SIMILAR PATTERNS OF AMINO ACIDS FOR 1R15_C_NCAC339_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
3 GLU A 274
ASN A 270
TRP A 226
None
1.15A 1r15C-1ciyA:
undetectable
1r15C-1ciyA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 GLU A 384
ASN A 382
TRP A 401
None
0.83A 1r15C-1coyA:
undetectable
1r15C-1coyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI


(Mycoplasma)
PF11407
(RestrictionMunI)
3 GLU A 195
ASN A 194
TRP A  12
None
1.30A 1r15C-1d02A:
undetectable
1r15C-1d02A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)


(Planomicrobium
okeanokoites)
PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3)
3 GLU A 214
ASN A 218
TRP A 219
None
0.94A 1r15C-1fokA:
3.5
1r15C-1fokA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA
FORMATE
DEHYDROGENASE
SUBUNIT BETA


(Desulfovibrio
gigas;
Desulfovibrio
gigas)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF13247
(Fer4_11)
3 GLU A  41
ASN A  39
TRP B  24
None
0.90A 1r15C-1h0hA:
undetectable
1r15C-1h0hA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h67 CALPONIN ALPHA

(Gallus gallus)
PF00307
(CH)
3 GLU A  86
ASN A  76
TRP A  82
None
1.18A 1r15C-1h67A:
undetectable
1r15C-1h67A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN GAMMA
CHAIN


(Petromyzon
marinus)
PF00147
(Fibrinogen_C)
3 GLU C 271
ASN C 317
TRP C 208
None
1.16A 1r15C-1lwuC:
undetectable
1r15C-1lwuC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE


(Trichoderma
reesei)
PF00150
(Cellulase)
3 GLU A 276
ASN A  25
TRP A  56
GOL  A 410 (-3.8A)
None
GOL  A 411 (-4.0A)
1.25A 1r15C-1qnrA:
2.0
1r15C-1qnrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)


(Rattus
norvegicus)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
3 GLU A1221
ASN A1229
TRP A1255
None
1.24A 1r15C-1qqfA:
undetectable
1r15C-1qqfA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum)
PF00150
(Cellulase)
3 GLU A 318
ASN A  53
TRP A  88
None
1.23A 1r15C-1rh9A:
undetectable
1r15C-1rh9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B


([Haemophilus]
ducreyi)
PF03372
(Exo_endo_phos)
3 GLU B  42
ASN B  46
TRP B  93
None
1.23A 1r15C-1sr4B:
undetectable
1r15C-1sr4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08519
(RFC1)
PF13177
(DNA_pol3_delta2)
3 GLU A 628
ASN E 336
TRP A 669
None
1.19A 1r15C-1sxjA:
undetectable
1r15C-1sxjA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9w BH0236 PROTEIN

(Bacillus
halodurans)
PF03422
(CBM_6)
3 GLU A  29
ASN A 132
TRP A 102
BGC  A 601 (-2.8A)
BGC  A 601 (-2.8A)
None
1.30A 1r15C-1w9wA:
undetectable
1r15C-1w9wA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wtd ECOO109IR

(Escherichia
coli)
PF14511
(RE_EcoO109I)
3 GLU A 211
ASN A 208
TRP A 217
None
1.24A 1r15C-1wtdA:
2.6
1r15C-1wtdA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
3 GLU A 323
ASN A 321
TRP A 273
MAN  A3007 (-3.5A)
None
None
1.22A 1r15C-1xc6A:
1.8
1r15C-1xc6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE


(Chlorobaculum
tepidum)
PF04371
(PAD_porph)
3 GLU A 227
ASN A 163
TRP A  12
None
1.03A 1r15C-1xknA:
undetectable
1r15C-1xknA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana)
PF00962
(A_deaminase)
3 GLU A 539
ASN A 540
TRP A 787
None
0.96A 1r15C-2a3lA:
undetectable
1r15C-2a3lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cly ATP SYNTHASE D
CHAIN, MITOCHONDRIAL


(Bos taurus)
PF05873
(Mt_ATP-synt_D)
3 GLU B  35
ASN B  34
TRP B  12
None
1.18A 1r15C-2clyB:
undetectable
1r15C-2clyB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d13 HYPOTHETICAL PROTEIN
PH1257


(Pyrococcus
horikoshii)
PF01902
(Diphthami_syn_2)
3 GLU A 168
ASN A 165
TRP A 156
None
1.13A 1r15C-2d13A:
3.0
1r15C-2d13A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE


(Thermotoga
maritima)
PF00579
(tRNA-synt_1b)
3 GLU A 234
ASN A 232
TRP A 256
None
1.31A 1r15C-2g36A:
undetectable
1r15C-2g36A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
3 GLU A 474
ASN A 448
TRP A 477
None
1.29A 1r15C-2iwbA:
undetectable
1r15C-2iwbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
3 GLU A 506
ASN A 372
TRP A 626
None
1.26A 1r15C-2rdyA:
undetectable
1r15C-2rdyA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Melanocarpus
albomyces)
PF00840
(Glyco_hydro_7)
3 GLU A 217
ASN A 141
TRP A 375
CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
0.94A 1r15C-2rfzA:
undetectable
1r15C-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE


(Escherichia
coli)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
3 GLU A 332
ASN A 329
TRP A 528
None
1.16A 1r15C-2vycA:
undetectable
1r15C-2vycA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
3 GLU A 855
ASN A 867
TRP A 888
None
1.07A 1r15C-2wanA:
undetectable
1r15C-2wanA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN


(Homo sapiens)
PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
3 GLU B1199
ASN B1207
TRP B1233
None
1.29A 1r15C-2xwbB:
undetectable
1r15C-2xwbB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca)
PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372)
3 GLU A 513
ASN A 517
TRP A 885
None
1.25A 1r15C-2yocA:
undetectable
1r15C-2yocA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae)
PF00768
(Peptidase_S11)
PF07943
(PBP5_C)
3 GLU A 268
ASN A 217
TRP A 221
None
1.18A 1r15C-3a3jA:
undetectable
1r15C-3a3jA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE


(Cellulomonas
gilvus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
3 GLU A 659
ASN A 489
TRP A 488
BGC  A2901 (-2.8A)
None
K  A2903 (-4.0A)
1.01A 1r15C-3actA:
undetectable
1r15C-3actA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli)
PF01343
(Peptidase_S49)
3 GLU A 292
ASN A 307
TRP A 301
None
1.03A 1r15C-3bf0A:
undetectable
1r15C-3bf0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE


(Streptococcus
pneumoniae)
PF04914
(DltD)
3 GLU A 273
ASN A 264
TRP A 382
None
1.19A 1r15C-3bmaA:
1.3
1r15C-3bmaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima)
PF02230
(Abhydrolase_2)
3 GLU A 385
ASN A 383
TRP A 327
None
1.05A 1r15C-3dohA:
undetectable
1r15C-3dohA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
3 GLU A 178
ASN A   5
TRP A   3
None
1.03A 1r15C-3dy5A:
undetectable
1r15C-3dy5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli)
PF07091
(FmrO)
3 GLU A 129
ASN A 126
TRP A 125
None
1.03A 1r15C-3fzgA:
undetectable
1r15C-3fzgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i10 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Bacteroides
thetaiotaomicron)
PF03009
(GDPD)
PF16387
(DUF4996)
3 GLU A  73
ASN A 144
TRP A 245
None
1.05A 1r15C-3i10A:
undetectable
1r15C-3i10A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i9k ADP-RIBOSYL CYCLASE

(Aplysia
californica)
PF02267
(Rib_hydrolayse)
3 GLU A  98
ASN A 107
TRP A 140
None
0.33A 1r15C-3i9kA:
39.6
1r15C-3i9kA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm PRE-MRNA-SPLICING
FACTOR 6


(Saccharomyces
cerevisiae)
PF06424
(PRP1_N)
3 GLU G 265
ASN G 281
TRP G 278
None
1.21A 1r15C-3jcmG:
undetectable
1r15C-3jcmG:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 GLU A 423
ASN A 441
TRP A 426
DST  A 601 ( 3.3A)
None
None
1.15A 1r15C-3n0gA:
undetectable
1r15C-3n0gA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
3 GLU A 322
ASN A 320
TRP A 272
MAN  A1029 (-3.5A)
MAN  A1031 (-3.9A)
None
1.27A 1r15C-3ogrA:
undetectable
1r15C-3ogrA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5


(Thermotoga
petrophila)
PF00150
(Cellulase)
3 GLU A 317
ASN A  43
TRP A  73
None
1.18A 1r15C-3pz9A:
2.2
1r15C-3pz9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE


(Ruminiclostridium
thermocellum)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
3 GLU A 646
ASN A 482
TRP A 481
144  A 813 (-3.5A)
144  A 813 ( 4.9A)
144  A 813 (-3.9A)
1.07A 1r15C-3qdeA:
undetectable
1r15C-3qdeA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1j ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE


(Mycobacterium
avium)
PF02668
(TauD)
3 GLU A 282
ASN A 278
TRP A 150
None
1.25A 1r15C-3r1jA:
undetectable
1r15C-3r1jA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE


(Bacillus cereus)
PF00296
(Bac_luciferase)
3 GLU A 278
ASN A 296
TRP A 252
None
1.23A 1r15C-3raoA:
undetectable
1r15C-3raoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA


(Mycobacterium
tuberculosis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
3 GLU A 213
ASN A  32
TRP A  28
None
1.24A 1r15C-3rb9A:
undetectable
1r15C-3rb9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC


(Abies grandis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 GLU A 699
ASN A 717
TRP A 702
None
1.01A 1r15C-3s9vA:
undetectable
1r15C-3s9vA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr7 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Streptococcus
mutans)
PF01070
(FMN_dh)
3 GLU A 147
ASN A 143
TRP A 160
None
1.17A 1r15C-3sr7A:
undetectable
1r15C-3sr7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN


(Pseudomonas
putida)
PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N)
3 GLU M 499
ASN M 497
TRP M 315
None
1.21A 1r15C-3t63M:
undetectable
1r15C-3t63M:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1


(Bos taurus)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase)
3 GLU A 917
ASN A 918
TRP A 831
None
1.24A 1r15C-3tlmA:
undetectable
1r15C-3tlmA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfl BETA-MANNANASE

(Talaromyces
trachyspermus)
PF00150
(Cellulase)
3 GLU A 309
ASN A  57
TRP A  88
TRS  A 402 (-2.8A)
None
GOL  A 404 (-4.0A)
1.17A 1r15C-3wflA:
1.9
1r15C-3wflA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE


(Aspergillus
niger)
PF00150
(Cellulase)
3 GLU A 276
ASN A  23
TRP A  54
TRS  A 404 (-2.8A)
None
None
1.18A 1r15C-3wh9A:
2.1
1r15C-3wh9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE


(Podospora
anserina)
PF00150
(Cellulase)
3 GLU A 276
ASN A  25
TRP A  56
TRS  A1352 (-2.8A)
None
GOL  A1351 (-3.9A)
1.17A 1r15C-3zizA:
undetectable
1r15C-3zizA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
3 GLU A 274
ASN A 270
TRP A 226
None
1.24A 1r15C-4arxA:
undetectable
1r15C-4arxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE


(Neurospora
sitophila)
PF00150
(Cellulase)
3 GLU A 301
ASN A  27
TRP A  57
TRS  A1391 (-2.8A)
None
None
1.21A 1r15C-4aweA:
undetectable
1r15C-4aweA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051


(Burkholderia
pseudomallei)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
3 GLU A 397
ASN A 109
TRP A  88
None
1.18A 1r15C-4bkoA:
undetectable
1r15C-4bkoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE


(Azoarcus sp.
BH72)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 GLU A  89
ASN A  60
TRP A  57
None
1.23A 1r15C-4d5gA:
2.4
1r15C-4d5gA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9o IMV MEMBRANE PROTEIN

(Vaccinia virus)
PF00194
(Carb_anhydrase)
3 GLU X  90
ASN X  92
TRP X 182
None
1.18A 1r15C-4e9oX:
undetectable
1r15C-4e9oX:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbf PHIKZ131

(Pseudomonas
virus phiKZ)
no annotation 3 GLU A 406
ASN A 422
TRP A 424
None
1.26A 1r15C-4gbfA:
undetectable
1r15C-4gbfA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata)
PF00840
(Glyco_hydro_7)
3 GLU A 238
ASN A 162
TRP A 401
CBI  A 501 ( 4.3A)
None
CBI  A 501 ( 3.8A)
1.22A 1r15C-4haqA:
undetectable
1r15C-4haqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
3 GLU A 322
ASN A 320
TRP A 272
CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
1.16A 1r15C-4iugA:
undetectable
1r15C-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE


(Saccharomyces
cerevisiae)
PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N)
3 GLU A 771
ASN A 772
TRP A 710
None
1.05A 1r15C-4j5tA:
undetectable
1r15C-4j5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome)
PF00150
(Cellulase)
3 GLU A 132
ASN A 131
TRP A  28
TRS  A 301 (-2.7A)
TRS  A 301 (-3.3A)
TRS  A 301 ( 4.8A)
1.11A 1r15C-4m1rA:
undetectable
1r15C-4m1rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Streptococcus
pneumoniae)
PF01070
(FMN_dh)
3 GLU A 148
ASN A 144
TRP A 161
None
SO4  A 403 (-4.4A)
None
1.26A 1r15C-4n02A:
1.2
1r15C-4n02A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE


(Aquifex
aeolicus)
PF00772
(DnaB)
PF03796
(DnaB_C)
3 GLU A  26
ASN A  61
TRP A  56
None
1.26A 1r15C-4nmnA:
undetectable
1r15C-4nmnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF09994
(DUF2235)
3 GLU A 141
ASN A 145
TRP A 247
None
1.02A 1r15C-4o5pA:
undetectable
1r15C-4o5pA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oky RESTRICTION
ENDONUCLEASE PVURTS1
I


(Proteus
vulgaris)
no annotation 3 GLU C 228
ASN C 217
TRP C 205
None
1.15A 1r15C-4okyC:
undetectable
1r15C-4okyC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei)
PF00150
(Cellulase)
3 GLU A 293
ASN A  25
TRP A  55
None
1.23A 1r15C-4qp0A:
undetectable
1r15C-4qp0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus)
PF00476
(DNA_pol_A)
3 GLU A 340
ASN A 339
TRP A 455
None
1.00A 1r15C-4uqgA:
undetectable
1r15C-4uqgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x04 SOLUTE BINDING
PROTEIN


(Citrobacter
koseri)
PF03480
(DctP)
3 GLU A 240
ASN A  42
TRP A 275
BDP  A 401 (-2.9A)
None
None
1.25A 1r15C-4x04A:
undetectable
1r15C-4x04A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
3 GLU A 343
ASN A 288
TRP A 284
None
1.04A 1r15C-4x28A:
undetectable
1r15C-4x28A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Dictyostelium
purpureum)
PF00840
(Glyco_hydro_7)
3 GLU A 216
ASN A 140
TRP A 382
None
1.30A 1r15C-4zzpA:
undetectable
1r15C-4zzpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Dictyostelium
discoideum)
PF00840
(Glyco_hydro_7)
3 GLU A 216
ASN A 140
TRP A 382
None
1.16A 1r15C-4zzqA:
undetectable
1r15C-4zzqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE


(Homo sapiens)
PF05118
(Asp_Arg_Hydrox)
3 GLU A 617
ASN A 618
TRP A 625
LMR  A1760 ( 4.7A)
NI  A1759 ( 4.7A)
LMR  A1760 (-4.2A)
1.25A 1r15C-5apaA:
undetectable
1r15C-5apaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2


(Arabidopsis
thaliana)
PF16953
(PRORP)
PF17177
(PPR_long)
3 GLU A 405
ASN A 409
TRP A 380
None
1.24A 1r15C-5dizA:
undetectable
1r15C-5dizA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dze ENDO-GLUCANASE

(Vitis vinifera)
PF00722
(Glyco_hydro_16)
3 GLU A  93
ASN A  73
TRP A 181
BGC  A 305 ( 2.5A)
GLC  A 301 (-3.3A)
BGC  A 305 (-3.2A)
1.02A 1r15C-5dzeA:
undetectable
1r15C-5dzeA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes)
PF01547
(SBP_bac_1)
3 GLU A 228
ASN A 207
TRP A 171
None
1.14A 1r15C-5f7vA:
undetectable
1r15C-5f7vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fui ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16


(Zobellia
galactanivorans)
PF03422
(CBM_6)
3 GLU A 280
ASN A 377
TRP A 351
GOL  A 131 (-2.8A)
GOL  A 131 (-2.9A)
None
1.22A 1r15C-5fuiA:
undetectable
1r15C-5fuiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6


(Ruminiclostridium
thermocellum)
PF00150
(Cellulase)
PF03422
(CBM_6)
3 GLU A 411
ASN A 507
TRP A 481
MPD  A1747 (-3.0A)
MPD  A1747 (-3.2A)
None
1.27A 1r15C-5g56A:
2.0
1r15C-5g56A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE


(Pyrococcus
horikoshii)
PF02449
(Glyco_hydro_42)
3 GLU A 105
ASN A 396
TRP A 400
PO4  A 802 (-2.8A)
None
None
1.22A 1r15C-5gslA:
1.7
1r15C-5gslA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE


(Thermococcus
kodakarensis)
PF02449
(Glyco_hydro_42)
3 GLU A 103
ASN A 394
TRP A 398
GCS  A 801 (-2.9A)
None
None
1.24A 1r15C-5gsmA:
2.2
1r15C-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome)
PF00150
(Cellulase)
3 GLU A 143
ASN A 142
TRP A  43
GOL  A 402 (-2.9A)
GOL  A 402 (-3.5A)
GOL  A 401 (-4.3A)
1.07A 1r15C-5i2uA:
undetectable
1r15C-5i2uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A


(Aspergillus
niger)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
3 GLU A 322
ASN A 320
TRP A 272
MAN  A1626 (-3.7A)
MAN  A1627 (-3.7A)
None
1.25A 1r15C-5ihrA:
1.8
1r15C-5ihrA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1


(Hyoscyamus
muticus)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 GLU A 386
ASN A 404
TRP A 389
None
1.29A 1r15C-5jo7A:
undetectable
1r15C-5jo7A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN


(Sphingopyxis
alaskensis)
PF00326
(Peptidase_S9)
3 GLU A 214
ASN A 212
TRP A 170
None
1.24A 1r15C-5jrlA:
3.4
1r15C-5jrlA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE


(Arabidopsis
thaliana)
PF02458
(Transferase)
3 GLU A 346
ASN A  26
TRP A  23
None
1.11A 1r15C-5kjuA:
undetectable
1r15C-5kjuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjv HYDROXYCINNAMOYL
TRANSFERASE


(Plectranthus
scutellarioides)
PF02458
(Transferase)
3 GLU A 340
ASN A  26
TRP A  23
None
1.14A 1r15C-5kjvA:
undetectable
1r15C-5kjvA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6


(Ruminiclostridium
thermocellum)
PF00150
(Cellulase)
PF03422
(CBM_6)
3 GLU A 411
ASN A 507
TRP A 481
ARA  A 606 (-2.8A)
ARA  A 606 (-3.0A)
None
1.26A 1r15C-5la0A:
1.8
1r15C-5la0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mnd GRANULIN

(Cydia pomonella
granulovirus)
PF00738
(Polyhedrin)
3 GLU A 195
ASN A 193
TRP A 102
None
1.14A 1r15C-5mndA:
undetectable
1r15C-5mndA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN5


(Saccharomyces
cerevisiae)
PF01399
(PCI)
3 GLU P 319
ASN P 323
TRP P 338
None
1.00A 1r15C-5mpdP:
undetectable
1r15C-5mpdP:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2


(Escherichia
coli)
PF00884
(Sulfatase)
3 GLU A 453
ASN A 499
TRP A 497
None
1.25A 1r15C-5mx9A:
undetectable
1r15C-5mx9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngw OPGH99A

(Ochrovirga
pacifica)
no annotation 3 GLU A 341
ASN A 332
TRP A  42
None
1.31A 1r15C-5ngwA:
undetectable
1r15C-5ngwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tar RETINAL ROD
RHODOPSIN-SENSITIVE
CGMP 3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT DELTA


(Homo sapiens)
PF05351
(GMP_PDE_delta)
3 GLU B  62
ASN B  21
TRP B  19
None
1.28A 1r15C-5tarB:
undetectable
1r15C-5tarB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis)
PF01229
(Glyco_hydro_39)
3 GLU A 155
ASN A 154
TRP A 118
BTB  A 501 (-2.8A)
BTB  A 501 (-3.4A)
BTB  A 501 (-3.6A)
1.10A 1r15C-5u22A:
undetectable
1r15C-5u22A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usl IMV MEMBRANE PROTEIN

(Vaccinia virus)
no annotation 3 GLU X  90
ASN X  92
TRP X 182
None
1.14A 1r15C-5uslX:
undetectable
1r15C-5uslX:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v89 DCN1-LIKE PROTEIN 4

(Homo sapiens)
PF03556
(Cullin_binding)
3 GLU A 257
ASN A 254
TRP A 275
None
1.09A 1r15C-5v89A:
undetectable
1r15C-5v89A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-)
no annotation 3 GLU A 247
ASN A 245
TRP A 281
None
1.08A 1r15C-5xybA:
undetectable
1r15C-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN


(Bifidobacterium
longum)
no annotation 3 GLU A 725
ASN A 636
TRP A 229
None
1.00A 1r15C-5z9sA:
undetectable
1r15C-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus)
no annotation 3 GLU A  47
ASN A 130
TRP A  40
None
1.16A 1r15C-5zu5A:
undetectable
1r15C-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu6 CBM32 DOMAIN

(Vibrio)
no annotation 3 GLU A  47
ASN A 130
TRP A  40
None
1.08A 1r15C-5zu6A:
undetectable
1r15C-5zu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale)
no annotation 3 GLU A 262
ASN A 184
TRP A 277
None
1.26A 1r15C-6b3pA:
undetectable
1r15C-6b3pA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE


(Paenibacillus
sp. YM1)
no annotation 3 GLU A 732
ASN A 525
TRP A 524
G1P  A1002 (-3.7A)
None
G1P  A1002 (-3.3A)
1.08A 1r15C-6gh2A:
undetectable
1r15C-6gh2A:
undetectable