SIMILAR PATTERNS OF AMINO ACIDS FOR 1R9O_A_FLPA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 VAL A 123
ASN A 585
ILE A 586
GLY A 581
LEU A 102
 None
 0.71A 1r9oA-1b0kA:
undetectable		 1r9oA-1b0kA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 VAL A 280
ILE A 356
LEU A 330
ALA A 296
LEU A 282
 None
 0.99A 1r9oA-1fc9A:
0.0		 1r9oA-1fc9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5
CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR

(Homo sapiens) 		PF00069
(Pkinase)
PF03261
(CDK5_activator) 		5 VAL A  35
ILE D 265
LEU D 262
ALA A  48
LEU A  37
 None
 1.00A 1r9oA-1h4lA:
0.0		 1r9oA-1h4lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 LEU A 104
VAL A 185
GLY A 107
ALA A 108
THR A 114
 None
None
SAM  A 301 (-2.7A)
None
None
 1.03A 1r9oA-1i9gA:
undetectable		 1r9oA-1i9gA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
 0.97A 1r9oA-1kcxA:
undetectable		 1r9oA-1kcxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 VAL A 140
LEU A  25
GLY A  17
ALA A  18
LEU A  97
 None
None
FAD  A 800 ( 3.7A)
FAD  A 800 (-4.4A)
None
 1.09A 1r9oA-1knrA:
undetectable		 1r9oA-1knrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		5 VAL A 118
LEU A 147
VAL A 183
ASP A 139
GLY A 142
 None
None
None
HBI  A 500 ( 4.9A)
None
 1.04A 1r9oA-1ltzA:
0.0		 1r9oA-1ltzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 128
LEU A  21
VAL A  27
ASP A 125
ALA A 115
 None
 1.00A 1r9oA-1lxtA:
0.0		 1r9oA-1lxtA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		6 ASN A 204
ASP A 290
GLY A 293
ALA A 294
THR A 298
LEU A 363
 None
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.55A 1r9oA-1nr6A:
53.3		 1r9oA-1nr6A:
76.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F
CYTOCHROME B6F
COMPLEX SUBUNIT PETL
CYTOCHROME B6F
COMPLEX SUBUNIT PETM

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF05115
(PetL)
PF08041
(PetM)
PF16639
(Apocytochr_F_N) 		5 VAL A 267
LEU L  15
VAL M  90
GLY L  20
LEU A 263
 None
 1.05A 1r9oA-1q90A:
undetectable		 1r9oA-1q90A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 ILE A 469
VAL A 134
ASP A 252
GLY A 251
THR A 457
 None
 1.06A 1r9oA-1qb4A:
undetectable		 1r9oA-1qb4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 ARG A 374
ILE A 370
VAL A 425
ALA A 310
LEU A 300
 None
 1.09A 1r9oA-1rzvA:
undetectable		 1r9oA-1rzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 ARG A 374
ILE A 370
VAL A 425
ASP A 307
ALA A 310
 None
 1.06A 1r9oA-1rzvA:
undetectable		 1r9oA-1rzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 ILE A 163
LEU A  58
VAL A 347
GLY A 161
LEU A 178
 None
 1.04A 1r9oA-1uliA:
undetectable		 1r9oA-1uliA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL X 174
ILE X 123
VAL X 106
GLY X 156
ALA X 157
 None
 0.93A 1r9oA-1w52X:
undetectable		 1r9oA-1w52X:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		5 VAL A  99
ILE A 130
GLY A 128
ALA A 127
LEU A  91
 None
 1.09A 1r9oA-1xs5A:
undetectable		 1r9oA-1xs5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		5 VAL A 153
VAL A  56
GLY A  39
ALA A  40
LEU A 150
 None
 0.91A 1r9oA-2a9sA:
undetectable		 1r9oA-2a9sA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 VAL A 315
LEU A 271
GLY A 295
ALA A 296
LEU A 313
 None
 0.82A 1r9oA-2bnhA:
undetectable		 1r9oA-2bnhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byk CHRAC-14
CHRAC-16

(Drosophila
melanogaster) 		PF00808
(CBFD_NFYB_HMF) 		5 VAL A  82
VAL B  29
GLY A  59
ALA A  60
LEU A  89
 None
 0.96A 1r9oA-2bykA:
undetectable		 1r9oA-2bykA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		5 VAL A   9
ILE A 296
VAL A 258
ALA A  63
LEU A   7
 None
 0.97A 1r9oA-2c8jA:
undetectable		 1r9oA-2c8jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		5 VAL A 209
ILE A 167
VAL A 188
THR A   7
LEU A 207
 None
 0.90A 1r9oA-2dr3A:
undetectable		 1r9oA-2dr3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		6 VAL A 332
VAL A  28
ASP A 178
GLY A 306
THR A 301
LEU A 327
 None
 1.35A 1r9oA-2dv6A:
undetectable		 1r9oA-2dv6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 ASN A 485
ILE A 486
ASP A  35
ALA A  36
THR A 408
 None
GOL  A 602 ( 4.8A)
ZN  A 700 ( 3.0A)
None
None
 1.08A 1r9oA-2e0pA:
undetectable		 1r9oA-2e0pA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		5 ILE A  98
LEU A 336
VAL C 658
GLY A  67
ALA A  66
 FAD  A 801 (-4.8A)
None
None
FAD  A 801 (-3.4A)
None
 1.10A 1r9oA-2e1mA:
undetectable		 1r9oA-2e1mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 ILE A 234
LEU A 235
VAL A 243
GLY A 227
ALA A 229
 None
 1.03A 1r9oA-2e28A:
undetectable		 1r9oA-2e28A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 VAL A 439
LEU A 397
MET A 126
ALA A 414
LEU A 433
 None
 1.02A 1r9oA-2e7zA:
undetectable		 1r9oA-2e7zA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		5 LEU A 113
MET A 205
GLY A 118
ALA A  58
LEU A  39
 None
 1.00A 1r9oA-2h1yA:
undetectable		 1r9oA-2h1yA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzd REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 ILE A 593
LEU A 627
GLY A 609
ALA A 620
LEU A 648
 None
 1.05A 1r9oA-2jzdA:
undetectable		 1r9oA-2jzdA:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		6 ASN A 204
LEU A 208
VAL A 237
ASP A 293
ALA A 297
THR A 301
 None
225  A 501 ( 4.3A)
None
None
HEM  A 500 (-3.5A)
HEM  A 500 ( 3.7A)
 0.55A 1r9oA-2nnjA:
54.0		 1r9oA-2nnjA:
78.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 VAL A 383
ILE A 511
GLY A 489
ALA A 488
LEU A 385
 None
 1.02A 1r9oA-2nq5A:
undetectable		 1r9oA-2nq5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otm HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF14588
(YjgF_endoribonc) 		5 LEU A  99
VAL A  61
ASP A 113
GLY A 114
THR A  72
 None
 1.08A 1r9oA-2otmA:
undetectable		 1r9oA-2otmA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpi GMP SYNTHASE

(Homo sapiens) 		PF00117
(GATase) 		5 ASN A 111
VAL A 160
GLY A 186
ALA A 187
LEU A 151
 None
 1.08A 1r9oA-2vpiA:
undetectable		 1r9oA-2vpiA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv6 CFXB

(Citrobacter
freundii) 		PF01376
(Enterotoxin_b) 		5 ILE D  24
VAL D  50
ASP D  70
ALA D  74
THR D  78
 None
 1.06A 1r9oA-2wv6D:
undetectable		 1r9oA-2wv6D:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF05362
(Lon_C) 		5 VAL A 844
ILE A 816
GLY A 857
ALA A 856
LEU A 806
 None
 1.04A 1r9oA-2x36A:
undetectable		 1r9oA-2x36A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A 213
ILE A 285
LEU A 289
ALA A 167
LEU A 299
 None
 1.08A 1r9oA-2ymvA:
undetectable		 1r9oA-2ymvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 VAL A 131
LEU A  26
GLY A 170
ALA A 163
LEU A 103
 None
 1.00A 1r9oA-2ywgA:
undetectable		 1r9oA-2ywgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 VAL A  78
ILE A  93
LEU A  90
VAL A 150
LEU A  81
 None
 1.04A 1r9oA-3axxA:
undetectable		 1r9oA-3axxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by5 COBALAMIN
BIOSYNTHESIS PROTEIN

(Agrobacterium
fabrum) 		PF01890
(CbiG_C) 		5 VAL A  28
LEU A  54
GLY A  12
ALA A  11
LEU A  61
 None
 1.08A 1r9oA-3by5A:
undetectable		 1r9oA-3by5A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		5 VAL A 115
ASN A 131
ILE A 130
LEU A 129
LEU A 119
 None
 1.06A 1r9oA-3c3kA:
undetectable		 1r9oA-3c3kA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		7 ASN A 206
LEU A 210
VAL A 239
ASP A 295
ALA A 299
THR A 303
LEU A 368
 None
None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.90A 1r9oA-3e4eA:
49.2		 1r9oA-3e4eA:
59.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		5 VAL A   9
ASN A  73
LEU A  70
GLY A  43
ALA A  42
 None
 1.07A 1r9oA-3e9dA:
undetectable		 1r9oA-3e9dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 229
ILE A 390
GLY A 337
ALA A 339
THR A 325
 None
 1.01A 1r9oA-3hhdA:
undetectable		 1r9oA-3hhdA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 LEU A  15
VAL A  96
GLY A 106
ALA A 105
LEU A  29
 None
 1.08A 1r9oA-3hrxA:
undetectable		 1r9oA-3hrxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 ASN A 244
ILE A 245
ASP A 217
GLY A 239
ALA A 238
 LLP  A 243 ( 4.7A)
None
LLP  A 243 ( 2.9A)
None
None
 1.06A 1r9oA-3hvyA:
undetectable		 1r9oA-3hvyA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 ASN A 244
ILE A 245
ASP A 217
GLY A 239
ALA A 238
 None
 1.05A 1r9oA-3i16A:
undetectable		 1r9oA-3i16A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 VAL A  24
ILE A 447
LEU A 453
ALA A 442
LEU A 461
 None
 0.93A 1r9oA-3ifrA:
undetectable		 1r9oA-3ifrA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 ARG X 210
ILE X 318
LEU X 290
ASP X 293
LEU X 218
 None
 1.07A 1r9oA-3j8gX:
undetectable		 1r9oA-3j8gX:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 VAL A 381
GLY A 427
ALA A 428
THR A 118
LEU A 111
 None
None
None
EDO  A   1 ( 4.5A)
None
 1.10A 1r9oA-3k11A:
undetectable		 1r9oA-3k11A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		5 ILE A  60
LEU A  59
MET A  31
GLY A  12
LEU A  45
 None
None
None
FAD  A 401 (-3.3A)
FAD  A 401 ( 4.9A)
 1.06A 1r9oA-3kljA:
undetectable		 1r9oA-3kljA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		5 LEU A  24
VAL A 107
GLY A 117
ALA A 116
LEU A  38
 None
None
None
GOL  A 262 (-2.8A)
None
 0.97A 1r9oA-3laoA:
undetectable		 1r9oA-3laoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Brucella suis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 263
LEU A 275
GLY A 255
ALA A 253
LEU A 265
 None
 1.08A 1r9oA-3meqA:
undetectable		 1r9oA-3meqA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msp MAJOR SPERM PROTEIN

(Ascaris suum) 		PF00635
(Motile_Sperm) 		5 ASN A  95
ILE A  41
GLY A  37
ALA A  36
THR A  34
 None
 0.93A 1r9oA-3mspA:
undetectable		 1r9oA-3mspA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		6 LEU A 523
VAL A 485
ASP A 538
GLY A 539
ALA A 541
THR A 544
 None
 1.27A 1r9oA-3nowA:
undetectable		 1r9oA-3nowA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 ARG A 310
ASN A 547
LEU A 546
ASP A 554
LEU A 626
 None
 0.93A 1r9oA-3o8lA:
undetectable		 1r9oA-3o8lA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 ARG B 493
ASN B 735
LEU B 734
ASP B 742
LEU B 818
 None
 1.01A 1r9oA-3o8oB:
undetectable		 1r9oA-3o8oB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 ILE A 373
LEU A  37
GLY A 411
ALA A 413
LEU A 354
 None
 1.05A 1r9oA-3pplA:
undetectable		 1r9oA-3pplA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		5 VAL A 231
ILE A 262
GLY A  14
ALA A  15
LEU A 227
 None
None
FDA  A 483 (-3.1A)
None
None
 1.05A 1r9oA-3rhaA:
undetectable		 1r9oA-3rhaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 VAL A1782
ILE A1789
ASP A1786
GLY A1801
ALA A1802
 None
 1.09A 1r9oA-3va7A:
undetectable		 1r9oA-3va7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A  68
LEU A  71
GLY A 115
ALA A 116
LEU A  85
 None
 1.02A 1r9oA-3vc7A:
undetectable		 1r9oA-3vc7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 176
ILE A 286
VAL A 279
ALA A 235
LEU A 192
 None
 0.96A 1r9oA-3vpxA:
undetectable		 1r9oA-3vpxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 VAL A  78
ILE A  93
LEU A  90
VAL A 150
LEU A  81
 None
 1.04A 1r9oA-3w6mA:
undetectable		 1r9oA-3w6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 LEU A 404
VAL A1005
GLY A 983
ALA A 347
LEU A 376
 None
None
None
None
LMT  A1101 ( 4.4A)
 1.03A 1r9oA-3w9iA:
undetectable		 1r9oA-3w9iA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfj 2-DEHYDROPANTOATE
2-REDUCTASE

(Enterococcus
faecium) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A 139
ILE A   5
GLY A   9
ALA A  10
LEU A 141
 None
None
NAD  A 401 (-3.0A)
NAD  A 401 (-3.1A)
None
 0.93A 1r9oA-3wfjA:
undetectable		 1r9oA-3wfjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		5 VAL A 201
LEU A 151
GLY A 100
ALA A 101
THR A 103
 None
 0.91A 1r9oA-3zfcA:
undetectable		 1r9oA-3zfcA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		5 ILE A 229
LEU A 230
VAL A  61
GLY A 288
ALA A 287
 None
 1.08A 1r9oA-4c1nA:
undetectable		 1r9oA-4c1nA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB

(Bacillus
subtilis) 		PF01471
(PG_binding_1)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 VAL A 326
ASN A 362
ILE A 364
GLY A 316
ALA A 315
 None
 1.02A 1r9oA-4c2fA:
undetectable		 1r9oA-4c2fA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
EDO  A1491 ( 4.9A)
None
None
None
 0.96A 1r9oA-4cnsA:
undetectable		 1r9oA-4cnsA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
 0.95A 1r9oA-4cntA:
undetectable		 1r9oA-4cntA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514

(Mycobacterium
tuberculosis) 		PF02668
(TauD) 		5 ARG A 187
ASN A 246
ASP A 272
GLY A 271
THR A  66
 None
 1.05A 1r9oA-4cvyA:
undetectable		 1r9oA-4cvyA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 104
VAL A  98
ASP A 114
ALA A 116
THR A  51
 None
 1.03A 1r9oA-4drtA:
undetectable		 1r9oA-4drtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A  10
ILE A  76
LEU A  26
GLY A  29
ALA A  14
 None
 1.06A 1r9oA-4h5iA:
undetectable		 1r9oA-4h5iA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		5 VAL C 130
LEU C  75
ALA C 215
THR C  89
LEU C 238
 None
 1.07A 1r9oA-4ifdC:
undetectable		 1r9oA-4ifdC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 VAL A 243
ILE A 186
LEU A 185
GLY A 269
ALA A 270
 None
 0.94A 1r9oA-4j1sA:
undetectable		 1r9oA-4j1sA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2o UDP-N-ACETYLGLUCOSAM
INE
4,6-DEHYDRATASE/5-EP
IMERASE

(Acinetobacter
baumannii) 		PF02719
(Polysacc_synt_2)
PF08485
(Polysacc_syn_2C) 		5 VAL A  61
ILE A   9
LEU A   8
VAL A 119
ALA A  81
 NAP  A 400 (-3.5A)
None
None
None
NAP  A 400 (-3.4A)
 1.07A 1r9oA-4j2oA:
undetectable		 1r9oA-4j2oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		6 ILE A 397
VAL A 923
GLY A 400
ALA A 401
THR A 365
LEU A 349
 None
 1.47A 1r9oA-4k0eA:
undetectable		 1r9oA-4k0eA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 VAL A 793
ASN A 842
ILE A 846
VAL A 912
LEU A 790
 None
 1.08A 1r9oA-4knhA:
undetectable		 1r9oA-4knhA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXB

(Escherichia
coli) 		PF01376
(Enterotoxin_b) 		5 ILE B  24
VAL B  50
ASP B  70
ALA B  74
THR B  78
 None
 1.10A 1r9oA-4l63B:
undetectable		 1r9oA-4l63B:
13.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 209
ASP A 298
GLY A 301
ALA A 302
THR A 306
 3QZ  A 601 ( 4.8A)
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 3.0A)
3QZ  A 601 (-2.9A)
HEM  A 600 ( 3.2A)
 0.93A 1r9oA-4nkyA:
43.3		 1r9oA-4nkyA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu3 ICE-BINDING PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		5 ILE A  48
VAL A 116
MET A 119
ALA A 244
THR A 246
 None
 1.07A 1r9oA-4nu3A:
undetectable		 1r9oA-4nu3A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A 228
LEU A  88
GLY A 481
ALA A 482
LEU A 185
 None
 0.81A 1r9oA-4qs9A:
undetectable		 1r9oA-4qs9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r01 PUTATIVE NADH-FLAVIN
REDUCTASE

(Streptococcus
pneumoniae) 		PF13460
(NAD_binding_10) 		5 ARG A  23
ILE A  62
LEU A   3
ASP A 192
THR A 146
 None
 1.02A 1r9oA-4r01A:
undetectable		 1r9oA-4r01A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR

(Bacillus
anthracis) 		PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11) 		5 VAL A 250
ASN A 177
ILE A 178
LEU A 181
LEU A 252
 None
 1.04A 1r9oA-4r6iA:
undetectable		 1r9oA-4r6iA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		5 ARG A 383
ASN A 385
ILE A 387
ASP A 431
LEU A 428
 None
 1.08A 1r9oA-4rcwA:
undetectable		 1r9oA-4rcwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 VAL A 160
ASN A  84
VAL A 228
MET A 229
LEU A 174
 None
None
B3P  A 301 (-3.5A)
None
None
 1.08A 1r9oA-4uovA:
undetectable		 1r9oA-4uovA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		5 LEU A  38
ASP A  96
GLY A 100
ALA A  99
LEU A 242
 None
 1.07A 1r9oA-4wcjA:
undetectable		 1r9oA-4wcjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 ASN A 462
ILE A 461
ASP A 376
GLY A 459
LEU A 407
 None
 1.09A 1r9oA-4wxxA:
undetectable		 1r9oA-4wxxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ASN A 551
ILE A 552
GLY A 555
ALA A 557
LEU A 606
 None
 0.99A 1r9oA-4xhjA:
undetectable		 1r9oA-4xhjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 ILE A1532
LEU A1535
VAL A1502
GLY A1592
ALA A1593
 None
 1.01A 1r9oA-5cwvA:
undetectable		 1r9oA-5cwvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 VAL A 234
ASP A 220
ALA A 216
THR A 167
LEU A 236
 None
None
None
FMN  A 801 (-4.1A)
None
 1.06A 1r9oA-5gxuA:
undetectable		 1r9oA-5gxuA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 VAL B 793
ASN B 842
ILE B 846
VAL B 912
LEU B 790
 None
 1.01A 1r9oA-5hb4B:
undetectable		 1r9oA-5hb4B:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		5 VAL A  82
ASN A  26
GLY A  28
ALA A  29
LEU A  80
 None
 1.09A 1r9oA-5hhlA:
undetectable		 1r9oA-5hhlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ILE A 433
VAL A 269
GLY A 410
ALA A 409
LEU A 397
 None
 1.09A 1r9oA-5jryA:
undetectable		 1r9oA-5jryA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		5 ARG A  16
VAL A  19
ILE A 119
LEU A  93
ASP A  96
 None
 1.09A 1r9oA-5kh0A:
undetectable		 1r9oA-5kh0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 VAL B 229
ILE B 390
GLY B 337
ALA B 339
THR B 325
 None
 1.00A 1r9oA-5my0B:
undetectable		 1r9oA-5my0B:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o63 RESTRICTION
ENDONUCLEASE UBALAI

(unidentified) 		no annotation 5 ARG A 158
ILE A 148
GLY A 145
ALA A 141
LEU A 108
 None
 1.03A 1r9oA-5o63A:
undetectable		 1r9oA-5o63A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
 0.96A 1r9oA-5uqcA:
undetectable		 1r9oA-5uqcA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 10 VAL A 113
ASN A 204
ILE A 205
LEU A 208
VAL A 237
ASP A 293
GLY A 296
ALA A 297
THR A 301
LEU A 366
 HEM  A 504 ( 3.7A)
LSN  A 501 (-3.7A)
None
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.9A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
 0.59A 1r9oA-5xxiA:
54.8		 1r9oA-5xxiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 10 VAL A 113
ILE A 205
LEU A 208
VAL A 237
MET A 240
ASP A 293
GLY A 296
ALA A 297
THR A 301
LEU A 366
 HEM  A 504 ( 3.7A)
None
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.3A)
LSN  A 501 (-3.9A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
 0.75A 1r9oA-5xxiA:
54.8		 1r9oA-5xxiA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 5 ARG M 502
ILE M 320
LEU M 537
ASP M 540
ALA M 323
 A  N   1 ( 4.8A)
None
None
A  N   1 ( 3.7A)
None
 1.08A 1r9oA-6d6qM:
undetectable		 1r9oA-6d6qM:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 5 VAL D 118
LEU D 134
VAL D 105
ALA D 140
LEU D 120
 None
 1.08A 1r9oA-6h25D:
undetectable		 1r9oA-6h25D:
undetectable