SIMILAR PATTERNS OF AMINO ACIDS FOR 1RG7_A_MTXA161

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT

(Escherichia
virus RB69) 		PF02916
(DNA_PPF)
PF09116
(gp45-slide_C) 		5 ALA A  42
THR A  31
ILE A  21
LEU A  57
TYR A 216
 None
 1.04A 1rg7A-1b8hA:
undetectable		 1rg7A-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz3 DIHYDROFOLATE
REDUCTASE

(Thermotoga
maritima) 		PF00186
(DHFR_1) 		6 ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.58A 1rg7A-1cz3A:
19.6		 1rg7A-1cz3A:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		6 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.58A 1rg7A-1dr6A:
18.6		 1rg7A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		5 ALA A   9
THR A  56
SER A  59
ILE A  60
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
None
 0.87A 1rg7A-1dr6A:
18.6		 1rg7A-1dr6A:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 380
THR A 339
SER A 342
ILE A 343
LEU A 146
 None
 1.13A 1rg7A-1itzA:
undetectable		 1rg7A-1itzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		5 ALA A 122
ALA A 112
LEU A 239
SER A 106
ILE A 103
 None
 1.05A 1rg7A-1l5xA:
undetectable		 1rg7A-1l5xA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		5 ASP X 250
LEU X 253
THR X 240
ILE X 241
LEU X 302
 None
 1.07A 1rg7A-1pp1X:
undetectable		 1rg7A-1pp1X:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		5 ALA A 156
ASN A 243
THR A 269
ILE A 236
LEU A 320
 None
 1.13A 1rg7A-1t5oA:
2.1		 1rg7A-1t5oA:
17.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		7 ALA A   9
THR A  56
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.49A 1rg7A-1u70A:
18.5		 1rg7A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		6 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.50A 1rg7A-1u71A:
18.4		 1rg7A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		6 ALA A   9
THR A  56
SER A  59
ILE A  60
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
 0.78A 1rg7A-1u71A:
18.4		 1rg7A-1u71A:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LYS A 216
THR A 369
SER A 372
ILE A 373
LEU A 156
 None
 0.82A 1rg7A-1vdkA:
undetectable		 1rg7A-1vdkA:
16.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		6 ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 1.08A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		7 ALA A   7
ASP A  27
LEU A  28
LYS A  32
THR A  46
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.68A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		7 ALA A   7
ASP A  27
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.62A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 ALA X 144
LEU X 149
THR X 141
ILE X 181
LEU X 196
 None
 1.09A 1rg7A-2b5dX:
undetectable		 1rg7A-2b5dX:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		6 ALA A  15
ASP A  53
SER A 120
ILE A 121
LEU A 128
TYR A 179
 CP7  A1240 (-3.7A)
CP7  A1240 (-3.1A)
NDP  A1239 (-3.6A)
MES  A1241 ( 4.1A)
MES  A1241 (-4.5A)
None
 0.86A 1rg7A-2blbA:
18.4		 1rg7A-2blbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		6 ALA A  15
ASP A  53
SER A 120
LEU A 128
ARG A 131
TYR A 179
 CP7  A1240 (-3.7A)
CP7  A1240 (-3.1A)
NDP  A1239 (-3.6A)
MES  A1241 (-4.5A)
MES  A1241 (-2.7A)
None
 0.59A 1rg7A-2blbA:
18.4		 1rg7A-2blbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 ALA A 370
LEU A 355
SER A 326
ILE A 325
LEU A 448
 None
 1.11A 1rg7A-2glfA:
undetectable		 1rg7A-2glfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		7 ALA A  28
ASP A  48
THR A  80
ILE A  84
LEU A  91
ARG A  94
TYR A 160
 NAP  A 523 (-3.7A)
None
NAP  A 523 (-3.5A)
None
None
None
None
 0.65A 1rg7A-2h2qA:
17.9		 1rg7A-2h2qA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 ALA A  28
ASP A  48
THR A  80
SER A  83
ILE A  84
TYR A 160
 NAP  A 523 (-3.7A)
None
NAP  A 523 (-3.5A)
NAP  A 523 ( 4.4A)
None
None
 0.90A 1rg7A-2h2qA:
17.9		 1rg7A-2h2qA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh9 THIAMIN
PYROPHOSPHOKINASE

(Candida
albicans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 ASP A 233
THR A 207
SER A 210
ILE A 211
LEU A 270
 None
 0.99A 1rg7A-2hh9A:
undetectable		 1rg7A-2hh9A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE

(Homo sapiens) 		PF01923
(Cob_adeno_trans) 		5 ALA A 181
ALA A  99
LEU A 223
ILE A 117
LEU A 216
 None
 1.04A 1rg7A-2idxA:
undetectable		 1rg7A-2idxA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		5 ALA A 465
THR A 428
SER A 427
ILE A 472
LEU A 459
 None
 1.08A 1rg7A-2khoA:
undetectable		 1rg7A-2khoA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA

(Aspergillus
nidulans) 		PF01185
(Hydrophobin) 		5 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 0.99A 1rg7A-2lshA:
undetectable		 1rg7A-2lshA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvo PUTATIVE LIPOPROTEIN

(Microbispora
sp. ATCC
PTA-5024) 		PF10709
(DUF2511) 		5 ASN A  66
LEU A  52
THR A  79
ILE A  80
LEU A 137
 None
 1.01A 1rg7A-2mvoA:
undetectable		 1rg7A-2mvoA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		8 ALA A  11
ASP A  32
LEU A  33
THR A  58
ILE A  62
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
MTX  A 605 ( 4.6A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.55A 1rg7A-2oipA:
19.1		 1rg7A-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		8 ALA A  11
ASP A  32
LEU A  33
THR A  58
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
NDP  A 606 ( 3.5A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.66A 1rg7A-2oipA:
19.1		 1rg7A-2oipA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qk8 DIHYDROFOLATE
REDUCTASE

(Bacillus
anthracis) 		PF00186
(DHFR_1) 		7 ALA A   8
LEU A  29
LYS A  33
ILE A  51
LEU A  55
ARG A  58
TYR A 102
 MTX  A 200 ( 3.4A)
MTX  A 200 ( 4.3A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.2A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 2.8A)
None
 0.62A 1rg7A-2qk8A:
23.6		 1rg7A-2qk8A:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qk8 DIHYDROFOLATE
REDUCTASE

(Bacillus
anthracis) 		PF00186
(DHFR_1) 		6 ALA A   8
LEU A  29
LYS A  33
LEU A  55
ARG A  58
TYR A 102
 MTX  A 200 ( 3.4A)
MTX  A 200 ( 4.3A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 2.8A)
None
 1.35A 1rg7A-2qk8A:
23.6		 1rg7A-2qk8A:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		7 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.67A 1rg7A-2w3wA:
22.0		 1rg7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		7 ALA A  11
ASP A  31
THR A  50
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.77A 1rg7A-2w3wA:
22.0		 1rg7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 LYS A  36
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 1.08A 1rg7A-2w3wA:
22.0		 1rg7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		7 ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
TYR A  98
 TOP  A1160 ( 3.6A)
TOP  A1160 (-2.8A)
TOP  A1160 ( 4.6A)
None
None
None
None
 1.45A 1rg7A-2w9sA:
23.4		 1rg7A-2w9sA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		8 ALA A   7
ASP A  27
LEU A  28
LYS A  32
SER A  49
LEU A  54
ARG A  57
TYR A  98
 TOP  A1160 ( 3.6A)
TOP  A1160 (-2.8A)
TOP  A1160 ( 4.6A)
None
TOP  A1160 (-3.5A)
None
None
None
 0.75A 1rg7A-2w9sA:
23.4		 1rg7A-2w9sA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		9 ALA A   7
ASP A  27
LEU A  28
THR A  46
SER A  49
ILE A  50
LEU A  54
ARG A  57
TYR A  98
 TOP  A1160 ( 3.6A)
TOP  A1160 (-2.8A)
TOP  A1160 ( 4.6A)
NDP  A1159 (-3.3A)
TOP  A1160 (-3.5A)
TOP  A1160 (-4.4A)
None
None
None
 0.64A 1rg7A-2w9sA:
23.4		 1rg7A-2w9sA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN

(Escherichia
coli) 		PF09084
(NMT1) 		5 ALA A 219
ALA A 214
LEU A 230
ILE A  31
LEU A  49
 None
 1.10A 1rg7A-2x26A:
undetectable		 1rg7A-2x26A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ALA A 218
THR A 121
SER A 124
ILE A 125
LEU A 136
 DLL  A1441 ( 3.7A)
None
None
None
None
 0.90A 1rg7A-2y4oA:
undetectable		 1rg7A-2y4oA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 ALA A 251
THR A 139
SER A 142
ILE A 143
LEU A 216
 None
PLP  A1001 (-3.4A)
None
None
None
 1.13A 1rg7A-2z67A:
undetectable		 1rg7A-2z67A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		6 ALA A   6
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.44A 1rg7A-3dfrA:
22.4		 1rg7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		5 ALA A   6
ASP A  26
LEU A  27
THR A  45
SER A  48
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
 0.73A 1rg7A-3dfrA:
22.4		 1rg7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		7 ALA A  16
ASP A  54
SER A 111
ILE A 112
LEU A 119
ARG A 122
TYR A 170
 RJ6  A 609 (-3.7A)
RJ6  A 609 (-3.0A)
RJ6  A 609 ( 3.8A)
RJ6  A 609 (-4.8A)
RJ6  A 609 (-4.4A)
None
NDP  A 610 ( 4.9A)
 0.79A 1rg7A-3dg8A:
18.3		 1rg7A-3dg8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.13A 1rg7A-3h39A:
undetectable		 1rg7A-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 ALA A 190
ALA A 162
LEU A 183
ILE A 326
LEU A 271
 None
 1.13A 1rg7A-3i58A:
undetectable		 1rg7A-3i58A:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		9 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.71A 1rg7A-3i8aX:
23.4		 1rg7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		6 ALA X   7
ASP X  27
LYS X  32
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
 1.31A 1rg7A-3i8aX:
23.4		 1rg7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		9 ALA X   7
ASP X  27
LYS X  32
THR X  46
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.75A 1rg7A-3i8aX:
23.4		 1rg7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ia4 DIHYDROFOLATE
REDUCTASE

(Moritella
profunda) 		PF00186
(DHFR_1) 		6 ALA A   7
LYS A  33
THR A  47
SER A  50
ILE A  51
LEU A  55
 NDP  A 163 ( 3.9A)
MTX  A 164 (-3.2A)
NDP  A 163 (-3.4A)
NDP  A 163 ( 3.8A)
MTX  A 164 (-4.1A)
MTX  A 164 ( 4.4A)
 1.25A 1rg7A-3ia4A:
25.5		 1rg7A-3ia4A:
55.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ia4 DIHYDROFOLATE
REDUCTASE

(Moritella
profunda) 		PF00186
(DHFR_1) 		9 ALA A   8
LEU A  29
LYS A  33
THR A  47
SER A  50
ILE A  51
LEU A  55
ARG A  58
TYR A 102
 MTX  A 164 ( 3.7A)
MTX  A 164 (-4.0A)
MTX  A 164 (-3.2A)
NDP  A 163 (-3.4A)
NDP  A 163 ( 3.8A)
MTX  A 164 (-4.1A)
MTX  A 164 ( 4.4A)
MTX  A 164 (-2.9A)
None
 0.64A 1rg7A-3ia4A:
25.5		 1rg7A-3ia4A:
55.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix9 DIHYDROFOLATE
REDUCTASE

(Streptococcus
pneumoniae) 		PF00186
(DHFR_1) 		6 ALA A  10
LEU A  31
LYS A  35
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.80A 1rg7A-3ix9A:
22.8		 1rg7A-3ix9A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 ALA A 474
ALA A  94
LYS A  77
ILE A  25
LEU A  59
 None
 0.98A 1rg7A-3izkA:
undetectable		 1rg7A-3izkA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A 323
ALA A 301
LYS A 237
SER A 250
ILE A 249
 None
 1.02A 1rg7A-3k8zA:
undetectable		 1rg7A-3k8zA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		7 ALA A  16
ASP A  37
THR A  69
SER A  72
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.85A 1rg7A-3kjrA:
18.9		 1rg7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		7 ALA A  16
ASP A  37
THR A  69
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.73A 1rg7A-3kjrA:
18.9		 1rg7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 227
LEU A 216
THR A 232
ILE A 238
LEU A 240
 None
 0.95A 1rg7A-3ladA:
undetectable		 1rg7A-3ladA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8e STRESS-70 PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00012
(HSP70) 		5 ALA A 511
THR A 474
SER A 473
ILE A 518
LEU A 505
 None
 1.12A 1rg7A-3n8eA:
undetectable		 1rg7A-3n8eA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 ALA A 143
LEU A 148
THR A 140
ILE A 179
LEU A 209
 None
 1.09A 1rg7A-3n92A:
undetectable		 1rg7A-3n92A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz0 FACTOR H BINDING
PROTEIN

(Treponema
denticola) 		no annotation 5 ALA A  91
LEU A  42
THR A  81
SER A  82
LEU A  60
 None
 1.07A 1rg7A-3qz0A:
undetectable		 1rg7A-3qz0A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		6 ALA A  34
ASP A  54
THR A  86
LEU A  97
ARG A 100
TYR A 166
 WRA  A 602 (-3.9A)
WRA  A 602 (-2.9A)
NDP  A 601 ( 3.2A)
None
None
None
 0.46A 1rg7A-3rg9A:
17.8		 1rg7A-3rg9A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		5 ALA A  34
ASP A  54
THR A  86
SER A  89
TYR A 166
 WRA  A 602 (-3.9A)
WRA  A 602 (-2.9A)
NDP  A 601 ( 3.2A)
WRA  A 602 ( 4.2A)
None
 0.76A 1rg7A-3rg9A:
17.8		 1rg7A-3rg9A:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		6 ALA A   7
THR A  47
SER A  50
ILE A  51
LEU A  55
ARG A  58
 NDP  A1001 ( 4.1A)
NDP  A1001 (-3.1A)
NDP  A1001 ( 3.0A)
MTX  A2001 (-4.3A)
MTX  A2001 ( 4.5A)
MTX  A2001 (-2.8A)
 0.94A 1rg7A-3tq9A:
23.3		 1rg7A-3tq9A:
43.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		6 ALA A   8
ASP A  28
LEU A  29
LYS A  33
LEU A  55
ARG A  58
 MTX  A2001 ( 3.4A)
MTX  A2001 (-2.7A)
MTX  A2001 (-3.9A)
None
MTX  A2001 ( 4.5A)
MTX  A2001 (-2.8A)
 1.20A 1rg7A-3tq9A:
23.3		 1rg7A-3tq9A:
43.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		9 ALA A   8
ASP A  28
LEU A  29
LYS A  33
THR A  47
SER A  50
ILE A  51
LEU A  55
ARG A  58
 MTX  A2001 ( 3.4A)
MTX  A2001 (-2.7A)
MTX  A2001 (-3.9A)
None
NDP  A1001 (-3.1A)
NDP  A1001 ( 3.0A)
MTX  A2001 (-4.3A)
MTX  A2001 ( 4.5A)
MTX  A2001 (-2.8A)
 0.60A 1rg7A-3tq9A:
23.3		 1rg7A-3tq9A:
43.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 ASP A  54
THR A 108
ILE A 112
LEU A 119
ARG A 122
TYR A 170
 1CY  A 609 (-2.9A)
NDP  A 610 ( 3.4A)
1CY  A 609 (-4.4A)
None
None
None
 0.77A 1rg7A-3um6A:
18.6		 1rg7A-3um6A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 ASP A  54
THR A 108
SER A 111
ILE A 112
ARG A 122
TYR A 170
 1CY  A 609 (-2.9A)
NDP  A 610 ( 3.4A)
1CY  A 609 ( 4.4A)
1CY  A 609 (-4.4A)
None
None
 0.92A 1rg7A-3um6A:
18.6		 1rg7A-3um6A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		7 ALA A   8
ASP A  28
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 1.03A 1rg7A-3vcoA:
18.8		 1rg7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		8 ALA A   8
ASP A  28
THR A  53
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.77A 1rg7A-3vcoA:
18.8		 1rg7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 ALA A 732
LYS A 674
SER A 722
ILE A 723
LEU A 670
 None
 1.13A 1rg7A-3wfaA:
undetectable		 1rg7A-3wfaA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASN A 369
LEU A 392
SER A 361
ILE A 360
LEU A 405
 None
None
FAD  A3005 ( 4.6A)
FAD  A3005 (-3.8A)
None
 1.05A 1rg7A-3zyvA:
undetectable		 1rg7A-3zyvA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ALA A 122
ALA A 109
LEU A 415
ILE A 103
LEU A 173
 None
None
None
HEM  A1741 ( 3.9A)
None
 1.06A 1rg7A-4c51A:
undetectable		 1rg7A-4c51A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo0 ATTACHMENT PROTEIN
G3P

(Salmonella
virus IKe) 		no annotation 5 ALA A  51
THR A   7
SER A   5
ILE A   6
LEU A  62
 None
 1.01A 1rg7A-4eo0A:
undetectable		 1rg7A-4eo0A:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g8z DIHYDROFOLATE
REDUCTASE

(Pneumocystis
jirovecii) 		PF00186
(DHFR_1) 		7 ALA X  12
THR X  61
SER X  64
ILE X  65
LEU X  72
ARG X  75
TYR X 129
 NDP  X 302 ( 3.8A)
NDP  X 302 (-3.4A)
TOP  X 301 (-3.3A)
TOP  X 301 ( 4.3A)
None
None
None
 0.69A 1rg7A-4g8zX:
18.6		 1rg7A-4g8zX:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h96 DIHYDROFOLATE
REDUCTASE

(Candida
albicans) 		PF00186
(DHFR_1) 		8 ALA A  11
LYS A  37
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.84A 1rg7A-4h96A:
16.6		 1rg7A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h98 DIHYDROFOLATE
REDUCTASE

([Candida]
glabrata) 		PF00186
(DHFR_1) 		7 ALA A  11
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.63A 1rg7A-4h98A:
17.1		 1rg7A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7

(Clostridioides
difficile) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		5 ALA A 267
LEU A 281
SER A 256
ILE A 255
LEU A 213
 CL  A 403 ( 4.4A)
None
None
None
None
 1.06A 1rg7A-4hpeA:
undetectable		 1rg7A-4hpeA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		7 ALA A   7
ASP A  27
THR A  46
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
None
None
None
 0.67A 1rg7A-4m2xA:
20.7		 1rg7A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		5 ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.47A 1rg7A-4m7vA:
22.4		 1rg7A-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Toxoplasma
gondii) 		PF00215
(OMPdecase) 		5 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.86A 1rg7A-4mjzA:
undetectable		 1rg7A-4mjzA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		8 ALA A   7
ASP A  27
LYS A  32
THR A  46
SER A  49
ILE A  50
ARG A  57
TYR A 100
 MTX  A 201 ( 4.0A)
MTX  A 201 (-3.0A)
MTX  A 201 ( 3.9A)
NAP  A 202 (-3.2A)
MTX  A 201 ( 3.7A)
MTX  A 201 (-4.7A)
MTX  A 201 (-3.0A)
None
 0.65A 1rg7A-4p68A:
27.0		 1rg7A-4p68A:
97.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 272
ALA A 248
LEU A 215
SER A 253
ILE A 255
 None
 1.05A 1rg7A-4wv3A:
undetectable		 1rg7A-4wv3A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 272
ALA A 248
SER A 253
ILE A 255
LEU A 287
 None
 1.08A 1rg7A-4wv3A:
undetectable		 1rg7A-4wv3A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		5 ALA A 366
SER A 377
ILE A 376
LEU A 409
TYR A 198
 None
 0.96A 1rg7A-5ci5A:
undetectable		 1rg7A-5ci5A:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		6 ALA A   6
THR A  63
SER A  66
ILE A  67
LEU A  71
ARG A  74
 NAP  A 201 (-3.7A)
NAP  A 201 (-3.7A)
NAP  A 201 ( 4.9A)
PEG  A 202 ( 4.9A)
None
None
 0.99A 1rg7A-5dxvA:
16.8		 1rg7A-5dxvA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		7 ALA A   7
THR A  63
SER A  66
ILE A  67
LEU A  71
ARG A  74
TYR A 117
 NAP  A 201 (-3.7A)
NAP  A 201 (-3.7A)
NAP  A 201 ( 4.9A)
PEG  A 202 ( 4.9A)
None
None
None
 0.69A 1rg7A-5dxvA:
16.8		 1rg7A-5dxvA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		5 LEU A  45
ILE A  67
LEU A  71
ARG A  74
TYR A 117
 PEG  A 202 (-4.2A)
PEG  A 202 ( 4.9A)
None
None
None
 1.01A 1rg7A-5dxvA:
16.8		 1rg7A-5dxvA:
69.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 ALA A 223
LEU A 241
SER A 229
ILE A 228
LEU A 200
 None
 1.01A 1rg7A-5e31A:
undetectable		 1rg7A-5e31A:
13.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ecx DEHYDROFOLATE
REDUCTASE TYPE I

(Klebsiella
pneumoniae) 		PF00186
(DHFR_1) 		5 ALA A   7
THR A  46
SER A  49
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-3.2A)
5N1  A 202 (-3.6A)
5N1  A 202 ( 4.7A)
None
 1.04A 1rg7A-5ecxA:
21.9		 1rg7A-5ecxA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASN A 369
LEU A 392
SER A 361
ILE A 360
LEU A 405
 None
None
FAD  A3004 ( 3.7A)
FAD  A3004 ( 4.0A)
None
 1.02A 1rg7A-5epgA:
undetectable		 1rg7A-5epgA:
8.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fda DIHYDROFOLATE
REDUCTASE

(Yersinia pestis) 		PF00186
(DHFR_1) 		5 ALA A   7
THR A  47
SER A  50
ILE A  51
LEU A  55
 None
 1.13A 1rg7A-5fdaA:
19.9		 1rg7A-5fdaA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fda DIHYDROFOLATE
REDUCTASE

(Yersinia pestis) 		PF00186
(DHFR_1) 		6 ALA A   8
THR A  47
SER A  50
ILE A  51
LEU A  55
TYR A 101
 None
 0.70A 1rg7A-5fdaA:
19.9		 1rg7A-5fdaA:
80.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12) 		5 ALA A 785
LEU A 834
THR A 853
SER A 856
LEU A 846
 None
 1.09A 1rg7A-5ic9A:
undetectable		 1rg7A-5ic9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		7 ALA A  10
ASP A  31
THR A  83
SER A  86
LEU A  94
ARG A  97
TYR A 157
 73X  A 704 (-4.0A)
73X  A 704 (-2.8A)
NDP  A 702 (-3.2A)
NDP  A 702 (-3.8A)
None
None
None
 0.67A 1rg7A-5t0lA:
18.9		 1rg7A-5t0lA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 ALA A 271
THR A 558
SER A 559
ILE A 560
LEU A 526
 None
 1.13A 1rg7A-5vhaA:
undetectable		 1rg7A-5vhaA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 ALA A 145
LEU A 150
THR A 142
ILE A 181
LEU A 212
 None
 1.11A 1rg7A-5wu7A:
undetectable		 1rg7A-5wu7A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ALA A   8
ASP A  28
LEU A  29
LEU A  58
ARG A  61
 NAP  A 201 (-3.9A)
MMV  A 202 (-2.9A)
MMV  A 202 (-4.7A)
MMV  A 202 (-4.2A)
MMV  A 202 (-2.8A)
 0.89A 1rg7A-6cxmA:
19.5		 1rg7A-6cxmA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 6 ALA A   8
ASP A  28
LYS A  33
LEU A  58
ARG A  61
TYR A  98
 NAP  A 201 (-3.9A)
MMV  A 202 (-2.9A)
MMV  A 202 ( 4.6A)
MMV  A 202 (-4.2A)
MMV  A 202 (-2.8A)
None
 1.33A 1rg7A-6cxmA:
19.5		 1rg7A-6cxmA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 7 ALA A   8
ASP A  28
LYS A  33
THR A  47
LEU A  58
ARG A  61
TYR A  98
 NAP  A 201 (-3.9A)
MMV  A 202 (-2.9A)
MMV  A 202 ( 4.6A)
NAP  A 201 (-3.3A)
MMV  A 202 (-4.2A)
MMV  A 202 (-2.8A)
None
 0.50A 1rg7A-6cxmA:
19.5		 1rg7A-6cxmA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 6 ALA A   8
ASP A  28
LYS A  33
THR A  47
SER A  50
TYR A  98
 NAP  A 201 (-3.9A)
MMV  A 202 (-2.9A)
MMV  A 202 ( 4.6A)
NAP  A 201 (-3.3A)
NAP  A 201 ( 3.9A)
None
 0.72A 1rg7A-6cxmA:
19.5		 1rg7A-6cxmA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e4e -

(-) 		no annotation 8 ALA A   7
ASP A  27
LEU A  28
THR A  46
SER A  49
ILE A  50
LEU A  54
ARG A  57
 MMV  A 202 ( 3.5A)
MMV  A 202 (-2.9A)
MMV  A 202 (-4.2A)
NAP  A 201 ( 3.3A)
NAP  A 201 (-4.2A)
MMV  A 202 ( 4.9A)
None
None
 0.66A 1rg7A-6e4eA:
23.3		 1rg7A-6e4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 ALA A 116
ALA A 117
SER A 318
ILE A 319
LEU A  24
 None
 1.12A 1rg7A-6e85A:
undetectable		 1rg7A-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE

(Azotobacter
vinelandii) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ILE A 218
ILE A 251
THR A 115
 None
 0.60A 1rg7A-1a8pA:
2.9		 1rg7A-1a8pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 ILE A 715
ILE A 725
THR A 721
 None
 0.54A 1rg7A-1b0kA:
undetectable		 1rg7A-1b0kA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdo ALCOHOL
DEHYDROGENASE

(Gadus morhua) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ILE A  38
ILE A  36
THR A 146
 None
 0.47A 1rg7A-1cdoA:
undetectable		 1rg7A-1cdoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		3 ILE A 192
ILE A 163
THR A 217
 None
 0.62A 1rg7A-1dgmA:
1.4		 1rg7A-1dgmA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		3 ILE A 241
ILE A 270
THR A 266
 None
 0.50A 1rg7A-1ehyA:
undetectable		 1rg7A-1ehyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 ILE A 284
ILE A 274
THR A 270
 None
 0.55A 1rg7A-1em2A:
undetectable		 1rg7A-1em2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 ILE A 389
ILE A 405
THR A 401
 None
 0.62A 1rg7A-1em2A:
undetectable		 1rg7A-1em2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ILE A 508
ILE A 462
THR A 506
 None
 0.61A 1rg7A-1fepA:
undetectable		 1rg7A-1fepA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A

(Escherichia
coli) 		PF02253
(PLA1) 		3 ILE A  19
ILE A  18
THR A 124
 None
 0.47A 1rg7A-1fw3A:
undetectable		 1rg7A-1fw3A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ILE A 148
ILE A  74
THR A  70
 None
 0.64A 1rg7A-1gplA:
undetectable		 1rg7A-1gplA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 ILE A 169
ILE A 109
THR A 105
 None
 0.59A 1rg7A-1guqA:
undetectable		 1rg7A-1guqA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 ILE A 168
ILE A 212
THR A 216
 None
 0.54A 1rg7A-1hp1A:
undetectable		 1rg7A-1hp1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5k HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN K

(Homo sapiens) 		PF00013
(KH_1) 		3 ILE A  61
ILE A  20
THR A  16
 None
 0.63A 1rg7A-1j5kA:
undetectable		 1rg7A-1j5kA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ILE A  48
ILE A  46
THR A  35
 None
 0.48A 1rg7A-1j6uA:
3.3		 1rg7A-1j6uA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ja9 1,3,6,8-TETRAHYDROXY
NAPHTHALENE
REDUCTASE

(Magnaporthe
grisea) 		PF13561
(adh_short_C2) 		3 ILE A  45
ILE A 255
THR A  35
 None
 0.63A 1rg7A-1ja9A:
undetectable		 1rg7A-1ja9A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ja9 1,3,6,8-TETRAHYDROXY
NAPHTHALENE
REDUCTASE

(Magnaporthe
grisea) 		PF13561
(adh_short_C2) 		3 ILE A 160
ILE A 206
THR A 202
 None
 0.57A 1rg7A-1ja9A:
undetectable		 1rg7A-1ja9A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 ILE A 123
ILE A  64
THR A  68
 None
 0.53A 1rg7A-1jyeA:
2.0		 1rg7A-1jyeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0h GPFII

(Escherichia
virus Lambda) 		PF05354
(Phage_attach) 		3 ILE A  39
ILE A  29
THR A  25
 None
 0.60A 1rg7A-1k0hA:
undetectable		 1rg7A-1k0hA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ILE A 159
ILE A 175
THR A 157
 None
 0.60A 1rg7A-1kcwA:
undetectable		 1rg7A-1kcwA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ki9 ADENYLATE KINASE

(Methanothermococcus
thermolithotrophicus) 		PF13207
(AAA_17) 		3 ILE A 119
ILE A 173
THR A 169
 None
 0.60A 1rg7A-1ki9A:
2.4		 1rg7A-1ki9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		3 ILE A 205
ILE A 208
THR A 122
 None
 0.61A 1rg7A-1kskA:
undetectable		 1rg7A-1kskA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		3 ILE A  46
ILE A  70
THR A  19
 None
 0.57A 1rg7A-1ktnA:
undetectable		 1rg7A-1ktnA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		3 ILE A 140
ILE A 149
THR A 145
 None
None
CRM  A 501 (-4.0A)
 0.64A 1rg7A-1kzlA:
undetectable		 1rg7A-1kzlA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		3 ILE A 261
ILE A 227
THR A 223
 None
 0.63A 1rg7A-1lfwA:
undetectable		 1rg7A-1lfwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 ILE A 143
ILE A 119
THR A 187
 None
 0.57A 1rg7A-1moxA:
undetectable		 1rg7A-1moxA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt0 HEMOLYSIN SECRETION
ATP-BINDING PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran) 		3 ILE A 658
ILE A 500
THR A 656
 None
 0.60A 1rg7A-1mt0A:
undetectable		 1rg7A-1mt0A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 ILE A 293
ILE A 333
THR A 265
 None
 0.58A 1rg7A-1nhcA:
undetectable		 1rg7A-1nhcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nks ADENYLATE KINASE

(Sulfolobus
acidocaldarius) 		PF13207
(AAA_17) 		3 ILE A  90
ILE A   3
THR A   7
 None
 0.61A 1rg7A-1nksA:
2.3		 1rg7A-1nksA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00285
(Citrate_synt) 		3 ILE A 123
ILE A 124
THR A 100
 None
 0.64A 1rg7A-1o7xA:
undetectable		 1rg7A-1o7xA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		3 ILE A  99
ILE A 156
THR A 152
 None
NAP  A 800 (-4.1A)
None
 0.62A 1rg7A-1oaaA:
2.1		 1rg7A-1oaaA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocs SORTING NEXIN GRD19

(Saccharomyces
cerevisiae) 		PF00787
(PX) 		3 ILE A  38
ILE A  62
THR A  66
 None
 0.57A 1rg7A-1ocsA:
undetectable		 1rg7A-1ocsA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oni 14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN

(Homo sapiens) 		PF01042
(Ribonuc_L-PSP) 		3 ILE A  33
ILE A  31
THR A  79
 None
 0.65A 1rg7A-1oniA:
undetectable		 1rg7A-1oniA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ILE A 279
ILE A 303
THR A 299
 None
 0.56A 1rg7A-1ozhA:
undetectable		 1rg7A-1ozhA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3n HYPOTHETICAL PROTEIN
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 ILE A  32
ILE A   5
THR A  56
 None
 0.62A 1rg7A-1s3nA:
undetectable		 1rg7A-1s3nA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		3 ILE A 157
ILE A 155
THR A 193
 None
 0.59A 1rg7A-1ur4A:
undetectable		 1rg7A-1ur4A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ILE A 120
ILE A 114
THR A 123
 None
 0.43A 1rg7A-1v0zA:
undetectable		 1rg7A-1v0zA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjg PUTATIVE LIPASE FROM
THE G-D-S-L FAMILY

(Nostoc sp. PCC
7120) 		PF13472
(Lipase_GDSL_2) 		3 ILE A 100
ILE A 104
THR A  89
 None
 0.60A 1rg7A-1vjgA:
undetectable		 1rg7A-1vjgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ILE X 150
ILE X  76
THR X  72
 None
 0.62A 1rg7A-1w52X:
undetectable		 1rg7A-1w52X:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 ILE A 141
ILE A 174
THR A 170
 None
 0.60A 1rg7A-1w5fA:
undetectable		 1rg7A-1w5fA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ILE A 523
ILE A 610
THR A 348
 None
 0.63A 1rg7A-1w99A:
undetectable		 1rg7A-1w99A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ILE A 429
ILE A 410
THR A 414
 None
 0.62A 1rg7A-1w9xA:
undetectable		 1rg7A-1w9xA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 ILE A 428
ILE A 430
THR A 291
 None
 0.46A 1rg7A-1x3lA:
undetectable		 1rg7A-1x3lA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE B 204
ILE B 201
THR B 208
 None
 0.60A 1rg7A-1xv9B:
undetectable		 1rg7A-1xv9B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvs PROTEIN APAG

(Vibrio cholerae) 		PF04379
(DUF525) 		3 ILE A  34
ILE A  10
THR A  14
 None
 0.63A 1rg7A-1xvsA:
undetectable		 1rg7A-1xvsA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		3 ILE A  25
ILE A  70
THR A  74
 None
 0.56A 1rg7A-1yp4A:
undetectable		 1rg7A-1yp4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yub RRNA
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00398
(RrnaAD) 		3 ILE A  97
ILE A  36
THR A  32
 None
 0.55A 1rg7A-1yubA:
2.7		 1rg7A-1yubA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		3 ILE A   5
ILE A  96
THR A 115
 None
 0.11A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acg PROFILIN II

(Acanthamoeba
castellanii) 		PF00235
(Profilin) 		3 ILE A  97
ILE A  95
THR A  31
 None
 0.64A 1rg7A-2acgA:
undetectable		 1rg7A-2acgA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahd PHOSPHODIESTERASE
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 ILE A  32
ILE A   5
THR A  56
 None
 0.60A 1rg7A-2ahdA:
undetectable		 1rg7A-2ahdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		3 ILE A  36
ILE A  79
THR A  34
 None
 0.58A 1rg7A-2as9A:
undetectable		 1rg7A-2as9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8t THYMIDINE KINASE

(Ureaplasma
parvum) 		PF00265
(TK) 		3 ILE A 121
ILE A  14
THR A  18
 None
 0.59A 1rg7A-2b8tA:
undetectable		 1rg7A-2b8tA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b99 RIBOFLAVIN SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00885
(DMRL_synthase) 		3 ILE A   7
ILE A  34
THR A  38
 None
 0.62A 1rg7A-2b99A:
undetectable		 1rg7A-2b99A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		3 ILE A  13
ILE A 173
THR A 194
 CP7  A1240 (-4.1A)
CP7  A1240 ( 3.8A)
CP7  A1240 (-4.1A)
 0.31A 1rg7A-2blbA:
18.4		 1rg7A-2blbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		3 ILE A 195
ILE A 240
THR A 236
 None
 0.32A 1rg7A-2c07A:
1.9		 1rg7A-2c07A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cry KIN OF IRRE-LIKE
PROTEIN 3

(Homo sapiens) 		PF13927
(Ig_3) 		3 ILE A 106
ILE A  91
THR A 104
 None
 0.64A 1rg7A-2cryA:
undetectable		 1rg7A-2cryA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ILE A 429
ILE A 410
THR A 414
 None
 0.63A 1rg7A-2d3lA:
undetectable		 1rg7A-2d3lA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ILE A 441
ILE A 459
THR A 455
 None
 0.52A 1rg7A-2d5lA:
undetectable		 1rg7A-2d5lA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 ILE C 207
ILE C 204
THR C 211
 None
 0.64A 1rg7A-2d6fC:
undetectable		 1rg7A-2d6fC:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE

(Staphylococcus
aureus) 		PF02152
(FolB) 		3 ILE A 116
ILE A 114
THR A  94
 None
 0.61A 1rg7A-2dhnA:
undetectable		 1rg7A-2dhnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ILE A 295
ILE A 330
THR A 334
 None
 0.63A 1rg7A-2dphA:
3.0		 1rg7A-2dphA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 ILE A 136
ILE A  75
THR A  79
 None
 0.62A 1rg7A-2ebdA:
undetectable		 1rg7A-2ebdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		3 ILE A 137
ILE A 182
THR A 178
 None
 0.33A 1rg7A-2ewmA:
2.4		 1rg7A-2ewmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B

(Homo sapiens) 		PF00378
(ECH_1) 		3 ILE A 286
ILE A 297
THR A 301
 None
 0.59A 1rg7A-2fbmA:
undetectable		 1rg7A-2fbmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		3 ILE A 127
ILE A  53
THR A  31
 None
 0.60A 1rg7A-2fqzA:
undetectable		 1rg7A-2fqzA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvg ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		3 ILE A 299
ILE A 216
THR A 301
 None
 0.65A 1rg7A-2fvgA:
undetectable		 1rg7A-2fvgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2

(Homo sapiens) 		PF00378
(ECH_1) 		3 ILE A   6
ILE A  17
THR A  21
 None
 0.54A 1rg7A-2fw2A:
undetectable		 1rg7A-2fw2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g80 PROTEIN UTR4

(Saccharomyces
cerevisiae) 		no annotation 3 ILE A 184
ILE A 188
THR A 171
 None
 0.41A 1rg7A-2g80A:
undetectable		 1rg7A-2g80A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		3 ILE A 162
ILE A 201
THR A 197
 None
 0.61A 1rg7A-2ggtA:
undetectable		 1rg7A-2ggtA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		3 ILE A   7
ILE A  18
THR A  22
 None
 0.61A 1rg7A-2gtrA:
undetectable		 1rg7A-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvh AGR_L_2016P

(Agrobacterium
fabrum) 		PF03061
(4HBT) 		3 ILE A  20
ILE A  78
THR A  82
 None
 0.63A 1rg7A-2gvhA:
undetectable		 1rg7A-2gvhA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hn1 MAGNESIUM AND COBALT
TRANSPORTER

(Archaeoglobus
fulgidus) 		PF01544
(CorA) 		3 ILE A  31
ILE A  67
THR A  29
 None
 0.62A 1rg7A-2hn1A:
undetectable		 1rg7A-2hn1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		3 ILE A 223
ILE A 199
THR A 203
 None
None
ACT  A 602 ( 4.1A)
 0.65A 1rg7A-2horA:
undetectable		 1rg7A-2horA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		3 ILE A 233
ILE A 200
THR A 231
 None
 0.65A 1rg7A-2i7gA:
undetectable		 1rg7A-2i7gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iex DIHYDROXYNAPTHOIC
ACID SYNTHETASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		3 ILE A  61
ILE A  22
THR A  26
 None
 0.41A 1rg7A-2iexA:
undetectable		 1rg7A-2iexA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E

(Colletotrichum
lupini) 		PF00295
(Glyco_hydro_28) 		3 ILE A 285
ILE A 325
THR A 257
 None
 0.59A 1rg7A-2iq7A:
undetectable		 1rg7A-2iq7A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ly2 TUDOR
DOMAIN-CONTAINING
PROTEIN 7

(Mus musculus) 		PF12872
(OST-HTH) 		3 ILE A 422
ILE A 414
THR A 410
 None
 0.54A 1rg7A-2ly2A:
undetectable		 1rg7A-2ly2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1z LMO0427 PROTEIN

(Listeria
monocytogenes) 		PF02302
(PTS_IIB) 		3 ILE A  62
ILE A   5
THR A   9
 None
 0.53A 1rg7A-2m1zA:
undetectable		 1rg7A-2m1zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf2 MRNA INTERFERASE
MAZF

(Staphylococcus
aureus) 		PF02452
(PemK_toxin) 		3 ILE A  54
ILE A  91
THR A  52
 None
 0.65A 1rg7A-2mf2A:
undetectable		 1rg7A-2mf2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mr6 DE NOVO DESIGNED
PROTEIN OR462

(synthetic
construct) 		no annotation 3 ILE A  83
ILE A   5
THR A   9
 None
 0.64A 1rg7A-2mr6A:
undetectable		 1rg7A-2mr6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlv XISI PROTEIN-LIKE

(Trichormus
variabilis) 		PF08869
(XisI) 		3 ILE A  63
ILE A  68
THR A  36
 None
 0.59A 1rg7A-2nlvA:
undetectable		 1rg7A-2nlvA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ILE A 570
ILE A 566
THR A 618
 None
 0.49A 1rg7A-2nq5A:
undetectable		 1rg7A-2nq5A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		3 ILE A 154
ILE A 157
THR A 129
 None
 0.65A 1rg7A-2o04A:
undetectable		 1rg7A-2o04A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		3 ILE A  81
ILE A  77
THR A  88
 None
 0.61A 1rg7A-2oceA:
undetectable		 1rg7A-2oceA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		3 ILE A 168
ILE A 164
THR A 112
 None
 0.62A 1rg7A-2ocpA:
undetectable		 1rg7A-2ocpA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oys HYPOTHETICAL PROTEIN
SP1951

(Streptococcus
pneumoniae) 		PF03358
(FMN_red) 		3 ILE A   6
ILE A  36
THR A  40
 None
 0.50A 1rg7A-2oysA:
2.9		 1rg7A-2oysA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		3 ILE A  71
ILE A 158
THR A 162
 None
 0.41A 1rg7A-2ozeA:
2.8		 1rg7A-2ozeA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ILE A 257
ILE A 259
THR A  63
 None
 0.62A 1rg7A-2p1fA:
undetectable		 1rg7A-2p1fA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		3 ILE A 258
ILE A 186
THR A 261
 None
None
CL  A 800 ( 3.7A)
 0.64A 1rg7A-2p2vA:
undetectable		 1rg7A-2p2vA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9j HYPOTHETICAL PROTEIN
AQ2171

(Aquifex
aeolicus) 		PF08282
(Hydrolase_3) 		3 ILE A  13
ILE A  58
THR A  54
 None
 0.63A 1rg7A-2p9jA:
2.4		 1rg7A-2p9jA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paf LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 ILE A 123
ILE A  64
THR A  68
 None
 0.63A 1rg7A-2pafA:
undetectable		 1rg7A-2pafA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		3 ILE A 352
ILE A 353
THR A 372
 None
 0.64A 1rg7A-2pfvA:
undetectable		 1rg7A-2pfvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psb YERB PROTEIN

(Bacillus
subtilis) 		PF11258
(DUF3048)
PF17479
(DUF3048_C) 		3 ILE A  56
ILE A 297
THR A 293
 None
 0.60A 1rg7A-2psbA:
undetectable		 1rg7A-2psbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		3 ILE A 135
ILE A 180
THR A 176
 None
 0.37A 1rg7A-2q2vA:
undetectable		 1rg7A-2q2vA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		3 ILE A 116
ILE A  81
THR A 109
 None
 0.65A 1rg7A-2q7sA:
undetectable		 1rg7A-2q7sA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ILE A 446
ILE A 448
THR A 252
 None
JW5  A 482 ( 4.6A)
None
 0.61A 1rg7A-2qcmA:
undetectable		 1rg7A-2qcmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ILE A 218
ILE A 251
THR A 115
 None
 0.58A 1rg7A-2qdxA:
2.8		 1rg7A-2qdxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845

(Plasmodium
vivax) 		PF01633
(Choline_kinase) 		3 ILE A 123
ILE A 115
THR A 121
 None
 0.57A 1rg7A-2qg7A:
undetectable		 1rg7A-2qg7A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qki COMPLEMENT C3

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		3 ILE C1423
ILE C1380
THR C1421
 None
 0.39A 1rg7A-2qkiC:
undetectable		 1rg7A-2qkiC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		3 ILE A   8
ILE A  68
THR A  72
 None
 0.50A 1rg7A-2qm1A:
undetectable		 1rg7A-2qm1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		3 ILE A 298
ILE A 265
THR A 296
 None
 0.61A 1rg7A-2qm1A:
undetectable		 1rg7A-2qm1A:
21.53