7A:
undetectable		 1rlbE-3dg7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 219
ALA A 123
ALA A 151
LEU A 130
ASP A 126
 None
NAD  A 901 (-3.6A)
None
None
None
 1.16A 1rlbE-3docA:
undetectable		 1rlbE-3docA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  37
ALA A  55
ALA A  57
GLN A  98
ASP A 102
GLN A 117
PHE A 135
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.0A)
None
None
2T1  A 184 (-4.8A)
 0.92A 1rlbE-3fmzA:
29.9		 1rlbE-3fmzA:
92.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  37
ALA A  55
ALA A  57
MET A  73
GLN A  98
GLN A 117
PHE A 135
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.0A)
None
2T1  A 184 (-4.8A)
 1.14A 1rlbE-3fmzA:
29.9		 1rlbE-3fmzA:
92.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  37
ALA A  55
ALA A  57
VAL A  61
ASP A 102
GLN A 117
PHE A 135
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
None
None
None
2T1  A 184 (-4.8A)
 0.88A 1rlbE-3fmzA:
29.9		 1rlbE-3fmzA:
92.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 LEU A 230
ALA A 290
ALA A 314
VAL A 233
GLN A 382
 None
 1.31A 1rlbE-3gcwA:
undetectable		 1rlbE-3gcwA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME

(Corynebacterium
glutamicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 305
ALA A 143
LEU A 330
ASP A 251
PHE A  26
 LEU  A 305 ( 0.6A)
ALA  A 143 ( 0.0A)
LEU  A 330 ( 0.6A)
ASP  A 251 ( 0.6A)
PHE  A  26 ( 1.3A)
 1.30A 1rlbE-3i4kA:
undetectable		 1rlbE-3i4kA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 LEU A 221
ALA A  51
ALA A 242
VAL A 107
LEU A 235
 None
 1.23A 1rlbE-3ix1A:
undetectable		 1rlbE-3ix1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 341
ALA A 205
VAL A  27
MET A  78
PHE A 226
 None
 1.30A 1rlbE-3lmdA:
undetectable		 1rlbE-3lmdA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc3 DSRE/DSRF-LIKE
FAMILY PROTEIN

(Sulfolobus
solfataricus) 		PF02635
(DrsE) 		5 LEU A  60
ALA A  38
VAL A 108
ASP A  81
PHE A  76
 None
 1.28A 1rlbE-3mc3A:
undetectable		 1rlbE-3mc3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 ALA A 397
ALA A 393
VAL A 314
LEU A 344
ASP A 349
 None
None
None
ACJ  A 478 (-4.0A)
None
 1.12A 1rlbE-3nksA:
undetectable		 1rlbE-3nksA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
fluorescens) 		PF01965
(DJ-1_PfpI) 		5 LEU A 107
ALA A  94
ALA A  91
VAL A 106
LEU A   8
 None
 1.04A 1rlbE-3noqA:
undetectable		 1rlbE-3noqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 185
ALA A 123
ALA A 127
VAL A 137
LEU A 152
 None
 1.23A 1rlbE-3shoA:
undetectable		 1rlbE-3shoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 ALA A 150
VAL A  63
MET A 145
LEU A  47
GLN A 155
 None
 1.12A 1rlbE-3szbA:
undetectable		 1rlbE-3szbA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 ALA A  22
ALA A  91
VAL A 184
LEU A 104
GLN A  29
 None
 1.21A 1rlbE-3v2iA:
undetectable		 1rlbE-3v2iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A3959
ALA A3915
LEU A3971
GLN A3970
GLN A3910
 None
 1.22A 1rlbE-3vkgA:
undetectable		 1rlbE-3vkgA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.16A 1rlbE-3whlA:
undetectable		 1rlbE-3whlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 LEU A 485
ALA A 391
VAL A 476
MET A 450
LEU A 446
 None
 1.19A 1rlbE-4btpA:
undetectable		 1rlbE-4btpA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 264
ALA A 367
VAL A 313
LEU A 359
GLN A 358
 None
 1.24A 1rlbE-4cgnA:
undetectable		 1rlbE-4cgnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 LEU A 190
ALA A 116
ALA A 120
LEU A 136
PHE A 194
 None
PLM  A 301 (-3.5A)
PLM  A 301 ( 3.7A)
None
None
 1.20A 1rlbE-4dolA:
undetectable		 1rlbE-4dolA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edn BETA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		5 LEU A 268
ALA A 322
LEU A 278
GLN A 281
ASP A 284
 None
 1.25A 1rlbE-4ednA:
undetectable		 1rlbE-4ednA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 LEU A 122
ALA A 351
VAL A  37
LEU A  54
GLN A 140
 None
 1.32A 1rlbE-4eyoA:
undetectable		 1rlbE-4eyoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		5 ALA A 419
ALA A 423
VAL A 379
LEU A 447
ASP A 451
 None
None
None
ANP  A1001 (-4.7A)
None
 1.29A 1rlbE-4fieA:
undetectable		 1rlbE-4fieA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 LEU A 333
ALA A 359
ALA A 352
VAL A 332
LEU A 323
 None
 1.25A 1rlbE-4go4A:
undetectable		 1rlbE-4go4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		5 ALA A 231
VAL A  27
MET A 232
LEU A 220
ASP A 225
 None
 1.01A 1rlbE-4k3fA:
undetectable		 1rlbE-4k3fA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		5 LEU A 223
ALA A 240
ALA A 237
MET A 236
LEU A 180
 None
 1.32A 1rlbE-4kvsA:
undetectable		 1rlbE-4kvsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmo TELOMERASE REVERSE
TRANSCRIPTASE

(Takifugu
rubripes) 		PF12009
(Telomerase_RBD) 		5 LEU A 446
ALA A 509
VAL A 442
LEU A 420
PHE A 525
 None
 1.31A 1rlbE-4lmoA:
undetectable		 1rlbE-4lmoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 LEU A 185
ALA A 140
ALA A 182
VAL A 203
ASP A 118
 None
 1.04A 1rlbE-4lsbA:
undetectable		 1rlbE-4lsbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1b POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		5 LEU A 209
ALA A 221
VAL A 207
LEU A 229
GLN A 236
 None
 1.22A 1rlbE-4m1bA:
undetectable		 1rlbE-4m1bA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg4 PHOSPHONOMUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 LEU A 187
ALA A 182
ALA A 180
LEU A 173
ASP A 115
 None
 1.25A 1rlbE-4mg4A:
undetectable		 1rlbE-4mg4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 192
ALA A 207
VAL A 194
LEU A 100
GLN A  93
 None
 1.32A 1rlbE-4nnzA:
undetectable		 1rlbE-4nnzA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o26 TELOMERASE REVERSE
TRANSCRIPTASE

(Oryzias latipes) 		PF12009
(Telomerase_RBD) 		5 LEU A 462
ALA A 526
VAL A 458
LEU A 436
PHE A 542
 None
 1.28A 1rlbE-4o26A:
undetectable		 1rlbE-4o26A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 LEU A 333
ALA A 359
ALA A 352
VAL A 332
LEU A 323
 None
 1.23A 1rlbE-4o6rA:
undetectable		 1rlbE-4o6rA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		5 LEU A 362
ALA A 262
ALA A 266
VAL A 358
LEU A 463
 None
 1.02A 1rlbE-4oerA:
undetectable		 1rlbE-4oerA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		5 LEU A 187
ALA A 392
VAL A 368
MET A 387
LEU A 383
 None
 1.30A 1rlbE-4oo3A:
undetectable		 1rlbE-4oo3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ALA A 327
ALA A 329
LEU A 336
GLN A 337
ASP A 303
 None
 1.11A 1rlbE-4q05A:
undetectable		 1rlbE-4q05A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 LEU D 247
ALA D 116
ALA D 259
VAL D 242
LEU D 207
 None
 1.32A 1rlbE-4s1vD:
undetectable		 1rlbE-4s1vD:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 LEU A 277
VAL A 273
LEU A 343
GLN A 346
PHE A 302
 None
 1.23A 1rlbE-4y21A:
undetectable		 1rlbE-4y21A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 LEU A 549
ALA A 532
ALA A 489
VAL A 467
LEU A 455
 None
 1.30A 1rlbE-4z2aA:
undetectable		 1rlbE-4z2aA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 347
ALA A 287
VAL A 346
LEU A 260
ASP A 459
 None
None
None
ZN  A 501 ( 4.8A)
None
 1.29A 1rlbE-4zi6A:
undetectable		 1rlbE-4zi6A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 588
ALA A 614
ALA A 610
VAL A 584
ASP A 560
 None
 1.29A 1rlbE-5bp1A:
undetectable		 1rlbE-5bp1A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 LEU A 492
ALA A 298
ALA A 300
LEU A 247
ASP A 255
 None
 1.24A 1rlbE-5cm9A:
undetectable		 1rlbE-5cm9A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		5 LEU A 322
ALA A 268
VAL A  87
MET A 266
LEU A 264
 None
 1.19A 1rlbE-5d8gA:
undetectable		 1rlbE-5d8gA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.12A 1rlbE-5eqtA:
undetectable		 1rlbE-5eqtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhh ATP-DEPENDENT DNA
HELICASE PIF1

(Homo sapiens) 		PF02689
(Herpes_Helicase)
PF05970
(PIF1) 		5 LEU A 391
ALA A 585
VAL A 394
LEU A 407
ASP A 384
 None
 1.34A 1rlbE-5fhhA:
undetectable		 1rlbE-5fhhA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 ALA A  29
VAL A 375
GLN A 148
GLN A 210
PHE A 215
 None
 1.14A 1rlbE-5fw4A:
undetectable		 1rlbE-5fw4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 524
ALA A 442
MET A 502
LEU A 499
ASP A 493
 None
 1.24A 1rlbE-5gslA:
undetectable		 1rlbE-5gslA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 LEU A 640
ALA A 712
VAL A 638
LEU A 651
ASP A 648
 None
 1.29A 1rlbE-5hzwA:
undetectable		 1rlbE-5hzwA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 261
ALA A 298
ALA A 302
MET A 303
ASP A 355
 None
 1.25A 1rlbE-5jo7A:
undetectable		 1rlbE-5jo7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 261
ALA A 298
ALA A 302
MET A 303
LEU A 349
 None
 1.25A 1rlbE-5jo7A:
undetectable		 1rlbE-5jo7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 ALA X 136
ALA X 141
VAL X 159
LEU X 170
GLN X 166
 None
 1.21A 1rlbE-5liyX:
undetectable		 1rlbE-5liyX:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 ALA A 433
ALA A 437
VAL A 445
MET A 438
LEU A 489
 None
 1.29A 1rlbE-5lq3A:
undetectable		 1rlbE-5lq3A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtv EH DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF00350
(Dynamin_N)
PF16880
(EHD_N) 		5 LEU A 377
ALA A 307
ALA A 311
LEU A 345
ASP A 386
 None
 1.20A 1rlbE-5mtvA:
undetectable		 1rlbE-5mtvA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B

(Bos taurus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 LEU C  94
ALA C 125
VAL C  98
LEU C 301
PHE C  90
 HEM  C 502 (-4.9A)
None
HEM  C 502 (-4.1A)
HEM  C 502 ( 4.8A)
HEM  C 501 (-4.6A)
 1.32A 1rlbE-5nmiC:
undetectable		 1rlbE-5nmiC:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ALA A 535
ALA A 520
VAL A  32
LEU A 527
ASP A 144
 None
 1.30A 1rlbE-5tj3A:
undetectable		 1rlbE-5tj3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 184
ALA A 181
VAL A 143
MET A  82
LEU A  83
 None
 1.33A 1rlbE-5u2aA:
undetectable		 1rlbE-5u2aA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 LEU A 340
ALA A 371
VAL A 267
GLN A 363
PHE A 271
 None
 1.23A 1rlbE-5u6sA:
undetectable		 1rlbE-5u6sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 LEU A1209
VAL A1205
LEU A1275
GLN A1278
PHE A1234
 None
 1.21A 1rlbE-5ue8A:
undetectable		 1rlbE-5ue8A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A 299
ALA A 297
VAL A 228
LEU A 249
PHE A 360
 None
None
GDP  A 401 (-3.7A)
GDP  A 401 (-3.9A)
None
 1.17A 1rlbE-5uzhA:
undetectable		 1rlbE-5uzhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 5 ALA B  44
ALA B  42
VAL B  82
LEU B  71
GLN B 123
 None
 1.33A 1rlbE-5yllB:
undetectable		 1rlbE-5yllB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 6 LEU A 109
ALA A 200
ALA A 198
VAL A 113
LEU A 190
PHE A 231
 None
 1.46A 1rlbE-6b5iA:
undetectable		 1rlbE-6b5iA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 VAL I  90
MET I 701
LEU I  68
GLN I 481
PHE I 484
 None
 1.25A 1rlbE-6bnpI:
undetectable		 1rlbE-6bnpI:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 LEU A 620
ALA A 688
VAL A 663
ASP A 628
GLN A 624
 None
 1.24A 1rlbE-6etzA:
undetectable		 1rlbE-6etzA:
16.67