SIMILAR PATTERNS OF AMINO ACIDS FOR 1R5L_A_VIVA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 SER A 136
SER A 140
LEU A 183
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
None
VIV  A 301 (-3.9A)
 0.03A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Mus musculus) 		PF00400
(WD40) 		4 SER C 288
SER C 291
LEU C 312
PHE C 310
 None
 1.36A 1r5lA-1vyhC:
0.0		 1r5lA-1vyhC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc4 RAS-RELATED PROTEIN
RAL-A

(Homo sapiens) 		PF00071
(Ras) 		4 SER A 100
SER A  22
LEU A 124
PHE A 107
 None
 1.22A 1r5lA-1zc4A:
0.8		 1r5lA-1zc4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b18 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF06018
(CodY) 		4 SER A  37
SER A 129
LEU A 126
PHE A  40
 None
 1.43A 1r5lA-2b18A:
0.0		 1r5lA-2b18A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF10585
(UBA_e1_thiolCys) 		4 SER A 323
SER A 325
LEU A 361
PHE A 354
 None
 1.43A 1r5lA-2px9A:
undetectable		 1r5lA-2px9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adp LAMBDA-CRYSTALLIN

(Oryctolagus
cuniculus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 SER A 123
SER A 121
LEU A  99
PHE A 106
 NAI  A1001 ( 4.8A)
None
None
None
 1.46A 1r5lA-3adpA:
0.3		 1r5lA-3adpA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhg N-GLYCOSYLASE/DNA
LYASE

(Sulfolobus
solfataricus) 		PF00730
(HhH-GPD) 		4 SER A  50
SER A  46
LEU A  74
PHE A  81
 None
 1.48A 1r5lA-3fhgA:
0.0		 1r5lA-3fhgA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 374
SER A 386
LEU A 188
PHE A  89
 None
 1.42A 1r5lA-3n5fA:
0.6		 1r5lA-3n5fA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		4 SER A 248
SER A 246
LEU A 240
PHE A 242
 None
 1.35A 1r5lA-3phgA:
0.0		 1r5lA-3phgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		4 SER A 141
SER A 144
LEU A 138
PHE A  85
 None
 1.28A 1r5lA-3w0fA:
undetectable		 1r5lA-3w0fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		4 SER A 596
SER A 820
LEU A 795
PHE A 818
 None
 1.47A 1r5lA-3wxfA:
undetectable		 1r5lA-3wxfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF01344
(Kelch_1) 		4 SER A 344
SER A 342
LEU A 383
PHE A 385
 None
 1.23A 1r5lA-4ascA:
undetectable		 1r5lA-4ascA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtq XAC2610 PROTEIN

(Xanthomonas
citri) 		no annotation 4 SER A 192
SER A 194
LEU A 179
PHE A 189
 None
 1.25A 1r5lA-4qtqA:
undetectable		 1r5lA-4qtqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 SER A 127
SER A 121
LEU A 296
PHE A 119
 None
 1.15A 1r5lA-4w1wA:
undetectable		 1r5lA-4w1wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 SER A 222
SER A 218
LEU A 154
PHE A 156
 None
 1.04A 1r5lA-4ydhA:
undetectable		 1r5lA-4ydhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 4 SER A 296
SER A 300
LEU A 417
PHE A 363
 None
 1.21A 1r5lA-5fodA:
undetectable		 1r5lA-5fodA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 SER A 326
SER A 331
LEU A 314
PHE A 323
 None
 1.46A 1r5lA-5fqdA:
undetectable		 1r5lA-5fqdA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 609
SER A 697
LEU A 159
PHE A 155
 None
 1.25A 1r5lA-5jp0A:
undetectable		 1r5lA-5jp0A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 SER A 104
SER A 147
LEU A   4
PHE A  21
 None
 1.34A 1r5lA-5mrrA:
undetectable		 1r5lA-5mrrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 SER A 136
SER A 140
LEU A 183
PHE A 187
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
None
VIV  A 302 (-4.0A)
 0.14A 1r5lA-5mueA:
39.2		 1r5lA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 4 SER A 555
SER A 571
LEU A 200
PHE A 221
 None
 1.39A 1r5lA-5n4aA:
undetectable		 1r5lA-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR

(Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS) 		4 SER A 131
SER A 269
LEU A 128
PHE A 271
 GOL  A 301 (-3.5A)
None
None
None
 1.44A 1r5lA-5y7yA:
undetectable		 1r5lA-5y7yA:
19.93