SIMILAR PATTERNS OF AMINO ACIDS FOR 1RK3_A_VDXA500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 321
ILE A 240
ARG A 405
TYR A 416
 None
 1.42A 1rk3A-1hg4A:
19.2		 1rk3A-1hg4A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 LEU A 134
ILE A 177
ARG A 182
TYR A 141
 None
 1.47A 1rk3A-1k1xA:
0.0		 1rk3A-1k1xA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycd HYPOTHETICAL 27.3
KDA PROTEIN IN
AAP1-SMF2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF03959
(FSH1) 		4 LEU A 115
ILE A 157
ARG A 162
TYR A 142
 None
 1.49A 1rk3A-1ycdA:
0.0		 1rk3A-1ycdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 LEU A 277
ILE A 125
ARG A 111
TYR A 122
 None
 1.43A 1rk3A-1z26A:
0.0		 1rk3A-1z26A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 LEU A 704
ILE A 929
ARG A 851
TYR A 921
 None
 1.25A 1rk3A-2aqxA:
undetectable		 1rk3A-2aqxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 475
ILE A 402
ARG A 324
TYR A  37
 None
 1.49A 1rk3A-2ct8A:
0.0		 1rk3A-2ct8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1n PEX

(Synechococcus
elongatus) 		PF03551
(PadR) 		4 LEU A  81
ILE A  93
ARG A 120
TYR A 111
 None
 1.25A 1rk3A-2e1nA:
0.0		 1rk3A-2e1nA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 LEU A 108
ILE A  88
ARG A  89
TYR A 127
 None
 1.24A 1rk3A-2iu4A:
0.0		 1rk3A-2iu4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llz UNCHARACTERIZED
PROTEIN YJDK

(Escherichia
coli) 		PF11080
(GhoS) 		4 LEU A  52
ILE A  72
ARG A  73
TYR A  34
 None
 1.26A 1rk3A-2llzA:
undetectable		 1rk3A-2llzA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		4 LEU A 223
ILE A 267
ARG A 270
TYR A 397
 None
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
None
 0.18A 1rk3A-2o4jA:
41.9		 1rk3A-2o4jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C

(Listeria
monocytogenes) 		PF00388
(PI-PLC-X) 		4 LEU A 102
ILE A 121
ARG A  79
TYR A 146
 None
 1.41A 1rk3A-2plcA:
undetectable		 1rk3A-2plcA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnd V-SET AND
IMMUNOGLOBULIN
DOMAIN CONTAINING 4

(Mus musculus) 		PF07686
(V-set) 		4 LEU A  84
ILE A  58
ARG A  64
TYR A  92
 None
 1.29A 1rk3A-2pndA:
undetectable		 1rk3A-2pndA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		4 LEU A 116
ILE A  98
ARG A 102
TYR A  92
 None
 1.43A 1rk3A-2py6A:
undetectable		 1rk3A-2py6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 101
ILE A 232
ARG A 231
TYR A 212
 None
 1.03A 1rk3A-3iplA:
undetectable		 1rk3A-3iplA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtz INTEGRASE

(Yersinia pestis) 		PF13356
(Arm-DNA-bind_3) 		4 LEU A  53
ILE A   8
ARG A   9
TYR A  27
 None
 1.42A 1rk3A-3jtzA:
undetectable		 1rk3A-3jtzA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 LEU A  47
ILE A  33
ARG A  38
TYR A  65
 None
 1.42A 1rk3A-3ll7A:
undetectable		 1rk3A-3ll7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nad FERULATE
DECARBOXYLASE

(Bacillus
pumilus) 		PF05870
(PA_decarbox) 		4 LEU A  72
ILE A 144
ARG A  44
TYR A  19
 None
 1.29A 1rk3A-3nadA:
undetectable		 1rk3A-3nadA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no6 TRANSCRIPTIONAL
ACTIVATOR TENA

(Staphylococcus
epidermidis) 		PF03070
(TENA_THI-4) 		4 LEU A  89
ILE A  18
ARG A 209
TYR A 167
 None
 1.49A 1rk3A-3no6A:
2.7		 1rk3A-3no6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 316
ILE A 202
ARG A 204
TYR A 333
 None
None
SEP  A 241 ( 3.4A)
None
 1.48A 1rk3A-3nuuA:
undetectable		 1rk3A-3nuuA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 227
ILE A 271
ARG A 274
TYR A 401
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
None
 0.37A 1rk3A-3wgpA:
38.8		 1rk3A-3wgpA:
89.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		4 LEU A 205
ILE A 216
ARG A 220
TYR A 154
 None
None
PGE  A 401 (-3.7A)
None
 1.48A 1rk3A-3wjsA:
undetectable		 1rk3A-3wjsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		4 LEU A 155
ILE A  23
ARG A  63
TYR A 148
 None
 1.35A 1rk3A-4aoeA:
undetectable		 1rk3A-4aoeA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		4 LEU A  94
ILE A  43
ARG A  45
TYR A  62
 None
 1.40A 1rk3A-4g1gA:
undetectable		 1rk3A-4g1gA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 524
ILE A 632
ARG A 635
TYR A 610
 None
 1.44A 1rk3A-4iigA:
undetectable		 1rk3A-4iigA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 LEU A  26
ILE A  89
ARG A   5
TYR A  39
 None
 1.32A 1rk3A-4isaA:
undetectable		 1rk3A-4isaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE

(Streptococcus
sanguinis) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 LEU A 221
ILE A 244
ARG A 247
TYR A 213
 None
 1.36A 1rk3A-4mzwA:
undetectable		 1rk3A-4mzwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 LEU A 222
ILE A 245
ARG A 248
TYR A 214
 None
 1.37A 1rk3A-4puaA:
undetectable		 1rk3A-4puaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 4 LEU A 320
ILE A 196
ARG A 215
TYR A 327
 None
 1.38A 1rk3A-4rh0A:
undetectable		 1rk3A-4rh0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 LEU A 323
ILE A 318
ARG A 402
TYR A 283
 None
None
SO4  A 501 (-2.9A)
None
 1.47A 1rk3A-4s3kA:
undetectable		 1rk3A-4s3kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 LEU A  85
ILE A 121
ARG A 125
TYR A  57
 None
 1.20A 1rk3A-4tmuA:
undetectable		 1rk3A-4tmuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 LEU A 193
ILE A 313
ARG A 346
TYR A 210
 None
 1.44A 1rk3A-4upkA:
undetectable		 1rk3A-4upkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y05 KINESIN-LIKE PROTEIN
KIF2C

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 493
ILE A 259
ARG A 258
TYR A 581
 None
 1.24A 1rk3A-4y05A:
undetectable		 1rk3A-4y05A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6h ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
pseudotuberculosis) 		PF00156
(Pribosyltran) 		4 LEU A  52
ILE A  19
ARG A  33
TYR A  45
 None
 1.47A 1rk3A-5b6hA:
undetectable		 1rk3A-5b6hA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		4 LEU A  82
ILE A 277
ARG A 270
TYR A 219
 None
 1.44A 1rk3A-5fprA:
undetectable		 1rk3A-5fprA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6

(Arabidopsis
thaliana) 		PF00808
(CBFD_NFYB_HMF) 		4 LEU A 138
ILE A  71
ARG A  70
TYR A  97
 None
 1.48A 1rk3A-5g49A:
undetectable		 1rk3A-5g49A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 4 LEU Y 145
ILE Y 181
ARG Y 266
TYR Y 151
 None
 1.33A 1rk3A-5gaiY:
undetectable		 1rk3A-5gaiY:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 4 LEU B 537
ILE B 264
ARG B 262
TYR B 184
 None
 1.39A 1rk3A-5oarB:
undetectable		 1rk3A-5oarB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 LEU B 684
ILE B 320
ARG B 248
TYR B 625
 None
 1.35A 1rk3A-5swiB:
undetectable		 1rk3A-5swiB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ueb NEGOA.19184.A

(Neisseria
gonorrhoeae) 		PF14085
(DUF4265) 		4 LEU A  84
ILE A  36
ARG A  96
TYR A 112
 None
 1.14A 1rk3A-5uebA:
undetectable		 1rk3A-5uebA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 4 LEU A 816
ILE A 968
ARG A 971
TYR A 957
 None
 1.40A 1rk3A-6dbrA:
undetectable		 1rk3A-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 896
ILE A1371
ARG A 888
TYR A1364
 None
 1.23A 1rk3A-6f42A:
undetectable		 1rk3A-6f42A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 4 LEU A 255
ILE A 299
ARG A 302
TYR A 427
 None
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 (-4.9A)
 0.12A 1rk3A-6fobA:
38.9		 1rk3A-6fobA:
21.66