SIMILAR PATTERNS OF AMINO ACIDS FOR 1RG1_A_SPMA999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct8 LONG CHAIN
7C8 FAB FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP B 188
VAL B 211
PRO B 212
 None
 0.89A 1rg1A-1ct8B:
0.0		 1rg1A-1ct8B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fh5 MONOCLONAL ANTIBODY
MAK33

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP H 190
VAL H 213
PRO H 214
 None
 0.90A 1rg1A-1fh5H:
0.0		 1rg1A-1fh5H:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx6 MAJOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF09018
(Phage_Capsid_P3) 		3 TRP A 167
VAL A 168
PRO A 169
 None
 0.82A 1rg1A-1hx6A:
0.0		 1rg1A-1hx6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmt SPLICING FACTOR U2AF
35 KDA SUBUNIT
SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1)
no annotation 		3 TRP A 134
VAL B  94
PRO B  95
 None
 0.80A 1rg1A-1jmtA:
0.0		 1rg1A-1jmtA:
12.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		3 TRP A 605
VAL A 606
PRO A 607
 None
 0.22A 1rg1A-1jy1A:
66.1		 1rg1A-1jy1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 TRP A1112
VAL A 925
PRO A 924
 None
 0.82A 1rg1A-1k7yA:
undetectable		 1rg1A-1k7yA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lg7 VSV MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		3 TRP A 190
VAL A 221
PRO A 142
 None
 0.95A 1rg1A-1lg7A:
undetectable		 1rg1A-1lg7A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		3 TRP A1112
VAL A 925
PRO A 924
 None
 0.86A 1rg1A-1mskA:
undetectable		 1rg1A-1mskA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfu PROTEIN
(IMMUNOGLOBULIN
IGG1-KAPPA ANTIBODY
(HEAVY CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP H 188
VAL H 211
PRO H 212
 None
 0.78A 1rg1A-1qfuH:
undetectable		 1rg1A-1qfuH:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		3 TRP A 153
VAL A 154
PRO A 155
 None
 0.81A 1rg1A-1tdjA:
undetectable		 1rg1A-1tdjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1una GA UNASSEMBLED COAT
PROTEIN DIMER

(Escherichia
virus BZ13) 		PF01819
(Levi_coat) 		3 TRP A  32
VAL A  21
PRO A  22
 None
 0.95A 1rg1A-1unaA:
undetectable		 1rg1A-1unaA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		3 TRP A  44
VAL A  45
PRO A  46
 None
 0.78A 1rg1A-1vavA:
undetectable		 1rg1A-1vavA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		no annotation 3 TRP B   1
VAL B   1
PRO B   1
 None
None
PCA  B   1 ( 4.5A)
 0.88A 1rg1A-1ym0B:
undetectable		 1rg1A-1ym0B:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 TRP A 151
VAL A 184
PRO A 185
 None
 0.71A 1rg1A-2a2jA:
undetectable		 1rg1A-2a2jA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N) 		3 TRP A 227
VAL A 220
PRO A 221
 None
 0.62A 1rg1A-2b9sA:
undetectable		 1rg1A-2b9sA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		3 TRP A 199
VAL A  64
PRO A  65
 None
ODT  A1001 ( 4.4A)
None
 0.71A 1rg1A-2bacA:
undetectable		 1rg1A-2bacA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		3 TRP A  54
VAL A  68
PRO A  69
 None
 0.61A 1rg1A-2c2qA:
undetectable		 1rg1A-2c2qA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486

(Thermus
thermophilus) 		PF01894
(UPF0047) 		3 TRP A 125
VAL A  38
PRO A  39
 None
 0.85A 1rg1A-2cu5A:
undetectable		 1rg1A-2cu5A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13411
(MerR_1) 		3 TRP A  87
VAL A 130
PRO A 129
 None
 0.88A 1rg1A-2dg6A:
undetectable		 1rg1A-2dg6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga1 PROTEIN OF UNKNOWN
FUNCTION DUF433

(Trichormus
variabilis) 		PF04255
(DUF433) 		3 TRP A  54
VAL A  53
PRO A  52
 None
 0.95A 1rg1A-2ga1A:
undetectable		 1rg1A-2ga1A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		3 TRP A 496
VAL A 495
PRO A 494
 None
 0.95A 1rg1A-2jkmA:
undetectable		 1rg1A-2jkmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mta METHYLAMINE
DEHYDROGENASE (LIGHT
SUBUNIT)

(Paracoccus
denitrificans) 		PF02975
(Me-amine-dh_L) 		3 TRP L  13
VAL L  14
PRO L  15
 None
 0.37A 1rg1A-2mtaL:
undetectable		 1rg1A-2mtaL:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6j ZINC METALLOPROTEASE
ZMP1

(Clostridioides
difficile) 		PF07737
(ATLF) 		3 TRP A 110
VAL A  99
PRO A 100
 None
 0.87A 1rg1A-2n6jA:
undetectable		 1rg1A-2n6jA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		3 TRP A 540
VAL A 455
PRO A 456
 None
 0.65A 1rg1A-2pziA:
undetectable		 1rg1A-2pziA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Novosphingobium
aromaticivorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 402
VAL A 391
PRO A 390
 None
 0.82A 1rg1A-2qjjA:
1.7		 1rg1A-2qjjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13343
(SBP_bac_6) 		3 TRP A 112
VAL A 118
PRO A 119
 None
 0.84A 1rg1A-2qryA:
undetectable		 1rg1A-2qryA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 258
VAL A 290
PRO A 289
 None
 0.90A 1rg1A-2qt6A:
undetectable		 1rg1A-2qt6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		3 TRP A 449
VAL A  33
PRO A  34
 None
 0.96A 1rg1A-2vf8A:
undetectable		 1rg1A-2vf8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		3 TRP A 128
VAL A 127
PRO A 126
 None
 0.80A 1rg1A-2wa5A:
undetectable		 1rg1A-2wa5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 TRP A 465
VAL A 400
PRO A 401
 None
 0.82A 1rg1A-3b9eA:
undetectable		 1rg1A-3b9eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4r UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF06254
(YdaT_toxin) 		3 TRP A  15
VAL A  23
PRO A  24
 None
 0.98A 1rg1A-3c4rA:
undetectable		 1rg1A-3c4rA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdd PROPHAGE MUSO2, 43
KDA TAIL PROTEIN

(Shewanella
oneidensis) 		PF05954
(Phage_GPD) 		3 TRP A  78
VAL A  79
PRO A  80
 None
 0.52A 1rg1A-3cddA:
undetectable		 1rg1A-3cddA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		3 TRP A 191
VAL A 192
PRO A 193
 None
 0.57A 1rg1A-3d0qA:
undetectable		 1rg1A-3d0qA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 TRP A 442
VAL A 292
PRO A 293
 None
 0.84A 1rg1A-3d1jA:
undetectable		 1rg1A-3d1jA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 TRP A 146
VAL A 139
PRO A 140
 None
 1.00A 1rg1A-3dwbA:
undetectable		 1rg1A-3dwbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		3 TRP B 103
VAL B  77
PRO B  78
 None
 0.89A 1rg1A-3f8uB:
undetectable		 1rg1A-3f8uB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn1 NEDD8-CONJUGATING
ENZYME UBE2F

(Homo sapiens) 		PF00179
(UQ_con) 		3 TRP B 130
VAL B  94
PRO B  95
 None
 0.73A 1rg1A-3fn1B:
undetectable		 1rg1A-3fn1B:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gla LOW MOLECULAR WEIGHT
HEAT SHOCK PROTEIN

(Xanthomonas
citri) 		PF00011
(HSP20) 		3 TRP A  42
VAL A  43
PRO A  44
 None
 0.98A 1rg1A-3glaA:
undetectable		 1rg1A-3glaA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		3 TRP A 282
VAL A 283
PRO A 284
 None
 0.38A 1rg1A-3gzaA:
undetectable		 1rg1A-3gzaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hay SMALL NUCLEOLAR RNP
GAR1-LIKE PROTEIN

(Pyrococcus
furiosus) 		PF04410
(Gar1) 		3 TRP B  22
VAL B  23
PRO B  24
 None
 0.78A 1rg1A-3hayB:
undetectable		 1rg1A-3hayB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 127
VAL A 126
PRO A 125
 None
 1.00A 1rg1A-3i6eA:
undetectable		 1rg1A-3i6eA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE

(Mus musculus) 		PF00266
(Aminotran_5) 		3 TRP A 310
VAL A 213
PRO A 214
 None
 1.00A 1rg1A-3kgwA:
undetectable		 1rg1A-3kgwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 TRP A 103
VAL A 104
PRO A 105
 None
 0.75A 1rg1A-3khkA:
1.9		 1rg1A-3khkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		3 TRP A  14
VAL A  13
PRO A  12
 None
 0.85A 1rg1A-3m70A:
2.3		 1rg1A-3m70A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Mycobacterium
marinum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		3 TRP A 215
VAL A  89
PRO A  88
 None
 0.93A 1rg1A-3qdfA:
undetectable		 1rg1A-3qdfA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		3 TRP A 233
VAL A  33
PRO A  32
 None
 0.58A 1rg1A-3r3sA:
undetectable		 1rg1A-3r3sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5z PUTATIVE
UNCHARACTERIZED
PROTEIN

(Nocardia
farcinica) 		PF04075
(F420H2_quin_red) 		3 TRP A  80
VAL A  79
PRO A  78
 F42  A 201 (-4.4A)
F42  A 201 (-3.7A)
F42  A 201 (-4.4A)
 1.00A 1rg1A-3r5zA:
undetectable		 1rg1A-3r5zA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		3 TRP A 177
VAL A 201
PRO A 202
 None
 0.98A 1rg1A-3rjyA:
2.3		 1rg1A-3rjyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 TRP A 222
VAL A 223
PRO A 224
 None
5GP  A 951 ( 4.9A)
None
 0.77A 1rg1A-3rl3A:
undetectable		 1rg1A-3rl3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		3 TRP A 212
VAL A  86
PRO A  85
 None
None
EDO  A 268 (-4.8A)
 0.97A 1rg1A-3rr6A:
undetectable		 1rg1A-3rr6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 261
VAL A 293
PRO A 292
 None
 0.89A 1rg1A-3t6wA:
undetectable		 1rg1A-3t6wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 403
VAL A 392
PRO A 391
 None
 0.88A 1rg1A-3thuA:
1.9		 1rg1A-3thuA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		3 TRP A 365
VAL A 366
PRO A 367
 None
 1.00A 1rg1A-3tqgA:
undetectable		 1rg1A-3tqgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA

(Cellvibrio
japonicus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 402
VAL A 391
PRO A 390
 None
 0.85A 1rg1A-3v4bA:
2.1		 1rg1A-3v4bA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 403
VAL A 392
PRO A 391
 None
 0.86A 1rg1A-3vcnA:
undetectable		 1rg1A-3vcnA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		3 TRP A 129
VAL A 128
PRO A 127
 None
 1.00A 1rg1A-3w5fA:
undetectable		 1rg1A-3w5fA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 3 TRP A  44
VAL A  45
PRO A  46
 None
 0.68A 1rg1A-3wlaA:
undetectable		 1rg1A-3wlaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 3 TRP A  60
VAL A  61
PRO A  62
 None
 0.77A 1rg1A-3wweA:
undetectable		 1rg1A-3wweA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		3 TRP A 258
VAL A 198
PRO A 197
 None
 0.69A 1rg1A-4ag4A:
undetectable		 1rg1A-4ag4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 3 TRP A 537
VAL A 521
PRO A 522
 None
 0.68A 1rg1A-4b2nA:
undetectable		 1rg1A-4b2nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7l FILAMIN-B

(Homo sapiens) 		PF00307
(CH)
PF00630
(Filamin) 		3 TRP A 128
VAL A 127
PRO A 126
 None
 0.97A 1rg1A-4b7lA:
undetectable		 1rg1A-4b7lA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 404
VAL A 393
PRO A 392
 None
 0.80A 1rg1A-4e4fA:
1.4		 1rg1A-4e4fA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq2 INTERFERON GAMMA
RECEPTOR 1

(Gallus gallus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 TRP A 204
VAL A 205
PRO A 206
 None
 0.78A 1rg1A-4eq2A:
undetectable		 1rg1A-4eq2A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 TRP A 108
VAL A 107
PRO A 106
 None
 0.86A 1rg1A-4fffA:
undetectable		 1rg1A-4fffA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Caulobacter sp.
K31) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 403
VAL A 392
PRO A 391
 None
 0.86A 1rg1A-4fi4A:
undetectable		 1rg1A-4fi4A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		3 TRP A 321
VAL A 320
PRO A 319
 None
 0.88A 1rg1A-4g0bA:
undetectable		 1rg1A-4g0bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7o PUTATIVE SURFACE
CELL ANTIGEN SCA2

(Rickettsia
conorii) 		no annotation 3 TRP A  70
VAL A  76
PRO A  77
 None
GOL  A 502 (-3.7A)
None
 0.82A 1rg1A-4j7oA:
undetectable		 1rg1A-4j7oA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 405
VAL A 394
PRO A 393
 None
 0.80A 1rg1A-4kwsA:
undetectable		 1rg1A-4kwsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		3 TRP A 312
VAL A 313
PRO A 314
 None
 0.72A 1rg1A-4le6A:
undetectable		 1rg1A-4le6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		3 TRP X 285
VAL X  31
PRO X  32
 None
 0.85A 1rg1A-4n5iX:
undetectable		 1rg1A-4n5iX:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51

(Mus musculus) 		PF03281
(Mab-21) 		3 TRP A 248
VAL A 209
PRO A 180
 None
 0.88A 1rg1A-4oahA:
undetectable		 1rg1A-4oahA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		3 TRP A 230
VAL A 104
PRO A 103
 None
 0.95A 1rg1A-4pfzA:
undetectable		 1rg1A-4pfzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quv DELTA(14)-STEROL
REDUCTASE

(Methylomicrobium
alcaliphilum) 		PF01222
(ERG4_ERG24) 		3 TRP A 296
VAL A 295
PRO A 294
 None
 1.00A 1rg1A-4quvA:
undetectable		 1rg1A-4quvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE

(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		PF06722
(DUF1205) 		3 TRP A 267
VAL A 268
PRO A 269
 3R2  A 401 (-3.5A)
3R2  A 401 (-4.6A)
None
 0.73A 1rg1A-4rihA:
undetectable		 1rg1A-4rihA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 TRP A  25
VAL A  43
PRO A  44
 None
 0.70A 1rg1A-4v1yA:
2.2		 1rg1A-4v1yA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 3 TRP E  56
VAL E 426
PRO E 425
 None
 0.95A 1rg1A-4whbE:
undetectable		 1rg1A-4whbE:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		3 TRP A 129
VAL A 128
PRO A 127
 None
 0.99A 1rg1A-4xydA:
undetectable		 1rg1A-4xydA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		3 TRP A  72
VAL A  73
PRO A  74
 None
 0.39A 1rg1A-4yeuA:
undetectable		 1rg1A-4yeuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP A 211
VAL A 234
PRO A 235
 None
 0.97A 1rg1A-4yo0A:
undetectable		 1rg1A-4yo0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 TRP A 542
VAL A 621
PRO A 622
 None
 0.91A 1rg1A-5bp1A:
undetectable		 1rg1A-5bp1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		3 TRP A  33
VAL A  32
PRO A  31
 EDO  A1373 ( 3.9A)
None
None
 0.89A 1rg1A-5g4xA:
undetectable		 1rg1A-5g4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7n LOW MOLECULAR WEIGHT
HEAT SHOCK PROTEIN

(Xylella
fastidiosa) 		PF00011
(HSP20) 		3 TRP A  43
VAL A  44
PRO A  45
 None
 1.00A 1rg1A-5j7nA:
undetectable		 1rg1A-5j7nA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		3 TRP A 304
VAL A 241
PRO A 240
 None
 0.98A 1rg1A-5jozA:
undetectable		 1rg1A-5jozA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		3 TRP A 253
VAL A 254
PRO A 255
 None
SCN  A 621 ( 4.9A)
None
 0.27A 1rg1A-5k9hA:
undetectable		 1rg1A-5k9hA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjv HYDROXYCINNAMOYL
TRANSFERASE

(Plectranthus
scutellarioides) 		PF02458
(Transferase) 		3 TRP A 314
VAL A 313
PRO A 312
 None
 0.85A 1rg1A-5kjvA:
undetectable		 1rg1A-5kjvA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lda JAMM1
SAMP2

(Pyrococcus
furiosus) 		PF02597
(ThiS)
PF14464
(Prok-JAB) 		3 TRP A 108
VAL B  65
PRO B  64
 None
 0.76A 1rg1A-5ldaA:
undetectable		 1rg1A-5ldaA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 TRP A1937
VAL A1936
PRO A1935
 None
 0.94A 1rg1A-5m59A:
undetectable		 1rg1A-5m59A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 3 TRP A  73
VAL A  74
PRO A  75
 None
 0.98A 1rg1A-5oarA:
undetectable		 1rg1A-5oarA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 3 TRP A 227
VAL A 195
PRO A 196
 None
 0.65A 1rg1A-5oieA:
undetectable		 1rg1A-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL

(Homo sapiens) 		PF00830
(Ribosomal_L28) 		3 TRP X   9
VAL X   8
PRO X   7
 None
 0.97A 1rg1A-5oomX:
undetectable		 1rg1A-5oomX:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 3 TRP B 242
VAL B  31
PRO B  32
 None
 0.86A 1rg1A-5swiB:
undetectable		 1rg1A-5swiB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5win -

(-) 		no annotation 3 TRP A 737
VAL A 719
PRO A 720
 None
 0.78A 1rg1A-5winA:
undetectable		 1rg1A-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 3 TRP A  25
VAL A  26
PRO A  27
 None
 0.98A 1rg1A-5wm4A:
undetectable		 1rg1A-5wm4A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 TRP A  51
VAL A  52
PRO A  53
 None
 0.59A 1rg1A-5xevA:
undetectable		 1rg1A-5xevA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13

(Homo sapiens) 		PF06212
(GRIM-19) 		3 TRP W 116
VAL W 117
PRO W 118
 None
 0.69A 1rg1A-5xtcW:
undetectable		 1rg1A-5xtcW:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji 16KDA MEMBRANE
PROTEIN

(Zea mays) 		no annotation 3 TRP O  96
VAL O  91
PRO O  90
 None
 0.84A 1rg1A-5zjiO:
undetectable		 1rg1A-5zjiO:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 3 TRP B 604
VAL B 532
PRO B 533
 None
 0.93A 1rg1A-6b4jB:
undetectable		 1rg1A-6b4jB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 3 TRP B 755
VAL B 703
PRO B 702
 None
 0.87A 1rg1A-6bywB:
undetectable		 1rg1A-6bywB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13

(Mus musculus) 		no annotation 3 TRP Z 115
VAL Z 116
PRO Z 117
 None
 0.99A 1rg1A-6g72Z:
undetectable		 1rg1A-6g72Z:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 3 TRP A 173
VAL A 288
PRO A 289
 None
 0.73A 1rg1A-6gupA:
undetectable		 1rg1A-6gupA:
undetectable