SIMILAR PATTERNS OF AMINO ACIDS FOR 1RJD_B_SAMB802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLN A 369
GLY A 362
SER A 368
LEU A 313
LEU A 351
 None
 1.03A 1rjdB-1dnpA:
undetectable		 1rjdB-1dnpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 218
ALA A 181
GLY A 203
LEU A 234
LEU A 208
 None
 0.99A 1rjdB-1f8fA:
3.6		 1rjdB-1f8fA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ILE A 187
ALA A 156
GLY A 222
SER A 225
TYR A 166
 None
 1.05A 1rjdB-1fcdA:
undetectable		 1rjdB-1fcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 ILE A 341
THR A  86
ALA A 263
GLY A 360
LEU A 447
 None
 1.09A 1rjdB-1nbwA:
undetectable		 1rjdB-1nbwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3t CATABOLITE GENE
ACTIVATOR PROTEIN

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.02A 1rjdB-1o3tA:
undetectable		 1rjdB-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A1153
GLY A1121
GLY A1142
SER A1144
LEU A1122
 None
 1.06A 1rjdB-1p0cA:
3.8		 1rjdB-1p0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 101
ALA A 119
GLY A  62
SER A  96
LEU A  92
 None
 1.07A 1rjdB-1qorA:
4.9		 1rjdB-1qorA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrz PLASMINOGEN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A 682
THR A 759
ALA A 601
GLY A 590
LEU A 697
 None
 1.08A 1rjdB-1qrzA:
undetectable		 1rjdB-1qrzA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ILE A  48
GLY A 533
GLY A 540
SER A 523
LEU A 205
 None
 0.96A 1rjdB-1r8wA:
undetectable		 1rjdB-1r8wA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 THR A 103
ASP A 102
GLY A  96
GLY A  98
LEU A  42
 None
APR  A 389 ( 4.5A)
None
APR  A 389 (-3.2A)
APR  A 389 (-4.9A)
 1.05A 1rjdB-1rrmA:
2.1		 1rjdB-1rrmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		6 ASP A  13
ALA A 249
GLY A 378
LEU A 379
CYH A  49
TYR A 375
 None
 1.46A 1rjdB-1vftA:
undetectable		 1rjdB-1vftA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		5 ASP A 110
ALA A 109
GLY A 235
GLY A 121
LEU A 236
 None
 1.07A 1rjdB-1xtzA:
undetectable		 1rjdB-1xtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		5 GLN A 244
THR A 265
GLY A 309
SER A 235
LEU A 311
 None
 1.10A 1rjdB-1yifA:
undetectable		 1rjdB-1yifA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		6 ILE A1284
GLN A1285
THR A1282
GLY A1251
GLY A1249
LEU A1253
 None
 1.17A 1rjdB-1yrzA:
undetectable		 1rjdB-1yrzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 325
GLY A 332
GLY A 411
LEU A 405
LEU A 322
 None
None
SO4  A 501 (-4.2A)
None
None
 1.04A 1rjdB-1zzwA:
undetectable		 1rjdB-1zzwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 GLN A 590
THR A 706
ASP A 707
LEU A  14
LEU A 719
 None
 1.08A 1rjdB-2b0tA:
undetectable		 1rjdB-2b0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		5 ILE X  25
GLN X  27
GLY X 101
LEU X  39
LEU X   7
 None
 1.10A 1rjdB-2dchX:
undetectable		 1rjdB-2dchX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		5 ASP A 212
ALA A 238
GLY A 129
SER A 126
LEU A 135
 PLP  A1001 (-2.9A)
None
PLP  A1001 ( 4.2A)
None
None
 1.07A 1rjdB-2eh6A:
2.6		 1rjdB-2eh6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 152
GLY A 120
GLY A 141
SER A 143
LEU A 121
 None
 0.99A 1rjdB-2fzwA:
2.9		 1rjdB-2fzwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr8 ADHESIN

(Haemophilus
influenzae) 		PF03895
(YadA_anchor) 		5 GLN A1058
THR A1028
ALA A1031
GLY A1060
SER A1084
 None
 1.06A 1rjdB-2gr8A:
undetectable		 1rjdB-2gr8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4

(Mus musculus) 		no annotation 5 ILE F 168
GLY F  65
SER F  78
LEU F 154
LEU F 106
 None
 1.09A 1rjdB-2heyF:
undetectable		 1rjdB-2heyF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 ILE A 347
GLN A 348
GLY A  77
GLY A 111
LEU A  75
 None
 1.09A 1rjdB-2i3oA:
undetectable		 1rjdB-2i3oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzt PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF02847
(MA3) 		5 ILE A 273
THR A 233
ASP A 235
SER A 239
LEU A 222
 None
 0.99A 1rjdB-2kztA:
undetectable		 1rjdB-2kztA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 ILE A 483
GLN A 482
THR A 487
LEU A 477
LEU A 454
 None
 0.97A 1rjdB-2nrrA:
undetectable		 1rjdB-2nrrA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		7 ALA A  12
GLY A 105
GLY A 107
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.26A 1rjdB-2ob1A:
53.0		 1rjdB-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		7 ALA A  12
GLY A 105
SER A 132
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.66A 1rjdB-2ob1A:
53.0		 1rjdB-2ob1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 325
GLY A 332
GLY A 411
LEU A 405
LEU A 322
 None
 1.01A 1rjdB-2oudA:
undetectable		 1rjdB-2oudA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 173
ALA A 395
GLY A 215
LEU A 229
LEU A 195
 None
 1.00A 1rjdB-2pa6A:
undetectable		 1rjdB-2pa6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		5 ILE A 184
THR A 205
GLY A  19
LEU A 131
LEU A  23
 None
 0.89A 1rjdB-2pkeA:
2.7		 1rjdB-2pkeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		5 THR A  17
GLY A 112
LEU A 162
LEU A 188
TYR A 191
 None
 0.78A 1rjdB-2uyoA:
23.3		 1rjdB-2uyoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
 None
None
None
None
OMT  A2473 (-3.8A)
 1.07A 1rjdB-2vdcA:
undetectable		 1rjdB-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 ALA A 153
GLY A 123
GLY A 120
LEU A 284
LEU A 127
 NAP  A 701 (-3.3A)
None
None
None
EDO  A1332 (-3.9A)
 1.07A 1rjdB-2y05A:
5.8		 1rjdB-2y05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		7 ILE A  27
GLN A  28
THR A  30
GLY A 115
GLY A 117
LEU A 197
TYR A 229
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-4.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.7A)
None
 0.42A 1rjdB-2zwaA:
31.4		 1rjdB-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 THR A 146
ALA A 144
GLY A 125
SER A 116
LEU A 229
 None
 1.05A 1rjdB-3ce9A:
undetectable		 1rjdB-3ce9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 THR A 487
ASP A 423
ALA A 424
GLY A 310
GLY A 364
 None
 1.09A 1rjdB-3eh2A:
undetectable		 1rjdB-3eh2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guw UNCHARACTERIZED
PROTEIN AF_1765

(Archaeoglobus
fulgidus) 		PF01026
(TatD_DNase) 		5 THR A 130
ASP A 159
GLY A 177
LEU A 170
LEU A 166
 None
 1.10A 1rjdB-3guwA:
undetectable		 1rjdB-3guwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLN A 388
ALA A 422
GLY A 399
SER A 391
LEU A 400
 None
 1.01A 1rjdB-3ic9A:
undetectable		 1rjdB-3ic9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 419
ALA A 406
GLY A 410
SER A 413
LEU A 379
 None
 1.07A 1rjdB-3ifrA:
undetectable		 1rjdB-3ifrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 ILE A 383
THR A 220
ASP A 219
GLY A 386
GLY A 215
 None
 1.04A 1rjdB-3j1eA:
undetectable		 1rjdB-3j1eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kif 5-BLADED
BETA-PROPELLER
LECTIN

(synthetic
construct) 		PF14517
(Tachylectin) 		5 GLN A  30
ASP A  46
GLY A  72
LEU A  48
TYR A  49
 None
 1.02A 1rjdB-3kifA:
undetectable		 1rjdB-3kifA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		5 ILE A  33
THR A 147
ASP A 148
ALA A 149
SER A  20
 None
 1.11A 1rjdB-3ky7A:
undetectable		 1rjdB-3ky7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 ILE A  57
THR A  52
ALA A 117
GLY A  85
LEU A  91
 None
None
None
MLI  A 341 ( 4.9A)
None
 1.07A 1rjdB-3l6cA:
undetectable		 1rjdB-3l6cA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ILE A 371
GLY A 254
GLY A 227
LEU A 334
LEU A 253
 None
None
ANP  A 408 (-3.4A)
None
None
 1.10A 1rjdB-3ldoA:
undetectable		 1rjdB-3ldoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 ALA A  33
GLY A  98
GLY A 100
CYH A 199
TYR A 203
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.6A)
 0.54A 1rjdB-3o7wA:
30.3		 1rjdB-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 ALA A  33
GLY A  98
GLY A 100
LEU A 172
CYH A 199
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.7A)
SAM  A 801 (-4.9A)
 0.51A 1rjdB-3o7wA:
30.3		 1rjdB-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxn PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		5 ILE A 170
THR A 123
ALA A 219
LEU A 319
TYR A 291
 None
 0.99A 1rjdB-3oxnA:
undetectable		 1rjdB-3oxnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A  29
ASP A  98
ALA A 160
GLY A 131
LEU A  23
 None
 1.07A 1rjdB-3pfeA:
undetectable		 1rjdB-3pfeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 166
ALA A 388
GLY A 206
LEU A 220
LEU A 188
 None
 1.01A 1rjdB-3qn3A:
undetectable		 1rjdB-3qn3A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		5 ILE A 143
ALA A 195
GLY A 296
GLY A 245
LEU A 100
 None
None
None
CA  A 327 ( 4.9A)
None
 0.99A 1rjdB-3qqzA:
undetectable		 1rjdB-3qqzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 188
ASP A 185
GLY A 213
GLY A 215
LEU A 251
 None
 0.87A 1rjdB-3t9wA:
undetectable		 1rjdB-3t9wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44

(Escherichia
virus T4) 		PF00004
(AAA) 		5 THR B 207
ASP B 203
GLY B  55
GLY B  53
LEU B  25
 None
None
08T  B 700 (-3.1A)
08T  B 700 (-3.0A)
None
 1.09A 1rjdB-3u5zB:
2.9		 1rjdB-3u5zB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		5 ILE A  54
ALA A 194
GLY A 221
GLY A 189
LEU A 220
 None
 0.98A 1rjdB-3ucaA:
undetectable		 1rjdB-3ucaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va1 MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Mus musculus) 		PF00498
(FHA) 		5 ILE A 100
ASP A  91
ALA A  76
GLY A  97
LEU A 122
 None
 0.98A 1rjdB-3va1A:
undetectable		 1rjdB-3va1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		5 ILE A 159
ALA A 146
GLY A 162
GLY A 135
LEU A 167
 None
 1.07A 1rjdB-4c1nA:
undetectable		 1rjdB-4c1nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 ILE A 265
THR A 403
GLY A 374
LEU A 322
LEU A 324
 None
None
None
1PE  A 501 (-4.7A)
None
 0.99A 1rjdB-4dn7A:
undetectable		 1rjdB-4dn7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		5 ASP A  87
ALA A  86
GLY A 204
GLY A  98
LEU A 205
 PO4  A 301 (-2.6A)
None
None
PO4  A 301 (-4.0A)
None
 1.04A 1rjdB-4gmkA:
2.7		 1rjdB-4gmkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  10
THR A 257
ALA A 259
GLY A  93
GLY A  89
 None
 1.07A 1rjdB-4hacA:
undetectable		 1rjdB-4hacA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 ILE B 167
ALA B  98
GLY B 170
GLY B 304
LEU B 232
 None
 1.01A 1rjdB-4hdsB:
undetectable		 1rjdB-4hdsB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 ILE M 360
ALA M 317
GLY M 370
GLY M 444
LEU M 368
 None
 1.06A 1rjdB-4heaM:
undetectable		 1rjdB-4heaM:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		5 ILE A 271
ASP A 265
GLY A 111
GLY A 114
LEU A  82
 None
MG  A 403 (-2.7A)
None
None
None
 1.10A 1rjdB-4j72A:
undetectable		 1rjdB-4j72A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgb PUTATIVE EXPORTED
PROTEIN

(Burkholderia
pseudomallei) 		PF13460
(NAD_binding_10) 		5 THR A 206
ALA A 204
GLY A 105
GLY A 103
LEU A 115
 None
 1.01A 1rjdB-4jgbA:
3.7		 1rjdB-4jgbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 125
ALA A 152
GLY A  37
GLY A 118
LEU A 112
 None
None
None
PO4  A 201 (-3.8A)
None
 1.09A 1rjdB-4ki9A:
undetectable		 1rjdB-4ki9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ILE A 363
THR A 366
ASP A 384
LEU A 346
LEU A 389
 None
 1.08A 1rjdB-4kpgA:
2.2		 1rjdB-4kpgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		5 THR X 143
GLY X  74
GLY X 148
LEU X  84
TYR X  88
 None
2HD  X 401 (-3.9A)
None
None
None
 1.11A 1rjdB-4n5iX:
2.6		 1rjdB-4n5iX:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nml RIBULOSE 5-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 135
ASP A  91
ALA A  90
GLY A 233
GLY A 103
 None
MLT  A 303 (-4.5A)
None
None
CL  A 301 (-3.5A)
 1.02A 1rjdB-4nmlA:
undetectable		 1rjdB-4nmlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 ILE A  95
ASP A 130
GLY A 106
LEU A  91
LEU A 127
 None
 1.06A 1rjdB-4p6yA:
undetectable		 1rjdB-4p6yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ILE A 219
GLY A 242
SER A 309
LEU A 275
LEU A 245
 None
 1.01A 1rjdB-4re2A:
2.1		 1rjdB-4re2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 270
GLN A 269
GLY A 226
GLY A 224
LEU A 229
 None
 1.11A 1rjdB-4w7sA:
5.0		 1rjdB-4w7sA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 ILE A 218
ALA A 279
GLY A 225
GLY A 239
LEU A 221
 None
 1.06A 1rjdB-4x8fA:
2.7		 1rjdB-4x8fA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		5 ILE B 385
THR B 222
ASP B 221
GLY B 388
GLY B 217
 None
 0.94A 1rjdB-4xcgB:
undetectable		 1rjdB-4xcgB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 ILE A 178
ASP A  93
GLY A 160
GLY A  94
LEU A 145
 None
MN  A 402 ( 2.6A)
None
MN  A 401 (-4.2A)
None
 1.08A 1rjdB-4yzgA:
undetectable		 1rjdB-4yzgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ASP A 772
ALA A 301
GLY A 784
GLY A 589
LEU A 584
 None
 1.06A 1rjdB-5a22A:
8.4		 1rjdB-5a22A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ILE A 371
GLY A 254
GLY A 227
LEU A 334
LEU A 253
 None
None
ATP  A 801 (-3.8A)
None
None
 1.07A 1rjdB-5e84A:
undetectable		 1rjdB-5e84A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es2 UNCHARACTERIZED
PROTEIN LPG0634

(Legionella
pneumophila) 		PF16848
(SoDot-IcmSS) 		5 ILE A 298
THR A 301
GLY A 282
SER A 308
TYR A 288
 None
SO4  A 507 (-3.3A)
None
None
None
 1.07A 1rjdB-5es2A:
undetectable		 1rjdB-5es2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A  86
GLY A  78
SER A 228
LEU A  33
LEU A  91
 None
None
5VV  A   1 ( 3.0A)
None
None
 1.10A 1rjdB-5fbzA:
2.2		 1rjdB-5fbzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 ILE E  16
GLY E  21
GLY E  39
LEU E  92
LEU E  23
 None
 1.06A 1rjdB-5h36E:
undetectable		 1rjdB-5h36E:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 ILE A  82
ALA A 267
GLY A   9
GLY A  13
SER A 252
 None
 1.05A 1rjdB-5hn4A:
undetectable		 1rjdB-5hn4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 ILE B 172
GLN B 169
LEU B 130
CYH B 105
LEU B 106
 None
 1.06A 1rjdB-5iklB:
undetectable		 1rjdB-5iklB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		5 ILE A 340
THR A 343
ALA A 347
LEU A 312
LEU A 386
 None
 1.10A 1rjdB-5jayA:
undetectable		 1rjdB-5jayA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		5 GLN A 157
THR A 162
ALA A 164
GLY A 186
GLY A 190
 None
None
None
LLP  A  42 ( 3.7A)
None
 1.10A 1rjdB-5jjcA:
undetectable		 1rjdB-5jjcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		5 ILE A 167
THR A 182
ALA A 186
GLY A  72
LEU A 164
 None
 1.02A 1rjdB-5jxuA:
undetectable		 1rjdB-5jxuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		5 ILE A 261
THR A 167
ASP A 161
GLY A 290
GLY A 288
 None
None
MG  A 401 (-3.8A)
None
ADP  A 402 ( 4.2A)
 0.99A 1rjdB-5jygA:
undetectable		 1rjdB-5jygA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Trichormus
variabilis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 GLN A  61
GLY A  83
GLY A  87
LEU A  67
LEU A  92
 None
 1.10A 1rjdB-5kt0A:
3.9		 1rjdB-5kt0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 ILE J 183
ALA J 156
GLY J   6
LEU J 103
LEU J 115
 None
 1.10A 1rjdB-5m32J:
undetectable		 1rjdB-5m32J:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A  33
GLY A  24
GLY A  26
LEU A  37
LEU A  64
 None
 0.96A 1rjdB-5mdhA:
4.4		 1rjdB-5mdhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 5 ILE K 234
THR K 232
ALA K 290
GLY K 304
LEU K 244
 None
 0.98A 1rjdB-5mm7K:
undetectable		 1rjdB-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 ALA B  99
GLY B 150
GLY B 148
SER B 190
LEU B 137
 G2P  B 501 ( 4.6A)
None
None
None
None
 1.02A 1rjdB-5n5nB:
undetectable		 1rjdB-5n5nB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9y ZINC TRANSPORT
PROTEIN ZNTB

(Escherichia
coli) 		no annotation 5 ILE A 230
THR A 155
GLY A 235
GLY A 237
TYR A 208
 None
 0.98A 1rjdB-5n9yA:
undetectable		 1rjdB-5n9yA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na2 CAPSID PROTEIN (P24)

(Feline
immunodeficiency
virus) 		no annotation 5 ILE A 135
ASP A  64
GLY A  32
GLY A  29
SER A 180
 None
 1.08A 1rjdB-5na2A:
undetectable		 1rjdB-5na2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE

(Bacillus
subtilis) 		no annotation 5 ILE A  17
THR A  21
ALA A  25
GLY A  47
GLY A  51
 None
 1.07A 1rjdB-5np9A:
undetectable		 1rjdB-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 5 GLN B 379
ALA B 385
GLY B 307
SER B 429
LEU B 311
 None
None
Y01  B1003 ( 4.3A)
Y01  B1003 ( 3.8A)
None
 1.05A 1rjdB-5ochB:
2.4		 1rjdB-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 GLN A 489
ASP A 496
GLY A 493
LEU A 557
LEU A 570
 None
 1.08A 1rjdB-5t8vA:
undetectable		 1rjdB-5t8vA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ILE A 202
GLN A 201
THR A 206
LEU A 196
LEU A 224
 None
None
None
GDP  A 603 ( 4.6A)
GDP  A 603 ( 4.3A)
 1.04A 1rjdB-5tc3A:
undetectable		 1rjdB-5tc3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		6 ILE B 116
THR B 120
ALA B 316
GLY B  97
LEU B  39
LEU B  89
 None
 1.33A 1rjdB-5tpwB:
undetectable		 1rjdB-5tpwB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ILE A  39
GLY A  21
GLY A  19
LEU A  52
LEU A  26
 None
NAP  A 301 ( 4.2A)
NAP  A 301 (-3.7A)
None
None
 1.06A 1rjdB-5u9pA:
5.8		 1rjdB-5u9pA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 ILE C 137
ASP C  87
GLY C 113
LEU C 144
LEU C  84
 None
 1.07A 1rjdB-5xxuC:
undetectable		 1rjdB-5xxuC:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 GLN A 565
THR A 155
ALA A 152
SER A 561
LEU A 389
 None
 1.10A 1rjdB-5z9sA:
undetectable		 1rjdB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus) 		no annotation 5 ILE F  27
GLN F  40
THR F  44
ALA F  46
GLY F 126
 None
 1.10A 1rjdB-6cfwF:
undetectable		 1rjdB-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e2q -

(-) 		no annotation 5 ILE A 289
THR A 267
GLY A 294
GLY A 292
LEU A 316
 None
 0.92A 1rjdB-6e2qA:
undetectable		 1rjdB-6e2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 5 ILE A 371
GLY A 254
GLY A 227
LEU A 334
LEU A 253
 None
None
ADP  A 603 ( 2.9A)
None
None
 1.10A 1rjdB-6eoeA:
undetectable		 1rjdB-6eoeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ARG A 295
TYR A 327
ASN A  52
GLU A  58
 None
 1.26A 1rjdB-1a2vA:
undetectable		 1rjdB-1a2vA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 TYR A 426
ASP A 488
ASN A 490
GLU A 450
 None
 1.22A 1rjdB-1b41A:
undetectable		 1rjdB-1b41A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 TYR A 426
ASP A 488
ASN A 490
GLU A 450
 None
 1.10A 1rjdB-1c2oA:
undetectable		 1rjdB-1c2oA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 ARG A  52
ASP A  40
ASP A 165
ASN A 170
 None
 1.04A 1rjdB-1crzA:
undetectable		 1rjdB-1crzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2o COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05738
(Cna_B) 		4 ASP A 608
TYR A 609
ASP A 547
ASN A 550
 None
 1.14A 1rjdB-1d2oA:
undetectable		 1rjdB-1d2oA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2p COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05738
(Cna_B) 		4 ASP A 608
TYR A 609
ASP A 547
ASN A 550
 None
 1.10A 1rjdB-1d2pA:
undetectable		 1rjdB-1d2pA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5m GAF

(Saccharomyces
cerevisiae) 		PF13185
(GAF_2) 		4 ASP A 154
TYR A 155
ASP A 115
ASN A 117
 None
 0.96A 1rjdB-1f5mA:
undetectable		 1rjdB-1f5mA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f99 R-PHYCOCYANIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		4 ARG A  33
ASP A 155
ASN A 138
GLU A 149
 None
 1.10A 1rjdB-1f99A:
undetectable		 1rjdB-1f99A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ARG A 815
ASP A 115
ASN A 716
GLU A 812
 None
 1.15A 1rjdB-1g8kA:
3.3		 1rjdB-1g8kA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ARG B 982
ASP B 558
TYR B 578
ASP B 642
 None
 1.28A 1rjdB-1gl9B:
3.0		 1rjdB-1gl9B:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 ASP A 456
TYR A 472
ASP A 474
ASN A 476
 None
 0.99A 1rjdB-1hxjA:
undetectable		 1rjdB-1hxjA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L15E

(Haloarcula
marismortui) 		PF00827
(Ribosomal_L15e) 		4 ARG N  64
ASP N 135
ASN N 111
GLU N 130
 None
G  A 135 ( 3.3A)
U  A 134 ( 3.0A)
None
 1.21A 1rjdB-1kc8N:
undetectable		 1rjdB-1kc8N:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kmq TRANSFORMING PROTEIN
RHOA

(Homo sapiens) 		PF00071
(Ras) 		4 ASP A  87
ASP A  13
ASN A  94
GLU A 137
 None
None
MG  A 402 (-2.7A)
None
 1.33A 1rjdB-1kmqA:
undetectable		 1rjdB-1kmqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of3 BETA-MANNOSIDASE

(Thermotoga
maritima) 		PF09212
(CBM27) 		4 TYR A  83
ASP A  81
ASN A 166
GLU A  38
 None
None
CA  A1174 ( 4.7A)
None
 0.91A 1rjdB-1of3A:
undetectable		 1rjdB-1of3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 4 ASP R  42
TYR R 117
ASP R 114
GLU R 131
 None
 1.28A 1rjdB-1pp2R:
undetectable		 1rjdB-1pp2R:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 TYR A 720
ASP A 668
ASN A 302
GLU A 723
 None
 0.87A 1rjdB-1uf2A:
undetectable		 1rjdB-1uf2A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ARG A 212
TYR A  70
ASP A  75
GLU A  39
 None
 1.31A 1rjdB-1v43A:
undetectable		 1rjdB-1v43A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986

(Pyrococcus
horikoshii) 		PF03746
(LamB_YcsF) 		4 ASP A  21
ASP A   8
ASN A  32
GLU A  54
 None
 1.33A 1rjdB-1v6tA:
undetectable		 1rjdB-1v6tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE

(Escherichia
coli) 		PF04962
(KduI) 		4 ARG A  21
TYR A 127
ASN A 129
GLU A  27
 None
 1.32A 1rjdB-1xruA:
undetectable		 1rjdB-1xruA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ARG A 283
ASP A 120
ASN A 116
GLU A 252
 None
 1.30A 1rjdB-1yx2A:
undetectable		 1rjdB-1yx2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2av4 THIOREDOXIN-LIKE
PROTEIN 4A (DIM1)

(Plasmodium
yoelii) 		PF02966
(DIM1) 		4 ASP A  53
ASP A  95
ASN A 121
GLU A  61
 None
 1.29A 1rjdB-2av4A:
undetectable		 1rjdB-2av4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 ARG A  91
TYR A 111
ASP A  27
ASN A  25
 None
 1.12A 1rjdB-2azkA:
undetectable		 1rjdB-2azkA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASP A 615
TYR A 614
ASN A 522
GLU A 154
 None
 1.16A 1rjdB-2gv9A:
undetectable		 1rjdB-2gv9A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 ARG A 380
TYR A 446
ASP A 448
ASN A 414
 None
GUN  A1647 (-4.0A)
None
None
 0.91A 1rjdB-2jh9A:
6.7		 1rjdB-2jh9A:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		5 ARG A  81
ASP A 128
ASP A 175
ASN A 177
GLU A 201
 None
 0.38A 1rjdB-2ob1A:
53.0		 1rjdB-2ob1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 TYR A 390
ASP A 454
ASN A 456
GLU A 412
 TYR  A 390 ( 1.3A)
ASP  A 454 ( 0.6A)
ASN  A 456 ( 0.6A)
GLU  A 412 ( 0.6A)
 1.02A 1rjdB-2ogsA:
2.4		 1rjdB-2ogsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE

(Anopheles
gambiae) 		PF01048
(PNP_UDP_1) 		4 ASP A 213
TYR A 209
ASP A 300
GLU A 269
 None
 1.19A 1rjdB-2p4sA:
undetectable		 1rjdB-2p4sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r79 PERIPLASMIC BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF01497
(Peripla_BP_2) 		4 ARG A 272
ASP A  54
TYR A  71
GLU A  39
 None
None
HEM  A 500 (-3.6A)
None
 1.28A 1rjdB-2r79A:
undetectable		 1rjdB-2r79A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 ARG A 120
ASP A  72
ASN A  75
GLU A 105
 None
 1.33A 1rjdB-2r7mA:
2.5		 1rjdB-2r7mA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 4 ARG B  14
ASP B 177
ASN B 179
GLU B 114
 None
 1.29A 1rjdB-2vduB:
undetectable		 1rjdB-2vduB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ARG A 451
TYR A 165
ASP A 221
ASN A 518
 None
FAD  A 601 (-3.5A)
FAD  A 601 (-3.5A)
None
 1.30A 1rjdB-2wu5A:
undetectable		 1rjdB-2wu5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		6 ARG A  88
ASP A 146
TYR A 147
ASP A 196
ASN A 198
GLU A 224
 SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-3.8A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.9A)
SAH  A 801 (-3.0A)
 0.24A 1rjdB-2zwaA:
31.4		 1rjdB-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ARG A 132
ASP A 579
TYR A 586
GLU A 556
 None
 0.92A 1rjdB-2zwsA:
undetectable		 1rjdB-2zwsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 275
TYR A 216
ASN A 223
GLU A 263
 None
 1.32A 1rjdB-3a62A:
undetectable		 1rjdB-3a62A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 ASP A 176
TYR A 175
ASP A 166
ASN A 169
 None
 1.30A 1rjdB-3afgA:
2.2		 1rjdB-3afgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 ASP A 350
ASP A 283
ASN A 285
GLU A 357
 None
None
None
ZN  A 565 ( 4.6A)
 1.11A 1rjdB-3ahmA:
undetectable		 1rjdB-3ahmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		4 TYR A 468
ASP A 535
ASN A 537
GLU A 492
 None
 1.08A 1rjdB-3be8A:
2.6		 1rjdB-3be8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 TYR A 504
ASP A 571
ASN A 573
GLU A 528
 None
 1.02A 1rjdB-3biwA:
undetectable		 1rjdB-3biwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 ASP A 179
TYR A 208
ASN A 186
GLU A 175
 None
 1.20A 1rjdB-3bjrA:
undetectable		 1rjdB-3bjrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ARG A 208
ASP A  54
ASN A 256
GLU A 449
 None
 1.26A 1rjdB-3ehmA:
undetectable		 1rjdB-3ehmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		4 ARG A 265
TYR A 309
ASN A 217
GLU A 202
 None
 1.10A 1rjdB-3epmA:
undetectable		 1rjdB-3epmA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 ARG A 138
TYR A 214
ASP A 221
GLU A 248
 PO4  A 401 (-3.0A)
None
None
None
 1.12A 1rjdB-3eufA:
undetectable		 1rjdB-3eufA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 272
TYR A 218
ASN A 147
GLU A 132
 None
 1.03A 1rjdB-3fbgA:
4.5		 1rjdB-3fbgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 TYR A 133
ASP A 112
ASN A 118
GLU A 127
 None
 1.31A 1rjdB-3fzgA:
8.7		 1rjdB-3fzgA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		4 ARG A 270
TYR A 340
ASP A  24
GLU A 329
 None
 1.24A 1rjdB-3gmiA:
undetectable		 1rjdB-3gmiA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B  86
ASP B  29
ASN B  32
GLU B 158
 None
 1.09A 1rjdB-3hkzB:
undetectable		 1rjdB-3hkzB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ARG A 229
ASP A 123
ASN A 124
GLU A 209
 None
None
SO4  A 297 ( 4.7A)
None
 1.27A 1rjdB-3hulA:
undetectable		 1rjdB-3hulA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 ARG A 325
ASP A 352
ASP A 376
GLU A 289
 None
 1.10A 1rjdB-3i04A:
2.4		 1rjdB-3i04A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00437
(T2SSE) 		4 ARG A 180
ASP A 145
ASN A 148
GLU A 177
 None
 1.08A 1rjdB-3jvvA:
4.6		 1rjdB-3jvvA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 ARG A 137
TYR A 213
ASP A 220
GLU A 247
 SO4  A 311 ( 3.0A)
None
None
R2B  A 313 ( 4.4A)
 1.10A 1rjdB-3kvyA:
undetectable		 1rjdB-3kvyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		4 ARG A 333
ASP A  77
TYR A 300
ASP A  84
 None
 1.31A 1rjdB-3mizA:
undetectable		 1rjdB-3mizA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		4 ARG A  73
ASP A 122
ASP A 171
GLU A 198
 SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.1A)
 0.21A 1rjdB-3o7wA:
30.3		 1rjdB-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 ASP A 331
TYR A 272
ASN A 279
GLU A 319
 ASP  A 331 ( 0.6A)
TYR  A 272 (-1.3A)
ASN  A 279 ( 0.6A)
GLU  A 319 ( 0.5A)
 1.28A 1rjdB-3o96A:
undetectable		 1rjdB-3o96A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 ARG A 144
TYR A 220
ASP A 227
GLU A 254
 None
 1.10A 1rjdB-3p0fA:
undetectable		 1rjdB-3p0fA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ARG A 355
TYR A 697
ASN A 332
GLU A 350
 None
 1.32A 1rjdB-3qdeA:
undetectable		 1rjdB-3qdeA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 ARG A 199
ASP A  58
ASN A  22
GLU A 196
 None
MG  A 401 ( 4.0A)
None
None
 1.17A 1rjdB-3r9wA:
undetectable		 1rjdB-3r9wA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb2 1-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ARG A 152
ASP A  42
ASP A  80
GLU A  50
 None
 0.91A 1rjdB-3tb2A:
undetectable		 1rjdB-3tb2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		4 ASP A 237
TYR A 233
ASP A 196
GLU A 295
 None
 1.28A 1rjdB-3tdwA:
undetectable		 1rjdB-3tdwA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 ARG A 385
ASP A  69
ASP A  66
ASN A  93
 ACP  A1589 (-2.8A)
CA  A1592 ( 4.5A)
EDO  A1598 ( 3.7A)
EDO  A1598 (-3.4A)
 1.29A 1rjdB-4amfA:
undetectable		 1rjdB-4amfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 ASP A  48
ASP A  35
ASN A  31
GLU A 119
 None
 1.33A 1rjdB-4bl3A:
undetectable		 1rjdB-4bl3A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esf PADR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Bacillus cereus) 		PF03551
(PadR) 		4 ARG A  22
ASP A  94
ASN A 101
GLU A  18
 None
 1.29A 1rjdB-4esfA:
undetectable		 1rjdB-4esfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		4 ARG A 223
ASP A  71
ASN A 269
GLU A 464
 None
 1.18A 1rjdB-4f53A:
undetectable		 1rjdB-4f53A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ARG A 139
ASP A 226
ASN A 224
GLU A 182
 None
 1.28A 1rjdB-4fffA:
undetectable		 1rjdB-4fffA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 TYR A 612
ASP A 832
ASN A 833
GLU A 597
 None
 1.20A 1rjdB-4fm9A:
undetectable		 1rjdB-4fm9A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 ASP A 431
TYR A 447
ASP A 449
GLU A 437
 None
 0.93A 1rjdB-4mdpA:
undetectable		 1rjdB-4mdpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nao PUTATIVE OXYGENASE

(Claviceps
purpurea) 		PF05721
(PhyH) 		4 ARG A  59
TYR A 125
ASN A 162
GLU A 130
 None
 1.24A 1rjdB-4naoA:
undetectable		 1rjdB-4naoA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASP A1498
TYR A1522
ASP A1839
ASN A1843
 None
 1.13A 1rjdB-4o9xA:
undetectable		 1rjdB-4o9xA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 ASP A  78
ASP A  32
ASN A  33
GLU A  81
 None
 1.26A 1rjdB-4ow8A:
undetectable		 1rjdB-4ow8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Lactococcus
lactis) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 ARG A  11
TYR A 137
ASP A 202
GLU A   7
 None
 1.19A 1rjdB-4pczA:
undetectable		 1rjdB-4pczA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 ASP A 275
TYR A 271
ASP A 285
ASN A 280
 None
TRS  A 617 (-3.5A)
TRS  A 617 (-2.7A)
NAG  A 601 ( 1.8A)
 1.15A 1rjdB-4pspA:
undetectable		 1rjdB-4pspA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B  93
ASP B  36
ASN B  39
GLU B 165
 None
 1.25A 1rjdB-4qiwB:
undetectable		 1rjdB-4qiwB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		4 ARG A 366
ASP A 237
ASN A 240
GLU A 362
 None
 1.31A 1rjdB-4qlbA:
2.6		 1rjdB-4qlbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 ARG A 280
ASP A 209
TYR A 395
GLU A 385
 None
 1.08A 1rjdB-4r7fA:
undetectable		 1rjdB-4r7fA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 ARG A 274
TYR A 318
ASN A 226
GLU A 211
 None
 1.10A 1rjdB-4s28A:
undetectable		 1rjdB-4s28A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 ARG A 453
ASP A 129
ASN A  85
GLU A 451
 None
 1.32A 1rjdB-4xiiA:
undetectable		 1rjdB-4xiiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 TYR A 599
ASP A 628
ASN A 657
GLU A 651
 None
 1.33A 1rjdB-4xprA:
undetectable		 1rjdB-4xprA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00149
(Metallophos) 		4 ARG A 181
ASP A 116
ASP A   8
GLU A 178
 None
None
MN  A 301 ( 4.9A)
None
 1.20A 1rjdB-5b4cA:
undetectable		 1rjdB-5b4cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 ASP A 318
TYR A 314
ASP A  75
GLU A 411
 None
 1.30A 1rjdB-5cerA:
undetectable		 1rjdB-5cerA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		4 ASP B 327
ASP B 375
ASN B 278
GLU B 335
 None
 1.27A 1rjdB-5cscB:
undetectable		 1rjdB-5cscB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		4 ARG A 217
ASP A 151
ASP A 156
GLU A 214
 None
 1.04A 1rjdB-5f8eA:
13.3		 1rjdB-5f8eA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		4 ARG A 507
ASP A 589
ASP A 587
GLU A 535
 None
 1.32A 1rjdB-5fnuA:
undetectable		 1rjdB-5fnuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP B 599
ASP B 597
ASN B 596
GLU B 961
 None
 1.28A 1rjdB-5fq6B:
undetectable		 1rjdB-5fq6B:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq1 GENOME POLYPROTEIN

(Enterovirus A) 		PF00910
(RNA_helicase) 		4 ARG A 317
ASP A 294
ASP A 247
GLU A 313
 None
 1.24A 1rjdB-5gq1A:
undetectable		 1rjdB-5gq1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF03105
(SPX)
PF09359
(VTC) 		4 ASP A 389
ASP A 469
ASN A 468
GLU A 385
 None
 1.21A 1rjdB-5iigA:
undetectable		 1rjdB-5iigA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		4 ASP A 113
TYR A 149
ASN A 220
GLU A  21
 MES  A 401 (-2.8A)
MES  A 401 ( 2.6A)
None
None
 1.11A 1rjdB-5jipA:
undetectable		 1rjdB-5jipA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ARG A 660
TYR A 630
ASP A 701
GLU A 662
 None
 1.26A 1rjdB-5jxkA:
undetectable		 1rjdB-5jxkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 343
ASP A 344
ASN A 325
GLU A 502
 None
 1.25A 1rjdB-5lx8A:
undetectable		 1rjdB-5lx8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 4 ARG A1016
ASP A1253
ASP A 939
GLU A 920
 None
 1.27A 1rjdB-5ng6A:
undetectable		 1rjdB-5ng6A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njo PUTATIVE CUPIN_2
DOMAIN-CONTAINING
ISOMERASE

(Streptomyces
coeruleorubidus) 		no annotation 4 ARG A 112
ASP A  20
ASN A  15
GLU A  45
 None
 1.09A 1rjdB-5njoA:
undetectable		 1rjdB-5njoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noa FAMILY 88 GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		4 TYR A 103
ASP A 154
ASN A 152
GLU A 142
 None
 1.32A 1rjdB-5noaA:
undetectable		 1rjdB-5noaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 4 ARG A 168
ASP A 176
ASP A 206
ASN A 209
 None
 1.30A 1rjdB-5o0jA:
undetectable		 1rjdB-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 ARG A  11
ASP A 183
ASN A 177
GLU A 146
 None
 1.08A 1rjdB-5x4jA:
undetectable		 1rjdB-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT

(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		PF13656
(RNA_pol_L_2)
PF03604
(DNA_RNApol_7kD)
PF00467
(KOW) 		4 ARG W 777
ASP K   5
ASP L  70
ASN W 784
 None
 1.28A 1rjdB-5xogW:
undetectable		 1rjdB-5xogW:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 4 ASP A   4
ASP A   6
ASN A 191
GLU A 210
 None
 1.10A 1rjdB-5zb8A:
undetectable		 1rjdB-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 ARG A 482
TYR A 152
ASP A 562
GLU A 147
 GOL  A 704 (-4.0A)
None
None
GOL  A 704 ( 4.5A)
 1.26A 1rjdB-5zl9A:
undetectable		 1rjdB-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 125
ASP A 240
TYR A 241
GLU A 106
 None
 1.33A 1rjdB-6c2hA:
2.1		 1rjdB-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 4 ASP A 320
TYR A 129
ASP A 127
ASN A 327
 None
 0.95A 1rjdB-6dzsA:
undetectable		 1rjdB-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 4 ASP A 221
TYR A 217
ASN A 215
GLU A 326
 None
 1.03A 1rjdB-6eomA:
undetectable		 1rjdB-6eomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ASP B  85
TYR B  88
ASP B  91
GLU A1061
 None
 1.29A 1rjdB-6f9nB:
undetectable		 1rjdB-6f9nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 4 ARG A 507
ASP A 589
ASP A 587
GLU A 535
 None
 1.30A 1rjdB-6fmqA:
undetectable		 1rjdB-6fmqA:
undetectable