SIMILAR PATTERNS OF AMINO ACIDS FOR 1RJD_A_SAMA801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLN A 369
GLY A 362
SER A 368
LEU A 313
LEU A 351
 None
 1.03A 1rjdA-1dnpA:
2.9		 1rjdA-1dnpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 218
ALA A 181
GLY A 203
LEU A 234
LEU A 208
 None
 0.98A 1rjdA-1f8fA:
3.9		 1rjdA-1f8fA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ILE A 187
ALA A 156
GLY A 222
SER A 225
TYR A 166
 None
 1.08A 1rjdA-1fcdA:
undetectable		 1rjdA-1fcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 ILE A 105
ALA A  65
GLY A  73
GLY A  70
LEU A 112
 None
 1.10A 1rjdA-1fuuA:
4.5		 1rjdA-1fuuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 ILE A 286
ASP A 328
ALA A 341
GLY A 373
GLY A 371
 None
NO  A 603 (-3.9A)
None
None
DHE  A 602 ( 3.9A)
 1.08A 1rjdA-1hzvA:
undetectable		 1rjdA-1hzvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3t CATABOLITE GENE
ACTIVATOR PROTEIN

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.04A 1rjdA-1o3tA:
undetectable		 1rjdA-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A1153
GLY A1121
GLY A1142
SER A1144
LEU A1122
 None
 1.05A 1rjdA-1p0cA:
4.0		 1rjdA-1p0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 171
ALA A 401
GLY A 213
LEU A 227
LEU A 193
 None
 1.11A 1rjdA-1p43A:
undetectable		 1rjdA-1p43A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		5 ILE E 208
ALA E 158
GLY E 203
GLY E 181
SER E 190
 None
 1.09A 1rjdA-1pekE:
2.8		 1rjdA-1pekE:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 101
ALA A 119
GLY A  62
SER A  96
LEU A  92
 None
 1.05A 1rjdA-1qorA:
undetectable		 1rjdA-1qorA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrz PLASMINOGEN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A 682
THR A 759
ALA A 601
GLY A 590
LEU A 697
 None
 1.10A 1rjdA-1qrzA:
undetectable		 1rjdA-1qrzA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ILE A  48
GLY A 533
GLY A 540
SER A 523
LEU A 205
 None
 0.98A 1rjdA-1r8wA:
undetectable		 1rjdA-1r8wA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 THR A 103
ASP A 102
GLY A  96
GLY A  98
LEU A  42
 None
APR  A 389 ( 4.5A)
None
APR  A 389 (-3.2A)
APR  A 389 (-4.9A)
 1.05A 1rjdA-1rrmA:
2.5		 1rjdA-1rrmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		6 ASP A  13
ALA A 249
GLY A 378
LEU A 379
CYH A  49
TYR A 375
 None
 1.43A 1rjdA-1vftA:
undetectable		 1rjdA-1vftA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		5 GLN A 244
THR A 265
GLY A 309
SER A 235
LEU A 311
 None
 1.09A 1rjdA-1yifA:
undetectable		 1rjdA-1yifA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		6 ILE A1284
GLN A1285
THR A1282
GLY A1251
GLY A1249
LEU A1253
 None
 1.19A 1rjdA-1yrzA:
undetectable		 1rjdA-1yrzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 325
GLY A 332
GLY A 411
LEU A 405
LEU A 322
 None
None
SO4  A 501 (-4.2A)
None
None
 1.05A 1rjdA-1zzwA:
undetectable		 1rjdA-1zzwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 GLN A 590
THR A 706
ASP A 707
LEU A  14
LEU A 719
 None
 1.04A 1rjdA-2b0tA:
undetectable		 1rjdA-2b0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		5 ILE X  25
GLN X  27
GLY X 101
LEU X  39
LEU X   7
 None
 1.10A 1rjdA-2dchX:
undetectable		 1rjdA-2dchX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		5 ASP A 212
ALA A 238
GLY A 129
SER A 126
LEU A 135
 PLP  A1001 (-2.9A)
None
PLP  A1001 ( 4.2A)
None
None
 1.08A 1rjdA-2eh6A:
undetectable		 1rjdA-2eh6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 152
GLY A 120
GLY A 141
SER A 143
LEU A 121
 None
 0.98A 1rjdA-2fzwA:
3.2		 1rjdA-2fzwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		5 ALA A  90
GLY A  47
GLY A 374
LEU A  69
LEU A  48
 None
 1.10A 1rjdA-2gmhA:
undetectable		 1rjdA-2gmhA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr8 ADHESIN

(Haemophilus
influenzae) 		PF03895
(YadA_anchor) 		5 GLN A1058
THR A1028
ALA A1031
GLY A1060
SER A1084
 None
 1.03A 1rjdA-2gr8A:
undetectable		 1rjdA-2gr8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4

(Mus musculus) 		no annotation 5 ILE F 168
GLY F  65
SER F  78
LEU F 154
LEU F 106
 None
 1.11A 1rjdA-2heyF:
undetectable		 1rjdA-2heyF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 ILE A 347
GLN A 348
GLY A  77
GLY A 111
LEU A  75
 None
 1.10A 1rjdA-2i3oA:
undetectable		 1rjdA-2i3oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ILE A  70
ALA A 148
GLY A  94
LEU A  88
LEU A 115
 None
 1.11A 1rjdA-2iyoA:
3.7		 1rjdA-2iyoA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A

(Homo sapiens) 		PF04051
(TRAPP) 		5 GLN B  46
GLY B  41
GLY B  39
CYH B 124
LEU B 126
 None
 1.09A 1rjdA-2j3tB:
undetectable		 1rjdA-2j3tB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzt PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF02847
(MA3) 		5 ILE A 273
THR A 233
ASP A 235
SER A 239
LEU A 222
 None
 0.98A 1rjdA-2kztA:
undetectable		 1rjdA-2kztA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 ILE A 483
GLN A 482
THR A 487
LEU A 477
LEU A 454
 None
 0.97A 1rjdA-2nrrA:
undetectable		 1rjdA-2nrrA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		7 ALA A  12
GLY A 105
GLY A 107
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.26A 1rjdA-2ob1A:
53.6		 1rjdA-2ob1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		7 ALA A  12
GLY A 105
SER A 132
LEU A 176
CYH A 202
LEU A 203
TYR A 206
 None
 0.66A 1rjdA-2ob1A:
53.6		 1rjdA-2ob1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 325
GLY A 332
GLY A 411
LEU A 405
LEU A 322
 None
 1.03A 1rjdA-2oudA:
undetectable		 1rjdA-2oudA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 173
ALA A 395
GLY A 215
LEU A 229
LEU A 195
 None
 0.96A 1rjdA-2pa6A:
undetectable		 1rjdA-2pa6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		5 ILE A 184
THR A 205
GLY A  19
LEU A 131
LEU A  23
 None
 0.89A 1rjdA-2pkeA:
2.5		 1rjdA-2pkeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1
SNURPORTIN-1

(Homo sapiens;
Homo sapiens) 		PF13513
(HEAT_EZ)
PF11538
(Snurportin1) 		5 ILE A 724
ALA B  62
GLY A 771
LEU A 732
LEU A 776
 None
 1.02A 1rjdA-2qnaA:
undetectable		 1rjdA-2qnaA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		5 THR A  17
GLY A 112
LEU A 162
LEU A 188
TYR A 191
 None
 0.72A 1rjdA-2uyoA:
23.3		 1rjdA-2uyoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
 None
None
None
None
OMT  A2473 (-3.8A)
 1.08A 1rjdA-2vdcA:
undetectable		 1rjdA-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		7 ILE A  27
GLN A  28
THR A  30
GLY A 115
GLY A 117
LEU A 197
TYR A 229
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-4.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.7A)
None
 0.42A 1rjdA-2zwaA:
31.5		 1rjdA-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs6 INNER MEMBRANE
PROTEIN OXAA

(Escherichia
coli) 		PF14849
(YidC_periplas) 		6 THR A 237
ASP A 236
ALA A 239
GLY A 220
LEU A 256
TYR A 233
 None
 1.32A 1rjdA-3bs6A:
undetectable		 1rjdA-3bs6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 THR A 146
ALA A 144
GLY A 125
SER A 116
LEU A 229
 None
 1.05A 1rjdA-3ce9A:
undetectable		 1rjdA-3ce9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 THR A 487
ASP A 423
ALA A 424
GLY A 310
GLY A 364
 None
 1.08A 1rjdA-3eh2A:
undetectable		 1rjdA-3eh2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guw UNCHARACTERIZED
PROTEIN AF_1765

(Archaeoglobus
fulgidus) 		PF01026
(TatD_DNase) 		5 THR A 130
ASP A 159
GLY A 177
LEU A 170
LEU A 166
 None
 1.10A 1rjdA-3guwA:
undetectable		 1rjdA-3guwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLN A 388
ALA A 422
GLY A 399
SER A 391
LEU A 400
 None
 1.04A 1rjdA-3ic9A:
undetectable		 1rjdA-3ic9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 419
ALA A 406
GLY A 410
SER A 413
LEU A 379
 None
 1.08A 1rjdA-3ifrA:
undetectable		 1rjdA-3ifrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 ILE A 383
THR A 220
ASP A 219
GLY A 386
GLY A 215
 None
 1.04A 1rjdA-3j1eA:
undetectable		 1rjdA-3j1eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1
VP0
VP3

(Parechovirus B;
Parechovirus B;
Parechovirus B) 		no annotation
PF00073
(Rhv)
PF00073
(Rhv) 		5 ILE C 225
GLN C 224
ALA A 235
GLY C  78
GLY B 172
 None
 1.06A 1rjdA-3jb4C:
undetectable		 1rjdA-3jb4C:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 ILE A 105
ASP A  81
GLY A  84
LEU A 100
LEU A  66
 None
MG  A 700 (-3.3A)
None
None
None
 0.99A 1rjdA-3k8kA:
undetectable		 1rjdA-3k8kA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		5 ILE A  33
THR A 147
ASP A 148
ALA A 149
SER A  20
 None
 1.11A 1rjdA-3ky7A:
undetectable		 1rjdA-3ky7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 ILE A  57
THR A  52
ALA A 117
GLY A  85
LEU A  91
 None
None
None
MLI  A 341 ( 4.9A)
None
 1.09A 1rjdA-3l6cA:
2.8		 1rjdA-3l6cA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 ALA A  33
GLY A  98
GLY A 100
CYH A 199
TYR A 203
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.6A)
 0.50A 1rjdA-3o7wA:
30.7		 1rjdA-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxn PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		5 ILE A 170
THR A 123
ALA A 219
LEU A 319
TYR A 291
 None
 1.00A 1rjdA-3oxnA:
undetectable		 1rjdA-3oxnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 166
ALA A 388
GLY A 206
LEU A 220
LEU A 188
 None
 0.97A 1rjdA-3qn3A:
undetectable		 1rjdA-3qn3A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		5 ILE A 143
ALA A 195
GLY A 296
GLY A 245
LEU A 100
 None
None
None
CA  A 327 ( 4.9A)
None
 1.01A 1rjdA-3qqzA:
undetectable		 1rjdA-3qqzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		5 ILE A 268
THR A 242
GLY A 237
GLY A 239
LEU A 261
 None
 1.08A 1rjdA-3r5bA:
undetectable		 1rjdA-3r5bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 188
ASP A 185
GLY A 213
GLY A 215
LEU A 251
 None
 0.88A 1rjdA-3t9wA:
undetectable		 1rjdA-3t9wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44

(Escherichia
virus T4) 		PF00004
(AAA) 		5 THR B 207
ASP B 203
GLY B  55
GLY B  53
LEU B  25
 None
None
08T  B 700 (-3.1A)
08T  B 700 (-3.0A)
None
 1.11A 1rjdA-3u5zB:
undetectable		 1rjdA-3u5zB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		5 ILE A  54
ALA A 194
GLY A 221
GLY A 189
LEU A 220
 None
 1.00A 1rjdA-3ucaA:
undetectable		 1rjdA-3ucaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va1 MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Mus musculus) 		PF00498
(FHA) 		5 ILE A 100
ASP A  91
ALA A  76
GLY A  97
LEU A 122
 None
 1.00A 1rjdA-3va1A:
undetectable		 1rjdA-3va1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 ILE A 298
GLN A 297
ALA A 276
GLY A 515
GLY A 290
 None
None
None
None
NAG  A 808 ( 4.5A)
 1.11A 1rjdA-3zk4A:
undetectable		 1rjdA-3zk4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		5 ILE A 159
ALA A 146
GLY A 162
GLY A 135
LEU A 167
 None
 1.06A 1rjdA-4c1nA:
undetectable		 1rjdA-4c1nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		5 ASP A  87
ALA A  86
GLY A 204
GLY A  98
LEU A 205
 PO4  A 301 (-2.6A)
None
None
PO4  A 301 (-4.0A)
None
 1.04A 1rjdA-4gmkA:
undetectable		 1rjdA-4gmkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  10
THR A 257
ALA A 259
GLY A  93
GLY A  89
 None
 1.07A 1rjdA-4hacA:
undetectable		 1rjdA-4hacA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 ILE M 360
ALA M 317
GLY M 370
GLY M 444
LEU M 368
 None
 1.07A 1rjdA-4heaM:
undetectable		 1rjdA-4heaM:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgb PUTATIVE EXPORTED
PROTEIN

(Burkholderia
pseudomallei) 		PF13460
(NAD_binding_10) 		5 THR A 206
ALA A 204
GLY A 105
GLY A 103
LEU A 115
 None
 0.98A 1rjdA-4jgbA:
undetectable		 1rjdA-4jgbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 125
ALA A 152
GLY A  37
GLY A 118
LEU A 112
 None
None
None
PO4  A 201 (-3.8A)
None
 1.09A 1rjdA-4ki9A:
undetectable		 1rjdA-4ki9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ILE A 363
THR A 366
ASP A 384
LEU A 346
LEU A 389
 None
 1.10A 1rjdA-4kpgA:
undetectable		 1rjdA-4kpgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		5 THR X 143
GLY X  74
GLY X 148
LEU X  84
TYR X  88
 None
2HD  X 401 (-3.9A)
None
None
None
 1.09A 1rjdA-4n5iX:
undetectable		 1rjdA-4n5iX:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nml RIBULOSE 5-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 135
ASP A  91
ALA A  90
GLY A 233
GLY A 103
 None
MLT  A 303 (-4.5A)
None
None
CL  A 301 (-3.5A)
 1.04A 1rjdA-4nmlA:
undetectable		 1rjdA-4nmlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 ILE A  95
ASP A 130
GLY A 106
LEU A  91
LEU A 127
 None
 1.05A 1rjdA-4p6yA:
undetectable		 1rjdA-4p6yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ILE A 219
GLY A 242
SER A 309
LEU A 275
LEU A 245
 None
 1.03A 1rjdA-4re2A:
undetectable		 1rjdA-4re2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rza PRE-MRNA-SPLICING
FACTOR 38A

(Homo sapiens) 		PF03371
(PRP38) 		5 ILE A  91
ASP A 115
GLY A 111
LEU A 105
LEU A 151
 None
 1.11A 1rjdA-4rzaA:
undetectable		 1rjdA-4rzaA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		5 ILE B 385
THR B 222
ASP B 221
GLY B 388
GLY B 217
 None
 0.94A 1rjdA-4xcgB:
undetectable		 1rjdA-4xcgB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 ILE A 178
ASP A  93
GLY A 160
GLY A  94
LEU A 145
 None
MN  A 402 ( 2.6A)
None
MN  A 401 (-4.2A)
None
 1.08A 1rjdA-4yzgA:
undetectable		 1rjdA-4yzgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ASP A 772
ALA A 301
GLY A 784
GLY A 589
LEU A 584
 None
 1.06A 1rjdA-5a22A:
8.4		 1rjdA-5a22A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ILE A 371
GLY A 254
GLY A 227
LEU A 334
LEU A 253
 None
None
ATP  A 801 (-3.8A)
None
None
 1.09A 1rjdA-5e84A:
undetectable		 1rjdA-5e84A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es2 UNCHARACTERIZED
PROTEIN LPG0634

(Legionella
pneumophila) 		PF16848
(SoDot-IcmSS) 		5 ILE A 298
THR A 301
GLY A 282
SER A 308
TYR A 288
 None
SO4  A 507 (-3.3A)
None
None
None
 1.04A 1rjdA-5es2A:
undetectable		 1rjdA-5es2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A  86
GLY A  78
SER A 228
LEU A  33
LEU A  91
 None
None
5VV  A   1 ( 3.0A)
None
None
 1.10A 1rjdA-5fbzA:
undetectable		 1rjdA-5fbzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 ILE E  16
GLY E  21
GLY E  39
LEU E  92
LEU E  23
 None
 1.10A 1rjdA-5h36E:
undetectable		 1rjdA-5h36E:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 ILE A  82
ALA A 267
GLY A   9
GLY A  13
SER A 252
 None
 1.06A 1rjdA-5hn4A:
undetectable		 1rjdA-5hn4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 ILE B 172
GLN B 169
LEU B 130
CYH B 105
LEU B 106
 None
 1.05A 1rjdA-5iklB:
undetectable		 1rjdA-5iklB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		5 ILE A 340
THR A 343
ALA A 347
LEU A 312
LEU A 386
 None
 1.08A 1rjdA-5jayA:
3.4		 1rjdA-5jayA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		5 ILE A 167
THR A 182
ALA A 186
GLY A  72
LEU A 164
 None
 1.05A 1rjdA-5jxuA:
undetectable		 1rjdA-5jxuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		5 ILE A 261
THR A 167
ASP A 161
GLY A 290
GLY A 288
 None
None
MG  A 401 (-3.8A)
None
ADP  A 402 ( 4.2A)
 1.02A 1rjdA-5jygA:
undetectable		 1rjdA-5jygA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Trichormus
variabilis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 GLN A  61
GLY A  83
GLY A  87
LEU A  67
LEU A  92
 None
 1.09A 1rjdA-5kt0A:
undetectable		 1rjdA-5kt0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 THR B 753
ASP B 689
ALA B 690
GLY B 576
GLY B 630
 None
 1.07A 1rjdA-5kyuB:
undetectable		 1rjdA-5kyuB:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 ILE J 183
ALA J 156
GLY J   6
LEU J 103
LEU J 115
 None
 1.10A 1rjdA-5m32J:
undetectable		 1rjdA-5m32J:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A  33
GLY A  24
GLY A  26
LEU A  37
LEU A  64
 None
 0.97A 1rjdA-5mdhA:
4.5		 1rjdA-5mdhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 5 ILE K 234
THR K 232
ALA K 290
GLY K 304
LEU K 244
 None
 0.98A 1rjdA-5mm7K:
undetectable		 1rjdA-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 ALA B  99
GLY B 150
GLY B 148
SER B 190
LEU B 137
 G2P  B 501 ( 4.6A)
None
None
None
None
 1.01A 1rjdA-5n5nB:
3.5		 1rjdA-5n5nB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9y ZINC TRANSPORT
PROTEIN ZNTB

(Escherichia
coli) 		no annotation 5 ILE A 230
THR A 155
GLY A 235
GLY A 237
TYR A 208
 None
 1.02A 1rjdA-5n9yA:
undetectable		 1rjdA-5n9yA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na2 CAPSID PROTEIN (P24)

(Feline
immunodeficiency
virus) 		no annotation 5 ILE A 135
ASP A  64
GLY A  32
GLY A  29
SER A 180
 None
 1.09A 1rjdA-5na2A:
undetectable		 1rjdA-5na2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE

(Bacillus
subtilis) 		no annotation 5 ILE A  17
THR A  21
ALA A  25
GLY A  47
GLY A  51
 None
 1.05A 1rjdA-5np9A:
undetectable		 1rjdA-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 5 GLN B 379
ALA B 385
GLY B 307
SER B 429
LEU B 311
 None
None
Y01  B1003 ( 4.3A)
Y01  B1003 ( 3.8A)
None
 1.09A 1rjdA-5ochB:
undetectable		 1rjdA-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 GLN A 489
ASP A 496
GLY A 493
LEU A 557
LEU A 570
 None
 1.09A 1rjdA-5t8vA:
undetectable		 1rjdA-5t8vA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ILE A 202
GLN A 201
THR A 206
LEU A 196
LEU A 224
 None
None
None
GDP  A 603 ( 4.6A)
GDP  A 603 ( 4.3A)
 1.02A 1rjdA-5tc3A:
undetectable		 1rjdA-5tc3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ILE A  39
GLY A  21
GLY A  19
LEU A  52
LEU A  26
 None
NAP  A 301 ( 4.2A)
NAP  A 301 (-3.7A)
None
None
 1.08A 1rjdA-5u9pA:
5.9		 1rjdA-5u9pA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 ILE C 137
ASP C  87
GLY C 113
LEU C 144
LEU C  84
 None
 1.06A 1rjdA-5xxuC:
undetectable		 1rjdA-5xxuC:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 GLN A 565
THR A 155
ALA A 152
SER A 561
LEU A 389
 None
 1.09A 1rjdA-5z9sA:
undetectable		 1rjdA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 GLN A 505
ALA A 566
GLY A 460
GLY A 454
LEU A 556
 None
 1.08A 1rjdA-5ze4A:
undetectable		 1rjdA-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e2q -

(-) 		no annotation 5 ILE A 289
THR A 267
GLY A 294
GLY A 292
LEU A 316
 None
 0.92A 1rjdA-6e2qA:
undetectable		 1rjdA-6e2qA:
undetectable