SIMILAR PATTERNS OF AMINO ACIDS FOR 1R30_B_SAMB501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		5 THR A 122
ASN A 123
HIS A 124
ILE A 145
LEU A 140
 None
 1.03A 1r30B-1b8iA:
undetectable		 1r30B-1b8iA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 THR A 422
GLY A 424
HIS A 366
LEU A 434
VAL A 435
 MCN  A 914 (-4.3A)
2MO  A 910 ( 3.5A)
None
None
None
 1.06A 1r30B-1dgjA:
undetectable		 1r30B-1dgjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		5 GLY A  22
HIS A  20
ARG A 327
ILE A 300
LEU A 305
 None
 1.19A 1r30B-1h3gA:
6.2		 1r30B-1h3gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kng THIOL:DISULFIDE
INTERCHANGE PROTEIN
CYCY

(Bradyrhizobium
japonicum) 		PF08534
(Redoxin) 		6 GLY A 106
ASN A  86
ILE A 116
LEU A  57
VAL A 141
LEU A 129
 None
 1.48A 1r30B-1kngA:
undetectable		 1r30B-1kngA:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		6 TYR A  59
PRO A  61
ARG A 168
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SF4  A 401 ( 4.4A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 1.18A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		6 TYR A  59
PRO A  61
GLY A 132
HIS A 152
ARG A 173
LEU A 232
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-2.7A)
SAM  A 501 ( 4.9A)
SAM  A 501 (-3.8A)
None
 1.49A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		12 TYR A  59
PRO A  61
THR A 130
GLY A 132
ASN A 151
HIS A 152
ASN A 153
ARG A 173
ILE A 192
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 ( 4.0A)
SAM  A 501 (-2.7A)
DTB  A 502 (-3.9A)
SAM  A 501 ( 4.9A)
DTB  A 502 ( 3.7A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 0.05A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sl8 AEQUORIN 1

(Aequorea
victoria) 		PF13202
(EF-hand_5) 		5 TYR A 134
GLY A 173
ILE A 118
LEU A  50
VAL A  46
 None
 1.10A 1r30B-1sl8A:
undetectable		 1r30B-1sl8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 251
ILE A 373
LEU A 355
VAL A 352
LEU A 384
 None
 1.14A 1r30B-1v8bA:
undetectable		 1r30B-1v8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		5 GLY A 223
ASN A 221
ASN A 163
ILE A 339
LEU A 337
 None
MG  A 400 (-2.8A)
None
None
None
 1.19A 1r30B-1xfiA:
undetectable		 1r30B-1xfiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		6 PRO A 150
THR A 374
GLY A 370
ASN A 375
ILE A 393
LEU A  58
 None
 1.50A 1r30B-1ybeA:
2.9		 1r30B-1ybeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 GLY A 231
HIS A 146
ILE A  55
LEU A  85
VAL A 102
 None
 1.08A 1r30B-1yp4A:
2.2		 1r30B-1yp4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Streptococcus
pneumoniae) 		PF02390
(Methyltransf_4) 		5 ASN A  37
ASN A  64
ILE A  66
LEU A  93
VAL A  21
 None
 1.08A 1r30B-1yzhA:
undetectable		 1r30B-1yzhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 TYR A  54
THR A 115
GLY A  45
ILE A 292
VAL A 170
 None
 1.14A 1r30B-2etvA:
undetectable		 1r30B-2etvA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzr UBIQUITIN
THIOESTERASE OTU1

(Mus musculus) 		no annotation 5 THR A  34
GLY A  35
ILE A  43
LEU A  64
LEU A  14
 None
 1.04A 1r30B-2kzrA:
undetectable		 1r30B-2kzrA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 GLY A 563
ASN A 570
ASN A 584
VAL A 530
LEU A 538
 None
 1.13A 1r30B-2o1sA:
undetectable		 1r30B-2o1sA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 422
ILE A 453
LEU A 145
VAL A 147
LEU A 180
 None
 1.17A 1r30B-2pokA:
undetectable		 1r30B-2pokA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		5 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.20A 1r30B-2qz6A:
undetectable		 1r30B-2qz6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		5 PRO A 162
GLY A 242
ILE A 165
LEU A 191
LEU A 141
 None
 1.18A 1r30B-2rliA:
undetectable		 1r30B-2rliA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1w PDZ AND LIM DOMAIN
PROTEIN 4

(Homo sapiens) 		PF00595
(PDZ) 		5 PRO A  26
GLY A  85
ILE A  29
LEU A  17
VAL A  18
 None
 1.16A 1r30B-2v1wA:
undetectable		 1r30B-2v1wA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 TYR A 540
ILE A 394
LEU A 516
VAL A 513
LEU A 547
 None
 1.20A 1r30B-2w1zA:
undetectable		 1r30B-2w1zA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 163
ASN A 184
ASN A  81
ILE A   7
LEU A   5
 EDO  A1510 (-3.4A)
None
None
None
None
 1.16A 1r30B-2w40A:
undetectable		 1r30B-2w40A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		5 PRO A 177
HIS A  69
ILE A 180
LEU A 152
VAL A 151
 None
 1.20A 1r30B-2x3lA:
undetectable		 1r30B-2x3lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01661
(Macro) 		5 TYR A 314
GLY A 273
ILE A 303
LEU A 156
LEU A 307
 None
 1.21A 1r30B-2x47A:
undetectable		 1r30B-2x47A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 GLY A 674
ASN A 698
ILE A 635
LEU A 619
LEU A 729
 None
None
None
None
NIY  A 730 ( 4.0A)
 1.07A 1r30B-2xaxA:
2.7		 1r30B-2xaxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc7 BETA-LACTAMASE ACT-1

(Klebsiella
pneumoniae) 		PF00144
(Beta-lactamase) 		5 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.15A 1r30B-2zc7A:
undetectable		 1r30B-2zc7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		5 TYR A 252
THR A  10
GLY A   9
ILE A 202
LEU A 188
 None
 1.11A 1r30B-3cgwA:
undetectable		 1r30B-3cgwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 THR A 420
GLY A 422
HIS A 365
LEU A 432
VAL A 433
 PCD  A 921 (-4.2A)
PCD  A 921 (-3.4A)
None
None
None
 1.08A 1r30B-3fahA:
undetectable		 1r30B-3fahA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbf PHPD

(Streptomyces
viridochromogenes) 		no annotation 5 TYR A 184
THR A 303
GLY A 301
ILE A 194
LEU A 113
 None
 1.17A 1r30B-3gbfA:
undetectable		 1r30B-3gbfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 TYR A  66
THR A 120
GLY A  80
ILE A  69
LEU A 130
 None
NAD  A 400 ( 4.3A)
NAD  A 400 (-4.5A)
None
None
 1.19A 1r30B-3gvhA:
undetectable		 1r30B-3gvhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		5 PRO A  30
ASN A 144
ILE A  26
LEU A  20
VAL A  17
 None
 1.00A 1r30B-3h4yA:
undetectable		 1r30B-3h4yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ARG A  97
ILE A  77
LEU A 116
VAL A 150
LEU A  91
 None
 1.18A 1r30B-3h55A:
10.2		 1r30B-3h55A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 TYR A 185
GLY A 204
ILE A 235
LEU A 181
LEU A 285
 None
None
None
MRD  A 302 ( 3.4A)
None
 1.20A 1r30B-3hwrA:
undetectable		 1r30B-3hwrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 ASN A 217
HIS A 222
ILE A 283
LEU A 281
VAL A 278
 None
 1.21A 1r30B-3i5bA:
undetectable		 1r30B-3i5bA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 GLY 3 294
ASN 3 225
ILE 3 226
LEU 3 200
VAL 3 199
 SF4  3 786 (-3.4A)
None
None
None
None
 1.08A 1r30B-3i9v3:
undetectable		 1r30B-3i9v3:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 THR A 294
GLY A 268
ASN A 270
HIS A 269
VAL A 366
 None
 1.10A 1r30B-3ikmA:
undetectable		 1r30B-3ikmA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 PRO A  72
THR A 145
ILE A 109
LEU A 102
VAL A  98
 None
 1.14A 1r30B-3l06A:
undetectable		 1r30B-3l06A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PRO A 467
GLY A 313
ASN A 360
ASN A  82
ILE A  75
 None
 1.19A 1r30B-3ljpA:
undetectable		 1r30B-3ljpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 PRO A 336
THR A 349
ILE A 331
LEU A 320
VAL A 316
 None
 1.21A 1r30B-3m1mA:
undetectable		 1r30B-3m1mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		5 HIS A 260
ILE A 156
LEU A  92
VAL A  91
LEU A  78
 None
 1.19A 1r30B-3md0A:
undetectable		 1r30B-3md0A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		5 HIS A 216
ILE A 154
LEU A 271
VAL A 270
LEU A 264
 None
 0.99A 1r30B-3mt0A:
undetectable		 1r30B-3mt0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PRO A  76
GLY A  69
ASN A  71
ARG A 257
VAL A 734
 None
 1.12A 1r30B-3n23A:
undetectable		 1r30B-3n23A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0d TRIACYLGLYCEROL
LIPASE

(Yarrowia
lipolytica) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		5 GLY A  32
HIS A  60
ILE A 140
LEU A 144
LEU A  55
 None
None
None
NAG  A 302 ( 4.9A)
None
 0.98A 1r30B-3o0dA:
undetectable		 1r30B-3o0dA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 THR B 224
GLY B 220
ASN B 227
ILE B 189
LEU B 128
 None
 1.14A 1r30B-3o8qB:
undetectable		 1r30B-3o8qB:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 5 TYR I 278
ASN I 127
ASN I 248
LEU I 276
LEU I 124
 None
 1.09A 1r30B-3opyI:
undetectable		 1r30B-3opyI:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		5 TYR A 136
THR A 105
GLY A 269
LEU A 147
VAL A 126
 None
 1.18A 1r30B-3rq1A:
1.9		 1r30B-3rq1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		5 THR A 191
GLY A 189
ASN A 133
LEU A 375
VAL A 376
 None
 1.07A 1r30B-3s30A:
undetectable		 1r30B-3s30A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 THR A 325
GLY A 324
ILE A 313
VAL A 305
LEU A 317
 None
 1.20A 1r30B-3s46A:
5.8		 1r30B-3s46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slt SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		5 PRO A1201
GLY A1284
LEU A1173
VAL A1174
LEU A1019
 None
C8E  A1301 ( 4.4A)
None
None
None
 1.17A 1r30B-3sltA:
undetectable		 1r30B-3sltA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 500 (-3.4A)
None
None
 1.10A 1r30B-3tk3A:
undetectable		 1r30B-3tk3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		5 TYR A 275
GLY A 266
ASN A 259
ILE A  28
LEU A  32
 None
 1.13A 1r30B-3w9uA:
undetectable		 1r30B-3w9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 ASN A 352
HIS A 280
ASN A 354
ILE A 400
LEU A 219
 None
 1.15A 1r30B-3wa1A:
undetectable		 1r30B-3wa1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 THR A  59
ASN A 342
ILE A  26
LEU A  20
VAL A  17
 None
 1.01A 1r30B-3wrtA:
undetectable		 1r30B-3wrtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 363
ASN A 329
ASN A 312
LEU A 143
VAL A 144
 None
 1.19A 1r30B-4aipA:
undetectable		 1r30B-4aipA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 GLY A 386
HIS A 431
ILE A 271
LEU A 452
VAL A 453
 None
 1.18A 1r30B-4am6A:
undetectable		 1r30B-4am6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 THR R 113
GLY R 111
HIS R 145
ILE R  77
LEU R  67
 None
 1.21A 1r30B-4bv4R:
undetectable		 1r30B-4bv4R:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 GLY A 125
ILE A  17
LEU A  27
VAL A  26
LEU A 394
 None
 1.16A 1r30B-4dykA:
7.1		 1r30B-4dykA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		5 THR A 166
GLY A 168
ILE A  90
LEU A 113
LEU A  37
 None
 1.15A 1r30B-4eogA:
undetectable		 1r30B-4eogA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		5 GLY A 154
ILE A  98
LEU A  99
VAL A 102
LEU A 113
 None
 1.17A 1r30B-4hbzA:
undetectable		 1r30B-4hbzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
sp. H13-3) 		PF00701
(DHDPS) 		5 GLY A 194
ASN A 196
ILE A 204
LEU A 101
VAL A 131
 None
 1.17A 1r30B-4i7uA:
7.0		 1r30B-4i7uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF00092
(VWA) 		5 GLY A 169
HIS A 202
ASN A 201
ILE A 262
VAL A 220
 None
 1.04A 1r30B-4jduA:
undetectable		 1r30B-4jduA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 PRO A 204
GLY A 271
ILE A 154
LEU A 214
LEU A 206
 None
 1.16A 1r30B-4k05A:
undetectable		 1r30B-4k05A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 5 GLY A1627
ILE A1754
LEU A1746
VAL A1742
LEU A1667
 None
 1.20A 1r30B-4kf8A:
undetectable		 1r30B-4kf8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 THR A 113
GLY A 111
HIS A 145
ILE A  77
LEU A  67
 None
 1.14A 1r30B-4lxrA:
undetectable		 1r30B-4lxrA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npl RNA DEMETHYLASE
ALKBH5

(Danio rerio) 		PF13532
(2OG-FeII_Oxy_2) 		5 GLY A  67
ASN A 119
ILE A 146
LEU A 187
VAL A 186
 None
 1.13A 1r30B-4nplA:
undetectable		 1r30B-4nplA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 TYR A1274
GLY A 664
ILE A1240
VAL A1225
LEU A1249
 None
EDO  A1305 (-3.4A)
None
None
None
 1.20A 1r30B-4o3mA:
undetectable		 1r30B-4o3mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o65 PUTATIVE ARCHAEAL
AMMONIA
MONOOXYGENASE
SUBUNIT B

(Candidatus
Nitrosocaldus
yellowstonensis) 		PF04744
(Monooxygenase_B) 		5 TYR A 143
GLY A 173
HIS A 158
ILE A 108
LEU A  90
 None
CU  A 201 ( 4.5A)
CU  A 201 (-3.2A)
None
None
 1.20A 1r30B-4o65A:
undetectable		 1r30B-4o65A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 GLY A 155
ASN A 218
ILE A 101
LEU A  84
LEU A  42
 None
X2X  A 402 (-2.8A)
None
None
None
 1.20A 1r30B-4oanA:
undetectable		 1r30B-4oanA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq1 PUTATIVE ELECTRON
TRANSPORT RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00578
(AhpC-TSA) 		5 GLY A  47
ILE A 157
LEU A  77
VAL A  76
LEU A 185
 None
 1.19A 1r30B-4pq1A:
undetectable		 1r30B-4pq1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uut HOMEOTIC PROTEIN
ULTRABITHORAX

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		5 THR A  22
ASN A  23
HIS A  24
ILE A  45
LEU A  40
 None
 1.16A 1r30B-4uutA:
undetectable		 1r30B-4uutA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		5 THR A 320
GLY A 308
ILE A 176
LEU A 167
VAL A 168
 None
 1.19A 1r30B-4wr2A:
undetectable		 1r30B-4wr2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 THR A 210
GLY A 208
ILE A 570
LEU A 544
LEU A 239
 None
 1.14A 1r30B-4xqkA:
undetectable		 1r30B-4xqkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 THR A  71
GLY A 409
HIS A 410
VAL A 450
LEU A 434
 None
 0.92A 1r30B-4xzcA:
undetectable		 1r30B-4xzcA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 TYR A 438
GLY A 522
ILE A 402
LEU A 418
VAL A 417
 None
 1.21A 1r30B-4ye5A:
undetectable		 1r30B-4ye5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfz OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 5 GLY A 223
HIS A 161
ILE A  84
LEU A 202
LEU A  65
 None
 1.20A 1r30B-4yfzA:
undetectable		 1r30B-4yfzA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 GLY A 488
HIS A 504
LEU A 354
VAL A 361
LEU A 317
 None
 1.19A 1r30B-5bu1A:
undetectable		 1r30B-5bu1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 501 (-3.5A)
None
None
 1.04A 1r30B-5e0eA:
undetectable		 1r30B-5e0eA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 259
ASN A 232
ASN A 122
ARG A 118
VAL A  96
 None
 1.22A 1r30B-5fr8A:
undetectable		 1r30B-5fr8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 THR A  49
GLY A  46
ILE A 462
LEU A 458
VAL A 457
 None
 1.16A 1r30B-5glgA:
undetectable		 1r30B-5glgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 TYR A 183
PRO A 182
GLY A 509
ILE A 219
LEU A 187
 None
 1.16A 1r30B-5h8wA:
undetectable		 1r30B-5h8wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASN A  19
ILE A  71
LEU A  81
VAL A  82
LEU A  30
 None
 1.20A 1r30B-5i2tA:
undetectable		 1r30B-5i2tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 TYR A  73
THR A 436
GLY A 434
LEU A 107
LEU A  68
 None
 1.07A 1r30B-5jbkA:
11.3		 1r30B-5jbkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmu PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

([Eubacterium]
rectale) 		PF01522
(Polysacc_deac_1) 		5 THR A 342
GLY A 340
HIS A 341
ILE A 292
VAL A 450
 None
 1.21A 1r30B-5jmuA:
3.5		 1r30B-5jmuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		5 GLY C1537
HIS C1467
LEU C1579
VAL C1549
LEU C1490
 None
 1.19A 1r30B-5jpnC:
undetectable		 1r30B-5jpnC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 PRO A 776
THR A 767
GLY A 768
LEU A 845
VAL A 838
 None
 1.19A 1r30B-5ju6A:
3.0		 1r30B-5ju6A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 259
ASN A 232
ASN A 114
ARG A 110
VAL A  88
 None
 1.21A 1r30B-5mzsA:
undetectable		 1r30B-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 THR A 359
GLY A 408
ILE A 371
LEU A 447
LEU A 437
 None
 1.05A 1r30B-5odoA:
undetectable		 1r30B-5odoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Thermus
thermophilus) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 PRO A 265
GLY A 213
ILE A 218
LEU A 229
VAL A 230
 None
 1.19A 1r30B-5t3oA:
undetectable		 1r30B-5t3oA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 THR A  48
GLY A 164
ILE A 240
LEU A 266
LEU A 197
 None
 1.21A 1r30B-5tzbA:
undetectable		 1r30B-5tzbA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 PRO E 566
THR E 245
HIS E 126
LEU E 569
VAL E 568
 None
 1.20A 1r30B-5u8sE:
undetectable		 1r30B-5u8sE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 TYR A  66
THR A 120
GLY A  80
ILE A  69
LEU A 130
 None
 1.14A 1r30B-5ulvA:
undetectable		 1r30B-5ulvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v38 HCHA

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 THR A 982
GLY A1037
ASN A 925
ILE A 923
LEU A 918
 None
 1.20A 1r30B-5v38A:
undetectable		 1r30B-5v38A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 PRO A 268
GLY A 351
ASN A 230
ILE A 250
LEU A  88
 None
 1.21A 1r30B-5w19A:
undetectable		 1r30B-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 5 PRO C 408
GLY C 556
ASN C 330
ILE C 258
LEU C 354
 None
 1.21A 1r30B-5w7cC:
undetectable		 1r30B-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 5 PRO A 407
GLY A 555
ASN A 329
ILE A 257
LEU A 353
 None
 1.21A 1r30B-5w7dA:
undetectable		 1r30B-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 501 ( 3.9A)
None
None
 1.04A 1r30B-5wbgA:
undetectable		 1r30B-5wbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 THR A  46
GLY A  45
ILE A 167
LEU A 126
LEU A 144
 None
 1.17A 1r30B-5wdxA:
undetectable		 1r30B-5wdxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus) 		no annotation 5 THR M 197
GLY M 194
LEU M  93
VAL M  92
LEU M  55
 None
 1.20A 1r30B-5x41M:
undetectable		 1r30B-5x41M:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE
STAPHYLOCOCCAL
PEROXIDASE INHIBITOR

(Homo sapiens;
Staphylococcus
aureus) 		no annotation
no annotation 		5 GLY A 439
ASN A 358
ASN A 355
LEU B  49
LEU B  72
 None
NAG  A 802 (-3.6A)
NAG  A 802 (-1.6A)
None
None
 1.10A 1r30B-6azpA:
undetectable		 1r30B-6azpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes) 		no annotation 5 THR A  56
ASN A 338
ILE A  23
LEU A  17
VAL A  14
 None
 1.09A 1r30B-6fm7A:
undetectable		 1r30B-6fm7A:
undetectable