SIMILAR PATTERNS OF AMINO ACIDS FOR 1RBP_A_RTLA183

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		5 LEU A   3
ALA A 128
ALA A 125
ALA A 129
LEU A 182
 None
 1.21A 1rbpA-1ajzA:
undetectable		 1rbpA-1ajzA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bm8 TRANSCRIPTION FACTOR
MBP1

(Saccharomyces
cerevisiae) 		PF04383
(KilA-N) 		5 LEU A  80
ALA A  43
ALA A  42
VAL A  34
LEU A  99
 None
 1.18A 1rbpA-1bm8A:
undetectable		 1rbpA-1bm8A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ALA A 461
PHE A 463
ALA A 446
ALA A 448
LEU A 662
 None
 1.12A 1rbpA-1cb8A:
1.5		 1rbpA-1cb8A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cns CHITINASE

(Hordeum vulgare) 		PF00182
(Glyco_hydro_19) 		5 LEU A 226
ALA A  39
ALA A  38
VAL A   6
LEU A  61
 None
 1.32A 1rbpA-1cnsA:
undetectable		 1rbpA-1cnsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 LEU A 142
ALA A 125
VAL A  80
MET A 122
HIS A 105
 None
 1.38A 1rbpA-1dy6A:
0.0		 1rbpA-1dy6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		5 ALA B2305
PHE B2386
ALA B2304
GLN C3239
HIS B2233
 None
 1.37A 1rbpA-1e6yB:
0.0		 1rbpA-1e6yB:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		12 LEU A  35
LEU A  37
ALA A  43
PHE A  45
ALA A  55
ALA A  57
VAL A  61
MET A  73
MET A  88
LEU A  97
GLN A  98
HIS A 104
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.5A)
RTL  A 176 ( 4.1A)
RTL  A 176 ( 4.8A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
 0.39A 1rbpA-1iiuA:
31.9		 1rbpA-1iiuA:
84.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 LEU A  35
LEU A  37
PHE A  77
MET A  73
LEU A  97
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.5A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
 1.30A 1rbpA-1iiuA:
31.9		 1rbpA-1iiuA:
84.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		5 LEU A 218
ALA A 110
ALA A 106
VAL A 160
LEU A  99
 None
 1.27A 1rbpA-1iw8A:
undetectable		 1rbpA-1iw8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		5 LEU A 304
ALA A 215
PHE A 219
ALA A 189
LEU A 198
 None
None
None
PLP  A 401 (-4.6A)
None
 1.29A 1rbpA-1j0aA:
0.0		 1rbpA-1j0aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 207
ALA A 212
ALA A 215
ALA A 211
VAL A 331
 ADP  A 635 (-4.9A)
None
None
None
ADP  A 635 (-3.7A)
 1.39A 1rbpA-1jedA:
0.0		 1rbpA-1jedA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 132
PHE A 403
ALA A 144
ALA A 140
VAL A 217
 None
 1.38A 1rbpA-1l6jA:
undetectable		 1rbpA-1l6jA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb1 MLU1-BOX BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF04383
(KilA-N) 		5 LEU A  80
ALA A  43
ALA A  42
VAL A  34
LEU A  99
 None
 1.16A 1rbpA-1mb1A:
undetectable		 1rbpA-1mb1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  67
ALA A 170
ALA A 172
VAL A  14
LEU A 128
 None
 1.29A 1rbpA-1mzjA:
undetectable		 1rbpA-1mzjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK

(Escherichia
coli) 		PF04107
(GCS2) 		5 LEU A 314
ALA A 167
ALA A 345
ALA A 166
LEU A 307
 None
 1.34A 1rbpA-1r8gA:
undetectable		 1rbpA-1r8gA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 ALA A 119
PHE A 120
ALA A  70
VAL A  13
LEU A  51
 None
 1.27A 1rbpA-1rtrA:
undetectable		 1rbpA-1rtrA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.) 		PF08787
(Alginate_lyase2) 		5 ALA A 116
PHE A 162
ALA A 192
VAL A  54
LEU A  13
 None
 1.33A 1rbpA-1uaiA:
undetectable		 1rbpA-1uaiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.) 		PF08787
(Alginate_lyase2) 		5 LEU A 216
PHE A 162
ALA A 192
VAL A  54
LEU A  13
 None
 1.38A 1rbpA-1uaiA:
undetectable		 1rbpA-1uaiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		5 LEU A 273
PHE A 105
ALA A  55
VAL A 275
MET A 184
 None
 1.07A 1rbpA-1wraA:
undetectable		 1rbpA-1wraA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 303
ALA A  58
ALA A  55
ALA A 159
LEU A 118
 None
 1.28A 1rbpA-1x9eA:
undetectable		 1rbpA-1x9eA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 LEU A 150
ALA A  62
PHE A  43
ALA A  90
LEU A 116
 None
 1.17A 1rbpA-1yyaA:
undetectable		 1rbpA-1yyaA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 LEU A  17
ALA A 231
ALA A 228
VAL A  59
MET A 225
 None
 1.08A 1rbpA-1z34A:
undetectable		 1rbpA-1z34A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		5 LEU A 190
ALA A  79
ALA A  81
ALA A 170
LEU A  95
 None
 1.33A 1rbpA-1zosA:
undetectable		 1rbpA-1zosA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 421
ALA A 315
ALA A 314
VAL A 425
LEU A 437
 None
 1.09A 1rbpA-2am2A:
undetectable		 1rbpA-2am2A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		5 LEU A 248
PHE A  80
ALA A  30
VAL A 250
MET A 159
 None
 1.09A 1rbpA-2bibA:
undetectable		 1rbpA-2bibA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 ALA A 550
PHE A 552
ALA A 505
ALA A 503
LEU A 629
 None
 1.04A 1rbpA-2dkhA:
undetectable		 1rbpA-2dkhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 LEU A 471
LEU A 480
ALA A 412
ALA A 435
ALA A 413
 None
 1.23A 1rbpA-2ja2A:
undetectable		 1rbpA-2ja2A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k70 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1943

(Thermus
thermophilus) 		PF04314
(PCuAC) 		5 LEU A 111
LEU A 101
ALA A  17
ALA A  18
VAL A 113
 None
 1.18A 1rbpA-2k70A:
undetectable		 1rbpA-2k70A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus) 		PF08913
(VBS) 		5 LEU A1968
ALA A1906
ALA A1903
VAL A1964
LEU A1896
 None
 1.37A 1rbpA-2kvpA:
undetectable		 1rbpA-2kvpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00027
(cNMP_binding) 		5 LEU A  98
ALA A  32
ALA A  92
MET A  55
LEU A  67
 None
 1.28A 1rbpA-2mhfA:
undetectable		 1rbpA-2mhfA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		5 LEU A 221
LEU A  59
ALA A 208
ALA A 210
VAL A  37
 None
 1.16A 1rbpA-2o2gA:
undetectable		 1rbpA-2o2gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 174
LEU A  64
ALA A  81
VAL A 172
LEU A 106
 None
 1.34A 1rbpA-2popA:
undetectable		 1rbpA-2popA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 284
LEU A 267
ALA A 263
ALA A 264
VAL A 294
 None
 1.35A 1rbpA-2qdeA:
undetectable		 1rbpA-2qdeA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR

(Mycobacterium
tuberculosis) 		PF13185
(GAF_2) 		5 LEU A 203
ALA A 189
ALA A 191
VAL A  86
LEU A  66
 None
 1.23A 1rbpA-2vzwA:
undetectable		 1rbpA-2vzwA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  43
PHE A  45
ALA A  55
ALA A  57
MET A  73
MET A  88
LEU A  97
GLN A  98
HIS A 104
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
 0.57A 1rbpA-2wq9A:
31.6		 1rbpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  43
PHE A  45
ALA A  55
ALA A  57
VAL A  61
MET A  88
LEU A  97
GLN A  98
HIS A 104
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
 0.79A 1rbpA-2wq9A:
31.6		 1rbpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  63
ALA A  43
ALA A  55
ALA A  57
MET A  73
 None
OLA  A1179 ( 4.0A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
 1.29A 1rbpA-2wq9A:
31.6		 1rbpA-2wq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 LEU A 388
ALA A 133
ALA A 130
VAL A 342
LEU A 125
 None
 1.36A 1rbpA-3aflA:
undetectable		 1rbpA-3aflA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		5 ALA B  88
ALA B 496
ALA B 493
VAL B 397
LEU B 127
 None
 1.34A 1rbpA-3aq1B:
undetectable		 1rbpA-3aq1B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 ALA A 260
PHE A 262
ALA A 267
VAL A  36
LEU A  22
 None
 1.17A 1rbpA-3blwA:
undetectable		 1rbpA-3blwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		5 LEU A 986
LEU A 957
ALA A 929
VAL A 954
LEU A 942
 None
 0.88A 1rbpA-3bsxA:
undetectable		 1rbpA-3bsxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A 408
LEU A 406
ALA A 363
ALA A 366
ALA A 362
 None
 0.99A 1rbpA-3ctzA:
undetectable		 1rbpA-3ctzA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdu PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Acinetobacter
baumannii) 		PF00378
(ECH_1) 		5 LEU A  39
LEU A  97
ALA A 102
ALA A 101
LEU A  24
 None
 1.24A 1rbpA-3fduA:
undetectable		 1rbpA-3fduA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  43
ALA A  55
ALA A  57
MET A  73
GLN A  98
 2T1  A 184 ( 4.7A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.0A)
 1.02A 1rbpA-3fmzA:
30.6		 1rbpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 ALA A  43
PHE A  45
ALA A  55
ALA A  57
MET A  88
GLN A  98
HIS A 104
 2T1  A 184 ( 4.7A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.48A 1rbpA-3fmzA:
30.6		 1rbpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  35
LEU A  37
ALA A  43
ALA A  55
ALA A  57
MET A  73
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.7A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
 0.84A 1rbpA-3fmzA:
30.6		 1rbpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
LEU A  37
ALA A  43
PHE A  45
ALA A  55
ALA A  57
MET A  88
HIS A 104
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.7A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
 0.51A 1rbpA-3fmzA:
30.6		 1rbpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
LEU A  37
ALA A  43
PHE A  45
ALA A  55
ALA A  57
VAL A  61
HIS A 104
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.7A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.7A)
 0.65A 1rbpA-3fmzA:
30.6		 1rbpA-3fmzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 322
PHE A 226
ALA A 227
VAL A 239
LEU A 247
 None
 1.14A 1rbpA-3il4A:
undetectable		 1rbpA-3il4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 LEU A 226
LEU A 103
ALA A 110
ALA A 113
LEU A 244
 None
 1.39A 1rbpA-3im8A:
undetectable		 1rbpA-3im8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		5 LEU D 441
LEU D 553
ALA D 588
ALA D 591
ALA D 589
 None
 1.37A 1rbpA-3k70D:
undetectable		 1rbpA-3k70D:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 163
ALA A 207
ALA A 107
ALA A 208
VAL A 366
 None
 1.16A 1rbpA-3ledA:
undetectable		 1rbpA-3ledA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 LEU A 486
ALA A 405
ALA A 481
VAL A 460
LEU A 412
 None
 1.13A 1rbpA-3mplA:
undetectable		 1rbpA-3mplA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
mutans) 		PF00440
(TetR_N) 		5 LEU A  32
LEU A  74
ALA A 133
ALA A 139
HIS A 126
 None
 1.28A 1rbpA-3mvpA:
undetectable		 1rbpA-3mvpA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 257
LEU A 224
ALA A 194
ALA A 193
VAL A 221
 None
 1.14A 1rbpA-3pfrA:
undetectable		 1rbpA-3pfrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Vibrio cholerae) 		PF01648
(ACPS) 		5 LEU A 123
ALA A  58
ALA A  55
ALA A  59
VAL A 103
 None
 1.17A 1rbpA-3qmnA:
undetectable		 1rbpA-3qmnA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		5 ALA A 298
PHE A 310
ALA A 308
LEU A 302
GLN A 282
 None
 1.09A 1rbpA-3scyA:
undetectable		 1rbpA-3scyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 247
LEU A 231
ALA A 126
ALA A 127
LEU A 152
 None
 1.38A 1rbpA-3shoA:
undetectable		 1rbpA-3shoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t36 ENDO-TYPE
MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF01464
(SLT) 		5 ALA A  29
ALA A 202
ALA A 199
VAL A 143
LEU A  56
 None
 1.20A 1rbpA-3t36A:
undetectable		 1rbpA-3t36A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		5 LEU A 246
ALA A   2
ALA A   8
VAL A 270
MET A   9
 None
 1.12A 1rbpA-3u7bA:
undetectable		 1rbpA-3u7bA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		5 ALA A  60
ALA A  84
ALA A  59
MET A  57
LEU A  48
 None
 1.30A 1rbpA-3u7vA:
undetectable		 1rbpA-3u7vA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		5 LEU A 628
LEU A 604
ALA A 579
VAL A 633
LEU A 641
 None
 0.93A 1rbpA-3ucqA:
undetectable		 1rbpA-3ucqA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 LEU A 381
ALA A 346
ALA A 343
VAL A 385
LEU A  54
 None
 1.00A 1rbpA-3v7pA:
undetectable		 1rbpA-3v7pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x27 CUCUMOPINE SYNTHASE

(Marinactinospora
thermotolerans) 		no annotation 5 LEU A  88
LEU A  52
ALA A 121
ALA A 118
VAL A  90
 None
 1.21A 1rbpA-3x27A:
undetectable		 1rbpA-3x27A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 701 ( 4.6A)
None
 1.20A 1rbpA-4fxsA:
undetectable		 1rbpA-4fxsA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 ALA A 273
PHE A 231
ALA A 269
LEU A  10
HIS A 218
 None
 1.29A 1rbpA-4g6cA:
undetectable		 1rbpA-4g6cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8a UREIDOGLYCOLATE
DEHYDROGENASE

(Escherichia
coli) 		PF02615
(Ldh_2) 		5 ALA A  84
PHE A  67
ALA A  89
ALA A  85
LEU A  33
 None
 1.08A 1rbpA-4h8aA:
undetectable		 1rbpA-4h8aA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 ALA A 355
PHE A 461
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 501 (-4.4A)
None
 1.36A 1rbpA-4ix2A:
undetectable		 1rbpA-4ix2A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lda TADZ

(Pseudomonas
aeruginosa) 		PF16968
(TadZ_N) 		5 LEU A  42
LEU A  51
ALA A  99
ALA A  97
VAL A   6
 None
 1.32A 1rbpA-4ldaA:
undetectable		 1rbpA-4ldaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 LEU A 402
LEU A 656
ALA A 596
PHE A 558
VAL A 531
 None
 1.37A 1rbpA-4ojzA:
undetectable		 1rbpA-4ojzA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 LEU B 283
ALA B 299
ALA B 300
VAL B 285
GLN B 275
 None
 1.28A 1rbpA-4ov6B:
undetectable		 1rbpA-4ov6B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 281
LEU A 313
ALA A 327
VAL A 284
LEU A 271
 None
 1.05A 1rbpA-4perA:
undetectable		 1rbpA-4perA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgw UNCHARACTERIZED
PROTEIN YETJ

(Bacillus
subtilis) 		PF01027
(Bax1-I) 		5 LEU A 204
LEU A  81
ALA A  74
ALA A  27
VAL A  85
 None
 1.08A 1rbpA-4pgwA:
undetectable		 1rbpA-4pgwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 LEU A 436
LEU A 257
ALA A 244
ALA A 757
VAL A 434
 NAG  A 904 ( 4.5A)
None
None
None
None
 1.32A 1rbpA-4qi6A:
undetectable		 1rbpA-4qi6A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		5 LEU A 433
ALA A 405
ALA A 408
LEU A 278
GLN A 272
 None
 1.35A 1rbpA-4s1wA:
undetectable		 1rbpA-4s1wA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		PF05609
(LAP1C) 		5 LEU A 465
ALA A 475
ALA A 430
ALA A 476
VAL A 461
 None
 1.36A 1rbpA-4tvsA:
undetectable		 1rbpA-4tvsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF02348
(CTP_transf_3) 		5 LEU A  90
ALA A 124
ALA A 125
VAL A  96
LEU A 197
 None
 1.28A 1rbpA-4xwiA:
undetectable		 1rbpA-4xwiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 119
ALA A 184
ALA A 187
ALA A 185
GLN A 142
 None
 1.14A 1rbpA-4y1bA:
undetectable		 1rbpA-4y1bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 LEU A 277
ALA A 303
VAL A 273
LEU A 343
GLN A 346
 None
 1.18A 1rbpA-4y21A:
undetectable		 1rbpA-4y21A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 5 LEU J 167
LEU J 176
ALA J 199
PHE J 224
VAL J 175
 None
 1.33A 1rbpA-4ymwJ:
undetectable		 1rbpA-4ymwJ:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU E 253
ALA E 293
ALA E 262
VAL E 129
LEU E 357
 None
EDO  E 617 (-4.6A)
None
None
EDO  E 618 ( 4.3A)
 1.13A 1rbpA-5e24E:
undetectable		 1rbpA-5e24E:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU C 205
ALA C 245
ALA C 214
VAL C  81
LEU C 309
 None
EDO  C 502 ( 3.7A)
None
None
None
 1.14A 1rbpA-5eg6C:
undetectable		 1rbpA-5eg6C:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.05A 1rbpA-5eqtA:
undetectable		 1rbpA-5eqtA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		5 LEU A 141
LEU A 154
ALA A 204
ALA A 201
LEU A  98
 None
 1.36A 1rbpA-5fifA:
undetectable		 1rbpA-5fifA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU b 493
ALA b 130
ALA b 414
ALA b 131
VAL b 497
 None
 1.18A 1rbpA-5gw5b:
undetectable		 1rbpA-5gw5b:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		5 LEU A 417
ALA A 449
ALA A 453
ALA A 450
VAL A 484
 None
 1.34A 1rbpA-5hlbA:
undetectable		 1rbpA-5hlbA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9f NIPSNAP DOMAIN
PROTEIN

(Paraburkholderia
xenovorans) 		PF07978
(NIPSNAP) 		5 LEU A  18
ALA A  39
ALA A  36
VAL A  59
LEU A  27
 None
 1.36A 1rbpA-5k9fA:
undetectable		 1rbpA-5k9fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 ALA A 414
PHE A 412
ALA A 493
ALA A 495
VAL A 499
 None
 1.33A 1rbpA-5nbsA:
undetectable		 1rbpA-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL

(Homo sapiens) 		PF00297
(Ribosomal_L3) 		5 LEU e 173
ALA e  50
LEU e  53
GLN e  54
HIS e 212
 None
 1.37A 1rbpA-5oole:
undetectable		 1rbpA-5oole:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		5 LEU A 133
ALA A 147
ALA A 146
VAL A  99
LEU A 184
 None
 1.26A 1rbpA-5tcbA:
undetectable		 1rbpA-5tcbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 222
ALA A  22
ALA A  19
VAL A 225
MET A  16
 None
 1.34A 1rbpA-5tjzA:
undetectable		 1rbpA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ALA A 311
ALA A 391
ALA A 389
LEU A 382
GLN A 381
 None
 1.20A 1rbpA-5tvjA:
undetectable		 1rbpA-5tvjA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v76 MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		no annotation 5 LEU A 176
ALA A 188
ALA A 159
ALA A 156
VAL A 167
 None
 1.25A 1rbpA-5v76A:
undetectable		 1rbpA-5v76A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 5 LEU B 216
ALA B 144
ALA B 147
ALA B 145
LEU B 190
 None
 1.36A 1rbpA-5vqiB:
undetectable		 1rbpA-5vqiB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU G 548
LEU G 553
PHE G 645
VAL G 552
LEU G 461
 None
 1.01A 1rbpA-5x6oG:
undetectable		 1rbpA-5x6oG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S14

(Trichomonas
vaginalis) 		PF00411
(Ribosomal_S11) 		5 ALA O  69
ALA O  81
ALA O  85
VAL O  52
LEU O 127
 None
 1.09A 1rbpA-5xyiO:
undetectable		 1rbpA-5xyiO:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 LEU A 454
ALA A 481
ALA A 478
VAL A 431
LEU A 165
 None
 1.32A 1rbpA-5yl7A:
undetectable		 1rbpA-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 5 ALA A 110
PHE A 101
ALA A 107
ALA A 111
VAL A 200
 None
 1.31A 1rbpA-6cblA:
undetectable		 1rbpA-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		5 LEU B 600
ALA B 546
PHE B 511
ALA B 543
VAL A 431
 None
 1.28A 1rbpA-6f5oB:
undetectable		 1rbpA-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 5 LEU A 137
ALA A 142
ALA A 145
ALA A 141
VAL A  80
 None
 1.36A 1rbpA-6gngA:
undetectable		 1rbpA-6gngA:
undetectable