SIMILAR PATTERNS OF AMINO ACIDS FOR 1RI4_A_SAMA299_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli)
PF00328
(His_Phos_2)
5 GLY A  59
GLY A 103
ILE A  55
ALA A  99
GLN A  64
None
1.04A 1ri4A-1dkpA:
undetectable
1ri4A-1dkpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 GLY A 224
ILE A 230
ALA A 191
ASP A 234
SER A 232
SO4  A 421 ( 4.9A)
None
None
None
None
1.08A 1ri4A-1gtmA:
4.0
1ri4A-1gtmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00180
(Iso_dh)
5 GLY A  10
GLY A  12
ILE A 277
ALA A 283
ASP A 276
None
1.21A 1ri4A-1idmA:
undetectable
1ri4A-1idmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im4 DBH

(Sulfolobus
solfataricus)
PF00817
(IMS)
PF11798
(IMS_HHH)
5 GLY A 165
GLY A 144
ILE A 167
ALA A 146
SER A 159
None
1.15A 1ri4A-1im4A:
undetectable
1ri4A-1im4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A1158
GLY A1182
ILE A1164
ALA A1186
SER A1263
None
1.05A 1ri4A-1jqbA:
6.9
1ri4A-1jqbA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE


(Bacillus
subtilis)
PF01238
(PMI_typeI)
5 GLY A  19
ILE A  16
ASP A 201
SER A 202
PHE A  12
None
0.95A 1ri4A-1qwrA:
undetectable
1ri4A-1qwrA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi)
PF03291
(Pox_MCEL)
5 GLY A  92
ALA A 120
ASP A 122
SER A 123
TYR A 124
None
None
SAH  A 299 (-3.2A)
SAH  A 299 (-3.1A)
SAH  A 299 (-4.0A)
1.19A 1ri4A-1ri3A:
43.3
1ri4A-1ri3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi)
PF03291
(Pox_MCEL)
12 LYS A  54
GLY A  72
GLY A  74
ILE A  95
ALA A  96
ASP A 122
SER A 123
TYR A 124
GLN A 140
PHE A 141
SER A 142
TYR A 145
SAH  A 299 (-3.0A)
SAH  A 299 (-3.3A)
SAH  A 299 (-3.5A)
SAH  A 299 (-3.8A)
SAH  A 299 ( 3.8A)
SAH  A 299 (-3.2A)
SAH  A 299 (-3.1A)
SAH  A 299 (-4.0A)
None
None
SAH  A 299 (-3.0A)
SAH  A 299 (-4.2A)
0.41A 1ri4A-1ri3A:
43.3
1ri4A-1ri3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS


(Escherichia
coli)
PF04960
(Glutaminase)
5 GLY A 261
GLY A 263
ALA A  27
TYR A 244
SER A  66
None
0.94A 1ri4A-1u60A:
undetectable
1ri4A-1u60A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus)
PF00581
(Rhodanese)
5 GLY A 178
GLY A 283
ILE A 280
ALA A 281
GLN A 174
None
1.03A 1ri4A-1uarA:
undetectable
1ri4A-1uarA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis)
PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C)
5 GLY A  10
GLY A   7
ILE A 212
ALA A 207
ASP A 146
None
None
None
None
CA  A2001 (-3.0A)
0.91A 1ri4A-1ulvA:
undetectable
1ri4A-1ulvA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897


(Pyrococcus
horikoshii)
PF00459
(Inositol_P)
5 GLY A  88
ILE A 175
ALA A 176
ASP A 192
TYR A 196
None
EDO  A1002 (-4.0A)
None
None
None
1.13A 1ri4A-1vdwA:
undetectable
1ri4A-1vdwA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE


(Pseudomonas
syringae group
genomosp. 3)
PF00009
(GTP_EFTU)
5 GLY B 406
GLY B 414
ILE B 433
ALA B 337
SER B 408
None
1.15A 1ri4A-1zunB:
2.9
1ri4A-1zunB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE


(Ruminiclostridium
thermocellum)
PF02012
(BNR)
5 GLY A 119
GLY A 152
ALA A  70
SER A  97
TYR A  96
None
None
GLC  A1769 (-3.5A)
None
XYS  A1774 ( 4.7A)
1.21A 1ri4A-2cn3A:
undetectable
1ri4A-2cn3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens)
PF03972
(MmgE_PrpD)
5 GLY A 159
GLY A 156
ALA A 206
PHE A  93
TYR A 126
None
1.19A 1ri4A-2hp3A:
undetectable
1ri4A-2hp3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE


(Chlamydia
trachomatis)
PF00132
(Hexapep)
PF04613
(LpxD)
5 GLY A 262
GLY A 280
ALA A 264
ASP A 224
GLN A 278
PLM  A1349 ( 4.2A)
PLM  A1349 (-3.7A)
PLM  A1349 (-3.2A)
None
None
1.14A 1ri4A-2iu8A:
undetectable
1ri4A-2iu8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myu GLUTAREDOXIN
ARSENATE REDUCTASE


(Synechocystis
sp. PCC 6803)
PF01451
(LMWPc)
5 GLY A  26
ILE A  30
ALA A  31
SER A 131
PHE A  21
None
0.97A 1ri4A-2myuA:
undetectable
1ri4A-2myuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o57 PUTATIVE SARCOSINE
DIMETHYLGLYCINE
METHYLTRANSFERASE


(Galdieria
sulphuraria)
PF08241
(Methyltransf_11)
5 GLY A  90
GLY A  92
ILE A 113
ALA A 114
GLN A 157
None
0.95A 1ri4A-2o57A:
16.3
1ri4A-2o57A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN


(Archaeoglobus
fulgidus)
PF00437
(T2SSE)
5 GLY 1 357
ILE 1 337
PHE 1 261
SER 1 262
TYR 1 361
None
1.05A 1ri4A-2oap1:
undetectable
1ri4A-2oap1:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba)
PF00089
(Trypsin)
6 GLY A  19
GLY A  44
ILE A  17
TYR A 120
PHE A 199
SER A 139
None
1.41A 1ri4A-2ouaA:
undetectable
1ri4A-2ouaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME


(Bos taurus)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
5 GLY A 368
ALA A 523
SER A 643
PHE A 388
SER A 386
None
1.21A 1ri4A-2pncA:
undetectable
1ri4A-2pncA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE


(Escherichia
virus N4)
no annotation 5 GLY A 574
GLY A1042
ILE A 980
SER A 808
TYR A 811
None
1.20A 1ri4A-2po4A:
undetectable
1ri4A-2po4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLY A 426
ILE A 431
ALA A  60
PHE A 452
SER A 453
None
None
None
TPP  A3001 (-4.4A)
None
1.00A 1ri4A-2q27A:
3.5
1ri4A-2q27A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867


(Thermobifida
fusca)
PF04672
(Methyltransf_19)
5 GLY A  84
GLY A  86
ILE A 111
ASP A 135
TYR A 168
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 ( 4.5A)
0.60A 1ri4A-2qe6A:
13.7
1ri4A-2qe6A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens)
no annotation 5 GLY A 198
ILE A 136
ALA A 135
GLN A 230
SER A 231
None
1.11A 1ri4A-2quaA:
undetectable
1ri4A-2quaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN


(Treponema
pallidum)
PF13416
(SBP_bac_8)
5 LYS A 305
GLY A 115
GLY A 208
ASP A 226
TYR A 294
MES  A1326 (-2.9A)
None
None
None
None
1.20A 1ri4A-2v84A:
undetectable
1ri4A-2v84A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
5 LYS A 573
GLY A 600
GLN A 678
PHE A 679
TYR A 683
SAH  A1846 (-2.9A)
SAH  A1846 (-3.2A)
None
SAH  A1846 (-4.9A)
SAH  A1846 ( 3.7A)
0.45A 1ri4A-2vdwA:
27.1
1ri4A-2vdwA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 GLY A  58
GLY A  91
ALA A 128
ASP A 365
SER A 344
None
1.11A 1ri4A-2vhlA:
undetectable
1ri4A-2vhlA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus)
PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2)
5 GLY A 178
ILE A 173
ALA A 175
PHE A 140
SER A 142
None
1.17A 1ri4A-2vsaA:
undetectable
1ri4A-2vsaA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans)
PF03069
(FmdA_AmdA)
5 GLY A 106
GLY A 264
ILE A  52
ASP A  60
SER A 127
None
ZN  A 412 ( 4.6A)
None
None
None
1.14A 1ri4A-2wknA:
undetectable
1ri4A-2wknA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D


(Bacillus
subtilis)
PF09423
(PhoD)
PF16655
(PhoD_N)
5 GLY A 416
GLY A 414
ASP A 500
SER A 499
PHE A 461
None
None
None
None
EDO  A 533 ( 4.2A)
1.06A 1ri4A-2yeqA:
undetectable
1ri4A-2yeqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE


(Lactobacillus
paracasei)
PF13649
(Methyltransf_25)
6 GLY A  50
GLY A  52
ILE A  75
ALA A  76
SER A 130
TYR A 133
None
0.96A 1ri4A-3bkxA:
13.1
1ri4A-3bkxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes)
PF08241
(Methyltransf_11)
5 GLY A  69
GLY A  71
ILE A  92
ASP A 119
SER A 138
SAH  A 274 (-3.1A)
SAH  A 274 (-3.4A)
SAH  A 274 (-4.0A)
SAH  A 274 (-3.6A)
None
0.48A 1ri4A-3busA:
17.2
1ri4A-3busA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE


(Streptomyces
venezuelae)
PF13649
(Methyltransf_25)
5 GLY A  48
ASP A  89
PHE A 106
SER A 108
TYR A 111
SAM  A 238 ( 3.7A)
SAM  A 238 (-3.0A)
UPP  A 239 ( 3.6A)
SAM  A 238 (-3.2A)
SAM  A 238 ( 4.7A)
0.98A 1ri4A-3bxoA:
18.3
1ri4A-3bxoA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE


(Exiguobacterium
sibiricum)
PF13649
(Methyltransf_25)
5 GLY A  40
GLY A  42
ASP A  86
SER A 105
TYR A 108
None
1.08A 1ri4A-3d2lA:
19.2
1ri4A-3d2lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN


(Agrobacterium
fabrum)
PF03358
(FMN_red)
5 GLY A  96
GLY A  61
ALA A  24
TYR A 176
PHE A  94
None
1.13A 1ri4A-3d7nA:
undetectable
1ri4A-3d7nA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
5 GLY A 656
GLY A 619
ILE A 671
ALA A 622
SER A 654
None
1.12A 1ri4A-3ecqA:
undetectable
1ri4A-3ecqA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Burkholderia
pseudomallei)
PF00698
(Acyl_transf_1)
5 GLY A 168
GLY A 128
ILE A 166
ALA A 130
SER A 199
None
1.09A 1ri4A-3ezoA:
undetectable
1ri4A-3ezoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE


(Leptospira
interrogans)
no annotation 5 GLY B 428
GLY B 426
ILE B 399
ALA B 409
TYR B 430
None
0.87A 1ri4A-3f6gB:
undetectable
1ri4A-3f6gB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 158
GLY A 182
ILE A 164
ALA A 186
SER A 263
None
1.02A 1ri4A-3fsrA:
7.7
1ri4A-3fsrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4e ISOCITRATE LYASE

(Burkholderia
pseudomallei)
PF00463
(ICL)
5 GLY A 273
ALA A 228
ASP A 281
GLN A 305
TYR A 279
None
1.19A 1ri4A-3i4eA:
undetectable
1ri4A-3i4eA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
5 GLY C 215
GLY C 218
ILE C 160
ALA C  71
ASP C 161
None
0.92A 1ri4A-3if6C:
undetectable
1ri4A-3if6C:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793


(Pyrococcus
horikoshii)
PF02475
(Met_10)
5 GLY A 135
GLY A 137
ILE A 154
ALA A 153
PHE A 163
None
1.07A 1ri4A-3k6rA:
14.4
1ri4A-3k6rA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE


(Streptomyces
coelicolor)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 GLY A 122
GLY A 179
ILE A  34
ALA A  33
PHE A 174
SER A  86
None
1.27A 1ri4A-3krtA:
6.3
1ri4A-3krtA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksu 3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE


(Oenococcus oeni)
PF13561
(adh_short_C2)
5 GLY A 139
ILE A  92
ALA A  93
TYR A   4
GLN A 181
None
1.21A 1ri4A-3ksuA:
7.2
1ri4A-3ksuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8d METHYLTRANSFERASE

(Bacillus
thuringiensis)
PF08241
(Methyltransf_11)
5 GLY A  61
GLY A  63
ILE A  83
ASP A 106
SER A 125
None
0.70A 1ri4A-3l8dA:
15.0
1ri4A-3l8dA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mk3 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


(Salmonella
enterica)
no annotation 5 GLY A 130
GLY A 134
ALA A 138
ASP A  32
SER A  29
None
1.08A 1ri4A-3mk3A:
undetectable
1ri4A-3mk3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN


(Corynebacterium
diphtheriae)
PF13614
(AAA_31)
5 GLY A 175
ILE A 157
ALA A 145
PHE A 179
SER A   5
None
1.10A 1ri4A-3pg5A:
undetectable
1ri4A-3pg5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2y SULFIDE-QUINONE
REDUCTASE, PUTATIVE


(Acidithiobacillus
ferrooxidans)
PF07992
(Pyr_redox_2)
5 GLY A  10
GLY A  12
ALA A  17
SER A  34
PHE A  41
FAD  A 500 (-3.1A)
FAD  A 500 (-3.7A)
None
FAD  A 500 (-3.4A)
None
1.10A 1ri4A-3t2yA:
2.8
1ri4A-3t2yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 GLY A  14
ILE A  39
ALA A  40
ASP A  77
GLN A  19
NAD  A 274 (-3.2A)
NAD  A 274 (-3.8A)
None
NAD  A 274 (-3.4A)
NAD  A 274 (-3.3A)
1.15A 1ri4A-3tscA:
6.2
1ri4A-3tscA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 GLY A 553
GLY A 549
ILE A 236
ALA A 233
ASP A 240
None
1.10A 1ri4A-3u1kA:
undetectable
1ri4A-3u1kA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
5 GLY A 221
ILE A 218
SER A 216
PHE A 169
TYR A 165
None
None
None
ADN  A 401 (-3.7A)
None
1.19A 1ri4A-3vasA:
2.6
1ri4A-3vasA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta)
PF04261
(Dyp_perox)
5 GLY A 424
GLY A 425
ALA A  98
ASP A 104
GLN A 150
None
0.99A 1ri4A-3vxiA:
undetectable
1ri4A-3vxiA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayi LIPOPROTEIN GNA1870
CCOMPND 7


(Neisseria
meningitidis)
PF08794
(Lipoprot_C)
5 GLY D 318
GLY D 219
ILE D 316
ALA D 221
GLN D 320
None
1.06A 1ri4A-4ayiD:
undetectable
1ri4A-4ayiD:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius)
PF03512
(Glyco_hydro_52)
5 GLY A 598
GLY A 534
ILE A 596
ALA A 595
PHE A 617
None
1.04A 1ri4A-4c1oA:
undetectable
1ri4A-4c1oA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7


(Mus musculus)
PF06325
(PrmA)
5 GLY A  72
ILE A 119
ALA A  92
ASP A 133
PHE A  96
SAH  A1689 (-3.0A)
None
None
None
None
1.17A 1ri4A-4c4aA:
8.9
1ri4A-4c4aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT)
5 LYS A 573
GLY A 600
GLN A 678
PHE A 679
TYR A 683
SAH  A1845 (-2.8A)
SAH  A1845 (-3.4A)
None
None
SAH  A1845 (-3.5A)
0.38A 1ri4A-4ckbA:
27.5
1ri4A-4ckbA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus)
PF00817
(IMS)
PF11798
(IMS_HHH)
5 GLY A 165
GLY A 144
ILE A 167
ALA A 146
SER A 159
None
1.13A 1ri4A-4f4wA:
undetectable
1ri4A-4f4wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius)
PF01547
(SBP_bac_1)
5 GLY B 304
ILE B 302
ALA B 377
SER B 374
TYR B 301
None
None
XYP  B 802 (-3.4A)
None
None
1.01A 1ri4A-4g68B:
undetectable
1ri4A-4g68B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes)
PF07537
(CamS)
5 GLY A 226
GLY A 234
ALA A 232
ASP A 229
SER A 170
None
1.18A 1ri4A-4hn3A:
undetectable
1ri4A-4hn3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius)
PF00817
(IMS)
PF11798
(IMS_HHH)
5 GLY A 165
GLY A 144
ILE A 167
ALA A 146
SER A 159
None
1.15A 1ri4A-4hykA:
undetectable
1ri4A-4hykA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI


(Escherichia
coli)
PF13561
(adh_short_C2)
5 GLY A  93
ILE A 115
ALA A  95
PHE A 124
SER A 123
NAD  A 302 (-3.9A)
None
AE6  A 301 (-3.7A)
None
None
1.10A 1ri4A-4jx8A:
5.7
1ri4A-4jx8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE


(Homo sapiens)
PF01008
(IF-2B)
5 GLY A 144
GLY A 147
ALA A 279
TYR A 178
SER A 187
None
0.99A 1ri4A-4ldqA:
6.0
1ri4A-4ldqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
5 GLY A 668
GLY A 706
ILE A 702
ALA A 703
ASP A 700
None
1.17A 1ri4A-4lq1A:
undetectable
1ri4A-4lq1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ


(Streptomyces
hygroscopicus)
PF13649
(Methyltransf_25)
5 GLY A 166
GLY A 168
ILE A 190
ALA A 191
ASP A 217
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.5A)
SAH  A 401 ( 3.7A)
0.33A 1ri4A-4m73A:
15.5
1ri4A-4m73A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m85 N-ACETYLTRANSFERASE

(Staphylococcus
aureus)
PF00583
(Acetyltransf_1)
5 ILE A 113
TYR A 111
GLN A  55
PHE A  53
TYR A  73
None
1.17A 1ri4A-4m85A:
undetectable
1ri4A-4m85A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
vivax)
PF13649
(Methyltransf_25)
5 GLY A  60
GLY A  62
ILE A  83
ASP A 107
SER A 126
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.2A)
0.52A 1ri4A-4mwzA:
16.0
1ri4A-4mwzA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n72 PYRUVATE
DEHYDROGENASE
(DIHYDROLIPOYLTRANSA
CETYLASE COMPONENT)


(Escherichia
coli)
PF00198
(2-oxoacid_dh)
5 GLY A 545
GLY A 496
ILE A 493
TYR A 492
GLN A 543
None
1.13A 1ri4A-4n72A:
undetectable
1ri4A-4n72A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA


(Yersinia pestis)
PF00496
(SBP_bac_5)
5 GLY A 149
GLY A 151
ILE A 132
ASP A  81
PHE A  17
None
1.09A 1ri4A-4oflA:
undetectable
1ri4A-4oflA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis)
PF13561
(adh_short_C2)
5 GLY A 143
GLY A 154
ILE A 141
ASP A 243
SER A 139
None
1.20A 1ri4A-4qedA:
5.3
1ri4A-4qedA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus)
PF03512
(Glyco_hydro_52)
5 GLY A 576
GLY A 512
ILE A 574
ALA A 573
PHE A 595
None
1.07A 1ri4A-4rhhA:
undetectable
1ri4A-4rhhA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ua3 UNCHARACTERIZED
N-ACETYLTRANSFERASE
C825.04C


(Schizosaccharomyces
pombe)
PF00583
(Acetyltransf_1)
5 GLY A 100
ILE A  88
TYR A  41
GLN A  51
TYR A  87
None
1.20A 1ri4A-4ua3A:
undetectable
1ri4A-4ua3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
6 GLY A  57
GLY A 119
ILE A 116
ALA A 254
GLN A  62
SER A  71
None
0.98A 1ri4A-4ubtA:
undetectable
1ri4A-4ubtA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udj UHGB_MP

(uncultured
organism)
PF04041
(Glyco_hydro_130)
5 GLY A 152
ILE A 180
ALA A 215
SER A 183
TYR A 182
None
0.98A 1ri4A-4udjA:
undetectable
1ri4A-4udjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uds MBDR REGULATOR

(Azoarcus sp.
CIB)
PF00440
(TetR_N)
5 GLY A  46
ILE A  52
ALA A  42
TYR A  55
SER A  16
None
1.17A 1ri4A-4udsA:
undetectable
1ri4A-4udsA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae)
PF00415
(RCC1)
5 GLY B  16
GLY B  18
SER B  48
GLN B  27
SER B  29
None
DXE  B 406 (-4.5A)
None
None
None
1.12A 1ri4A-4x33B:
undetectable
1ri4A-4x33B:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE


(Escherichia
coli;
Escherichia
coli)
PF05861
(PhnI)
PF06007
(PhnJ)
5 ILE D 188
ALA D 172
ASP D 192
TYR D 250
PHE C 337
None
1.10A 1ri4A-4xb6D:
undetectable
1ri4A-4xb6D:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpu ENDONUCLEASE V

(Escherichia
coli)
PF04493
(Endonuclease_5)
5 GLY A 106
GLY A 177
ILE A 174
ALA A 185
SER A 108
None
1.19A 1ri4A-4xpuA:
undetectable
1ri4A-4xpuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE


(Sphingobium sp.
SYK-6)
PF00106
(adh_short)
5 GLY A  13
GLY A  15
ILE A  39
ASP A  64
GLN A  22
NAI  A 500 (-3.4A)
NAI  A 500 ( 4.2A)
NAI  A 500 (-3.8A)
NAI  A 500 (-3.6A)
None
0.91A 1ri4A-4yacA:
6.9
1ri4A-4yacA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Acinetobacter
baumannii)
PF13561
(adh_short_C2)
5 GLY A  95
ILE A 117
ALA A  97
PHE A 126
SER A 125
NAD  A 300 (-3.7A)
None
None
None
None
1.21A 1ri4A-4zjuA:
5.1
1ri4A-4zjuA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
5 GLY A 656
GLY A 619
ILE A 671
ALA A 622
SER A 654
None
1.13A 1ri4A-5a55A:
undetectable
1ri4A-5a55A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
5 GLY A 162
GLY A 123
ILE A 160
ALA A 125
SER A 194
None
1.14A 1ri4A-5dz6A:
undetectable
1ri4A-5dz6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
5 GLY A 162
GLY A 123
ILE A 160
ALA A 125
SER A 194
None
1.12A 1ri4A-5dz7A:
undetectable
1ri4A-5dz7A:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE


(Homo sapiens)
PF03291
(Pox_MCEL)
10 LYS A 180
GLY A 205
GLY A 207
ILE A 228
ALA A 229
ASP A 261
SER A 262
GLN A 284
PHE A 285
TYR A 289
SAH  A 501 (-2.3A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.8A)
SAH  A 501 ( 4.2A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
None
SAH  A 501 (-4.0A)
0.52A 1ri4A-5e9jA:
31.7
1ri4A-5e9jA:
32.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE


(Homo sapiens)
PF03291
(Pox_MCEL)
10 LYS A 180
GLY A 205
GLY A 207
ILE A 228
ALA A 229
ASP A 261
SER A 262
GLN A 284
PHE A 285
TYR A 289
SAH  A 500 (-2.6A)
SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.7A)
SAH  A 500 ( 3.9A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.1A)
None
None
SAH  A 500 (-4.0A)
0.53A 1ri4A-5e9wA:
32.2
1ri4A-5e9wA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana)
PF00230
(MIP)
5 GLY A 194
SER A 201
TYR A 217
PHE A 191
SER A 192
None
1.15A 1ri4A-5i32A:
undetectable
1ri4A-5i32A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN


(Bacteroides
cellulosilyticus)
no annotation 5 GLY A 284
GLY A 289
ALA A 294
SER A 312
TYR A 311
None
1.02A 1ri4A-5jvkA:
undetectable
1ri4A-5jvkA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
5 GLY A 259
ILE A 247
ALA A 250
SER A 217
TYR A 218
None
1.15A 1ri4A-5kf7A:
undetectable
1ri4A-5kf7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Aggregatibacter
actinomycetemcomitans)
no annotation 5 GLY A 532
GLY A 535
ILE A 277
SER A 281
SER A 617
None
1.14A 1ri4A-5lj6A:
undetectable
1ri4A-5lj6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC


(Pseudomonas
protegens)
no annotation 5 GLY C 114
GLY C 216
ALA C 214
PHE C  95
SER C  91
None
1.15A 1ri4A-5mg5C:
undetectable
1ri4A-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT


(Xanthobacter
autotrophicus)
PF02538
(Hydantoinase_B)
5 GLY A 517
GLY A 464
ALA A 433
SER A 508
SER A 473
None
1.14A 1ri4A-5svcA:
undetectable
1ri4A-5svcA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uin FORMYLTRANSFERASE

(Salmonella
enterica)
PF00551
(Formyl_trans_N)
PF13637
(Ank_4)
5 LYS A 149
GLY A 304
ASP A 371
TYR A 372
PHE A  42
None
1.21A 1ri4A-5uinA:
undetectable
1ri4A-5uinA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5was HOMOSERINE KINASE

(Corynebacterium
glutamicum)
no annotation 5 GLY A 101
GLY A  99
ALA A  20
SER A 144
GLN A  96
PO4  A 401 (-4.0A)
PO4  A 401 ( 4.3A)
None
None
None
0.89A 1ri4A-5wasA:
undetectable
1ri4A-5wasA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wat HOMOSERINE KINASE

(Corynebacterium
glutamicum)
no annotation 5 GLY A 101
GLY A  99
ALA A  20
SER A 144
GLN A  96
PO4  A 401 (-3.9A)
PO4  A 402 (-3.4A)
PO4  A 403 ( 4.4A)
None
None
0.64A 1ri4A-5watA:
undetectable
1ri4A-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN


(SFTS
phlebovirus)
PF07243
(Phlebovirus_G1)
5 GLY C  76
GLY C  28
ILE C  55
GLN C  79
SER C 169
None
1.11A 1ri4A-5y10C:
undetectable
1ri4A-5y10C:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium)
no annotation 5 GLY A 209
GLY A 226
ILE A 184
SER A 187
TYR A 206
None
PMS  A 302 (-3.6A)
None
None
None
1.05A 1ri4A-5z6oA:
2.0
1ri4A-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum)
no annotation 5 GLY A 161
GLY A 122
ILE A 159
ALA A 124
SER A 192
None
1.17A 1ri4A-6apgA:
undetectable
1ri4A-6apgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE


(Micromonospora
echinospora)
no annotation 5 GLY A 244
GLY A 102
ILE A 229
ALA A 110
GLN A  93
None
1.10A 1ri4A-6cboA:
undetectable
1ri4A-6cboA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens)
no annotation 5 GLY A 275
ALA A 234
ASP A 281
GLN A  11
SER A  13
None
1.18A 1ri4A-6dd6A:
2.0
1ri4A-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9wga WHEAT GERM LECTIN

(Triticum
aestivum)
PF00187
(Chitin_bind_1)
5 GLY A 108
GLY A  90
ILE A  87
GLN A 106
SER A 105
None
0.99A 1ri4A-9wgaA:
undetectable
1ri4A-9wgaA:
20.88