SIMILAR PATTERNS OF AMINO ACIDS FOR 1R30_A_SAMA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2
METALLOCARBOXYPEPTID
ASE INHIBITOR

(Homo sapiens;
Hirudo
medicinalis) 		PF00246
(Peptidase_M14)
no annotation 		5 PRO B  64
GLY A 422
ASN A 500
ASP A 498
VAL B  17
 None
None
GLU  A 300 (-3.4A)
GLU  A 300 ( 4.5A)
None
 1.17A 1r30A-1dtdB:
undetectable		 1r30A-1dtdB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR A 139
GLY B 691
ASP B  27
ILE B  31
LEU A  86
 FES  A1907 ( 4.7A)
None
None
None
None
 1.18A 1r30A-1ffvA:
undetectable		 1r30A-1ffvA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		5 PRO A 139
GLY A  95
LEU A 111
VAL A 107
LEU A  75
 None
 1.22A 1r30A-1k7jA:
undetectable		 1r30A-1k7jA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kng THIOL:DISULFIDE
INTERCHANGE PROTEIN
CYCY

(Bradyrhizobium
japonicum) 		PF08534
(Redoxin) 		6 GLY A 106
ASN A  86
ILE A 116
LEU A  57
VAL A 141
LEU A 129
 None
 1.48A 1r30A-1kngA:
undetectable		 1r30A-1kngA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ARG A  81
ILE A  60
LEU A 100
VAL A 134
LEU A  75
 None
 1.22A 1r30A-1ktcA:
7.0		 1r30A-1ktcA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		6 TYR A  59
PRO A  61
ARG A 168
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SF4  A 401 ( 4.4A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 1.18A 1r30A-1r30A:
58.6		 1r30A-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		12 TYR A  59
PRO A  61
THR A 130
GLY A 132
ASN A 151
ASN A 153
ASP A 155
ARG A 173
ILE A 192
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 ( 4.0A)
SAM  A 501 (-2.7A)
DTB  A 502 (-3.9A)
DTB  A 502 ( 3.7A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 0.05A 1r30A-1r30A:
58.6		 1r30A-1r30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 TYR A 382
PRO A 375
ASP A 179
ILE A 225
LEU A 356
 None
None
CA  A   1 (-2.8A)
None
None
 1.09A 1r30A-1r6vA:
undetectable		 1r30A-1r6vA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sl8 AEQUORIN 1

(Aequorea
victoria) 		PF13202
(EF-hand_5) 		5 TYR A 134
GLY A 173
ILE A 118
LEU A  50
VAL A  46
 None
 1.10A 1r30A-1sl8A:
undetectable		 1r30A-1sl8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 251
ILE A 373
LEU A 355
VAL A 352
LEU A 384
 None
 1.14A 1r30A-1v8bA:
undetectable		 1r30A-1v8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		6 PRO A 150
THR A 374
GLY A 370
ASN A 375
ILE A 393
LEU A  58
 None
 1.50A 1r30A-1ybeA:
2.9		 1r30A-1ybeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzh TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Streptococcus
pneumoniae) 		PF02390
(Methyltransf_4) 		5 ASN A  37
ASN A  64
ILE A  66
LEU A  93
VAL A  21
 None
 1.08A 1r30A-1yzhA:
undetectable		 1r30A-1yzhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d28 TYPE II SECRETION
ATPASE XPSE

(Xanthomonas
campestris) 		PF05157
(T2SSE_N) 		5 TYR C 114
ASP C 112
LEU C  62
VAL C  61
LEU C  14
 None
 1.14A 1r30A-2d28C:
undetectable		 1r30A-2d28C:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 TYR A  54
THR A 115
GLY A  45
ILE A 292
VAL A 170
 None
 1.14A 1r30A-2etvA:
undetectable		 1r30A-2etvA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzr UBIQUITIN
THIOESTERASE OTU1

(Mus musculus) 		no annotation 5 THR A  34
GLY A  35
ILE A  43
LEU A  64
LEU A  14
 None
 1.04A 1r30A-2kzrA:
undetectable		 1r30A-2kzrA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 GLY A 563
ASN A 570
ASN A 584
VAL A 530
LEU A 538
 None
 1.13A 1r30A-2o1sA:
undetectable		 1r30A-2o1sA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 422
ILE A 453
LEU A 145
VAL A 147
LEU A 180
 None
 1.17A 1r30A-2pokA:
undetectable		 1r30A-2pokA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		5 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.19A 1r30A-2qz6A:
undetectable		 1r30A-2qz6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		5 PRO A 162
GLY A 242
ILE A 165
LEU A 191
LEU A 141
 None
 1.17A 1r30A-2rliA:
undetectable		 1r30A-2rliA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1w PDZ AND LIM DOMAIN
PROTEIN 4

(Homo sapiens) 		PF00595
(PDZ) 		5 PRO A  26
GLY A  85
ILE A  29
LEU A  17
VAL A  18
 None
 1.16A 1r30A-2v1wA:
undetectable		 1r30A-2v1wA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 TYR A 540
ILE A 394
LEU A 516
VAL A 513
LEU A 547
 None
 1.20A 1r30A-2w1zA:
undetectable		 1r30A-2w1zA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 163
ASN A 184
ASN A  81
ILE A   7
LEU A   5
 EDO  A1510 (-3.4A)
None
None
None
None
 1.16A 1r30A-2w40A:
undetectable		 1r30A-2w40A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01661
(Macro) 		5 TYR A 314
GLY A 273
ILE A 303
LEU A 156
LEU A 307
 None
 1.21A 1r30A-2x47A:
undetectable		 1r30A-2x47A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 GLY A 307
ASP A 346
ILE A  54
LEU A 297
VAL A 298
 None
ZN  A1476 (-2.3A)
None
None
None
 1.17A 1r30A-2x98A:
undetectable		 1r30A-2x98A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 GLY A 674
ASN A 698
ILE A 635
LEU A 619
LEU A 729
 None
None
None
None
NIY  A 730 ( 4.0A)
 1.07A 1r30A-2xaxA:
2.8		 1r30A-2xaxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc7 BETA-LACTAMASE ACT-1

(Klebsiella
pneumoniae) 		PF00144
(Beta-lactamase) 		5 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.14A 1r30A-2zc7A:
undetectable		 1r30A-2zc7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 THR A  84
GLY A  86
ASP A 221
LEU A 236
VAL A 233
 None
PLP  A 501 ( 4.8A)
PLP  A 501 (-2.6A)
None
None
 1.04A 1r30A-3a9xA:
undetectable		 1r30A-3a9xA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		5 GLY A  19
ASP A 155
ILE A 214
LEU A 215
LEU A 101
 ADP  A 500 (-3.3A)
None
None
None
None
 0.94A 1r30A-3akkA:
undetectable		 1r30A-3akkA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		5 TYR A 252
THR A  10
GLY A   9
ILE A 202
LEU A 188
 None
 1.11A 1r30A-3cgwA:
undetectable		 1r30A-3cgwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbf PHPD

(Streptomyces
viridochromogenes) 		no annotation 5 TYR A 184
THR A 303
GLY A 301
ILE A 194
LEU A 113
 None
 1.17A 1r30A-3gbfA:
undetectable		 1r30A-3gbfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 TYR A  66
THR A 120
GLY A  80
ILE A  69
LEU A 130
 None
NAD  A 400 ( 4.3A)
NAD  A 400 (-4.5A)
None
None
 1.19A 1r30A-3gvhA:
undetectable		 1r30A-3gvhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 THR C  96
GLY C  98
ASP C 233
LEU C 248
VAL C 245
 None
PLR  C 500 ( 4.5A)
PLR  C 500 (-2.7A)
None
None
 1.07A 1r30A-3gzdC:
undetectable		 1r30A-3gzdC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		5 PRO A  30
ASN A 144
ILE A  26
LEU A  20
VAL A  17
 None
 1.00A 1r30A-3h4yA:
undetectable		 1r30A-3h4yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ARG A  97
ILE A  77
LEU A 116
VAL A 150
LEU A  91
 None
 1.19A 1r30A-3h55A:
9.2		 1r30A-3h55A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 THR A 667
GLY A 651
ASP A 419
LEU A 426
LEU A 570
 None
 1.10A 1r30A-3hjeA:
6.5		 1r30A-3hjeA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 TYR A 185
GLY A 204
ILE A 235
LEU A 181
LEU A 285
 None
None
None
MRD  A 302 ( 3.4A)
None
 1.20A 1r30A-3hwrA:
undetectable		 1r30A-3hwrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 GLY 3 294
ASN 3 225
ILE 3 226
LEU 3 200
VAL 3 199
 SF4  3 786 (-3.4A)
None
None
None
None
 1.08A 1r30A-3i9v3:
undetectable		 1r30A-3i9v3:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 PRO A  72
THR A 145
ILE A 109
LEU A 102
VAL A  98
 None
 1.13A 1r30A-3l06A:
undetectable		 1r30A-3l06A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PRO A 467
GLY A 313
ASN A 360
ASN A  82
ILE A  75
 None
 1.20A 1r30A-3ljpA:
undetectable		 1r30A-3ljpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 PRO A 336
THR A 349
ILE A 331
LEU A 320
VAL A 316
 None
 1.21A 1r30A-3m1mA:
undetectable		 1r30A-3m1mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 TYR K 358
GLY K  83
ASN K  86
LEU K 366
VAL K 360
 None
 1.23A 1r30A-3mvdK:
undetectable		 1r30A-3mvdK:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PRO A  76
GLY A  69
ASN A  71
ARG A 257
VAL A 734
 None
 1.12A 1r30A-3n23A:
undetectable		 1r30A-3n23A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 THR B 224
GLY B 220
ASN B 227
ILE B 189
LEU B 128
 None
 1.14A 1r30A-3o8qB:
undetectable		 1r30A-3o8qB:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 5 TYR I 278
ASN I 127
ASN I 248
LEU I 276
LEU I 124
 None
 1.09A 1r30A-3opyI:
undetectable		 1r30A-3opyI:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		5 TYR A 136
THR A 105
GLY A 269
LEU A 147
VAL A 126
 None
 1.18A 1r30A-3rq1A:
2.5		 1r30A-3rq1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		5 THR A 191
GLY A 189
ASN A 133
LEU A 375
VAL A 376
 None
 1.07A 1r30A-3s30A:
undetectable		 1r30A-3s30A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 THR A 325
GLY A 324
ILE A 313
VAL A 305
LEU A 317
 None
 1.20A 1r30A-3s46A:
5.9		 1r30A-3s46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slt SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		5 PRO A1201
GLY A1284
LEU A1173
VAL A1174
LEU A1019
 None
C8E  A1301 ( 4.4A)
None
None
None
 1.17A 1r30A-3sltA:
undetectable		 1r30A-3sltA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 500 (-3.4A)
None
None
 1.10A 1r30A-3tk3A:
undetectable		 1r30A-3tk3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		5 TYR A 275
GLY A 266
ASN A 259
ILE A  28
LEU A  32
 None
 1.13A 1r30A-3w9uA:
undetectable		 1r30A-3w9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 THR A  59
ASN A 342
ILE A  26
LEU A  20
VAL A  17
 None
 1.01A 1r30A-3wrtA:
undetectable		 1r30A-3wrtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 363
ASN A 329
ASN A 312
LEU A 143
VAL A 144
 None
 1.19A 1r30A-4aipA:
undetectable		 1r30A-4aipA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 GLY A  80
ILE A 158
LEU A 207
VAL A 208
LEU A 150
 None
 1.22A 1r30A-4azwA:
undetectable		 1r30A-4azwA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 TYR P 379
ASP P 447
ILE P 366
LEU P 364
VAL P 356
 None
 1.17A 1r30A-4dvyP:
undetectable		 1r30A-4dvyP:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 GLY A 125
ILE A  17
LEU A  27
VAL A  26
LEU A 394
 None
 1.17A 1r30A-4dykA:
7.5		 1r30A-4dykA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		5 THR A 166
GLY A 168
ILE A  90
LEU A 113
LEU A  37
 None
 1.15A 1r30A-4eogA:
undetectable		 1r30A-4eogA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		5 GLY A 154
ILE A  98
LEU A  99
VAL A 102
LEU A 113
 None
 1.17A 1r30A-4hbzA:
undetectable		 1r30A-4hbzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
sp. H13-3) 		PF00701
(DHDPS) 		5 GLY A 194
ASN A 196
ILE A 204
LEU A 101
VAL A 131
 None
 1.17A 1r30A-4i7uA:
10.9		 1r30A-4i7uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jla ADENYLATE KINASE

(Aquifex
aeolicus) 		PF00406
(ADK) 		5 PRO A   8
GLY A  32
ASP A 153
ARG A 150
ILE A 158
 None
ADP  A 302 (-3.5A)
None
ADP  A 302 (-3.1A)
None
 1.19A 1r30A-4jlaA:
undetectable		 1r30A-4jlaA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 PRO A 204
GLY A 271
ILE A 154
LEU A 214
LEU A 206
 None
 1.16A 1r30A-4k05A:
undetectable		 1r30A-4k05A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 5 GLY A1627
ILE A1754
LEU A1746
VAL A1742
LEU A1667
 None
 1.20A 1r30A-4kf8A:
undetectable		 1r30A-4kf8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npl RNA DEMETHYLASE
ALKBH5

(Danio rerio) 		PF13532
(2OG-FeII_Oxy_2) 		5 GLY A  67
ASN A 119
ILE A 146
LEU A 187
VAL A 186
 None
 1.14A 1r30A-4nplA:
undetectable		 1r30A-4nplA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 TYR A1274
GLY A 664
ILE A1240
VAL A1225
LEU A1249
 None
EDO  A1305 (-3.4A)
None
None
None
 1.20A 1r30A-4o3mA:
undetectable		 1r30A-4o3mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 GLY A 155
ASN A 218
ILE A 101
LEU A  84
LEU A  42
 None
X2X  A 402 (-2.8A)
None
None
None
 1.20A 1r30A-4oanA:
undetectable		 1r30A-4oanA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq1 PUTATIVE ELECTRON
TRANSPORT RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00578
(AhpC-TSA) 		5 GLY A  47
ILE A 157
LEU A  77
VAL A  76
LEU A 185
 None
 1.19A 1r30A-4pq1A:
undetectable		 1r30A-4pq1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 GLY A 520
ASP A 290
ARG A 250
LEU A 328
VAL A 325
 None
 1.18A 1r30A-4q73A:
9.4		 1r30A-4q73A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		5 THR A 320
GLY A 308
ILE A 176
LEU A 167
VAL A 168
 None
 1.18A 1r30A-4wr2A:
undetectable		 1r30A-4wr2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2h PUTATIVE MRNA EXPORT
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 TYR A 406
PRO A 403
ASP A 546
ARG A 526
LEU A 399
 None
 1.20A 1r30A-4x2hA:
undetectable		 1r30A-4x2hA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 THR A 210
GLY A 208
ILE A 570
LEU A 544
LEU A 239
 None
 1.14A 1r30A-4xqkA:
undetectable		 1r30A-4xqkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 TYR A 438
GLY A 522
ILE A 402
LEU A 418
VAL A 417
 None
 1.21A 1r30A-4ye5A:
undetectable		 1r30A-4ye5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF02097
(Filo_VP35)
PF05505
(Ebola_NP) 		5 ASN A 146
ASN A 228
ASP A 229
ILE A 232
LEU A  77
 None
 1.13A 1r30A-4ztiA:
undetectable		 1r30A-4ztiA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coa IRIDOID SYNTHASE

(Catharanthus
roseus) 		no annotation 5 TYR A  62
ASP A 100
ILE A 101
LEU A  33
VAL A  34
 None
 1.21A 1r30A-5coaA:
undetectable		 1r30A-5coaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 501 (-3.5A)
None
None
 1.04A 1r30A-5e0eA:
undetectable		 1r30A-5e0eA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 GLY A 265
ASN A  49
ASP A 260
ILE A  32
VAL A 102
 None
None
NA  A 401 (-3.5A)
None
None
 1.19A 1r30A-5ey7A:
2.4		 1r30A-5ey7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 259
ASN A 232
ASN A 122
ARG A 118
VAL A  96
 None
 1.22A 1r30A-5fr8A:
undetectable		 1r30A-5fr8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 THR A  49
GLY A  46
ILE A 462
LEU A 458
VAL A 457
 None
 1.16A 1r30A-5glgA:
undetectable		 1r30A-5glgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 TYR A 183
PRO A 182
GLY A 509
ILE A 219
LEU A 187
 None
 1.16A 1r30A-5h8wA:
undetectable		 1r30A-5h8wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASN A  19
ILE A  71
LEU A  81
VAL A  82
LEU A  30
 None
 1.20A 1r30A-5i2tA:
undetectable		 1r30A-5i2tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 GLY A 288
ASP A 142
LEU A 252
VAL A 349
LEU A 216
 None
 1.21A 1r30A-5j84A:
undetectable		 1r30A-5j84A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 TYR A  73
THR A 436
GLY A 434
LEU A 107
LEU A  68
 None
 1.07A 1r30A-5jbkA:
6.3		 1r30A-5jbkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 PRO A 776
THR A 767
GLY A 768
LEU A 845
VAL A 838
 None
 1.20A 1r30A-5ju6A:
6.9		 1r30A-5ju6A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldy IG DOMAIN PROTEIN
GROUP 1 DOMAIN
PROTEIN

(Yersinia
pseudotuberculosis) 		PF09134
(Invasin_D3) 		5 GLY A1710
ASN A1774
ASP A1770
ILE A1776
LEU A1779
 None
 1.23A 1r30A-5ldyA:
undetectable		 1r30A-5ldyA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 259
ASN A 232
ASN A 114
ARG A 110
VAL A  88
 None
 1.21A 1r30A-5mzsA:
undetectable		 1r30A-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 THR A 359
GLY A 408
ILE A 371
LEU A 447
LEU A 437
 None
 1.05A 1r30A-5odoA:
undetectable		 1r30A-5odoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Thermus
thermophilus) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 PRO A 265
GLY A 213
ILE A 218
LEU A 229
VAL A 230
 None
 1.19A 1r30A-5t3oA:
3.2		 1r30A-5t3oA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 THR A  48
GLY A 164
ILE A 240
LEU A 266
LEU A 197
 None
 1.21A 1r30A-5tzbA:
undetectable		 1r30A-5tzbA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 TYR A  66
THR A 120
GLY A  80
ILE A  69
LEU A 130
 None
 1.14A 1r30A-5ulvA:
undetectable		 1r30A-5ulvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usx THIOREDOXIN
REDUCTASE

(Vibrio
vulnificus) 		PF07992
(Pyr_redox_2) 		5 TYR A 104
ASP A  83
ILE A  85
LEU A  97
VAL A  96
 None
None
FAD  A 402 (-4.2A)
None
None
 1.22A 1r30A-5usxA:
undetectable		 1r30A-5usxA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v38 HCHA

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 THR A 982
GLY A1037
ASN A 925
ILE A 923
LEU A 918
 None
 1.20A 1r30A-5v38A:
undetectable		 1r30A-5v38A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		5 GLY A 522
ASP A 456
LEU A 417
VAL A 418
LEU A 529
 None
 0.96A 1r30A-5va3A:
undetectable		 1r30A-5va3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 PRO A 268
GLY A 351
ASN A 230
ILE A 250
LEU A  88
 None
 1.21A 1r30A-5w19A:
undetectable		 1r30A-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 5 PRO C 408
GLY C 556
ASN C 330
ILE C 258
LEU C 354
 None
 1.22A 1r30A-5w7cC:
undetectable		 1r30A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 5 PRO A 407
GLY A 555
ASN A 329
ILE A 257
LEU A 353
 None
 1.21A 1r30A-5w7dA:
undetectable		 1r30A-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 501 ( 3.9A)
None
None
 1.04A 1r30A-5wbgA:
undetectable		 1r30A-5wbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 THR A  46
GLY A  45
ILE A 167
LEU A 126
LEU A 144
 None
 1.17A 1r30A-5wdxA:
undetectable		 1r30A-5wdxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus) 		no annotation 5 THR M 197
GLY M 194
LEU M  93
VAL M  92
LEU M  55
 None
 1.20A 1r30A-5x41M:
undetectable		 1r30A-5x41M:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjv DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13 ISOFORM A

(Homo sapiens) 		no annotation 5 GLY A  31
ASP A  39
LEU A 126
VAL A 127
LEU A 141
 None
 1.19A 1r30A-5xjvA:
undetectable		 1r30A-5xjvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE
STAPHYLOCOCCAL
PEROXIDASE INHIBITOR

(Homo sapiens;
Staphylococcus
aureus) 		no annotation
no annotation 		5 GLY A 439
ASN A 358
ASN A 355
LEU B  49
LEU B  72
 None
NAG  A 802 (-3.6A)
NAG  A 802 (-1.6A)
None
None
 1.10A 1r30A-6azpA:
undetectable		 1r30A-6azpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6da0 GLUCOKINASE

(Naegleria
fowleri) 		no annotation 5 TYR A 259
THR A 127
ASN A 128
ASP A 269
ILE A 258
 None
BGC  A 500 (-3.0A)
BGC  A 500 (-4.0A)
None
None
 1.14A 1r30A-6da0A:
undetectable		 1r30A-6da0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes) 		no annotation 5 THR A  56
ASN A 338
ILE A  23
LEU A  17
VAL A  14
 None
 1.08A 1r30A-6fm7A:
undetectable		 1r30A-6fm7A:
undetectable