SIMILAR PATTERNS OF AMINO ACIDS FOR 1R35_B_H4BB1902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 SER A 334
MET A 336
ARG A 596
TRP A 678
 None
H4B  A 760 ( 3.8A)
H4B  A 760 (-3.5A)
H4B  A 760 ( 3.6A)
 0.78A 1r35B-1lzxA:
56.2		 1r35B-1lzxA:
62.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 SER A 112
MET A 114
ARG A 375
ILE A 456
TRP A 457
 H4B  A 901 (-4.8A)
H4B  A 901 (-4.0A)
H4B  A 901 (-3.4A)
H4B  A 901 (-4.7A)
H4B  A 901 ( 3.7A)
 0.57A 1r35B-1qw5A:
61.2		 1r35B-1qw5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsg COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN

(Homo sapiens) 		PF00169
(PH) 		4 SER A  89
ARG A  43
ILE A  88
TRP A  95
 None
 1.44A 1r35B-2rsgA:
undetectable		 1r35B-2rsgA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjh MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM13

(Saccharomyces
cerevisiae) 		PF02953
(zf-Tim10_DDP) 		4 SER A  84
MET A  82
ILE A  88
TRP A  85
 None
 1.49A 1r35B-3cjhA:
undetectable		 1r35B-3cjhA:
9.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.70A 1r35B-3e7gA:
58.9		 1r35B-3e7gA:
87.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfz FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER L  49
MET L  33
ILE L  48
TRP L  35
 None
 1.44A 1r35B-4jfzL:
0.0		 1r35B-4jfzL:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		4 SER A 113
ARG A  68
ILE A 119
TRP A 120
 None
 1.40A 1r35B-4wepA:
0.0		 1r35B-4wepA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  59
MET H  48
ILE H  69
TRP H  36
 None
 1.20A 1r35B-5alcH:
0.0		 1r35B-5alcH:
17.43