SIMILAR PATTERNS OF AMINO ACIDS FOR 1RG9_B_SAMB485_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.11A 1rg9B-1c30A:
undetectable		 1rg9B-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.05A 1rg9B-1ddkA:
undetectable		 1rg9B-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		4 PRO A 194
ASP A 196
PHE A 233
ASP A 200
 None
 1.17A 1rg9B-1iipA:
undetectable		 1rg9B-1iipA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.20A 1rg9B-1j5sA:
undetectable		 1rg9B-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.16A 1rg9B-1kcxA:
undetectable		 1rg9B-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 HIS A 244
PRO A 245
SER A 389
THR A 119
 CL  A 541 (-4.8A)
None
FAD  A 800 (-4.3A)
None
 1.21A 1rg9B-1knrA:
undetectable		 1rg9B-1knrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.12A 1rg9B-1lf9A:
undetectable		 1rg9B-1lf9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.03A 1rg9B-1ltzA:
undetectable		 1rg9B-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 HIS B 339
PRO B 337
THR B 556
ASP B 551
 None
 1.19A 1rg9B-1m2vB:
undetectable		 1rg9B-1m2vB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 HIS B 213
PRO B 214
SER B 381
THR B  97
 None
 1.14A 1rg9B-1n60B:
undetectable		 1rg9B-1n60B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
 None
 1.09A 1rg9B-1rajA:
undetectable		 1rg9B-1rajA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
 None
 1.11A 1rg9B-1rdrA:
undetectable		 1rg9B-1rdrA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyo NALP

(Neisseria
meningitidis) 		PF03797
(Autotransporter) 		4 ASP X1050
SER X 993
THR X1005
PHE X1003
 None
 1.06A 1rg9B-1uyoX:
undetectable		 1rg9B-1uyoX:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		4 HIS A 164
PRO A 165
THR A 350
ASP A 136
 None
 1.05A 1rg9B-1vtkA:
undetectable		 1rg9B-1vtkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.17A 1rg9B-1xngA:
undetectable		 1rg9B-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 HIS A 422
PRO A 389
PHE A 460
ASP A 215
 None
 1.04A 1rg9B-1xr5A:
undetectable		 1rg9B-1xr5A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  14
PRO A  15
ASP A 163
LYS A 165
SER A 186
THR A 227
PHE A 230
ASP A 238
 None
 0.83A 1rg9B-1xrcA:
57.3		 1rg9B-1xrcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 HIS A  49
PRO A  48
ASP A  47
ASP A 142
 None
 1.08A 1rg9B-2gzbA:
undetectable		 1rg9B-2gzbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 HIS 1 606
PRO 1 573
PHE 1 644
ASP 1 398
 None
 1.09A 1rg9B-2ijd1:
undetectable		 1rg9B-2ijd1:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3t FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 HIS A2506
PRO A2511
LYS A2500
SER A2463
 None
 0.82A 1rg9B-2k3tA:
undetectable		 1rg9B-2k3tA:
16.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.7A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.6A)
 0.30A 1rg9B-2obvA:
57.4		 1rg9B-2obvA:
56.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.19A 1rg9B-2pfrA:
undetectable		 1rg9B-2pfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845

(Plasmodium
vivax) 		PF01633
(Choline_kinase) 		4 HIS A 294
ASP A 363
THR A 239
ASP A 296
 None
 1.21A 1rg9B-2qg7A:
undetectable		 1rg9B-2qg7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.82A 1rg9B-2v28A:
undetectable		 1rg9B-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.10A 1rg9B-2vg2A:
undetectable		 1rg9B-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 HIS A 266
ASP A 221
THR A 260
PHE A 262
 MES  A 504 (-4.0A)
None
None
None
 1.14A 1rg9B-2zm2A:
undetectable		 1rg9B-2zm2A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 HIS A 439
PRO A 481
ASP A 438
LYS A 436
 None
 0.95A 1rg9B-3d45A:
undetectable		 1rg9B-3d45A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feg CHOLINE/ETHANOLAMINE
KINASE

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 HIS A 240
ASP A 276
SER A 269
THR A 191
ASP A 242
 None
None
None
None
HC7  A   1 (-2.8A)
 1.33A 1rg9B-3fegA:
undetectable		 1rg9B-3fegA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i86 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00877
(NLPC_P60) 		4 PRO A 171
THR A 235
PHE A 196
ASP A 176
 None
 1.08A 1rg9B-3i86A:
undetectable		 1rg9B-3i86A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 HIS A 225
ASP A 228
LYS A 224
ASP A 191
 None
 1.06A 1rg9B-3ij6A:
undetectable		 1rg9B-3ij6A:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  16
PRO A  17
ASP A 167
LYS A 169
SER A 190
THR A 231
PHE A 234
 None
 0.70A 1rg9B-3imlA:
54.1		 1rg9B-3imlA:
69.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  16
PRO A  17
LYS A 169
SER A 190
THR A 231
ASP A 242
 None
 1.10A 1rg9B-3imlA:
54.1		 1rg9B-3imlA:
69.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		4 ASP A 201
LYS A 168
THR A  80
ASP A 240
 FE  A 334 ( 3.2A)
UNL  A 337 ( 2.9A)
UNL  A 337 ( 3.8A)
FE  A 333 (-2.5A)
 1.13A 1rg9B-3ktcA:
undetectable		 1rg9B-3ktcA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.10A 1rg9B-3lscA:
undetectable		 1rg9B-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.16A 1rg9B-3n6nA:
undetectable		 1rg9B-3n6nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.19A 1rg9B-3pbiA:
undetectable		 1rg9B-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyg CO-TYPE NITRILE
HYDRATASE BETA
SUBUNIT

(Pseudomonas
putida) 		PF02211
(NHase_beta) 		4 HIS B 147
PRO B 171
ASP B 172
THR B 154
 None
 1.18A 1rg9B-3qygB:
undetectable		 1rg9B-3qygB:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  17
PRO A  18
ASP A 179
LYS A 181
SER A 202
PHE A 251
 None
 0.35A 1rg9B-3rv2A:
50.2		 1rg9B-3rv2A:
59.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  17
PRO A  18
ASP A 179
SER A 202
THR A 248
PHE A 251
 None
 0.66A 1rg9B-3rv2A:
50.2		 1rg9B-3rv2A:
59.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  17
PRO A  18
ASP A 179
THR A 248
PHE A 251
ASP A 259
 None
None
None
None
None
CA  A 404 (-3.4A)
 1.00A 1rg9B-3rv2A:
50.2		 1rg9B-3rv2A:
59.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.13A 1rg9B-3rxzA:
undetectable		 1rg9B-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbc PEROXIREDOXIN TSA1

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PRO A   9
THR A  73
PHE A  38
ASP A 110
 None
 0.90A 1rg9B-3sbcA:
undetectable		 1rg9B-3sbcA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  16
PRO A  17
ASP A 166
LYS A 168
SER A 193
PHE A 237
ASP A 245
 None
None
None
ACT  A 400 ( 4.9A)
None
None
None
 0.53A 1rg9B-3so4A:
53.2		 1rg9B-3so4A:
50.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		4 HIS A 194
ASP A 230
THR A 143
ASP A 196
 None
 1.18A 1rg9B-3tdwA:
undetectable		 1rg9B-3tdwA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 HIS A 143
ASP A 161
PHE A 217
ASP A 221
 None
 0.90A 1rg9B-3v8uA:
undetectable		 1rg9B-3v8uA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LYS A  71
THR A  12
PHE A  45
ASP A  21
 None
 1.15A 1rg9B-3v98A:
undetectable		 1rg9B-3v98A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		4 PRO A 307
THR A 481
PHE A 448
ASP A 490
 None
 1.21A 1rg9B-4ag6A:
undetectable		 1rg9B-4ag6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 ASP A  99
SER A 251
PHE A 209
ASP A 244
 None
 1.08A 1rg9B-4c9mA:
undetectable		 1rg9B-4c9mA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 HIS A 304
ASP A 342
SER A 335
THR A 252
ASP A 306
 None
None
None
None
0H7  A 502 (-3.1A)
 1.35A 1rg9B-4da5A:
undetectable		 1rg9B-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.04A 1rg9B-4dmgA:
undetectable		 1rg9B-4dmgA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.13A 1rg9B-4e1oA:
undetectable		 1rg9B-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fh8 ACEPRX-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.86A 1rg9B-4fh8A:
undetectable		 1rg9B-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		4 HIS A 182
ASP A 216
THR A 134
ASP A 184
 None
 1.19A 1rg9B-4h05A:
undetectable		 1rg9B-4h05A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.15A 1rg9B-4hjwA:
undetectable		 1rg9B-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.83A 1rg9B-4hpvA:
27.4		 1rg9B-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		4 HIS A 224
ASP A 265
PHE A 172
ASP A 291
 None
None
None
ZN  A 401 (-3.0A)
 0.97A 1rg9B-4igmA:
undetectable		 1rg9B-4igmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 132
ASP A 162
SER A 157
THR A 111
 None
 1.14A 1rg9B-4k9qA:
undetectable		 1rg9B-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA) 		4 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.82A 1rg9B-4kw6A:
undetectable		 1rg9B-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.84A 1rg9B-4l4qA:
27.9		 1rg9B-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.42A 1rg9B-4l4qA:
27.9		 1rg9B-4l4qA:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  13
PRO A  14
ASP A 168
LYS A 170
SER A 197
ASP A 250
 None
 0.66A 1rg9B-4le5A:
49.8		 1rg9B-4le5A:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  13
PRO A  14
ASP A 168
SER A 197
THR A 239
ASP A 250
 None
 0.86A 1rg9B-4le5A:
49.8		 1rg9B-4le5A:
40.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me9 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF00440
(TetR_N)
PF16295
(TetR_C_10) 		4 LYS A 116
SER A 115
PHE A  56
ASP A 107
 None
 1.19A 1rg9B-4me9A:
undetectable		 1rg9B-4me9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 4 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.09A 1rg9B-4mkiB:
undetectable		 1rg9B-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 HIS A 425
PRO A 393
PHE A 459
ASP A 215
 None
 1.11A 1rg9B-4nz0A:
undetectable		 1rg9B-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		4 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.09A 1rg9B-4nz6A:
undetectable		 1rg9B-4nz6A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  34
PRO A  35
ASP A 187
LYS A 189
SER A 214
PHE A 258
ASP A 266
 SAM  A 500 ( 3.8A)
SAM  A 500 (-4.3A)
SAM  A 500 (-2.8A)
3PO  A 501 ( 2.7A)
SAM  A 500 ( 4.0A)
SAM  A 500 (-3.5A)
SAM  A 500 (-3.3A)
 0.32A 1rg9B-4odjA:
56.1		 1rg9B-4odjA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		4 PRO A 300
THR A 261
PHE A 165
ASP A 168
 None
 1.20A 1rg9B-4opmA:
undetectable		 1rg9B-4opmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo6 ADENYLATE
CYCLASE-LIKE PROTEIN

(Chlamydia
trachomatis) 		PF04972
(BON) 		4 ASP A 568
SER A 613
PHE A 614
ASP A 564
 None
 1.10A 1rg9B-4qo6A:
undetectable		 1rg9B-4qo6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		4 PRO A 163
ASP A 193
THR A 259
ASP A 219
 None
 1.11A 1rg9B-4qrjA:
undetectable		 1rg9B-4qrjA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 HIS A 180
PRO A 201
LYS A 172
THR A 394
 None
 1.08A 1rg9B-4r40A:
undetectable		 1rg9B-4r40A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rft COAT PROTEIN

(Redspotted
grouper nervous
necrosis virus) 		no annotation 4 SER A 211
THR A 169
PHE A  99
ASP A  54
 None
 1.18A 1rg9B-4rftA:
undetectable		 1rg9B-4rftA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.10A 1rg9B-4s17A:
undetectable		 1rg9B-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		4 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.21A 1rg9B-4uzjA:
undetectable		 1rg9B-4uzjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN

(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		PF12317
(IFT46_B_C)
no annotation 		4 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1rg9B-4uzzA:
undetectable		 1rg9B-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 HIS A 142
SER A 115
THR A 107
ASP A 221
 None
 1.13A 1rg9B-4wb0A:
undetectable		 1rg9B-4wb0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		4 HIS B 795
ASP B 792
SER B 598
THR B 625
 None
 1.21A 1rg9B-4wwxB:
undetectable		 1rg9B-4wwxB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		4 HIS A 220
ASP A 218
PHE A 336
ASP A 271
 None
 0.85A 1rg9B-4xdtA:
undetectable		 1rg9B-4xdtA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.13A 1rg9B-4zpdA:
undetectable		 1rg9B-4zpdA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.29A 1rg9B-5a1iA:
57.2		 1rg9B-5a1iA:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1

(Bacillus phage
SPP1) 		PF06199
(Phage_tail_2) 		4 ASP H 105
SER H 154
THR H  22
ASP H  95
 None
 1.08A 1rg9B-5a20H:
undetectable		 1rg9B-5a20H:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 HIS M 339
ASP M 221
SER M 337
THR M 318
 None
 1.14A 1rg9B-5a5tM:
undetectable		 1rg9B-5a5tM:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		4 HIS A  22
ASP A  10
SER A  19
PHE A  12
 None
 1.09A 1rg9B-5cz3A:
undetectable		 1rg9B-5cz3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156

(uncultured
organism) 		no annotation 4 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.15A 1rg9B-5d8mA:
undetectable		 1rg9B-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 HIS A  64
PRO A  65
SER A 490
THR A 494
 GOL  A 602 (-4.2A)
GOL  A 602 ( 4.7A)
None
None
 1.07A 1rg9B-5ddsA:
undetectable		 1rg9B-5ddsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ept PEROXIREDOXIN TSA2

(Saccharomyces
cerevisiae) 		no annotation 4 PRO H  10
THR H  74
PHE H  39
ASP H 111
 None
 1.15A 1rg9B-5eptH:
undetectable		 1rg9B-5eptH:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fll 6-CARBOXYHEXANOATE-C
OA LIGASE

(Bacillus
subtilis) 		PF03744
(BioW) 		4 HIS A 131
ASP A 129
THR A 239
ASP A 232
 None
 1.12A 1rg9B-5fllA:
undetectable		 1rg9B-5fllA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 6 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
 None
 0.63A 1rg9B-5h9uC:
56.1		 1rg9B-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 5 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
 None
 1.23A 1rg9B-5h9uC:
56.1		 1rg9B-5h9uC:
59.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.18A 1rg9B-5jjuA:
undetectable		 1rg9B-5jjuA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ASP A 166
LYS A 168
SER A 191
PHE A 235
 None
 0.46A 1rg9B-5t8tA:
58.0		 1rg9B-5t8tA:
67.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  15
PRO A  16
ASP A 166
SER A 191
THR A 232
PHE A 235
 None
 0.72A 1rg9B-5t8tA:
58.0		 1rg9B-5t8tA:
67.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  15
PRO A  16
ASP A 166
THR A 232
PHE A 235
ASP A 243
 None
 1.02A 1rg9B-5t8tA:
58.0		 1rg9B-5t8tA:
67.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 4 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.03A 1rg9B-5txfA:
undetectable		 1rg9B-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4c THIOREDOXIN
REDUCTASE

(Cryptococcus
neoformans) 		no annotation 4 HIS A 278
THR A  74
PHE A  67
ASP A 316
 None
None
None
FAD  A 401 (-3.0A)
 1.10A 1rg9B-5w4cA:
undetectable		 1rg9B-5w4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 HIS A  20
LYS A  23
SER A  85
THR A 114
 None
 1.03A 1rg9B-5x9wA:
undetectable		 1rg9B-5x9wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 HIS A 419
PRO A 386
PHE A 457
ASP A 211
 None
 1.14A 1rg9B-5xe0A:
undetectable		 1rg9B-5xe0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		4 HIS A 326
ASP A  91
SER A 322
THR A 156
 None
 1.04A 1rg9B-5xoyA:
undetectable		 1rg9B-5xoyA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 HIS A 392
ASP A 389
THR A 285
PHE A 333
 None
 1.14A 1rg9B-5yimA:
undetectable		 1rg9B-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN

(Heartland virus) 		no annotation 4 PRO A  99
SER A 123
THR A  83
ASP A  93
 None
 1.15A 1rg9B-5yowA:
undetectable		 1rg9B-5yowA:
20.61