SIMILAR PATTERNS OF AMINO ACIDS FOR 1RG9_C_SAMC685

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		4 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.73A 1rg9C-1a3xA:
undetectable		 1rg9C-1a3xA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		4 ALA A 174
ASP A 115
ILE A 116
ILE A 144
 None
 0.79A 1rg9C-1cvmA:
undetectable		 1rg9C-1cvmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 GLN M  80
ASP M  82
ILE M  83
ILE M 133
 None
 0.92A 1rg9C-1dwaM:
undetectable		 1rg9C-1dwaM:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.76A 1rg9C-1e6vB:
undetectable		 1rg9C-1e6vB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B2156
ASP B2074
ILE B2075
ILE B2082
 None
 0.86A 1rg9C-1e6yB:
undetectable		 1rg9C-1e6yB:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 ALA A  95
GLU A  66
ASP A  70
ILE A 183
 None
 0.88A 1rg9C-1eyyA:
undetectable		 1rg9C-1eyyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 ALA A  54
ASP A  61
ILE A  60
ILE A  63
 None
 0.89A 1rg9C-1g2pA:
undetectable		 1rg9C-1g2pA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		4 ALA A 123
ASP A 101
ILE A  99
ILE A 171
 None
 0.87A 1rg9C-1gz0A:
0.0		 1rg9C-1gz0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.92A 1rg9C-1hp1A:
0.0		 1rg9C-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 GLN A 127
ASP A 177
ILE A 181
ILE A 184
 None
 0.72A 1rg9C-1q5nA:
undetectable		 1rg9C-1q5nA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tsj CONSERVED
HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF06983
(3-dmu-9_3-mt) 		4 ALA A 130
ASP A   2
ILE A   3
ILE A  53
 None
 0.74A 1rg9C-1tsjA:
undetectable		 1rg9C-1tsjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.89A 1rg9C-1ty2A:
undetectable		 1rg9C-1ty2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.87A 1rg9C-1v59A:
undetectable		 1rg9C-1v59A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 ALA A 208
GLN A 216
ASP A  80
ASP A 123
 None
None
None
CA  A1237 ( 2.4A)
 0.90A 1rg9C-1v6mA:
undetectable		 1rg9C-1v6mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		4 ALA A  24
ASP A 450
ILE A 451
ILE A  14
 None
 0.80A 1rg9C-1w5dA:
undetectable		 1rg9C-1w5dA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		4 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.81A 1rg9C-1xocA:
undetectable		 1rg9C-1xocA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF16554
(OAM_dimer) 		4 ALA B 245
ASP B 159
ILE B 158
ILE B 113
 None
 0.90A 1rg9C-1xrsB:
undetectable		 1rg9C-1xrsB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 258
ASP A 241
ILE A 239
ILE A 263
 None
 0.90A 1rg9C-1ykwA:
undetectable		 1rg9C-1ykwA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE

(Klebsiella
aerogenes) 		PF00144
(Beta-lactamase) 		4 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.93A 1rg9C-1zkjA:
undetectable		 1rg9C-1zkjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.65A 1rg9C-2as9A:
undetectable		 1rg9C-2as9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		4 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.84A 1rg9C-2au3A:
undetectable		 1rg9C-2au3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.83A 1rg9C-2b0tA:
undetectable		 1rg9C-2b0tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE

(Thermotoga
maritima) 		PF00696
(AA_kinase) 		4 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.86A 1rg9C-2btyA:
undetectable		 1rg9C-2btyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 ALA A 579
ASP A 548
ILE A 549
ILE A 423
 None
 0.83A 1rg9C-2d0oA:
undetectable		 1rg9C-2d0oA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 ALA A 213
ASP A 178
ILE A 179
ILE A 171
 None
 0.92A 1rg9C-2e28A:
undetectable		 1rg9C-2e28A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		4 ALA A 208
ASP A 156
ILE A 157
ILE A 184
 None
 0.93A 1rg9C-2iy8A:
undetectable		 1rg9C-2iy8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.93A 1rg9C-2nq9A:
undetectable		 1rg9C-2nq9A:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.42A 1rg9C-2obvA:
57.3		 1rg9C-2obvA:
56.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 258
ASP A 241
ILE A 239
ILE A 263
 None
 0.90A 1rg9C-2qygA:
undetectable		 1rg9C-2qygA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4

(Caenorhabditis
elegans) 		no annotation 4 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.83A 1rg9C-2yv9A:
undetectable		 1rg9C-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.78A 1rg9C-2zsgA:
undetectable		 1rg9C-2zsgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 4 GLN A 497
ASP A 530
ILE A 529
ILE A 568
 None
 0.91A 1rg9C-3afbA:
undetectable		 1rg9C-3afbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 GLU A  47
ASP A 295
ILE A  49
ILE A 316
 None
 0.81A 1rg9C-3ay0A:
undetectable		 1rg9C-3ay0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.88A 1rg9C-3cwrA:
undetectable		 1rg9C-3cwrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		4 ALA A 272
ASP A 132
ASP A 127
ILE A 309
 None
 0.79A 1rg9C-3d02A:
undetectable		 1rg9C-3d02A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 ALA C 119
ASP C 154
ILE C 153
ILE C 147
 None
 0.89A 1rg9C-3degC:
undetectable		 1rg9C-3degC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 ALA A  96
ASP A  67
ILE A  66
ILE A  84
 None
SAM  A   1 (-2.7A)
None
SAM  A   1 (-3.9A)
 0.90A 1rg9C-3douA:
undetectable		 1rg9C-3douA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		4 ALA A 426
ASP A 467
ILE A 468
ILE A 336
 None
 0.90A 1rg9C-3drkA:
undetectable		 1rg9C-3drkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES

(Salmonella
enterica) 		PF01380
(SIS) 		4 GLN A  19
ASP A  14
ILE A  15
ILE A 101
 None
 0.88A 1rg9C-3fkjA:
undetectable		 1rg9C-3fkjA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 IMD  A 171 (-3.4A)
FE  A 164 ( 2.5A)
None
None
 0.88A 1rg9C-3fvbA:
undetectable		 1rg9C-3fvbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A 163 (-2.0A)
None
None
 0.88A 1rg9C-3gvyA:
undetectable		 1rg9C-3gvyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		4 ALA A 161
GLN A  26
ASP A  24
ASP A 172
 None
 0.92A 1rg9C-3hnrA:
undetectable		 1rg9C-3hnrA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6

(Saccharomyces
cerevisiae) 		PF01918
(Alba) 		4 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.90A 1rg9C-3iabA:
undetectable		 1rg9C-3iabA:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ALA A  42
GLU A  57
ASP A 122
LYS A 273
 None
 0.62A 1rg9C-3imlA:
54.0		 1rg9C-3imlA:
69.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 GLU A 332
ASP A 327
ILE A 328
ASP A 250
 None
 0.88A 1rg9C-3j1cA:
undetectable		 1rg9C-3j1cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 159
ASP B  77
ILE B  78
ILE B  85
 None
 0.86A 1rg9C-3m2rB:
undetectable		 1rg9C-3m2rB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 ALA A 413
ASP A 444
ILE A 445
ILE A 427
 None
 0.66A 1rg9C-3nm1A:
undetectable		 1rg9C-3nm1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		4 ALA B 240
ASP B 221
ILE B 246
ILE B 223
 None
 0.93A 1rg9C-3o1hB:
undetectable		 1rg9C-3o1hB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		4 GLU A   6
GLN A   7
ASP A 431
ILE A  60
 None
 0.77A 1rg9C-3oksA:
undetectable		 1rg9C-3oksA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyo HEMOPEXIN FOLD
PROTEIN CP4

(Vigna
unguiculata) 		PF00045
(Hemopexin) 		4 ALA A 185
ASP A 121
ILE A 173
ILE A 157
 None
 0.88A 1rg9C-3oyoA:
undetectable		 1rg9C-3oyoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ALA A 287
GLU A  59
ASP A 347
ILE A 269
 None
 0.78A 1rg9C-3snxA:
undetectable		 1rg9C-3snxA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ALA A  42
ASP A 121
LYS A 276
ILE A 309
 None
 0.58A 1rg9C-3so4A:
53.1		 1rg9C-3so4A:
50.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ALA A  42
GLU A  57
ASP A 121
LYS A 276
 None
 0.45A 1rg9C-3so4A:
53.1		 1rg9C-3so4A:
50.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 119
ASP A 113
ASP A 142
ILE A 145
 None
 0.69A 1rg9C-3sszA:
undetectable		 1rg9C-3sszA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  96
ASP A  90
ASP A 119
ILE A 122
 None
 0.69A 1rg9C-3stpA:
undetectable		 1rg9C-3stpA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.74A 1rg9C-3tbkA:
undetectable		 1rg9C-3tbkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.86A 1rg9C-3tv2A:
undetectable		 1rg9C-3tv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ALA A 354
GLN A 239
ILE A 199
ILE A 203
 None
 0.85A 1rg9C-3u3xA:
undetectable		 1rg9C-3u3xA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.67A 1rg9C-3ufaA:
undetectable		 1rg9C-3ufaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		4 ALA A 107
ASP A 115
ILE A 114
ILE A 120
 None
 0.90A 1rg9C-3vnkA:
undetectable		 1rg9C-3vnkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am2 BACTERIOFERRITIN

(Blastochloris
viridis) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A1161 ( 2.6A)
None
None
 0.87A 1rg9C-4am2A:
undetectable		 1rg9C-4am2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.84A 1rg9C-4atqA:
undetectable		 1rg9C-4atqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 135
GLU A  74
ASP A  84
ILE A  91
 None
CA  A1371 ( 4.5A)
None
None
 0.89A 1rg9C-4czpA:
undetectable		 1rg9C-4czpA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.86A 1rg9C-4dfeA:
undetectable		 1rg9C-4dfeA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.82A 1rg9C-4j5tA:
undetectable		 1rg9C-4j5tA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 ALA A  39
GLU A  54
GLN A 105
ASP A 124
LYS A 281
ILE A 314
 None
 0.57A 1rg9C-4le5A:
49.8		 1rg9C-4le5A:
40.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Rattus
norvegicus) 		PF00777
(Glyco_transf_29) 		4 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.64A 1rg9C-4mpsA:
undetectable		 1rg9C-4mpsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 105
ASP A  72
ILE A  73
ILE A  63
 None
 0.71A 1rg9C-4nhdA:
undetectable		 1rg9C-4nhdA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 ALA A  60
GLU A  75
GLN A 118
ILE A 122
ASP A 139
LYS A 297
ILE A 330
 None
 0.43A 1rg9C-4odjA:
56.0		 1rg9C-4odjA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2

(Mycolicibacterium
smegmatis) 		PF13452
(MaoC_dehydrat_N) 		4 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.89A 1rg9C-4rv2A:
undetectable		 1rg9C-4rv2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toc BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.92A 1rg9C-4tocA:
undetectable		 1rg9C-4tocA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.71A 1rg9C-4u9cA:
undetectable		 1rg9C-4u9cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 GLN A 111
ASP A 120
ILE A 119
ASP A  91
 None
 0.92A 1rg9C-4wt7A:
undetectable		 1rg9C-4wt7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		no annotation 4 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.87A 1rg9C-4yomA:
undetectable		 1rg9C-4yomA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.93A 1rg9C-4z0vA:
undetectable		 1rg9C-4z0vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 GLU A  58
ASP A  61
ILE A  60
ASP A 185
 None
MG  A2002 ( 4.0A)
None
None
 0.91A 1rg9C-4zu9A:
undetectable		 1rg9C-4zu9A:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.44A 1rg9C-5a1iA:
57.1		 1rg9C-5a1iA:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLU A 358
GLN A 361
ILE A 357
ILE A 384
 None
 0.93A 1rg9C-5boeA:
undetectable		 1rg9C-5boeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.86A 1rg9C-5cslA:
undetectable		 1rg9C-5cslA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		4 ALA A 204
ASP A 241
ILE A 242
ILE A 229
 None
 0.82A 1rg9C-5fifA:
undetectable		 1rg9C-5fifA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.78A 1rg9C-5giuA:
undetectable		 1rg9C-5giuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLU A 247
ILE A 249
ASP A 186
ILE A 206
 None
 0.84A 1rg9C-5gndA:
undetectable		 1rg9C-5gndA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.93A 1rg9C-5i7nA:
undetectable		 1rg9C-5i7nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES

(Corynebacterium
glutamicum) 		PF00933
(Glyco_hydro_3) 		4 ALA A  90
GLN A  86
ASP A 105
ILE A 100
 None
 0.91A 1rg9C-5iobA:
undetectable		 1rg9C-5iobA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus musculus) 		no annotation 4 ALA A 646
ASP A 623
ILE A 624
ILE A 667
 None
 0.77A 1rg9C-5iriA:
undetectable		 1rg9C-5iriA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Trichormus
variabilis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 GLU A 198
GLN A 263
ILE A 196
ILE A 249
 None
 0.91A 1rg9C-5kt0A:
undetectable		 1rg9C-5kt0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 ALA N 702
ASP N 677
ILE N 678
ILE N 638
 None
 0.90A 1rg9C-5mpdN:
undetectable		 1rg9C-5mpdN:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S2

(Mycolicibacterium
smegmatis) 		PF00318
(Ribosomal_S2) 		4 ALA V  84
GLU V  83
ILE V 217
ILE V 184
 None
 0.84A 1rg9C-5o5jV:
undetectable		 1rg9C-5o5jV:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 ALA A  41
GLU A  56
GLN A  99
ASP A 102
ILE A 103
ASP A 121
LYS A 274
ILE A 307
 None
 0.45A 1rg9C-5t8tA:
57.9		 1rg9C-5t8tA:
67.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ALA A 169
GLU A 120
ASP A 117
ILE A 119
ILE A 149
 None
 1.46A 1rg9C-5u5gA:
undetectable		 1rg9C-5u5gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 ALA Z 803
ASP Z 574
ILE Z 573
ILE Z 855
 None
MG  Z1202 (-2.3A)
None
None
 0.93A 1rg9C-5wtiZ:
undetectable		 1rg9C-5wtiZ:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 ALA A 166
ASP A 210
ILE A 209
ILE A 162
 None
 0.90A 1rg9C-5wugA:
undetectable		 1rg9C-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhz SH3
DOMAIN-CONTAINING
KINASE-BINDING
PROTEIN 1

(Mus musculus) 		no annotation 4 GLU A 136
ASP A 133
ILE A 135
ILE A 162
 None
 0.88A 1rg9C-5xhzA:
undetectable		 1rg9C-5xhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF04446
(Thg1)
PF14413
(Thg1C) 		4 ALA A  58
ASP A  68
ILE A  69
ILE A  70
 None
 0.85A 1rg9C-5xoxA:
undetectable		 1rg9C-5xoxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xx9 BACTERIOFERRITIN

(Streptomyces
coelicolor) 		no annotation 4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 201 (-2.2A)
None
None
 0.86A 1rg9C-5xx9A:
undetectable		 1rg9C-5xx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.89A 1rg9C-6apeA:
undetectable		 1rg9C-6apeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 4 ALA S 131
GLU S 125
ILE S 123
ILE S  83
 None
 0.88A 1rg9C-6criS:
undetectable		 1rg9C-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 4 ALA A 254
ASP A 199
ILE A 200
ILE A 142
 None
 0.82A 1rg9C-6d3uA:
undetectable		 1rg9C-6d3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 4 ALA L 130
GLU L 182
ASP L 118
ILE L 155
 None
 0.92A 1rg9C-6ehsL:
undetectable		 1rg9C-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gru ADP-SUGAR
PYROPHOSPHATASE

(Homo sapiens) 		no annotation 4 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.75A 1rg9C-6gruA:
undetectable		 1rg9C-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.11A 1rg9D-1c30A:
undetectable		 1rg9D-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.05A 1rg9D-1ddkA:
undetectable		 1rg9D-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.18A 1rg9D-1j5sA:
undetectable		 1rg9D-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.14A 1rg9D-1kcxA:
undetectable		 1rg9D-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 HIS A 244
PRO A 245
SER A 389
THR A 119
 CL  A 541 (-4.8A)
None
FAD  A 800 (-4.3A)
None
 1.22A 1rg9D-1knrA:
undetectable		 1rg9D-1knrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.14A 1rg9D-1lf9A:
undetectable		 1rg9D-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.04A 1rg9D-1ltzA:
undetectable		 1rg9D-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 HIS B 339
PRO B 337
THR B 556
ASP B 551
 None
 1.19A 1rg9D-1m2vB:
undetectable		 1rg9D-1m2vB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 HIS B 213
PRO B 214
SER B 381
THR B  97
 None
 1.13A 1rg9D-1n60B:
undetectable		 1rg9D-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 HIS A 339
PRO A 337
THR A 556
ASP A 551
 None
 1.22A 1rg9D-1pd1A:
undetectable		 1rg9D-1pd1A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
 None
 1.07A 1rg9D-1rajA:
undetectable		 1rg9D-1rajA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
 None
 1.10A 1rg9D-1rdrA:
undetectable		 1rg9D-1rdrA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		4 HIS A 212
PRO A 211
SER A 179
THR A 373
 None
 1.21A 1rg9D-1t3iA:
undetectable		 1rg9D-1t3iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyo NALP

(Neisseria
meningitidis) 		PF03797
(Autotransporter) 		4 ASP X1050
SER X 993
THR X1005
PHE X1003
 None
 1.06A 1rg9D-1uyoX:
undetectable		 1rg9D-1uyoX:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		4 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.05A 1rg9D-1vtkA:
undetectable		 1rg9D-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.19A 1rg9D-1xngA:
undetectable		 1rg9D-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 HIS A 422
PRO A 389
PHE A 460
ASP A 215
 None
 1.03A 1rg9D-1xr5A:
undetectable		 1rg9D-1xr5A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  14
PRO A  15
ASP A 163
LYS A 165
SER A 186
THR A 227
PHE A 230
ASP A 238
 None
 0.83A 1rg9D-1xrcA:
57.3		 1rg9D-1xrcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 HIS A  49
PRO A  48
ASP A  47
ASP A 142
 None
 1.08A 1rg9D-2gzbA:
undetectable		 1rg9D-2gzbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PRO A2797
THR A3072
PHE A3112
ASP A2981
 None
 1.22A 1rg9D-2h84A:
undetectable		 1rg9D-2h84A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 HIS 1 606
PRO 1 573
PHE 1 644
ASP 1 398
 None
 1.08A 1rg9D-2ijd1:
undetectable		 1rg9D-2ijd1:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3t FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 HIS A2506
PRO A2511
LYS A2500
SER A2463
 None
 0.83A 1rg9D-2k3tA:
undetectable		 1rg9D-2k3tA:
16.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.7A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.6A)
 0.32A 1rg9D-2obvA:
57.3		 1rg9D-2obvA:
56.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.19A 1rg9D-2pfrA:
undetectable		 1rg9D-2pfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.83A 1rg9D-2v28A:
undetectable		 1rg9D-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.13A 1rg9D-2vg2A:
undetectable		 1rg9D-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 HIS A 266
ASP A 221
THR A 260
PHE A 262
 MES  A 504 (-4.0A)
None
None
None
 1.14A 1rg9D-2zm2A:
undetectable		 1rg9D-2zm2A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 HIS A 439
PRO A 481
ASP A 438
LYS A 436
 None
 0.99A 1rg9D-3d45A:
undetectable		 1rg9D-3d45A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feg CHOLINE/ETHANOLAMINE
KINASE

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.33A 1rg9D-3fegA:
undetectable		 1rg9D-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		4 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 FE  A 401 (-3.3A)
None
None
FE  A 401 (-2.1A)
 1.21A 1rg9D-3hh8A:
undetectable		 1rg9D-3hh8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i86 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00877
(NLPC_P60) 		4 PRO A 171
THR A 235
PHE A 196
ASP A 176
 None
 1.10A 1rg9D-3i86A:
undetectable		 1rg9D-3i86A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 HIS A 225
ASP A 228
LYS A 224
ASP A 191
 None
 1.06A 1rg9D-3ij6A:
undetectable		 1rg9D-3ij6A:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  16
PRO A  17
ASP A 167
LYS A 169
SER A 190
THR A 231
PHE A 234
 None
 0.72A 1rg9D-3imlA:
18.3		 1rg9D-3imlA:
69.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  16
PRO A  17
LYS A 169
SER A 190
THR A 231
ASP A 242
 None
 1.10A 1rg9D-3imlA:
18.3		 1rg9D-3imlA:
69.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		4 ASP A 201
LYS A 168
THR A  80
ASP A 240
 FE  A 334 ( 3.2A)
UNL  A 337 ( 2.9A)
UNL  A 337 ( 3.8A)
FE  A 333 (-2.5A)
 1.12A 1rg9D-3ktcA:
undetectable		 1rg9D-3ktcA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.08A 1rg9D-3lscA:
undetectable		 1rg9D-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.14A 1rg9D-3n6nA:
undetectable		 1rg9D-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.20A 1rg9D-3pbiA:
undetectable		 1rg9D-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyg CO-TYPE NITRILE
HYDRATASE BETA
SUBUNIT

(Pseudomonas
putida) 		PF02211
(NHase_beta) 		4 HIS B 147
PRO B 171
ASP B 172
THR B 154
 None
 1.20A 1rg9D-3qygB:
undetectable		 1rg9D-3qygB:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  17
PRO A  18
ASP A 179
LYS A 181
SER A 202
PHE A 251
 None
 0.35A 1rg9D-3rv2A:
50.2		 1rg9D-3rv2A:
59.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  17
PRO A  18
ASP A 179
SER A 202
THR A 248
PHE A 251
 None
 0.65A 1rg9D-3rv2A:
50.2		 1rg9D-3rv2A:
59.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  17
PRO A  18
ASP A 179
THR A 248
PHE A 251
ASP A 259
 None
None
None
None
None
CA  A 404 (-3.4A)
 1.00A 1rg9D-3rv2A:
50.2		 1rg9D-3rv2A:
59.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.12A 1rg9D-3rxzA:
undetectable		 1rg9D-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbc PEROXIREDOXIN TSA1

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PRO A   9
THR A  73
PHE A  38
ASP A 110
 None
 0.89A 1rg9D-3sbcA:
undetectable		 1rg9D-3sbcA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  16
PRO A  17
ASP A 166
LYS A 168
SER A 193
PHE A 237
ASP A 245
 None
None
None
ACT  A 400 ( 4.9A)
None
None
None
 0.54A 1rg9D-3so4A:
53.2		 1rg9D-3so4A:
50.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 HIS A 143
ASP A 161
PHE A 217
ASP A 221
 None
 0.90A 1rg9D-3v8uA:
undetectable		 1rg9D-3v8uA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		4 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.20A 1rg9D-4ag6A:
undetectable		 1rg9D-4ag6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 ASP A  99
SER A 251
PHE A 209
ASP A 244
 None
 1.09A 1rg9D-4c9mA:
undetectable		 1rg9D-4c9mA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		4 HIS A 304
ASP A 342
SER A 335
THR A 252
 None
 1.20A 1rg9D-4da5A:
undetectable		 1rg9D-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.12A 1rg9D-4e1oA:
undetectable		 1rg9D-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fh8 ACEPRX-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.86A 1rg9D-4fh8A:
undetectable		 1rg9D-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.13A 1rg9D-4hjwA:
undetectable		 1rg9D-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.36A 1rg9D-4hpvA:
27.4		 1rg9D-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.87A 1rg9D-4hpvA:
27.4		 1rg9D-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		4 HIS A 224
ASP A 265
PHE A 172
ASP A 291
 None
None
None
ZN  A 401 (-3.0A)
 0.95A 1rg9D-4igmA:
undetectable		 1rg9D-4igmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 132
ASP A 162
SER A 157
THR A 111
 None
 1.14A 1rg9D-4k9qA:
undetectable		 1rg9D-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA) 		4 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.82A 1rg9D-4kw6A:
undetectable		 1rg9D-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.85A 1rg9D-4l4qA:
27.9		 1rg9D-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.39A 1rg9D-4l4qA:
27.9		 1rg9D-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.20A 1rg9D-4lanA:
undetectable		 1rg9D-4lanA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  13
PRO A  14
ASP A 168
LYS A 170
SER A 197
ASP A 250
 None
 0.67A 1rg9D-4le5A:
49.7		 1rg9D-4le5A:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  13
PRO A  14
ASP A 168
SER A 197
THR A 239
ASP A 250
 None
 0.88A 1rg9D-4le5A:
49.7		 1rg9D-4le5A:
40.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me9 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF00440
(TetR_N)
PF16295
(TetR_C_10) 		4 LYS A 116
SER A 115
PHE A  56
ASP A 107
 None
 1.17A 1rg9D-4me9A:
undetectable		 1rg9D-4me9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 4 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.09A 1rg9D-4mkiB:
undetectable		 1rg9D-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 HIS A 425
PRO A 393
PHE A 459
ASP A 215
 None
 1.10A 1rg9D-4nz0A:
undetectable		 1rg9D-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		4 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.10A 1rg9D-4nz6A:
undetectable		 1rg9D-4nz6A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  34
PRO A  35
ASP A 187
LYS A 189
SER A 214
PHE A 258
ASP A 266
 SAM  A 500 ( 3.8A)
SAM  A 500 (-4.3A)
SAM  A 500 (-2.8A)
3PO  A 501 ( 2.7A)
SAM  A 500 ( 4.0A)
SAM  A 500 (-3.5A)
SAM  A 500 (-3.3A)
 0.32A 1rg9D-4odjA:
56.0		 1rg9D-4odjA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		4 PRO A 300
THR A 261
PHE A 165
ASP A 168
 None
 1.20A 1rg9D-4opmA:
undetectable		 1rg9D-4opmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 PRO A 170
SER A 235
THR A  39
PHE A 145
 G3P  A 407 (-4.2A)
None
None
None
 1.22A 1rg9D-4pfbA:
undetectable		 1rg9D-4pfbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		4 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 1.00A 1rg9D-4q3rA:
undetectable		 1rg9D-4q3rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo6 ADENYLATE
CYCLASE-LIKE PROTEIN

(Chlamydia
trachomatis) 		PF04972
(BON) 		4 ASP A 568
SER A 613
PHE A 614
ASP A 564
 None
 1.12A 1rg9D-4qo6A:
3.5		 1rg9D-4qo6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		4 PRO A 163
ASP A 193
THR A 259
ASP A 219
 None
 1.11A 1rg9D-4qrjA:
undetectable		 1rg9D-4qrjA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 HIS A 180
PRO A 201
LYS A 172
THR A 394
 None
 1.08A 1rg9D-4r40A:
undetectable		 1rg9D-4r40A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rft COAT PROTEIN

(Redspotted
grouper nervous
necrosis virus) 		no annotation 4 SER A 211
THR A 169
PHE A  99
ASP A  54
 None
 1.17A 1rg9D-4rftA:
undetectable		 1rg9D-4rftA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 1rg9D-4s17A:
undetectable		 1rg9D-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN

(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		PF12317
(IFT46_B_C)
no annotation 		4 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1rg9D-4uzzA:
undetectable		 1rg9D-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.09A 1rg9D-4wb0A:
undetectable		 1rg9D-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		4 HIS A 220
ASP A 218
PHE A 336
ASP A 271
 None
 0.85A 1rg9D-4xdtA:
undetectable		 1rg9D-4xdtA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.11A 1rg9D-4zpdA:
undetectable		 1rg9D-4zpdA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.30A 1rg9D-5a1iA:
57.2		 1rg9D-5a1iA:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1

(Bacillus phage
SPP1) 		PF06199
(Phage_tail_2) 		4 ASP H 105
SER H 154
THR H  22
ASP H  95
 None
 1.03A 1rg9D-5a20H:
undetectable		 1rg9D-5a20H:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		4 HIS A  22
ASP A  10
SER A  19
PHE A  12
 None
 1.10A 1rg9D-5cz3A:
undetectable		 1rg9D-5cz3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156

(uncultured
organism) 		no annotation 4 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.15A 1rg9D-5d8mA:
undetectable		 1rg9D-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 HIS A  64
PRO A  65
SER A 490
THR A 494
 GOL  A 602 (-4.2A)
GOL  A 602 ( 4.7A)
None
None
 1.08A 1rg9D-5ddsA:
undetectable		 1rg9D-5ddsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ept PEROXIREDOXIN TSA2

(Saccharomyces
cerevisiae) 		no annotation 4 PRO H  10
THR H  74
PHE H  39
ASP H 111
 None
 1.14A 1rg9D-5eptH:
undetectable		 1rg9D-5eptH:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fll 6-CARBOXYHEXANOATE-C
OA LIGASE

(Bacillus
subtilis) 		PF03744
(BioW) 		4 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.11A 1rg9D-5fllA:
undetectable		 1rg9D-5fllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftg CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 HIS A 304
ASP A 342
SER A 335
THR A 252
ASP A 306
 None
None
None
None
EDO  A1466 ( 3.0A)
 1.38A 1rg9D-5ftgA:
undetectable		 1rg9D-5ftgA:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 6 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
 None
 0.62A 1rg9D-5h9uC:
56.1		 1rg9D-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 5 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
 None
 1.25A 1rg9D-5h9uC:
56.1		 1rg9D-5h9uC:
59.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.17A 1rg9D-5jjuA:
undetectable		 1rg9D-5jjuA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ASP A 166
LYS A 168
SER A 191
PHE A 235
 None
 0.40A 1rg9D-5t8tA:
57.9		 1rg9D-5t8tA:
67.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  15
PRO A  16
ASP A 166
SER A 191
THR A 232
PHE A 235
 None
 0.71A 1rg9D-5t8tA:
57.9		 1rg9D-5t8tA:
67.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  15
PRO A  16
ASP A 166
THR A 232
PHE A 235
ASP A 243
 None
 1.02A 1rg9D-5t8tA:
57.9		 1rg9D-5t8tA:
67.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 4 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.01A 1rg9D-5txfA:
undetectable		 1rg9D-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4c THIOREDOXIN
REDUCTASE

(Cryptococcus
neoformans) 		no annotation 4 HIS A 278
THR A  74
PHE A  67
ASP A 316
 None
None
None
FAD  A 401 (-3.0A)
 1.11A 1rg9D-5w4cA:
undetectable		 1rg9D-5w4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 HIS A  20
LYS A  23
SER A  85
THR A 114
 None
 1.04A 1rg9D-5x9wA:
undetectable		 1rg9D-5x9wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 HIS A 419
PRO A 386
PHE A 457
ASP A 211
 None
 1.13A 1rg9D-5xe0A:
undetectable		 1rg9D-5xe0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		4 HIS A 326
ASP A  91
SER A 322
THR A 156
 None
 1.05A 1rg9D-5xoyA:
2.9		 1rg9D-5xoyA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 HIS A 392
ASP A 389
THR A 285
PHE A 333
 None
 1.13A 1rg9D-5yimA:
undetectable		 1rg9D-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN

(Heartland virus) 		no annotation 4 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1rg9D-5yowA:
undetectable		 1rg9D-5yowA:
20.61