SIMILAR PATTERNS OF AMINO ACIDS FOR 1RA8_A_FOLA161_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 ASP A 546
LYS A 416
ARG A 428
 None
 1.10A 1ra8A-1biyA:
undetectable		 1ra8A-1biyA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		3 ASP A 424
LYS A 311
ARG A 310
 None
 0.86A 1ra8A-1fkmA:
undetectable		 1ra8A-1fkmA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fns VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		3 ASP A 514
LYS A 569
ARG A 571
 None
 0.96A 1ra8A-1fnsA:
0.0		 1ra8A-1fnsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g82 FIBROBLAST GROWTH
FACTOR 9

(Homo sapiens) 		PF00167
(FGF) 		3 ASP A 203
LYS A  58
ARG A  62
 None
 1.12A 1ra8A-1g82A:
undetectable		 1ra8A-1g82A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		3 ASP C 403
LYS C 447
ARG C 450
 None
 1.09A 1ra8A-1h2tC:
undetectable		 1ra8A-1h2tC:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		3 ASP A 112
LYS A 110
ARG A 212
 None
 1.03A 1ra8A-1hg0A:
0.0		 1ra8A-1hg0A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ASP A 434
LYS A 438
ARG A 375
 None
 1.15A 1ra8A-1nugA:
undetectable		 1ra8A-1nugA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A  97
LYS A 100
ARG A 103
 None
 1.18A 1ra8A-1nxkA:
undetectable		 1ra8A-1nxkA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 245
LYS A 212
ARG A 103
 None
 1.19A 1ra8A-1nxkA:
undetectable		 1ra8A-1nxkA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		3 ASP A  20
LYS A  62
ARG A  56
 None
 0.89A 1ra8A-1o54A:
0.0		 1ra8A-1o54A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oht CG14704 PROTEIN

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		3 ASP A  85
LYS A  58
ARG A  61
 None
 0.90A 1ra8A-1ohtA:
undetectable		 1ra8A-1ohtA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p16 MRNA CAPPING ENZYME
ALPHA SUBUNIT

(Candida
albicans) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		3 ASP A 206
LYS A 376
ARG A 379
 None
 0.71A 1ra8A-1p16A:
undetectable		 1ra8A-1p16A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9i DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		3 ASP A  69
LYS A  48
ARG A  51
 None
 1.11A 1ra8A-1t9iA:
undetectable		 1ra8A-1t9iA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 ASP C 344
LYS C 348
ARG C 351
 None
 0.69A 1ra8A-1u6gC:
undetectable		 1ra8A-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf6 PALS1-ASSOCIATED
TIGHT JUNCTION
PROTEIN

(Homo sapiens) 		PF09045
(L27_2) 		3 ASP A  28
LYS A  22
ARG A  18
 None
 1.14A 1ra8A-1vf6A:
undetectable		 1ra8A-1vf6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		3 ASP A 163
LYS A  34
ARG A  37
 None
 0.77A 1ra8A-1x7pA:
2.7		 1ra8A-1x7pA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		3 ASP A 163
LYS A 168
ARG A 171
 None
 0.56A 1ra8A-1x7pA:
2.7		 1ra8A-1x7pA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		3 ASP B 316
LYS B 186
ARG B 238
 None
 1.02A 1ra8A-1xdkB:
undetectable		 1ra8A-1xdkB:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		3 ASP A  27
LYS A  32
ARG A  57
 None
SO4  A3484 (-3.1A)
SO4  A3484 (-3.3A)
 0.72A 1ra8A-1zdrA:
24.3		 1ra8A-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 ASP A 393
LYS A 421
ARG A 419
 None
 1.20A 1ra8A-2d1cA:
undetectable		 1ra8A-2d1cA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASP A 139
LYS A 145
ARG A 147
 None
 1.15A 1ra8A-2ebaA:
undetectable		 1ra8A-2ebaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edp SHROOM FAMILY MEMBER
4

(Homo sapiens) 		PF00595
(PDZ) 		3 ASP A  58
LYS A  28
ARG A  72
 None
 1.19A 1ra8A-2edpA:
undetectable		 1ra8A-2edpA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 ASP A 479
LYS A 373
ARG A 375
 None
 1.15A 1ra8A-2fvmA:
undetectable		 1ra8A-2fvmA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 ASP A 416
LYS A 481
ARG A 183
 BOG  A2000 (-3.0A)
None
None
 0.70A 1ra8A-2g3nA:
undetectable		 1ra8A-2g3nA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		3 ASP A 176
LYS A 255
ARG A 273
 None
 0.95A 1ra8A-2gt1A:
1.9		 1ra8A-2gt1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		3 ASP A 302
LYS A 307
ARG A 310
 None
 1.05A 1ra8A-2gw1A:
undetectable		 1ra8A-2gw1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 ASP A 163
LYS A 322
ARG A 292
 None
 1.02A 1ra8A-2iksA:
2.3		 1ra8A-2iksA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it2 UPF0130 PROTEIN
PH1069

(Pyrococcus
horikoshii) 		PF02676
(TYW3) 		3 ASP A  34
LYS A 187
ARG A 190
 None
 1.15A 1ra8A-2it2A:
undetectable		 1ra8A-2it2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP

(Murid
betaherpesvirus
1) 		PF04843
(Herpes_teg_N) 		3 ASP A  59
LYS A  65
ARG A  68
 None
 1.14A 1ra8A-2j7qA:
undetectable		 1ra8A-2j7qA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		3 ASP A 791
LYS A 419
ARG A 422
 None
 1.15A 1ra8A-2jfdA:
undetectable		 1ra8A-2jfdA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Escherichia
coli) 		PF04381
(RdgC) 		3 ASP A 140
LYS A 251
ARG A 252
 None
 1.10A 1ra8A-2owlA:
undetectable		 1ra8A-2owlA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		3 ASP A  96
LYS A  99
ARG A 102
 None
 1.11A 1ra8A-2pftA:
undetectable		 1ra8A-2pftA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		3 ASP A 483
LYS A 472
ARG A 383
 None
 1.17A 1ra8A-2vwbA:
undetectable		 1ra8A-2vwbA:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		3 ASP A  31
LYS A  36
ARG A  64
 VG9  A1168 (-3.0A)
VG9  A1168 ( 4.9A)
VG9  A1168 ( 3.7A)
 0.96A 1ra8A-2w3wA:
23.5		 1ra8A-2w3wA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 ASP C 170
LYS C 175
ARG C 312
 None
 0.80A 1ra8A-2wbeC:
undetectable		 1ra8A-2wbeC:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eop THYMOCYTE NUCLEAR
PROTEIN 1

(Homo sapiens) 		PF01878
(EVE) 		3 ASP A 154
LYS A 157
ARG A  99
 None
 1.07A 1ra8A-3eopA:
undetectable		 1ra8A-3eopA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF01536
(SAM_decarbox)
PF01536
(SAM_decarbox) 		3 ASP A 100
LYS B  27
ARG B  20
 None
 1.15A 1ra8A-3ep7A:
undetectable		 1ra8A-3ep7A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C) 		3 ASP A 278
LYS A 283
ARG A 286
 None
 1.15A 1ra8A-3euhA:
undetectable		 1ra8A-3euhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF00392
(GntR)
PF07729
(FCD) 		3 ASP A  73
LYS A  77
ARG A  80
 None
 1.06A 1ra8A-3fmsA:
undetectable		 1ra8A-3fmsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		3 ASP A  28
LYS A 277
ARG A 279
 None
 1.14A 1ra8A-3hamA:
undetectable		 1ra8A-3hamA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ASP A 479
LYS A 486
ARG A 489
 None
 1.20A 1ra8A-3hz6A:
undetectable		 1ra8A-3hz6A:
15.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		3 ASP X  27
LYS X  32
ARG X  57
 N22  X 219 (-2.8A)
None
None
 0.69A 1ra8A-3i8aX:
24.8		 1ra8A-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		3 ASP A 125
LYS A  28
ARG A  33
 None
 0.95A 1ra8A-3j1eA:
undetectable		 1ra8A-3j1eA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S6,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S18C,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF01250
(Ribosomal_S6)
PF01084
(Ribosomal_S18) 		3 ASP F  67
LYS F  95
ARG R 114
 None
U  A 382 ( 2.8A)
C  A 380 ( 3.8A)
 1.12A 1ra8A-3jd5F:
undetectable		 1ra8A-3jd5F:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		3 ASP A 302
LYS A 308
ARG A 125
 None
 1.18A 1ra8A-3krbA:
undetectable		 1ra8A-3krbA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lje ZEBRAFISH RNASE5

(Danio rerio) 		PF00074
(RnaseA) 		3 ASP A   7
LYS A  12
ARG A  15
 None
ACT  A5000 ( 4.1A)
ACT  A5000 (-3.0A)
 0.99A 1ra8A-3ljeA:
undetectable		 1ra8A-3ljeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		3 ASP A 271
LYS A 434
ARG A 127
 None
 1.01A 1ra8A-3ogzA:
undetectable		 1ra8A-3ogzA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		3 ASP A 212
LYS A  68
ARG A  58
 None
 1.19A 1ra8A-3qboA:
undetectable		 1ra8A-3qboA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 ASP A 386
LYS A 393
ARG A 396
 None
 1.04A 1ra8A-3thzA:
undetectable		 1ra8A-3thzA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		3 ASP A  60
LYS A   3
ARG A  87
 None
 0.76A 1ra8A-3u9lA:
undetectable		 1ra8A-3u9lA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 ASP A 500
LYS A  93
ARG A 122
 None
None
SO4  A 802 (-3.8A)
 0.82A 1ra8A-3wevA:
undetectable		 1ra8A-3wevA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		3 ASP A 187
LYS A 192
ARG A 195
 None
 1.05A 1ra8A-3x0uA:
undetectable		 1ra8A-3x0uA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 152
LYS A 156
ARG A 216
 None
 1.17A 1ra8A-3x1bA:
undetectable		 1ra8A-3x1bA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ

(Neisseria
meningitidis) 		PF03958
(Secretin_N)
PF07660
(STN) 		3 ASP A 463
LYS A 504
ARG A 503
 None
 1.13A 1ra8A-4av2A:
undetectable		 1ra8A-4av2A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgw PRE-MRNA-SPLICING
FACTOR PRP21
PRE-MRNA-SPLICING
FACTOR PRP11

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01805
(Surp)
PF16835
(SF3A2) 		3 ASP C 234
LYS C 238
ARG B 225
 None
 1.12A 1ra8A-4dgwC:
undetectable		 1ra8A-4dgwC:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4

(Homo sapiens) 		PF00023
(Ank) 		3 ASP A 347
LYS A 352
ARG A 355
 None
 1.03A 1ra8A-4dx2A:
undetectable		 1ra8A-4dx2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8e GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 ASP A  84
LYS A  90
ARG A  95
 None
 1.13A 1ra8A-4e8eA:
undetectable		 1ra8A-4e8eA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		3 ASP A 511
LYS A 508
ARG A 500
 None
 0.92A 1ra8A-4eljA:
undetectable		 1ra8A-4eljA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 110
LYS A 216
ARG A 220
 None
 0.96A 1ra8A-4ez5A:
undetectable		 1ra8A-4ez5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		3 ASP W 923
LYS W 927
ARG W 932
 None
 1.14A 1ra8A-4f5xW:
undetectable		 1ra8A-4f5xW:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 ASP A 129
LYS A 134
ARG A 137
 None
 1.18A 1ra8A-4flcA:
undetectable		 1ra8A-4flcA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		3 ASP A  40
LYS A  46
ARG A  49
 None
 1.12A 1ra8A-4gc5A:
undetectable		 1ra8A-4gc5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcn PROTEIN STI-1

(Caenorhabditis
elegans) 		PF13414
(TPR_11) 		3 ASP A 112
LYS A  81
ARG A  85
 None
 1.14A 1ra8A-4gcnA:
undetectable		 1ra8A-4gcnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 3 ASP A   9
LYS A   4
ARG A 414
 None
 1.06A 1ra8A-4gjiA:
undetectable		 1ra8A-4gjiA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6x PROTEIN
DISULFIDE-ISOMERASE
A5

(Homo sapiens) 		no annotation 3 ASP A  35
LYS A  41
ARG A  44
 None
 0.88A 1ra8A-4i6xA:
undetectable		 1ra8A-4i6xA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 ASP A 214
LYS A 217
ARG A 172
 None
 1.18A 1ra8A-4kcdA:
2.0		 1ra8A-4kcdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		3 ASP A 412
LYS A 417
ARG A 420
 None
 1.05A 1ra8A-4mifA:
undetectable		 1ra8A-4mifA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP H 323
LYS H 543
ARG H 583
 None
ADP  H 801 (-3.1A)
None
 1.10A 1ra8A-4nl4H:
undetectable		 1ra8A-4nl4H:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4a LIPOPROTEIN,
PUTATIVE

(Bacillus
anthracis) 		no annotation 3 ASP A  48
LYS A 159
ARG A 162
 None
 1.17A 1ra8A-4o4aA:
undetectable		 1ra8A-4o4aA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		3 ASP A  47
LYS A  69
ARG A  67
 None
 1.15A 1ra8A-4oecA:
undetectable		 1ra8A-4oecA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		3 ASP A  27
LYS A  32
ARG A  57
 MTX  A 201 (-3.0A)
MTX  A 201 ( 3.9A)
MTX  A 201 (-3.0A)
 0.85A 1ra8A-4p68A:
29.2		 1ra8A-4p68A:
97.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pem PENICILLIN G ACYLASE
ALPHA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		3 ASP A 105
LYS A 127
ARG A  47
 None
 1.20A 1ra8A-4pemA:
undetectable		 1ra8A-4pemA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		3 ASP A 400
LYS A 410
ARG A 414
 None
 1.19A 1ra8A-4pkvA:
undetectable		 1ra8A-4pkvA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		3 ASP A 347
LYS A 353
ARG A 356
 None
NAD  A 601 (-3.2A)
None
 1.20A 1ra8A-4pxlA:
undetectable		 1ra8A-4pxlA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 ASP B 551
LYS B 557
ARG B 560
 None
 1.20A 1ra8A-4r3zB:
undetectable		 1ra8A-4r3zB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u63 DNA PHOTOLYASE

(Agrobacterium
fabrum) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ASP A 360
LYS A 366
ARG A 369
 None
 0.88A 1ra8A-4u63A:
undetectable		 1ra8A-4u63A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urp FATTY ACID
REPRESSION MUTANT
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00881
(Nitroreductase) 		3 ASP A  99
LYS A 105
ARG A 108
 None
 1.16A 1ra8A-4urpA:
undetectable		 1ra8A-4urpA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzx PROTEIN THO1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 131
LYS A 136
ARG A 139
 None
 1.17A 1ra8A-4uzxA:
undetectable		 1ra8A-4uzxA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		3 ASP A 201
LYS A 189
ARG A 324
 None
 1.19A 1ra8A-4wm0A:
undetectable		 1ra8A-4wm0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 ASP A  97
LYS A 319
ARG A 361
 None
 1.19A 1ra8A-4xzeA:
undetectable		 1ra8A-4xzeA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 ASP A 479
LYS A 485
ARG A 488
 None
 0.98A 1ra8A-4zajA:
undetectable		 1ra8A-4zajA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aey PLASMID SEGREGATION
PROTEIN PARM

(Escherichia
coli) 		PF06406
(StbA) 		3 ASP A   7
LYS A 123
ARG A 127
 None
 1.18A 1ra8A-5aeyA:
undetectable		 1ra8A-5aeyA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		3 ASP A 149
LYS A 154
ARG A 157
 None
 1.14A 1ra8A-5b1qA:
undetectable		 1ra8A-5b1qA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		3 ASP A 342
LYS A 348
ARG A 351
 None
 1.12A 1ra8A-5cdiA:
undetectable		 1ra8A-5cdiA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr8 PNEUMOLYSIN

(Streptococcus
pneumoniae) 		no annotation 3 ASP D 466
LYS D 450
ARG D 449
 None
 1.02A 1ra8A-5cr8D:
undetectable		 1ra8A-5cr8D:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		3 ASP A 116
LYS A1470
ARG A1474
 None
 1.11A 1ra8A-5d0fA:
undetectable		 1ra8A-5d0fA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		3 ASP A  56
LYS A  62
ARG A 400
 None
 1.04A 1ra8A-5ecoA:
undetectable		 1ra8A-5ecoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl6 RIBOSOME MATURATION
FACTOR RIMP

(Mycolicibacterium
smegmatis) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		3 ASP A  94
LYS A 110
ARG A 124
 None
 0.56A 1ra8A-5gl6A:
undetectable		 1ra8A-5gl6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 TRANSLATION
INITIATION FACTOR 1A

(Pyrococcus
abyssi) 		PF01176
(eIF-1a) 		3 ASP 6  81
LYS 6  54
ARG 6  57
 None
G  2 471 ( 2.6A)
G  2 483 ( 2.8A)
 1.18A 1ra8A-5jb36:
undetectable		 1ra8A-5jb36:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 ASP A  52
LYS A  55
ARG A  58
 None
 1.13A 1ra8A-5jryA:
undetectable		 1ra8A-5jryA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		3 ASP A 310
LYS A 315
ARG A 318
 None
 1.18A 1ra8A-5ladA:
undetectable		 1ra8A-5ladA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		3 ASP A 446
LYS A 450
ARG A  35
 None
 1.06A 1ra8A-5mq6A:
undetectable		 1ra8A-5mq6A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh INTERAPTIN

(Legionella
pneumophila) 		no annotation 3 ASP C 124
LYS C 122
ARG C  33
 None
 1.14A 1ra8A-5oshC:
undetectable		 1ra8A-5oshC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 ASP A 190
LYS A 483
ARG A 487
 None
 0.85A 1ra8A-5uqcA:
undetectable		 1ra8A-5uqcA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		3 ASP A 177
LYS A 284
ARG A 289
 None
 1.13A 1ra8A-5xw5A:
undetectable		 1ra8A-5xw5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zj5 -

(-) 		no annotation 3 ASP A  50
LYS A  54
ARG A  59
 None
 1.05A 1ra8A-5zj5A:
undetectable		 1ra8A-5zj5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 351
LYS A 360
ARG A 363
 None
 0.52A 1ra8A-6az0A:
undetectable		 1ra8A-6az0A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 3 ASP B 666
LYS B 184
ARG B 224
 None
 0.89A 1ra8A-6bywB:
undetectable		 1ra8A-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 3 ASP A  28
LYS A  33
ARG A  61
 MMV  A 202 (-2.9A)
MMV  A 202 ( 4.6A)
MMV  A 202 (-2.8A)
 0.61A 1ra8A-6cxmA:
20.5		 1ra8A-6cxmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4g PROBABLE U2 SMALL
NUCLEAR
RIBONUCLEOPROTEIN A'

(Drosophila
melanogaster) 		no annotation 3 ASP A  53
LYS A  56
ARG A  78
 None
 1.13A 1ra8A-6f4gA:
undetectable		 1ra8A-6f4gA:
undetectable