SIMILAR PATTERNS OF AMINO ACIDS FOR 1R5L_A_VIVA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 285
PHE A 117
ILE A 130
ILE A   8
ILE A 298
 None
 0.97A 1r5lA-1geuA:
undetectable		 1r5lA-1geuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ILE E 242
ILE E  47
VAL E 121
ILE E 212
ILE E 238
 None
 1.33A 1r5lA-1h9hE:
undetectable		 1r5lA-1h9hE:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 PHE A 113
ILE A 121
ILE A 195
ILE A 127
VAL A 145
 None
 0.98A 1r5lA-1hn0A:
undetectable		 1r5lA-1hn0A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		5 VAL B 347
ILE B 255
TRP B 369
ILE B 341
VAL B 261
 None
 1.09A 1r5lA-1i2mB:
undetectable		 1r5lA-1i2mB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j25 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF02732
(ERCC4) 		5 ILE A 101
ILE A 128
ILE A  79
VAL A 110
ILE A  47
 None
 1.19A 1r5lA-1j25A:
2.1		 1r5lA-1j25A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		5 ILE A  16
ILE A  87
ILE A 115
VAL A 134
ILE A  89
 None
None
None
CME  A 117 ( 4.7A)
None
 0.96A 1r5lA-1jeoA:
0.1		 1r5lA-1jeoA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 VAL A  98
ILE A 107
ILE A  50
VAL A  70
ILE A  61
 None
 1.31A 1r5lA-1k6dA:
1.7		 1r5lA-1k6dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 170
ILE A 121
VAL A  63
ILE A  75
ILE A 178
 None
 1.30A 1r5lA-1kfiA:
undetectable		 1r5lA-1kfiA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		5 PHE A 162
ILE A  73
ILE A 105
VAL A 107
ILE A 172
 None
 0.97A 1r5lA-1ktwA:
0.0		 1r5lA-1ktwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		5 ILE A 122
ILE A  25
ILE A 105
VAL A 129
ILE A  87
 None
 1.18A 1r5lA-1n1aA:
undetectable		 1r5lA-1n1aA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3y INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA) 		5 PHE A 184
ILE A 263
VAL A 134
ILE A 314
ILE A 159
 None
 1.18A 1r5lA-1n3yA:
undetectable		 1r5lA-1n3yA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 ILE A 281
ILE A 249
VAL A 247
VAL A 196
ILE A 198
 None
 1.21A 1r5lA-1nhcA:
undetectable		 1r5lA-1nhcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		5 VAL A 150
ILE A 186
VAL A  61
ILE A  63
ILE A 100
 None
 1.17A 1r5lA-1px8A:
2.0		 1r5lA-1px8A:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TRP A 122
VAL A 132
PHE A 133
ILE A 154
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
VAL A 191
ILE A 194
ILE A 210
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 3.9A)
None
VIV  A 301 (-3.9A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.02A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 VAL A 135
PHE A 133
PHE A 158
VAL A 182
ILE A 194
 None
VIV  A 301 ( 3.9A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 ( 4.5A)
 1.34A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A 184
ILE A 197
VAL A 211
VAL A 220
ILE A 222
 None
 0.88A 1r5lA-1rk2A:
undetectable		 1r5lA-1rk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 216
ILE A 256
VAL A 236
ILE A 173
ILE A 262
 None
 1.26A 1r5lA-1y9aA:
undetectable		 1r5lA-1y9aA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 VAL A  92
ILE A  60
ILE A  55
VAL A 156
ILE A   6
 None
 1.25A 1r5lA-1yt3A:
undetectable		 1r5lA-1yt3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu9 HISTONE CHAPERONE
CIA1

(Schizosaccharomyces
pombe) 		PF04729
(ASF1_hist_chap) 		5 PHE A  24
TRP A  40
ILE A   6
VAL A 114
ILE A  96
 None
 1.32A 1r5lA-2cu9A:
undetectable		 1r5lA-2cu9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		5 TRP A  40
VAL A  65
ILE A 213
VAL A  91
ILE A 106
 None
 1.28A 1r5lA-2d3rA:
undetectable		 1r5lA-2d3rA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcl HYPOTHETICAL UPF0166
PROTEIN PH1503

(Pyrococcus
horikoshii) 		PF02641
(DUF190) 		5 VAL A  30
ILE A  94
ILE A  14
VAL A  76
ILE A  99
 None
None
None
AMP  A 901 ( 4.5A)
None
 1.37A 1r5lA-2dclA:
undetectable		 1r5lA-2dclA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 ILE A 108
ILE A  86
VAL A 113
VAL A 122
ILE A 134
 None
 1.25A 1r5lA-2ew9A:
undetectable		 1r5lA-2ew9A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fno AGR_PAT_752P

(Agrobacterium
fabrum) 		no annotation 5 VAL A 234
ILE A 137
PHE A 129
ILE A 227
VAL A 176
 None
 1.18A 1r5lA-2fnoA:
undetectable		 1r5lA-2fnoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A2827
ILE A3081
ILE A3077
VAL A2974
ILE A2978
 None
 1.25A 1r5lA-2h84A:
undetectable		 1r5lA-2h84A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E

(Colletotrichum
lupini) 		PF00295
(Glyco_hydro_28) 		5 ILE A 273
ILE A 241
VAL A 239
VAL A 188
ILE A 190
 None
 1.23A 1r5lA-2iq7A:
undetectable		 1r5lA-2iq7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oys HYPOTHETICAL PROTEIN
SP1951

(Streptococcus
pneumoniae) 		PF03358
(FMN_red) 		5 VAL A 152
ILE A  84
ILE A 173
ILE A 181
ILE A  82
 None
 1.33A 1r5lA-2oysA:
undetectable		 1r5lA-2oysA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		5 VAL A  54
PHE A  47
ILE A 105
ILE A 119
ILE A 103
 None
 1.36A 1r5lA-2pyjA:
undetectable		 1r5lA-2pyjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		5 VAL A 165
ILE A 176
ILE A 193
ILE A 185
VAL A 235
 None
 1.32A 1r5lA-2q3oA:
undetectable		 1r5lA-2q3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		5 VAL A  89
ILE A 127
ILE A 139
VAL A 184
ILE A 152
 None
 1.17A 1r5lA-2qy1A:
undetectable		 1r5lA-2qy1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7b ACTIN-BINDING
PROTEIN ANILLIN

(Homo sapiens) 		PF00169
(PH) 		5 VAL A1073
ILE A 992
ILE A1032
ILE A1042
ILE A1014
 None
None
None
EDO  A2000 ( 4.7A)
None
 1.30A 1r5lA-2y7bA:
undetectable		 1r5lA-2y7bA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymz GALECTIN 2

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 PHE A  76
ILE A  33
VAL A  86
VAL A 103
ILE A  55
 None
 1.19A 1r5lA-2ymzA:
undetectable		 1r5lA-2ymzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00731
(AIRC) 		5 ILE A 130
ILE A  58
ILE A  56
VAL A  54
ILE A 117
 None
 1.35A 1r5lA-2ywxA:
undetectable		 1r5lA-2ywxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ILE A 253
PHE A 239
ILE A 197
ILE A 238
ILE A 232
 None
 1.09A 1r5lA-2zygA:
undetectable		 1r5lA-2zygA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5f DIHYDRODIPICOLINATE
SYNTHASE

(Clostridium
botulinum) 		PF00701
(DHDPS) 		5 ILE A  29
ILE A 132
ILE A  75
VAL A  68
ILE A   3
 None
KPI  A 162 ( 4.8A)
None
None
None
 1.01A 1r5lA-3a5fA:
1.5		 1r5lA-3a5fA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		5 ILE A 277
ILE A 269
VAL A 274
ILE A  35
ILE A  49
 None
 1.08A 1r5lA-3a5vA:
undetectable		 1r5lA-3a5vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 ILE A  44
ILE A  13
ILE A 115
ILE A  52
ILE A  28
 EDO  A 402 (-4.6A)
None
None
None
None
 1.11A 1r5lA-3ce9A:
undetectable		 1r5lA-3ce9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7i CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY
PROTEIN

(Methanocaldococcus
jannaschii) 		PF02627
(CMD) 		5 ILE A  73
ILE A  48
VAL A  51
ILE A 100
ILE A  78
 None
 1.21A 1r5lA-3d7iA:
undetectable		 1r5lA-3d7iA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		5 ILE A 133
ILE A 112
VAL A 237
ILE A 280
ILE A  29
 None
 1.28A 1r5lA-3e9zA:
undetectable		 1r5lA-3e9zA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD

(Ruegeria
pomeroyi) 		PF12680
(SnoaL_2) 		5 ILE A   5
PHE A 101
ILE A  20
VAL A  11
ILE A  98
 None
 1.26A 1r5lA-3fljA:
undetectable		 1r5lA-3fljA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD

(Ruegeria
pomeroyi) 		PF12680
(SnoaL_2) 		5 VAL A  52
PHE A 101
ILE A  20
VAL A  11
ILE A  98
 UNL  A 137 ( 4.9A)
None
None
None
None
 1.35A 1r5lA-3fljA:
undetectable		 1r5lA-3fljA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 216
ILE A 256
VAL A 236
ILE A 173
ILE A 262
 None
 1.25A 1r5lA-3fpcA:
undetectable		 1r5lA-3fpcA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 VAL A 164
ILE A 175
ILE A 192
ILE A 184
VAL A 234
 None
 1.29A 1r5lA-3hgoA:
2.2		 1r5lA-3hgoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 ILE A 117
PHE A 145
ILE A 158
VAL A 156
ILE A  24
 None
 1.32A 1r5lA-3ig4A:
undetectable		 1r5lA-3ig4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 PHE A 336
ILE A 211
ILE A 194
VAL A 209
ILE A 197
 None
 1.21A 1r5lA-3ihjA:
2.2		 1r5lA-3ihjA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		5 ILE A 247
ILE A 254
VAL A 103
VAL A 121
ILE A 128
 None
 1.31A 1r5lA-3lhlA:
undetectable		 1r5lA-3lhlA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 PHE A 447
ILE A 472
ILE A 511
VAL A 558
ILE A 468
 None
 1.20A 1r5lA-3lk6A:
undetectable		 1r5lA-3lk6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 ILE A 164
ILE A 221
VAL A 183
ILE A 187
ILE A 231
 None
 1.23A 1r5lA-3p4gA:
undetectable		 1r5lA-3p4gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		5 PHE A 119
PHE A 189
ILE A 131
ILE A 123
ILE A 193
 None
 1.25A 1r5lA-3qtaA:
undetectable		 1r5lA-3qtaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00171
(Aldedh) 		5 PHE A   7
ILE A 181
ILE A  92
ILE A 166
ILE A 111
 PHE  A   7 ( 1.3A)
ILE  A 181 ( 0.7A)
ILE  A  92 ( 0.7A)
ILE  A 166 ( 0.7A)
ILE  A 111 ( 0.7A)
 1.21A 1r5lA-3r64A:
undetectable		 1r5lA-3r64A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 ILE A 381
ILE A 292
VAL A 318
ILE A 332
ILE A 282
 None
 1.34A 1r5lA-3sucA:
undetectable		 1r5lA-3sucA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		5 PHE A 184
ILE A  91
ILE A   5
ILE A 201
ILE A  89
 None
 1.37A 1r5lA-3v3tA:
2.8		 1r5lA-3v3tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		5 VAL A  52
ILE A 112
ILE A  97
ILE A 105
ILE A 123
 None
 1.27A 1r5lA-3vmwA:
undetectable		 1r5lA-3vmwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		5 VAL A  52
ILE A 112
ILE A  97
VAL A  68
ILE A 123
 None
 1.25A 1r5lA-3vmwA:
undetectable		 1r5lA-3vmwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		5 ILE A 127
TRP A 142
ILE A 187
VAL A 184
ILE A  37
 None
None
HEZ  A 317 ( 4.3A)
HEZ  A 317 (-4.7A)
None
 1.14A 1r5lA-3wl4A:
undetectable		 1r5lA-3wl4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		5 VAL A 173
ILE A  70
ILE A  66
VAL A  61
ILE A  52
 None
 1.35A 1r5lA-3wyhA:
undetectable		 1r5lA-3wyhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		5 ILE A  89
ILE A 141
VAL A  86
ILE A   8
ILE A 132
 None
 1.03A 1r5lA-3ztoA:
undetectable		 1r5lA-3ztoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 VAL A 410
ILE A 545
ILE A 470
VAL A 677
ILE A 463
 None
 1.15A 1r5lA-4a01A:
undetectable		 1r5lA-4a01A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 VAL A 144
ILE A 108
ILE A 161
ILE A 172
ILE A 193
 None
 1.24A 1r5lA-4cvqA:
undetectable		 1r5lA-4cvqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Corynebacterium
diphtheriae) 		PF01625
(PMSR) 		5 ILE A 172
ILE A  48
VAL A 157
ILE A 176
ILE A  46
 None
 1.17A 1r5lA-4d7lA:
undetectable		 1r5lA-4d7lA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 VAL A 310
PHE A 313
ILE A 416
VAL A 178
ILE A 420
 None
 0.72A 1r5lA-4df9A:
undetectable		 1r5lA-4df9A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		5 ILE A  63
ILE A 381
ILE A 418
ILE A 435
ILE A 379
 None
 1.13A 1r5lA-4ffcA:
undetectable		 1r5lA-4ffcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 ILE A 288
ILE A 291
VAL A 315
VAL A 339
ILE A 310
 None
 1.17A 1r5lA-4fmzA:
undetectable		 1r5lA-4fmzA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 VAL A  96
PHE A  75
ILE A  86
ILE A  52
VAL A  54
 None
 1.22A 1r5lA-4hw6A:
undetectable		 1r5lA-4hw6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 ILE A 111
PHE A 167
ILE A 180
VAL A 119
ILE A 156
 None
 1.10A 1r5lA-4ixoA:
undetectable		 1r5lA-4ixoA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		5 VAL A 365
ILE A 336
PHE A 212
ILE A 121
ILE A 103
 None
 1.18A 1r5lA-4kq7A:
undetectable		 1r5lA-4kq7A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		5 ILE A 122
ILE A  25
ILE A 105
VAL A 129
ILE A  87
 None
None
None
None
DMS  A 304 (-3.8A)
 1.28A 1r5lA-4lawA:
undetectable		 1r5lA-4lawA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 174
VAL A 279
VAL A 265
ILE A 292
ILE A   5
 None
 1.26A 1r5lA-4nhdA:
undetectable		 1r5lA-4nhdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		5 ILE A  16
ILE A 334
ILE A   6
VAL A 104
ILE A  74
 None
 1.12A 1r5lA-4nwzA:
undetectable		 1r5lA-4nwzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 VAL A 306
PHE A 307
ILE A 466
ILE A 388
VAL A 465
 None
 1.01A 1r5lA-4ovdA:
undetectable		 1r5lA-4ovdA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 PHE A 252
ILE A 220
ILE A 250
ILE A 174
ILE A 248
 None
 1.34A 1r5lA-4p7hA:
undetectable		 1r5lA-4p7hA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 VAL A 266
PHE A 270
ILE A 229
ILE A 136
ILE A 172
 None
None
None
None
OLC  A1201 (-4.3A)
 1.05A 1r5lA-4rwaA:
undetectable		 1r5lA-4rwaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		5 ILE A 250
PHE A 274
VAL A 309
ILE A 311
ILE A 290
 None
 1.20A 1r5lA-4txgA:
1.2		 1r5lA-4txgA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 197
ILE A  89
ILE A  17
VAL A 194
ILE A  41
 None
 1.27A 1r5lA-4u39A:
undetectable		 1r5lA-4u39A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8l ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 PHE A 513
ILE A 527
VAL A 473
ILE A 477
ILE A 559
 None
 1.20A 1r5lA-4w8lA:
1.8		 1r5lA-4w8lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 ILE A 325
ILE A 335
VAL A 163
ILE A  23
ILE A 105
 None
 0.96A 1r5lA-4xywA:
undetectable		 1r5lA-4xywA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		5 ILE A 148
VAL A 146
VAL A  30
ILE A  27
ILE A 131
 None
 1.30A 1r5lA-4y4nA:
undetectable		 1r5lA-4y4nA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 377
ILE A 196
ILE A 426
VAL A 330
ILE A 210
 None
 1.35A 1r5lA-4ywoA:
undetectable		 1r5lA-4ywoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 174
VAL A 279
VAL A 265
ILE A 292
ILE A   5
 None
 1.33A 1r5lA-4z19A:
undetectable		 1r5lA-4z19A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z85 2-NITROBENZOATE
NITROREDUCTASE

(Pseudomonas
fluorescens) 		PF01613
(Flavin_Reduct) 		5 VAL A 129
ILE A  96
ILE A  81
VAL A  92
ILE A  59
 None
 1.12A 1r5lA-4z85A:
undetectable		 1r5lA-4z85A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 VAL A 898
ILE A 907
ILE A1044
ILE A 940
VAL A1025
 None
 1.20A 1r5lA-4zktA:
undetectable		 1r5lA-4zktA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0h LEUKOCYTE
CELL-DERIVED
CHEMOTAXIN-2

(Homo sapiens) 		PF01551
(Peptidase_M23) 		5 PHE A  52
ILE A  75
VAL A  82
ILE A  87
ILE A  56
 None
 0.68A 1r5lA-5b0hA:
undetectable		 1r5lA-5b0hA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idj CELL CYCLE HISTIDINE
KINASE CCKA

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 PHE A 392
ILE A 516
VAL A 417
ILE A 389
ILE A 538
 None
 1.17A 1r5lA-5idjA:
undetectable		 1r5lA-5idjA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioo AVPA

(Nanoarchaeota
archaeon JGI
OTU-1) 		no annotation 5 ILE A  40
ILE A 131
ILE A 167
ILE A 146
ILE A 169
 None
 1.17A 1r5lA-5iooA:
undetectable		 1r5lA-5iooA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B1055
ILE B1012
VAL B1052
ILE A 666
ILE B1017
 None
 1.33A 1r5lA-5ip9B:
undetectable		 1r5lA-5ip9B:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 PHE A 287
ILE A  85
ILE A 561
VAL A 154
ILE A 295
 None
 1.05A 1r5lA-5iw7A:
1.4		 1r5lA-5iw7A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 PHE A 207
ILE A 239
ILE A   8
VAL A   6
VAL A 215
 None
 1.26A 1r5lA-5kbpA:
undetectable		 1r5lA-5kbpA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l39 RMM MICROCOMPARTMENT
SHELL PROTEIN
MSM0275

(Mycolicibacterium
smegmatis) 		PF00936
(BMC) 		5 VAL A  83
ILE A  10
ILE A  38
ILE A  25
ILE A 150
 None
 1.18A 1r5lA-5l39A:
undetectable		 1r5lA-5l39A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbk COPPER-TRANSPORTING
ATPASE PAA2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 ILE A 687
ILE A 685
VAL A 573
VAL A 626
ILE A 592
 None
 1.29A 1r5lA-5lbkA:
undetectable		 1r5lA-5lbkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 ILE A 443
ILE A 453
ILE A 431
VAL A 414
ILE A 463
 None
 1.04A 1r5lA-5m60A:
undetectable		 1r5lA-5m60A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens;
Mus musculus) 		PF00452
(Bcl-2) 		5 VAL A 243
ILE A 294
VAL A 297
VAL A 253
ILE A 182
 None
None
None
7LW  A 401 (-4.0A)
None
 1.28A 1r5lA-5mevA:
undetectable		 1r5lA-5mevA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TRP A 122
VAL A 132
PHE A 133
ILE A 154
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
VAL A 191
ILE A 194
ILE A 210
 None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.1A)
None
VIV  A 302 (-3.9A)
None
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.9A)
VIV  A 302 ( 4.6A)
None
 0.24A 1r5lA-5mueA:
39.2		 1r5lA-5mueA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 VAL A 135
PHE A 133
PHE A 158
VAL A 182
ILE A 194
 None
VIV  A 302 ( 4.1A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.6A)
 1.34A 1r5lA-5mueA:
39.2		 1r5lA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whg PROTEIN VMS1

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A 282
ILE A 250
ILE A 324
VAL A 327
ILE A 353
 None
 1.01A 1r5lA-5whgA:
undetectable		 1r5lA-5whgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE A 127
ILE A 263
VAL A 209
ILE A 236
ILE A 266
 None
 1.26A 1r5lA-5wy3A:
undetectable		 1r5lA-5wy3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 PHE A 157
ILE A 201
ILE A 292
ILE A 273
ILE A 309
 None
 1.23A 1r5lA-5y09A:
undetectable		 1r5lA-5y09A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MONOBODY YSX1

(synthetic
construct) 		no annotation 5 VAL B  45
ILE B  59
ILE B  70
ILE B  86
ILE B  18
 None
 1.33A 1r5lA-6apxB:
undetectable		 1r5lA-6apxB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WDR5-BINDING
MONOBODY, MB(S4)

(Homo sapiens) 		no annotation 5 VAL M  45
ILE M  59
ILE M  70
ILE M  90
ILE M  20
 None
 1.36A 1r5lA-6bynM:
undetectable		 1r5lA-6bynM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 5 VAL A 308
ILE A 315
ILE A 392
VAL A 394
ILE A 354
 None
 1.20A 1r5lA-6co7A:
undetectable		 1r5lA-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 5 ILE A 206
ILE A 138
VAL A 207
ILE A 217
ILE A 182
 None
 0.98A 1r5lA-6d46A:
undetectable		 1r5lA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh8 -

(-) 		no annotation 5 ILE A 141
ILE A  88
ILE A 122
VAL A  59
ILE A  90
 None
 1.34A 1r5lA-6gh8A:
undetectable		 1r5lA-6gh8A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 SER A 136
SER A 140
LEU A 183
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
None
VIV  A 301 (-3.9A)
 0.03A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Mus musculus) 		PF00400
(WD40) 		4 SER C 288
SER C 291
LEU C 312
PHE C 310
 None
 1.36A 1r5lA-1vyhC:
0.0		 1r5lA-1vyhC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc4 RAS-RELATED PROTEIN
RAL-A

(Homo sapiens) 		PF00071
(Ras) 		4 SER A 100
SER A  22
LEU A 124
PHE A 107
 None
 1.22A 1r5lA-1zc4A:
0.8		 1r5lA-1zc4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b18 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF06018
(CodY) 		4 SER A  37
SER A 129
LEU A 126
PHE A  40
 None
 1.43A 1r5lA-2b18A:
0.0		 1r5lA-2b18A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF10585
(UBA_e1_thiolCys) 		4 SER A 323
SER A 325
LEU A 361
PHE A 354
 None
 1.43A 1r5lA-2px9A:
undetectable		 1r5lA-2px9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adp LAMBDA-CRYSTALLIN

(Oryctolagus
cuniculus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 SER A 123
SER A 121
LEU A  99
PHE A 106
 NAI  A1001 ( 4.8A)
None
None
None
 1.46A 1r5lA-3adpA:
0.3		 1r5lA-3adpA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhg N-GLYCOSYLASE/DNA
LYASE

(Sulfolobus
solfataricus) 		PF00730
(HhH-GPD) 		4 SER A  50
SER A  46
LEU A  74
PHE A  81
 None
 1.48A 1r5lA-3fhgA:
0.0		 1r5lA-3fhgA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 374
SER A 386
LEU A 188
PHE A  89
 None
 1.42A 1r5lA-3n5fA:
0.6		 1r5lA-3n5fA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		4 SER A 248
SER A 246
LEU A 240
PHE A 242
 None
 1.35A 1r5lA-3phgA:
0.0		 1r5lA-3phgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		4 SER A 141
SER A 144
LEU A 138
PHE A  85
 None
 1.28A 1r5lA-3w0fA:
undetectable		 1r5lA-3w0fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		4 SER A 596
SER A 820
LEU A 795
PHE A 818
 None
 1.47A 1r5lA-3wxfA:
undetectable		 1r5lA-3wxfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF01344
(Kelch_1) 		4 SER A 344
SER A 342
LEU A 383
PHE A 385
 None
 1.23A 1r5lA-4ascA:
undetectable		 1r5lA-4ascA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtq XAC2610 PROTEIN

(Xanthomonas
citri) 		no annotation 4 SER A 192
SER A 194
LEU A 179
PHE A 189
 None
 1.25A 1r5lA-4qtqA:
undetectable		 1r5lA-4qtqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 SER A 127
SER A 121
LEU A 296
PHE A 119
 None
 1.15A 1r5lA-4w1wA:
undetectable		 1r5lA-4w1wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 SER A 222
SER A 218
LEU A 154
PHE A 156
 None
 1.04A 1r5lA-4ydhA:
undetectable		 1r5lA-4ydhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 4 SER A 296
SER A 300
LEU A 417
PHE A 363
 None
 1.21A 1r5lA-5fodA:
undetectable		 1r5lA-5fodA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 SER A 326
SER A 331
LEU A 314
PHE A 323
 None
 1.46A 1r5lA-5fqdA:
undetectable		 1r5lA-5fqdA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 609
SER A 697
LEU A 159
PHE A 155
 None
 1.25A 1r5lA-5jp0A:
undetectable		 1r5lA-5jp0A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 SER A 104
SER A 147
LEU A   4
PHE A  21
 None
 1.34A 1r5lA-5mrrA:
undetectable		 1r5lA-5mrrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 SER A 136
SER A 140
LEU A 183
PHE A 187
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
None
VIV  A 302 (-4.0A)
 0.14A 1r5lA-5mueA:
39.2		 1r5lA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 4 SER A 555
SER A 571
LEU A 200
PHE A 221
 None
 1.39A 1r5lA-5n4aA:
undetectable		 1r5lA-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR

(Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS) 		4 SER A 131
SER A 269
LEU A 128
PHE A 271
 GOL  A 301 (-3.5A)
None
None
None
 1.44A 1r5lA-5y7yA:
undetectable		 1r5lA-5y7yA:
19.93