SIMILAR PATTERNS OF AMINO ACIDS FOR 1QZZ_A_ACTA421

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 TYR A 210
GLY A 377
GLY A 341
GLY A 340
SER A 310
 None
 1.31A 1qzzA-1e5fA:
undetectable		 1qzzA-1e5fA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 ASP A 215
GLY A 218
GLY A 221
LEU A 224
 None
 0.36A 1qzzA-1fpqA:
21.3		 1qzzA-1fpqA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 GLY A  14
GLY A  15
MET A  16
SER A  76
 SAH  A 392 ( 4.2A)
SAH  A 392 (-3.1A)
None
SAH  A 392 (-3.2A)
 0.59A 1qzzA-1g55A:
9.0		 1qzzA-1g55A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 GLY A  17
GLY A  19
GLY A 244
MET A 243
 None
 0.63A 1qzzA-1j2bA:
2.6		 1qzzA-1j2bA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 GLY A 175
GLY A 226
GLY A 227
LEU A 225
 None
 0.62A 1qzzA-1kv9A:
undetectable		 1qzzA-1kv9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 TYR A 405
GLY A 359
GLY A 381
LEU A 380
SER A 317
 IMP  A 801 (-4.6A)
IMP  A 801 (-3.3A)
IMP  A 801 (-3.5A)
None
IMP  A 801 (-2.6A)
 1.19A 1qzzA-1lrtA:
undetectable		 1qzzA-1lrtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 GLY A 168
GLY A 164
GLY A 163
LEU A 165
 None
 0.66A 1qzzA-1lzkA:
3.3		 1qzzA-1lzkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 TYR A 405
GLY A 359
GLY A 381
LEU A 380
SER A 317
 XMP  A 602 (-4.7A)
XMP  A 602 ( 3.8A)
XMP  A 602 (-3.6A)
XMP  A 602 (-4.9A)
XMP  A 602 (-3.0A)
 1.24A 1qzzA-1mewA:
undetectable		 1qzzA-1mewA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 GLY A  14
GLY A  16
GLY A  17
LEU A  20
 None
NAI  A 850 (-3.5A)
NAI  A 850 (-3.5A)
None
 0.66A 1qzzA-1mg5A:
5.9		 1qzzA-1mg5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1x RIBOSE-5-PHOSPHATE
ISOMERASE RPIB

(Thermotoga
maritima) 		PF02502
(LacAB_rpiB) 		5 TYR A  42
GLY A  66
GLY A  68
GLY A  70
MET A  71
 OCS  A  65 ( 3.8A)
OCS  A  65 ( 2.4A)
OCS  A  65 ( 2.9A)
OCS  A  65 ( 3.1A)
OCS  A  65 ( 4.8A)
 1.50A 1qzzA-1o1xA:
2.9		 1qzzA-1o1xA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 GLY A 193
GLY A 189
GLY A 188
LEU A 190
 None
 0.66A 1qzzA-1pojA:
undetectable		 1qzzA-1pojA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 GLY A 168
GLY A 170
GLY A 171
LEU A 173
 None
 0.63A 1qzzA-1pweA:
2.9		 1qzzA-1pweA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 GLY A 175
GLY A 171
GLY A 170
LEU A 172
 None
 0.67A 1qzzA-1pweA:
2.9		 1qzzA-1pweA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		8 TYR A 171
ASP A 188
GLY A 191
GLY A 194
GLY A 195
MET A 196
LEU A 197
SER A 255
 ACT  A 421 ( 4.2A)
ACT  A 421 (-2.8A)
SAM  A 635 ( 3.2A)
ACT  A 421 (-3.4A)
ACT  A 421 (-3.9A)
None
ACT  A 421 (-4.5A)
SAM  A 635 ( 2.7A)
 0.01A 1qzzA-1qzzA:
52.8		 1qzzA-1qzzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		5 TYR A 171
GLY A 192
GLY A 194
GLY A 195
MET A 196
 ACT  A 421 ( 4.2A)
SAM  A 635 (-3.5A)
ACT  A 421 (-3.4A)
ACT  A 421 (-3.9A)
None
 0.83A 1qzzA-1qzzA:
52.8		 1qzzA-1qzzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		4 ASP A 124
GLY A 138
GLY A 127
LEU A 126
 None
 0.64A 1qzzA-1srdA:
undetectable		 1qzzA-1srdA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcz HEAD DECORATION
PROTEIN

(Escherichia
virus Lambda) 		PF02924
(HDPD) 		4 GLY A  25
GLY A  26
LEU A  46
SER A  43
 None
 0.60A 1qzzA-1tczA:
undetectable		 1qzzA-1tczA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE

(Crithidia
fasciculata) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A  20
GLY A  16
GLY A  15
LEU A  17
 None
None
FAD  A 493 (-3.7A)
SPD  A 496 (-4.6A)
 0.66A 1qzzA-1typA:
2.3		 1qzzA-1typA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 184
GLY A 187
GLY A 190
MET A 189
LEU A 186
 None
 1.20A 1qzzA-1uufA:
7.0		 1qzzA-1uufA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		4 GLY A 183
GLY A 185
GLY A 186
LEU A 188
 PLP  A 350 (-3.3A)
PLP  A 350 (-3.4A)
PLP  A 350 (-3.1A)
None
 0.57A 1qzzA-1v71A:
undetectable		 1qzzA-1v71A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		4 GLY A 190
GLY A 186
GLY A 185
LEU A 187
 None
PLP  A 350 (-3.1A)
PLP  A 350 (-3.4A)
PLP  A 350 (-4.9A)
 0.65A 1qzzA-1v71A:
undetectable		 1qzzA-1v71A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLY A 178
GLY A 180
GLY A 181
LEU A 183
 PLP  A 413 (-3.3A)
PLP  A 413 (-3.5A)
PLP  A 413 (-3.2A)
None
 0.60A 1qzzA-1ve5A:
2.8		 1qzzA-1ve5A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLY A 185
GLY A 181
GLY A 180
LEU A 182
 None
PLP  A 413 (-3.2A)
PLP  A 413 (-3.5A)
PLP  A 413 (-4.5A)
 0.66A 1qzzA-1ve5A:
2.8		 1qzzA-1ve5A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY B  68
GLY B  64
GLY B  63
LEU B  65
 None
 0.64A 1qzzA-1w85B:
2.0		 1qzzA-1w85B:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 GLY A 501
GLY A 497
GLY A 496
LEU A 498
SER A 503
 None
 1.21A 1qzzA-1we5A:
undetectable		 1qzzA-1we5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02347
(GDC-P)
PF02347
(GDC-P) 		4 TYR A  95
GLY B 278
GLY B 276
GLY B 275
 None
 0.62A 1qzzA-1wytA:
undetectable		 1qzzA-1wytA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 129
GLY A 132
GLY A 133
LEU A 135
 None
 0.55A 1qzzA-1xj5A:
4.4		 1qzzA-1xj5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs3 HYPOTHETICAL PROTEIN
XC975

(Xanthomonas
euvesicatoria) 		PF01722
(BolA) 		4 GLY A  74
GLY A  73
MET A  72
LEU A  71
 None
 0.60A 1qzzA-1xs3A:
undetectable		 1qzzA-1xs3A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 ASP A 205
GLY A 208
GLY A 211
GLY A 212
 SAH  A3994 ( 4.6A)
SAH  A3994 ( 4.3A)
None
None
 0.45A 1qzzA-1zgjA:
19.3		 1qzzA-1zgjA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		4 GLY A 113
GLY A 115
GLY A 116
MET A 117
 SAM  A 601 (-3.2A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.5A)
None
 0.59A 1qzzA-2b25A:
14.1		 1qzzA-2b25A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 117
GLY A 120
GLY A 121
LEU A 123
 None
 0.53A 1qzzA-2b2cA:
11.5		 1qzzA-2b2cA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		4 GLY A 250
GLY A 251
MET A 252
LEU A 253
 None
 0.60A 1qzzA-2bufA:
4.6		 1qzzA-2bufA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		5 TYR A 249
GLY A 267
GLY A 270
LEU A 268
SER A 220
 ANP  A1304 ( 4.7A)
None
None
None
ANP  A1304 ( 4.0A)
 1.44A 1qzzA-2c49A:
4.2		 1qzzA-2c49A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		5 TYR A  99
GLY A 101
GLY A 100
MET A 103
LEU A 102
 None
 1.16A 1qzzA-2c5qA:
undetectable		 1qzzA-2c5qA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF02156
(Glyco_hydro_26) 		4 GLY A 188
GLY A 229
GLY A 230
SER A 225
 None
 0.50A 1qzzA-2citA:
undetectable		 1qzzA-2citA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 TYR A 381
GLY A 335
GLY A 357
LEU A 356
SER A 299
 XMP  A1001 (-4.5A)
XMP  A1001 (-3.4A)
XMP  A1001 (-3.3A)
None
XMP  A1001 (-2.7A)
 1.23A 1qzzA-2cu0A:
undetectable		 1qzzA-2cu0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 TYR A 188
GLY A 167
MET A 168
LEU A 169
 None
 0.66A 1qzzA-2cw7A:
undetectable		 1qzzA-2cw7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E

(Chlorobaculum
tepidum) 		PF00590
(TP_methylase) 		4 GLY A  15
GLY A  13
GLY A 105
LEU A  12
 SAH  A 300 ( 4.8A)
None
SAH  A 300 (-3.5A)
None
 0.63A 1qzzA-2e0nA:
2.3		 1qzzA-2e0nA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		5 TYR A 327
GLY A 248
GLY A 255
GLY A 252
LEU A 251
 None
 0.97A 1qzzA-2epjA:
undetectable		 1qzzA-2epjA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 ASP A 125
GLY A 130
GLY A 153
GLY A 152
 None
GLN  A 501 (-3.2A)
None
None
 0.59A 1qzzA-2f2aA:
undetectable		 1qzzA-2f2aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 TYR B 128
GLY B 121
GLY B 123
GLY B 124
 None
 0.63A 1qzzA-2fhxB:
undetectable		 1qzzA-2fhxB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		4 GLY A 191
GLY A 187
GLY A 186
LEU A 188
 None
LLP  A  58 ( 3.2A)
LLP  A  58 ( 3.4A)
LLP  A  58 ( 4.5A)
 0.65A 1qzzA-2gn1A:
2.5		 1qzzA-2gn1A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbo HYPOTHETICAL PROTEIN
(NP_422103.1)

(Caulobacter
vibrioides) 		PF03061
(4HBT) 		4 GLY A  62
GLY A  63
MET A  64
LEU A  65
 None
 0.55A 1qzzA-2hboA:
undetectable		 1qzzA-2hboA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ASP A 173
GLY A 176
GLY A 179
SER A 240
 None
 0.42A 1qzzA-2ip2A:
20.4		 1qzzA-2ip2A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ASP D 191
GLY D 138
GLY D 146
GLY D 145
LEU D 149
 MG  D1401 ( 4.0A)
None
None
None
None
 1.21A 1qzzA-2j7pD:
3.0		 1qzzA-2j7pD:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 243
GLY A 242
MET A 241
LEU A 240
 None
NAP  A1400 (-3.3A)
NAP  A1400 (-3.3A)
None
 0.66A 1qzzA-2obyA:
7.3		 1qzzA-2obyA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohg GLUTAMATE RACEMASE

(Streptococcus
pyogenes) 		PF01177
(Asp_Glu_race) 		5 TYR A 126
ASP A 205
GLY A 207
GLY A 182
LEU A 181
 None
 1.31A 1qzzA-2ohgA:
3.3		 1qzzA-2ohgA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		4 ASP A 123
GLY A 137
GLY A 126
LEU A 125
 None
 0.66A 1qzzA-2q2lA:
undetectable		 1qzzA-2q2lA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		4 GLY A 107
GLY A 103
GLY A 102
LEU A 104
 None
 0.62A 1qzzA-2qnuA:
undetectable		 1qzzA-2qnuA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		5 TYR A  17
GLY A 386
GLY A  10
GLY A  12
SER A 388
 None
 1.31A 1qzzA-2r8aA:
undetectable		 1qzzA-2r8aA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 GLY A 303
GLY A 300
GLY A 299
LEU A 301
SER A 313
 None
 1.19A 1qzzA-2r9hA:
undetectable		 1qzzA-2r9hA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 123
GLY A 119
GLY A 118
LEU A 120
 None
None
FAD  A1594 (-3.8A)
None
 0.67A 1qzzA-2v6oA:
2.3		 1qzzA-2v6oA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 GLY D 271
GLY D 267
GLY D 266
LEU D 268
 None
 0.56A 1qzzA-2vnuD:
undetectable		 1qzzA-2vnuD:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN

(Halomonas
elongata) 		PF03480
(DctP) 		4 GLY A 177
GLY A 173
GLY A 172
LEU A 174
 None
 0.59A 1qzzA-2vpnA:
undetectable		 1qzzA-2vpnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w68 SIALIDASE

(Vibrio cholerae) 		PF09264
(Sial-lect-inser) 		5 GLY A  70
GLY A 202
GLY A 106
MET A 107
SER A 197
 None
None
None
SIA  A1217 ( 4.7A)
SIA  A1217 (-3.7A)
 1.15A 1qzzA-2w68A:
undetectable		 1qzzA-2w68A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 GLY J 271
GLY J 267
GLY J 266
LEU J 268
 None
 0.59A 1qzzA-2wp8J:
undetectable		 1qzzA-2wp8J:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		5 GLY X   4
GLY X 106
GLY X 105
MET X 104
SER X 109
 None
 1.45A 1qzzA-2x27X:
undetectable		 1qzzA-2x27X:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE

(Paraburkholderia
xenovorans) 		PF12146
(Hydrolase_4) 		5 GLY A 106
GLY A 103
GLY A 102
MET A 101
LEU A 104
 None
 1.35A 1qzzA-2xuaA:
undetectable		 1qzzA-2xuaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]

(Methanocaldococcus
jannaschii) 		PF13847
(Methyltransf_31) 		4 GLY A  45
GLY A  47
GLY A  48
MET A  49
 SO4  A1001 ( 3.8A)
SO4  A1001 (-3.4A)
SO4  A1001 (-3.0A)
None
 0.49A 1qzzA-2yxdA:
14.1		 1qzzA-2yxdA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 ASP A 112
GLY A 117
GLY A 140
GLY A 139
 None
 0.64A 1qzzA-3al0A:
undetectable		 1qzzA-3al0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		5 ASP A 298
GLY A  20
GLY A  18
GLY A  17
SER A 296
 None
 1.14A 1qzzA-3bryA:
undetectable		 1qzzA-3bryA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 GLY A 242
GLY A 241
MET A 240
LEU A 239
 None
 0.64A 1qzzA-3c0kA:
15.0		 1qzzA-3c0kA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 199
GLY A 202
GLY A 203
LEU A 205
 MTA  A 401 (-3.9A)
None
None
None
 0.37A 1qzzA-3c6mA:
14.8		 1qzzA-3c6mA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 200
GLY A 202
GLY A 203
LEU A 205
 MTA  A 401 (-3.7A)
None
None
None
 0.61A 1qzzA-3c6mA:
14.8		 1qzzA-3c6mA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 GLY A 387
GLY A 383
GLY A 382
LEU A 384
 None
 0.66A 1qzzA-3c87A:
undetectable		 1qzzA-3c87A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE

(Leishmania
braziliensis) 		PF01182
(Glucosamine_iso) 		4 GLY A 125
GLY A 122
GLY A 121
LEU A 123
 None
 0.66A 1qzzA-3ch7A:
undetectable		 1qzzA-3ch7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 TYR A 599
GLY A 585
GLY A 586
MET A 587
LEU A 588
 None
 1.42A 1qzzA-3cihA:
undetectable		 1qzzA-3cihA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 GLY A 281
GLY A 240
GLY A 241
LEU A 283
 None
 0.66A 1qzzA-3cinA:
3.8		 1qzzA-3cinA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		5 GLY A 140
GLY A 153
GLY A 150
LEU A 154
SER A 143
 None
SXN  A1401 ( 4.0A)
None
None
None
 1.47A 1qzzA-3ddlA:
undetectable		 1qzzA-3ddlA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLY A 227
GLY A 172
MET A 171
LEU A 226
SER A 178
 None
 1.16A 1qzzA-3dmyA:
2.5		 1qzzA-3dmyA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		4 GLY A 207
GLY A 205
GLY A 204
LEU A 202
 None
 0.61A 1qzzA-3e49A:
undetectable		 1qzzA-3e49A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f42 PROTEIN HP0035

(Helicobacter
pylori) 		PF02575
(YbaB_DNA_bd) 		4 GLY A  12
GLY A   8
GLY A   7
LEU A   9
 None
 0.65A 1qzzA-3f42A:
undetectable		 1qzzA-3f42A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 102
GLY A 142
MET A 123
LEU A 122
SER A  57
 FAD  A   1 (-3.2A)
None
NAG  A 521 ( 4.2A)
FAD  A   1 (-4.7A)
None
 1.13A 1qzzA-3fw8A:
undetectable		 1qzzA-3fw8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		4 GLY A 147
GLY A 112
GLY A 113
MET A 114
 None
 0.59A 1qzzA-3gboA:
undetectable		 1qzzA-3gboA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 GLY A  15
GLY A  14
LEU A  16
SER A  21
 None
 0.60A 1qzzA-3gk3A:
6.4		 1qzzA-3gk3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		4 GLY A 258
GLY A 254
GLY A 253
LEU A 255
 None
 0.62A 1qzzA-3gkbA:
undetectable		 1qzzA-3gkbA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 ASP A 118
GLY A 123
GLY A 146
GLY A 145
 None
ASN  A 901 (-3.2A)
None
None
 0.62A 1qzzA-3h0lA:
undetectable		 1qzzA-3h0lA:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		6 ASP A 175
GLY A 178
GLY A 181
GLY A 182
LEU A 184
SER A 242
 SAH  A 401 ( 4.2A)
SAH  A 401 (-3.6A)
None
None
None
SAH  A 401 (-2.8A)
 0.68A 1qzzA-3i58A:
35.2		 1qzzA-3i58A:
43.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ima CYSTEINE PROTEINASE
INHIBITOR

(Colocasia
esculenta) 		PF16845
(SQAPI) 		4 GLY B   6
GLY B   5
MET B   4
LEU B   3
 None
 0.53A 1qzzA-3imaB:
undetectable		 1qzzA-3imaB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		4 GLY A 271
GLY A 267
GLY A 266
LEU A 268
 None
 0.67A 1qzzA-3kcuA:
undetectable		 1qzzA-3kcuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ASP E 112
GLY E 117
GLY E 140
GLY E 139
 None
 0.59A 1qzzA-3kfuE:
undetectable		 1qzzA-3kfuE:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A 185
GLY A 187
GLY A 188
MET A 189
LEU A 190
 LLP  A  56 ( 3.4A)
LLP  A  56 ( 3.6A)
LLP  A  56 ( 3.3A)
None
None
 0.73A 1qzzA-3l6rA:
2.6		 1qzzA-3l6rA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		5 ASP A 187
GLY A 190
GLY A 193
GLY A 194
LEU A 196
 SAH  A 346 ( 4.5A)
SAH  A 346 (-3.6A)
None
None
None
 0.43A 1qzzA-3lstA:
5.0		 1qzzA-3lstA:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ASP A 182
GLY A 185
GLY A 188
LEU A 191
 None
 0.41A 1qzzA-3mczA:
25.6		 1qzzA-3mczA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nut PRECORRIN-3
METHYLASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 GLY A  13
GLY A  11
GLY A  81
LEU A  10
 GOL  A 248 (-3.7A)
None
SAH  A1501 (-3.5A)
GOL  A 248 (-4.0A)
 0.54A 1qzzA-3nutA:
3.7		 1qzzA-3nutA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		5 GLY A 111
GLY A 119
MET A 117
LEU A 118
SER A 138
 None
None
GOL  A 311 ( 3.8A)
None
None
 1.30A 1qzzA-3nwoA:
undetectable		 1qzzA-3nwoA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 201
GLY A 136
GLY A 132
GLY A 131
LEU A 133
 None
None
FAD  A 499 (-3.2A)
FAD  A 499 (-3.5A)
FAD  A 499 (-4.0A)
 0.98A 1qzzA-3popA:
undetectable		 1qzzA-3popA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlj SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 GLY A  50
GLY A  49
LEU A  42
SER A  45
 None
 0.62A 1qzzA-3qljA:
6.9		 1qzzA-3qljA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 ASP A 479
GLY A 481
GLY A 508
GLY A 509
 None
 0.62A 1qzzA-3riqA:
undetectable		 1qzzA-3riqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 TYR A 388
GLY A 342
GLY A 364
LEU A 363
SER A 306
 XMP  A 500 (-4.8A)
XMP  A 500 (-3.3A)
XMP  A 500 (-3.5A)
None
XMP  A 500 (-2.7A)
 1.14A 1qzzA-3tsdA:
undetectable		 1qzzA-3tsdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 TYR A 388
GLY A 342
GLY A 364
LEU A 363
SER A 306
 XMP  A 500 (-4.8A)
XMP  A 500 (-3.3A)
XMP  A 500 (-3.5A)
None
XMP  A 500 (-2.7A)
 1.48A 1qzzA-3tsdA:
undetectable		 1qzzA-3tsdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 TYR A  58
GLY A 283
GLY A 278
LEU A 280
 None
None
LLP  A  61 ( 3.5A)
None
 0.66A 1qzzA-3vabA:
undetectable		 1qzzA-3vabA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		5 TYR A 177
GLY A 154
GLY A 156
GLY A 157
LEU A 126
 None
 1.02A 1qzzA-3vb9A:
undetectable		 1qzzA-3vb9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ASP A 227
GLY A 410
GLY A 411
LEU A 413
 None
 0.54A 1qzzA-3wmeA:
undetectable		 1qzzA-3wmeA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE

(Streptomyces
halstedii) 		PF00561
(Abhydrolase_1) 		5 GLY A  38
GLY A 112
GLY A 113
MET A 114
LEU A 115
 None
 1.17A 1qzzA-3wmrA:
2.2		 1qzzA-3wmrA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apm APICAL MEMBRANE
ANTIGEN 1

(Babesia
divergens) 		PF02430
(AMA-1) 		5 ASP A 119
GLY A 136
GLY A 121
GLY A 122
MET A 133
 None
 1.33A 1qzzA-4apmA:
undetectable		 1qzzA-4apmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 TYR A 634
GLY A 562
GLY A 565
GLY A 567
LEU A 564
 None
 1.31A 1qzzA-4cgyA:
undetectable		 1qzzA-4cgyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A 298
GLY A 164
GLY A 160
GLY A 159
LEU A 161
 None
 0.78A 1qzzA-4cpdA:
7.3		 1qzzA-4cpdA:
27.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d7k SAM-DEPENDENT
METHYLTRANSFERASES

(Streptomyces
davaonensis) 		PF00891
(Methyltransf_2) 		4 ASP A 184
GLY A 187
GLY A 190
LEU A 193
 None
 0.39A 1qzzA-4d7kA:
20.8		 1qzzA-4d7kA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddp BECLIN-1

(Homo sapiens) 		PF04111
(APG6) 		4 TYR A 413
GLY A 408
GLY A 410
GLY A 411
 None
 0.56A 1qzzA-4ddpA:
undetectable		 1qzzA-4ddpA:
20.11