SIMILAR PATTERNS OF AMINO ACIDS FOR 1RG2_A_SPMA999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 TRP A 590
ASN A 591
TRP A 605
VAL A 606
PRO A 607
 None
 0.32A 1rg2A-1jy1A:
66.3		 1rg2A-1jy1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Pseudomonas
putida) 		PF01323
(DSBA) 		4 ASN A 181
TRP A 179
VAL A 168
PRO A 169
 None
GSH  A 301 (-4.0A)
GSH  A 301 (-4.2A)
None
 1.31A 1rg2A-2imeA:
0.3		 1rg2A-2imeA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TRP A 337
ASN A 339
VAL A 321
PRO A 322
 None
 1.30A 1rg2A-5hjrA:
0.0		 1rg2A-5hjrA:
19.63