SIMILAR PATTERNS OF AMINO ACIDS FOR 1RKY_A_CUA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 456
HIS A 458
HIS A 624
 CU  A   1 (-3.3A)
CU  A   1 (-3.2A)
CU  A   1 (-3.1A)
 0.22A 1rkyA-1a2vA:
39.0		 1rkyA-1a2vA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A 147
HIS A 132
HIS A 130
 ZN  A  28 (-3.1A)
None
None
 0.69A 1rkyA-1do5A:
undetectable		 1rkyA-1do5A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.61A 1rkyA-1ehkA:
undetectable		 1rkyA-1ehkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 501 ( 3.2A)
CU  A 502 (-3.2A)
CU  A 502 (-3.3A)
 0.58A 1rkyA-1eqwA:
undetectable		 1rkyA-1eqwA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 149 ( 3.2A)
CU  A 150 ( 3.3A)
CU  A 150 ( 3.2A)
 0.56A 1rkyA-1esoA:
undetectable		 1rkyA-1esoA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 442
HIS A 444
HIS A 603
 CU  A 650 ( 3.3A)
CU  A 650 ( 3.3A)
CU  A 650 ( 3.2A)
 0.17A 1rkyA-1ksiA:
38.4		 1rkyA-1ksiA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 364
HIS A 324
HIS A 204
 CU  A 630 (-3.0A)
CU  A 630 (-3.3A)
CU  A 629 (-3.1A)
 0.69A 1rkyA-1llaA:
undetectable		 1rkyA-1llaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 212
HIS A 181
HIS A  70
 CU  A5012 (-3.1A)
CU  A5012 (-3.4A)
CU  A5001 ( 3.1A)
 0.62A 1rkyA-1lnlA:
undetectable		 1rkyA-1lnlA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.55A 1rkyA-1loxA:
undetectable		 1rkyA-1loxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzg SUFE PROTEIN

(Escherichia
coli) 		PF02657
(SufE) 		3 HIS A 144
HIS A 145
HIS A 142
 None
 0.45A 1rkyA-1mzgA:
undetectable		 1rkyA-1mzgA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		3 HIS A  70
HIS A  47
HIS A  45
 ZN  A 152 ( 3.1A)
CU  A 153 (-3.1A)
CU  A 153 (-3.0A)
 0.49A 1rkyA-1oalA:
undetectable		 1rkyA-1oalA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 202 (-3.1A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.1A)
 0.58A 1rkyA-1p1vA:
undetectable		 1rkyA-1p1vA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		3 HIS A  75
HIS A  49
HIS A  47
 CU  A 172 (-4.1A)
CU  A 172 (-3.2A)
CU  A 172 (-3.1A)
 0.50A 1rkyA-1pzsA:
undetectable		 1rkyA-1pzsA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 HIS A 524
HIS A 526
HIS A 689
 CU  A 801 (-3.4A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
 0.23A 1rkyA-1qafA:
41.3		 1rkyA-1qafA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 CU  A 155 ( 3.2A)
CU  A 155 (-3.2A)
CU  A 155 (-3.0A)
 0.60A 1rkyA-1srdA:
undetectable		 1rkyA-1srdA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxz PROTEIN (CU-ZN
SUPEROXIDE
DISMUTASE)

(Bos taurus) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 153 ( 3.1A)
CU  A 152 (-3.4A)
CU  A 152 ( 3.1A)
 0.60A 1rkyA-1sxzA:
undetectable		 1rkyA-1sxzA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2

(Homo sapiens) 		PF10275
(Peptidase_C65) 		3 HIS A 177
HIS A 205
HIS A 206
 None
 0.66A 1rkyA-1tffA:
undetectable		 1rkyA-1tffA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A 711 ( 3.1A)
CU  A 712 (-3.4A)
CU  A 712 (-3.3A)
 0.53A 1rkyA-1to5A:
undetectable		 1rkyA-1to5A:
12.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		3 HIS A 528
HIS A 530
HIS A 694
 CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.1A)
 0.05A 1rkyA-1w7cA:
65.6		 1rkyA-1w7cA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xso COPPER,ZINC
SUPEROXIDE DISMUTASE

(Xenopus laevis) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 152 (-3.1A)
CU  A   1 ( 3.4A)
CU  A   1 ( 3.0A)
 0.52A 1rkyA-1xsoA:
undetectable		 1rkyA-1xsoA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A  95
HIS A  72
HIS A  70
 ZN  A 201 ( 3.1A)
CU  A 200 (-3.2A)
CU  A 200 (-3.1A)
 0.46A 1rkyA-1z9nA:
undetectable		 1rkyA-1z9nA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A  95
HIS A  72
HIS A  70
 ZN  A 201 ( 3.1A)
CU  A 200 (-3.2A)
CU  A 200 (-3.1A)
 0.44A 1rkyA-1z9pA:
undetectable		 1rkyA-1z9pA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.47A 1rkyA-2a5vA:
undetectable		 1rkyA-2a5vA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		3 HIS A  85
HIS A  62
HIS A  60
 ZN  A 400 (-3.2A)
CU  A 402 ( 3.4A)
CU  A 402 ( 3.3A)
 0.54A 1rkyA-2apsA:
undetectable		 1rkyA-2apsA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.51A 1rkyA-2aqtC:
undetectable		 1rkyA-2aqtC:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 520
HIS A 522
HIS A 684
 CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
 0.27A 1rkyA-2c11A:
42.0		 1rkyA-2c11A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c41 DPS FAMILY
DNA-BINDING STRESS
RESPONSE PROTEIN

(Thermosynechococcus
elongatus) 		PF00210
(Ferritin) 		3 HIS A 106
HIS A 139
HIS A 142
 None
 0.68A 1rkyA-2c41A:
undetectable		 1rkyA-2c41A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs7 PNEUMOCOCCAL
HISTIDINE TRIAD A
PROTEIN

(Streptococcus
pneumoniae) 		PF04270
(Strep_his_triad) 		3 HIS A  31
HIS A  33
HIS A  28
 ZN  A 201 (-3.2A)
ZN  A 201 (-3.2A)
ZN  A 201 (-3.1A)
 0.34A 1rkyA-2cs7A:
undetectable		 1rkyA-2cs7A:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 HIS A  67
HIS A  52
HIS A  50
 ZN  A 172 ( 3.1A)
CU  A 171 (-3.2A)
CU  A 171 (-3.1A)
 0.53A 1rkyA-2e47A:
undetectable		 1rkyA-2e47A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		3 HIS A 141
HIS A  74
HIS A  75
 None
 0.69A 1rkyA-2eceA:
undetectable		 1rkyA-2eceA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		3 HIS A 290
HIS A 291
HIS A 240
 CU  A 517 ( 3.2A)
CU  A 517 ( 3.1A)
CU  A 517 (-3.1A)
 0.54A 1rkyA-2eijA:
undetectable		 1rkyA-2eijA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 HIS A 260
HIS A 261
HIS A 258
 CL  A 402 (-4.3A)
None
None
 0.53A 1rkyA-2h39A:
undetectable		 1rkyA-2h39A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig6 NIMC/NIMA FAMILY
PROTEIN

(Clostridium
acetobutylicum) 		PF01243
(Putative_PNPOx) 		3 HIS A  -8
HIS A  -7
HIS A -10
 None
SO4  A 132 (-3.6A)
SO4  A 132 (-3.6A)
 0.69A 1rkyA-2ig6A:
undetectable		 1rkyA-2ig6A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 HIS A  85
HIS A 151
HIS A 155
 None
 0.58A 1rkyA-2inpA:
undetectable		 1rkyA-2inpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 530
HIS A 525
HIS A 716
 FE  A 901 (-3.5A)
FE  A 901 (-3.3A)
FE  A 901 (-3.5A)
 0.69A 1rkyA-2iukA:
2.3		 1rkyA-2iukA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcb 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01812
(5-FTHF_cyc-lig) 		3 HIS A  -1
HIS A   0
HIS A  -3
 None
 0.64A 1rkyA-2jcbA:
undetectable		 1rkyA-2jcbA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A 113
HIS A  98
HIS A  96
 ZN  A 226 ( 3.1A)
CU  A 225 (-3.2A)
CU  A 225 (-3.2A)
 0.53A 1rkyA-2jlpA:
undetectable		 1rkyA-2jlpA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7h HYPOTHETICAL PROTEIN

(Pectobacterium
atrosepticum) 		PF13489
(Methyltransf_23) 		3 HIS A 114
HIS A 172
HIS A 170
 None
EDO  A 252 (-3.9A)
None
 0.68A 1rkyA-2p7hA:
undetectable		 1rkyA-2p7hA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A  78
HIS A  76
HIS A 137
 ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
None
 0.50A 1rkyA-2pajA:
undetectable		 1rkyA-2pajA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peb PUTATIVE DIOXYGENASE

(Nostoc
punctiforme) 		PF08883
(DOPA_dioxygen) 		3 HIS A  14
HIS A  84
HIS A  12
 ZN  A 200 ( 3.1A)
ZN  A 200 ( 3.4A)
ZN  A 200 ( 3.1A)
 0.64A 1rkyA-2pebA:
undetectable		 1rkyA-2pebA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 519
HIS A 521
HIS A 683
 CU  A 804 (-3.3A)
CU  A 804 ( 3.3A)
CU  A 804 (-3.2A)
 0.20A 1rkyA-2pncA:
40.5		 1rkyA-2pncA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A1001 (-3.1A)
None
None
 0.61A 1rkyA-2q2lA:
undetectable		 1rkyA-2q2lA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 HIS A 291
HIS A 295
HIS A 283
 None
 0.63A 1rkyA-2vr2A:
undetectable		 1rkyA-2vr2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		3 HIS A  79
HIS A  56
HIS A  54
 ZN  A1162 ( 3.2A)
ZN  A1165 (-3.4A)
ZN  A1165 (-3.3A)
 0.50A 1rkyA-2wwoA:
undetectable		 1rkyA-2wwoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.66A 1rkyA-2yevA:
undetectable		 1rkyA-2yevA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE

(Vibrio
parahaemolyticus) 		PF14583
(Pectate_lyase22) 		3 HIS A 287
HIS A 355
HIS A 353
 MN  A 401 (-3.1A)
MN  A 401 (-3.3A)
MN  A 401 (-3.3A)
 0.67A 1rkyA-3c5mA:
3.3		 1rkyA-3c5mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		3 HIS A  67
HIS A  52
HIS A  50
 ZN  A 202 ( 3.1A)
CU  A 201 (-3.2A)
CU  A 201 (-3.6A)
 0.50A 1rkyA-3ce1A:
undetectable		 1rkyA-3ce1A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		3 HIS A 365
HIS A 360
HIS A 540
 FE  A 801 (-3.0A)
FE  A 801 (-3.1A)
FE  A 801 (-3.1A)
 0.69A 1rkyA-3d3lA:
undetectable		 1rkyA-3d3lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		3 HIS A 243
HIS A 106
HIS A  60
 None
 0.62A 1rkyA-3dclA:
undetectable		 1rkyA-3dclA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE

(Alvinella
pompejana) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.52A 1rkyA-3f7lA:
undetectable		 1rkyA-3f7lA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcm HYDROLASE, NUDIX
FAMILY

(Clostridium
perfringens) 		PF00293
(NUDIX) 		3 HIS A  43
HIS A 129
HIS A 127
 MN  A 201 (-3.4A)
MN  A 201 (-3.5A)
MN  A 201 (-3.6A)
 0.69A 1rkyA-3fcmA:
undetectable		 1rkyA-3fcmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.66A 1rkyA-3fg4A:
undetectable		 1rkyA-3fg4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 155 (-3.2A)
None
None
 0.68A 1rkyA-3gttA:
undetectable		 1rkyA-3gttA:
12.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.17A 1rkyA-3higA:
42.3		 1rkyA-3higA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A  95
HIS A  93
HIS A 153
 ZN  A 480 (-3.3A)
ZN  A 480 (-3.3A)
None
 0.37A 1rkyA-3hpaA:
undetectable		 1rkyA-3hpaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km2 SUPEROXIDE DISMUTASE
[CU-ZN],
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 155 (-3.2A)
None
None
 0.62A 1rkyA-3km2A:
undetectable		 1rkyA-3km2A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kog PUTATIVE
PORE-FORMING TOXIN

(Bacteroides
vulgatus) 		PF12985
(DUF3869) 		3 HIS A 204
HIS A 256
HIS A 258
 None
 0.65A 1rkyA-3kogA:
undetectable		 1rkyA-3kogA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A 155 ( 3.1A)
CU  A 156 (-3.2A)
CU  A 156 (-3.2A)
 0.54A 1rkyA-3l9yA:
undetectable		 1rkyA-3l9yA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 HIS A 436
HIS A 438
HIS A 597
 CU  A 635 (-3.2A)
CU  A 635 (-3.2A)
CU  A 635 (-3.0A)
 0.14A 1rkyA-3loyA:
37.8		 1rkyA-3loyA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]

(Taenia solium) 		PF00080
(Sod_Cu) 		3 HIS A  60
HIS A  45
HIS A  43
 ZN  A 153 ( 3.1A)
CU  A 155 (-3.5A)
CU  A 155 (-3.1A)
 0.54A 1rkyA-3mndA:
undetectable		 1rkyA-3mndA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.67A 1rkyA-3omnA:
undetectable		 1rkyA-3omnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 HIS A 238
HIS A 202
HIS A 200
 None
 0.68A 1rkyA-3p77A:
undetectable		 1rkyA-3p77A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe7 OLIGOGALACTURONATE
LYASE

(Yersinia
enterocolitica) 		PF14583
(Pectate_lyase22) 		3 HIS A 287
HIS A 355
HIS A 353
 MN  A 389 ( 3.3A)
MN  A 389 ( 3.3A)
MN  A 389 ( 3.2A)
 0.67A 1rkyA-3pe7A:
undetectable		 1rkyA-3pe7A:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		3 HIS A 552
HIS A 554
HIS A 718
 CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
CU  A 901 (-3.1A)
 0.12A 1rkyA-3pgbA:
50.3		 1rkyA-3pgbA:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.64A 1rkyA-3ramA:
undetectable		 1rkyA-3ramA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 HIS A 366
HIS A 361
HIS A 541
 FE2  A   1 ( 3.4A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
 0.69A 1rkyA-3rdeA:
undetectable		 1rkyA-3rdeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 HIS A 541
HIS A 361
HIS A 545
 FE2  A   1 (-3.3A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
 0.56A 1rkyA-3rdeA:
undetectable		 1rkyA-3rdeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 HIS A 541
HIS A 366
HIS A 545
 FE2  A   1 (-3.3A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
 0.69A 1rkyA-3rdeA:
undetectable		 1rkyA-3rdeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF11838
(ERAP1_C) 		3 HIS A 943
HIS A 944
HIS A 945
 None
 0.64A 1rkyA-3rjoA:
undetectable		 1rkyA-3rjoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 372
HIS A 367
HIS A 550
 FE2  A 701 (-3.3A)
FE2  A 701 (-3.4A)
FE2  A 701 (-3.3A)
 0.69A 1rkyA-3v98A:
undetectable		 1rkyA-3v98A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 378
HIS A 373
HIS A 556
 FE2  A 701 (-3.3A)
FE2  A 701 (-3.4A)
FE2  A 701 (-3.3A)
 0.66A 1rkyA-3vf1A:
undetectable		 1rkyA-3vf1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 431
HIS A 433
HIS A 592
 CU  A 701 (-3.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.0A)
 0.12A 1rkyA-3x3yA:
36.5		 1rkyA-3x3yA:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfj PNEUMOCOCCAL
HISTIDINE TRIAD
PROTEIN D

(Streptococcus
pneumoniae) 		no annotation 3 HIS A  83
HIS A  86
HIS A  88
 ZN  A1159 (-3.2A)
ZN  A1159 (-3.2A)
ZN  A1159 (-3.1A)
 0.41A 1rkyA-3zfjA:
undetectable		 1rkyA-3zfjA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B1878
HIS B1847
HIS B1734
 CUO  B9005 (-3.3A)
CUO  B9005 (-3.2A)
CUO  B9005 (-3.4A)
 0.68A 1rkyA-4bedB:
undetectable		 1rkyA-4bedB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		3 HIS A 120
HIS A  48
HIS A 234
 None
 0.61A 1rkyA-4jqsA:
undetectable		 1rkyA-4jqsA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.50A 1rkyA-4l05A:
undetectable		 1rkyA-4l05A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4low ACRAF

(Thiomonas
intermedia) 		PF01329
(Pterin_4a) 		3 HIS A   7
HIS A   8
HIS A   5
 NI  A 107 (-4.1A)
NI  A 107 ( 4.2A)
NI  A 106 (-3.3A)
 0.60A 1rkyA-4lowA:
undetectable		 1rkyA-4lowA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn7 PUTATIVE
UNCHARACTERIZED
PROTEIN TA0848

(Thermoplasma
acidophilum) 		PF13185
(GAF_2) 		3 HIS A 146
HIS A 147
HIS A 144
 None
 0.58A 1rkyA-4mn7A:
undetectable		 1rkyA-4mn7A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.68A 1rkyA-4nreA:
undetectable		 1rkyA-4nreA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A 202 ( 3.2A)
CU  A 201 (-3.3A)
CU  A 201 (-3.4A)
 0.63A 1rkyA-4ojaA:
undetectable		 1rkyA-4ojaA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.65A 1rkyA-4ouaB:
undetectable		 1rkyA-4ouaB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		3 HIS A  75
HIS A  60
HIS A  58
 ZN  A 201 (-3.2A)
None
None
 0.65A 1rkyA-4rvpA:
undetectable		 1rkyA-4rvpA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1

(Homo sapiens) 		PF00569
(ZZ)
PF06701
(MIB_HERC2) 		3 HIS A 122
HIS A 118
HIS A 119
 ZN  A 402 (-3.1A)
ZN  A 402 (-3.2A)
None
 0.66A 1rkyA-4xibA:
undetectable		 1rkyA-4xibA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkz VALINE-TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF08264
(Anticodon_1) 		3 HIS A 636
HIS A 637
HIS A 634
 None
 0.67A 1rkyA-4xkzA:
undetectable		 1rkyA-4xkzA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		3 HIS B 145
HIS B 146
HIS B 143
 None
 0.65A 1rkyA-4ydoB:
undetectable		 1rkyA-4ydoB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 268
HIS A 249
HIS A 244
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.7A)
 0.67A 1rkyA-4zr0A:
undetectable		 1rkyA-4zr0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
 0.66A 1rkyA-4zr0A:
undetectable		 1rkyA-4zr0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.65A 1rkyA-4zr1A:
undetectable		 1rkyA-4zr1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.69A 1rkyA-5ek8A:
undetectable		 1rkyA-5ek8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		3 HIS A 289
HIS A 284
HIS A 469
 MN  A 606 (-3.4A)
MN  A 606 (-3.7A)
MN  A 606 (-3.3A)
 0.64A 1rkyA-5fnoA:
undetectable		 1rkyA-5fnoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		3 HIS A 294
HIS A 290
HIS A 478
 MN  A1000 (-3.3A)
MN  A1000 (-3.5A)
MN  A1000 (-3.4A)
 0.67A 1rkyA-5fx8A:
undetectable		 1rkyA-5fx8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]

(Onchocerca
volvulus) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 202 (-3.1A)
CU  A 203 ( 3.2A)
CU  A 203 ( 3.1A)
 0.53A 1rkyA-5in2A:
undetectable		 1rkyA-5in2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5

(Candida
albicans) 		PF00080
(Sod_Cu) 		3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.52A 1rkyA-5kbmA:
undetectable		 1rkyA-5kbmA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		3 HIS A 183
HIS A 304
HIS A 238
 FE2  A 502 (-4.0A)
FE2  A 502 (-3.8A)
FE2  A 502 (-4.5A)
 0.59A 1rkyA-5kjaA:
undetectable		 1rkyA-5kjaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		3 HIS A 382
HIS A 377
HIS A 555
 FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
 0.66A 1rkyA-5lc8A:
undetectable		 1rkyA-5lc8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.64A 1rkyA-5medA:
undetectable		 1rkyA-5medA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 HIS A1014
HIS A1016
HIS A 972
 CU  A1101 (-3.2A)
CU  A1104 (-3.1A)
CU  A1105 (-3.3A)
 0.67A 1rkyA-5n4lA:
undetectable		 1rkyA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 HIS A 204
HIS A 201
HIS A 227
 None
 0.68A 1rkyA-5olpA:
undetectable		 1rkyA-5olpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 3 HIS A 628
HIS A 630
HIS A 626
 ZN  A 803 (-3.2A)
ZN  A 803 (-3.1A)
ZN  A 803 (-3.1A)
 0.68A 1rkyA-5ze3A:
undetectable		 1rkyA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6csl HISTIDINE TRIAD
PROTEIN D

(Streptococcus
pneumoniae) 		no annotation 3 HIS A 317
HIS A 319
HIS A 314
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.0A)
 0.29A 1rkyA-6cslA:
undetectable		 1rkyA-6cslA:
undetectable