SIMILAR PATTERNS OF AMINO ACIDS FOR 1QZR_B_CDXB901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 THR A  26
ASN A  31
TYR A  36
LEU A 153
 None
 0.99A 1qzrA-1dt2A:
undetectable		 1qzrA-1dt2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		4 THR A  42
TYR A  46
ASN A  48
LEU A  74
 None
 1.09A 1qzrA-1ezfA:
1.5		 1qzrA-1ezfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 HIS C 276
TYR C 282
ASN C 120
TYR C 121
 None
 1.04A 1qzrA-1h2tC:
undetectable		 1qzrA-1h2tC:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		4 HIS A 911
TYR A 952
ASN A 954
LEU A 918
 None
 1.12A 1qzrA-1hu3A:
undetectable		 1qzrA-1hu3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 HIS A 228
TYR A 329
TYR A 234
LEU A 332
 None
 1.13A 1qzrA-1iq0A:
0.9		 1qzrA-1iq0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 TYR A 100
ASN A  18
LEU A  24
GLN A 102
 None
 1.00A 1qzrA-1j3bA:
0.0		 1qzrA-1j3bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 HIS A 189
TYR A 236
LEU A 195
GLN A 221
 None
 1.12A 1qzrA-1jaeA:
0.0		 1qzrA-1jaeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kri VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 THR A 215
TYR A 219
ASN A 222
LEU A 164
 None
 0.94A 1qzrA-1kriA:
0.4		 1qzrA-1kriA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 THR A 116
TYR A 117
ASN A 488
LEU A 375
 None
 1.05A 1qzrA-1l1fA:
0.0		 1qzrA-1l1fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 HIS D 163
THR D 501
LEU D 506
GLN D 498
 None
 1.11A 1qzrA-1mhzD:
undetectable		 1qzrA-1mhzD:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A 901 (-4.7A)
None
None
ANP  A 901 (-3.2A)
 0.18A 1qzrA-1pvgA:
62.4		 1qzrA-1pvgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcd L FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		4 HIS A 124
TYR A  68
LEU A  16
GLN A  69
 None
 1.10A 1qzrA-1rcdA:
undetectable		 1qzrA-1rcdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shc SHC

(Homo sapiens) 		PF00640
(PID) 		4 THR A  78
ASN A  72
LEU A 106
GLN A  76
 None
 0.90A 1qzrA-1shcA:
undetectable		 1qzrA-1shcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp8 AGGLUTININ ALPHA
CHAIN

(Artocarpus
hirsutus) 		PF01419
(Jacalin) 		4 THR A  85
TYR A  96
TYR A  19
LEU A  17
 None
 1.09A 1qzrA-1tp8A:
undetectable		 1qzrA-1tp8A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 HIS A  59
TYR A  70
TYR A  75
LEU A  71
 None
 1.08A 1qzrA-1v2aA:
undetectable		 1qzrA-1v2aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 THR A 530
TYR A 531
ASN A 537
LEU A 512
 None
 1.12A 1qzrA-1v7vA:
undetectable		 1qzrA-1v7vA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf5 SIDEKICK 2 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		4 HIS A  19
THR A  41
TYR A  53
LEU A  93
 None
 1.07A 1qzrA-1wf5A:
undetectable		 1qzrA-1wf5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 THR A 400
TYR A 363
LEU A 368
GLN A 398
 None
 1.09A 1qzrA-1y3nA:
undetectable		 1qzrA-1y3nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		4 TYR A  56
ASN A  61
TYR A  62
LEU A  57
 None
 1.07A 1qzrA-1ypfA:
undetectable		 1qzrA-1ypfA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 HIS A  42
THR A  49
TYR A  50
ASN A 163
TYR A 165
LEU A 169
 None
None
None
GOL  A 599 ( 4.7A)
None
None
 0.58A 1qzrA-1zxnA:
51.6		 1qzrA-1zxnA:
50.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 THR A 294
TYR A 293
TYR A 301
LEU A 256
 None
 1.12A 1qzrA-2avfA:
undetectable		 1qzrA-2avfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 THR A 487
ASN A 258
LEU A 251
GLN A 489
 None
 0.96A 1qzrA-2b3oA:
undetectable		 1qzrA-2b3oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ck2 HUMAN FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 THR A  58
TYR A  57
TYR A  36
LEU A  34
 None
 1.06A 1qzrA-2ck2A:
undetectable		 1qzrA-2ck2A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 THR A 305
TYR A 302
LEU A 299
GLN A 303
 None
 1.07A 1qzrA-2dw6A:
0.0		 1qzrA-2dw6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 THR A 459
ASN A 434
TYR A 438
LEU A 456
 None
DU  A 611 (-3.0A)
None
None
 1.01A 1qzrA-2h2qA:
undetectable		 1qzrA-2h2qA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd1 DNA
INTEGRATION/RECOMBIN
ATION/INVERTION
PROTEIN

(Bacillus cereus) 		PF14659
(Phage_int_SAM_3) 		4 HIS A  86
TYR A  11
TYR A   8
LEU A  48
 None
 1.12A 1qzrA-2kd1A:
undetectable		 1qzrA-2kd1A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt9 PROBABLE 30S
RIBOSOMAL PROTEIN
PSRP-3

(Synechocystis
sp. PCC 6803) 		PF04839
(PSRP-3_Ycf65) 		4 THR A  74
ASN A  68
LEU A  12
GLN A  72
 None
 1.07A 1qzrA-2kt9A:
undetectable		 1qzrA-2kt9A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgy TRANSLOCATOR PROTEIN

(Mus musculus) 		PF03073
(TspO_MBR) 		4 THR A 122
TYR A  85
ASN A  92
GLN A  88
 None
 0.98A 1qzrA-2mgyA:
undetectable		 1qzrA-2mgyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 THR A 373
TYR A 316
TYR A 201
LEU A 204
 None
LLP  A 232 ( 4.6A)
LLP  A 232 ( 4.3A)
None
 1.08A 1qzrA-2o0rA:
undetectable		 1qzrA-2o0rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2

(Plasmodium
vivax) 		PF00268
(Ribonuc_red_sm) 		4 THR A 135
ASN A 142
TYR A 143
LEU A  91
 None
 1.07A 1qzrA-2o1zA:
undetectable		 1qzrA-2o1zA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p31 GLUTATHIONE
PEROXIDASE 7

(Homo sapiens) 		PF00255
(GSHPx) 		4 THR A  60
TYR A  64
ASN A  52
LEU A  67
 None
 1.05A 1qzrA-2p31A:
undetectable		 1qzrA-2p31A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqf POLY [ADP-RIBOSE]
POLYMERASE 12

(Homo sapiens) 		PF00644
(PARP) 		4 HIS A 605
THR A 679
TYR A 677
GLN A 527
 None
 1.07A 1qzrA-2pqfA:
undetectable		 1qzrA-2pqfA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 HIS A 472
TYR A 522
TYR A 271
LEU A 261
 None
 1.00A 1qzrA-2qr4A:
undetectable		 1qzrA-2qr4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 THR A 268
TYR A 269
TYR A 273
LEU A 242
 EDO  A 295 ( 4.5A)
EDO  A 295 (-3.8A)
None
None
 1.00A 1qzrA-2r3bA:
undetectable		 1qzrA-2r3bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 289
TYR A 491
LEU A 499
GLN A 495
 None
None
None
NAG  A 557 (-3.4A)
 1.04A 1qzrA-2rjqA:
undetectable		 1qzrA-2rjqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 HIS A 303
THR A 334
TYR A 330
TYR A 327
 None
 1.01A 1qzrA-2v1uA:
undetectable		 1qzrA-2v1uA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 THR A 280
TYR A 279
TYR A 287
LEU A 242
 None
 1.13A 1qzrA-2vmjA:
undetectable		 1qzrA-2vmjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 THR A 411
TYR A 410
LEU A 244
GLN A 409
 None
 1.07A 1qzrA-2vobA:
undetectable		 1qzrA-2vobA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		4 HIS A 474
TYR A 476
TYR A 540
LEU A 522
 None
 1.14A 1qzrA-2vpjA:
undetectable		 1qzrA-2vpjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 THR A 621
TYR A 620
ASN A 616
TYR A 652
 None
 1.11A 1qzrA-2x2iA:
undetectable		 1qzrA-2x2iA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		4 TYR A 197
TYR A  71
LEU A  80
GLN A 194
 None
 1.14A 1qzrA-2x9oA:
0.1		 1qzrA-2x9oA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aad HISTONE CHAPERONE
ASF1A

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		4 TYR B  44
ASN B  80
LEU B  57
GLN B  55
 None
 0.85A 1qzrA-3aadB:
undetectable		 1qzrA-3aadB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7c UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF14534
(DUF4440) 		4 THR A  50
TYR A  54
TYR A  58
LEU A  22
 None
None
None
EDO  A 124 ( 4.1A)
 1.13A 1qzrA-3b7cA:
undetectable		 1qzrA-3b7cA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 TYR A 180
ASN A 147
TYR A 148
LEU A 166
 None
 0.88A 1qzrA-3dmkA:
undetectable		 1qzrA-3dmkA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 TYR A4078
ASN A4102
TYR A4106
LEU A4080
 None
 0.83A 1qzrA-3g1nA:
undetectable		 1qzrA-3g1nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE

(Klebsiella
pneumoniae) 		PF00571
(CBS) 		4 HIS A 326
THR A 309
LEU A 300
GLN A 304
 None
 1.05A 1qzrA-3k2vA:
undetectable		 1qzrA-3k2vA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		4 HIS A 470
TYR A 451
ASN A 449
LEU A 309
 None
None
ME8  A 801 (-4.6A)
None
 1.13A 1qzrA-3kflA:
undetectable		 1qzrA-3kflA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kij PROBABLE GLUTATHIONE
PEROXIDASE 8

(Homo sapiens) 		PF00255
(GSHPx) 		4 THR A  82
TYR A  86
ASN A  74
LEU A  89
 None
 1.09A 1qzrA-3kijA:
undetectable		 1qzrA-3kijA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc5 TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN F

(Vibrio cholerae) 		PF06340
(TcpF) 		4 THR A 117
TYR A 121
ASN A 123
LEU A 127
 None
 1.08A 1qzrA-3oc5A:
undetectable		 1qzrA-3oc5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 HIS A 230
THR A 382
TYR A 384
LEU A 330
 None
 1.10A 1qzrA-3ouhA:
undetectable		 1qzrA-3ouhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd8 PROBABLE
BACTERIOFERRITIN
BFRB

(Mycobacterium
tuberculosis) 		PF00210
(Ferritin) 		4 HIS A  12
ASN A  21
LEU A 109
GLN A  18
 None
 1.12A 1qzrA-3qd8A:
undetectable		 1qzrA-3qd8A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		4 HIS A 216
TYR A 279
TYR A 269
LEU A 283
 None
 1.14A 1qzrA-3qomA:
undetectable		 1qzrA-3qomA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		4 HIS A 314
THR A 320
TYR A 253
LEU A 368
 None
 1.08A 1qzrA-3s30A:
undetectable		 1qzrA-3s30A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 HIS B 395
THR B 342
TYR B 343
LEU B 407
 None
 1.01A 1qzrA-3t5vB:
undetectable		 1qzrA-3t5vB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 THR A 568
ASN A 735
LEU A 435
GLN A 430
 None
 1.02A 1qzrA-3ux1A:
undetectable		 1qzrA-3ux1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		4 THR A 179
ASN A 152
TYR A 150
LEU A  92
 None
 0.90A 1qzrA-3v10A:
undetectable		 1qzrA-3v10A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 HIS A 201
TYR A 247
LEU A 207
GLN A 232
 None
 1.05A 1qzrA-3vm5A:
undetectable		 1qzrA-3vm5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 HIS A 301
TYR A  30
ASN A  16
LEU A  33
 None
 1.07A 1qzrA-3wecA:
0.5		 1qzrA-3wecA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1

(Homo sapiens) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N)
PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 THR A 128
ASN B  90
LEU A  80
GLN A 106
 None
 1.10A 1qzrA-3zyjA:
undetectable		 1qzrA-3zyjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16543
(DFRP_C)
PF16897
(MMR_HSR1_Xtn) 		4 THR C 221
ASN A 268
TYR A 247
LEU A 249
 None
 0.99A 1qzrA-4a9aC:
undetectable		 1qzrA-4a9aC:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		4 THR A  92
ASN A 141
LEU A  40
GLN A 101
 None
 1.14A 1qzrA-4aa9A:
undetectable		 1qzrA-4aa9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		4 HIS A  60
ASN A 133
TYR A 137
LEU A  76
 None
 1.07A 1qzrA-4afrA:
undetectable		 1qzrA-4afrA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akd MANNOSE-SPECIFIC
LECTIN KM+

(Artocarpus
integer) 		PF01419
(Jacalin) 		4 THR A 101
TYR A 113
TYR A  34
LEU A  32
 None
 1.07A 1qzrA-4akdA:
undetectable		 1qzrA-4akdA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 HIS A1132
ASN A1484
TYR A1486
GLN A1452
 None
 1.09A 1qzrA-4amcA:
undetectable		 1qzrA-4amcA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae) 		PF07571
(TAF6_C) 		4 THR A 279
TYR A 280
TYR A 284
LEU A 287
 None
None
NHE  A 400 (-4.7A)
None
 1.03A 1qzrA-4atgA:
undetectable		 1qzrA-4atgA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		4 HIS A 250
THR A 256
TYR A 210
LEU A 214
 None
 1.14A 1qzrA-4b2gA:
undetectable		 1qzrA-4b2gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 HIS A 462
THR A 442
ASN A 415
LEU A 448
 None
 1.04A 1qzrA-4b3iA:
undetectable		 1qzrA-4b3iA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 THR A  13
TYR A  14
ASN A 113
LEU A  40
 None
 0.75A 1qzrA-4ckbA:
undetectable		 1qzrA-4ckbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 HIS A 307
THR A 175
TYR A 176
TYR A 359
 None
 0.91A 1qzrA-4fozA:
undetectable		 1qzrA-4fozA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A1202 (-4.6A)
None
None
ANP  A1202 (-3.0A)
 0.34A 1qzrA-4gfhA:
60.9		 1qzrA-4gfhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 HIS M 292
THR M 322
TYR M 321
LEU M 440
 None
 1.10A 1qzrA-4heaM:
undetectable		 1qzrA-4heaM:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		4 THR A 253
ASN A 228
TYR A 232
LEU A 250
 None
UMP  A 401 (-3.3A)
None
None
 1.12A 1qzrA-4iqqA:
undetectable		 1qzrA-4iqqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 HIS A  83
THR A 308
TYR A 129
LEU A  98
 None
 1.08A 1qzrA-4irqA:
undetectable		 1qzrA-4irqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		4 HIS A 188
TYR A  37
ASN A 351
LEU A 277
 None
 0.96A 1qzrA-4iw7A:
undetectable		 1qzrA-4iw7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		4 HIS A 223
THR A  32
TYR A  33
LEU A 230
 EDO  A 304 (-3.9A)
None
EDO  A 304 (-4.3A)
None
 0.99A 1qzrA-4ldnA:
undetectable		 1qzrA-4ldnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 4 ASN A 282
TYR A 281
LEU A 289
GLN A 284
 None
 1.01A 1qzrA-4mfzA:
undetectable		 1qzrA-4mfzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 THR E 485
TYR E 484
TYR E 415
LEU E 428
 None
 1.10A 1qzrA-4obuE:
undetectable		 1qzrA-4obuE:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 ASN A 286
TYR A 285
LEU A 293
GLN A 288
 None
 1.00A 1qzrA-4q38A:
0.0		 1qzrA-4q38A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		4 THR A 466
ASN A 501
LEU A 828
GLN A 465
 None
 1.10A 1qzrA-4q8gA:
undetectable		 1qzrA-4q8gA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 THR A 466
ASN A 501
LEU A 828
GLN A 465
 None
 1.15A 1qzrA-4q8hA:
undetectable		 1qzrA-4q8hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 HIS B 395
THR B 342
TYR B 343
LEU B 407
 None
 1.02A 1qzrA-4trqB:
0.0		 1qzrA-4trqB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 ASN C 130
TYR C 129
LEU C 126
GLN C  16
 None
 1.05A 1qzrA-4u8uC:
undetectable		 1qzrA-4u8uC:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		no annotation 4 THR G 466
ASN G 501
LEU G 828
GLN G 465
 None
 1.04A 1qzrA-4xr7G:
undetectable		 1qzrA-4xr7G:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		4 THR A 239
ASN A 214
TYR A 218
LEU A 236
 None
BVP  A1001 (-2.8A)
None
None
 1.09A 1qzrA-4xscA:
undetectable		 1qzrA-4xscA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 THR A  47
TYR A  48
TYR A  52
LEU A  37
 None
 0.90A 1qzrA-5a05A:
undetectable		 1qzrA-5a05A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2

(Mus musculus) 		PF06046
(Sec6) 		4 THR A 244
TYR A 245
TYR A 249
LEU A 224
 None
 1.06A 1qzrA-5b86A:
undetectable		 1qzrA-5b86A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 HIS A 122
THR A 107
ASN A 147
LEU A 153
 None
 1.11A 1qzrA-5c54A:
undetectable		 1qzrA-5c54A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		4 THR A 262
TYR A 263
LEU A 315
GLN A 266
 None
 1.02A 1qzrA-5czyA:
undetectable		 1qzrA-5czyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 TYR A 658
ASN A 747
LEU A 662
GLN A 659
 None
None
NAG  A 909 (-4.1A)
None
 0.73A 1qzrA-5gz4A:
undetectable		 1qzrA-5gz4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 THR A   9
ASN A  29
TYR A  32
LEU A  17
 None
 1.03A 1qzrA-5ikbA:
undetectable		 1qzrA-5ikbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 HIS A 707
ASN A 477
LEU A 631
GLN A 633
 None
 1.12A 1qzrA-5jrlA:
undetectable		 1qzrA-5jrlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juh ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		PF08548
(Peptidase_M10_C) 		4 THR A  78
TYR A 146
TYR A 151
LEU A 101
 None
 0.99A 1qzrA-5juhA:
undetectable		 1qzrA-5juhA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 HIS B 478
ASN B 448
TYR B 447
LEU B 427
 None
 1.10A 1qzrA-5ldrB:
undetectable		 1qzrA-5ldrB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 TYR B4078
ASN B4102
TYR B4106
LEU B4080
 None
 1.00A 1qzrA-5lp8B:
undetectable		 1qzrA-5lp8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 THR A 376
ASN A 279
LEU A 359
GLN A 355
 None
 1.07A 1qzrA-5nlmA:
undetectable		 1qzrA-5nlmA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugw TELOMERASE REVERSE
TRANSCRIPTASE

(Homo sapiens) 		no annotation 4 HIS A1013
THR A1088
TYR A1089
LEU A1092
 None
 0.76A 1qzrA-5ugwA:
undetectable		 1qzrA-5ugwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		4 THR A  43
ASN A 148
LEU A  22
GLN A  41
 None
 1.08A 1qzrA-5xtoA:
undetectable		 1qzrA-5xtoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbd PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D

(Sus scrofa) 		no annotation 4 THR A 285
ASN A 236
LEU A 353
GLN A 287
 None
 0.94A 1qzrA-6bbdA:
undetectable		 1qzrA-6bbdA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e12 -

(-) 		no annotation 4 HIS A 120
TYR A 143
LEU A 147
GLN A 146
 OLA  A 301 (-3.8A)
None
OLA  A 301 ( 4.2A)
None
 0.87A 1qzrA-6e12A:
0.5		 1qzrA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 THR P 339
TYR P 236
TYR P 244
LEU P 241
 None
 1.07A 1qzrA-6g2jP:
undetectable		 1qzrA-6g2jP:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR A  69
ASN A  93
LEU A   4
GLN A  90
 None
 1.02A 1qzrB-1fn4A:
0.0		 1qzrB-1fn4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 HIS C 276
TYR C 282
ASN C 120
TYR C 121
 None
 0.84A 1qzrB-1h2tC:
0.0		 1qzrB-1h2tC:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		4 HIS A 911
TYR A 952
ASN A 954
LEU A 918
 None
 1.05A 1qzrB-1hu3A:
undetectable		 1qzrB-1hu3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 HIS A 228
TYR A 329
TYR A 234
LEU A 332
 None
 1.13A 1qzrB-1iq0A:
0.8		 1qzrB-1iq0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 TYR A 100
ASN A  18
LEU A  24
GLN A 102
 None
 0.99A 1qzrB-1j3bA:
undetectable		 1qzrB-1j3bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 HIS A 189
TYR A 236
LEU A 195
GLN A 221
 None
 1.10A 1qzrB-1jaeA:
0.0		 1qzrB-1jaeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqr VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 THR A 186
TYR A 177
ASN A 183
LEU A 158
 GOL  A4000 (-2.8A)
None
None
None
 1.07A 1qzrB-1kqrA:
0.7		 1qzrB-1kqrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kri VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 THR A 215
TYR A 219
ASN A 222
LEU A 164
 None
 1.03A 1qzrB-1kriA:
0.4		 1qzrB-1kriA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lyb CATHEPSIN D

(Homo sapiens) 		PF00026
(Asp) 		4 THR A  23
ASN A  60
TYR A  59
GLN A  26
 None
 0.91A 1qzrB-1lybA:
undetectable		 1qzrB-1lybA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 HIS D 163
THR D 501
LEU D 506
GLN D 498
 None
 1.11A 1qzrB-1mhzD:
undetectable		 1qzrB-1mhzD:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A 901 (-4.7A)
None
None
ANP  A 901 (-3.2A)
 0.36A 1qzrB-1pvgA:
60.3		 1qzrB-1pvgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcd L FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		4 HIS A 124
TYR A  68
LEU A  16
GLN A  69
 None
 1.10A 1qzrB-1rcdA:
undetectable		 1qzrB-1rcdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shc SHC

(Homo sapiens) 		PF00640
(PID) 		4 THR A  78
ASN A  72
LEU A 106
GLN A  76
 None
 0.89A 1qzrB-1shcA:
undetectable		 1qzrB-1shcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp8 AGGLUTININ ALPHA
CHAIN

(Artocarpus
hirsutus) 		PF01419
(Jacalin) 		4 THR A  85
TYR A  96
TYR A  19
LEU A  17
 None
 1.09A 1qzrB-1tp8A:
undetectable		 1qzrB-1tp8A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 HIS A  59
TYR A  70
TYR A  75
LEU A  71
 None
 1.10A 1qzrB-1v2aA:
undetectable		 1qzrB-1v2aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf5 SIDEKICK 2 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		4 HIS A  19
THR A  41
TYR A  53
LEU A  93
 None
 1.06A 1qzrB-1wf5A:
undetectable		 1qzrB-1wf5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 THR A 400
TYR A 363
LEU A 368
GLN A 398
 None
 1.11A 1qzrB-1y3nA:
undetectable		 1qzrB-1y3nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		4 TYR A  56
ASN A  61
TYR A  62
LEU A  57
 None
 1.13A 1qzrB-1ypfA:
undetectable		 1qzrB-1ypfA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 HIS A  42
THR A  49
TYR A  50
ASN A 163
TYR A 165
LEU A 169
 None
None
None
GOL  A 599 ( 4.7A)
None
None
 0.55A 1qzrB-1zxnA:
50.8		 1qzrB-1zxnA:
50.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 THR A 294
TYR A 293
TYR A 301
LEU A 256
 None
 1.13A 1qzrB-2avfA:
undetectable		 1qzrB-2avfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ck2 HUMAN FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 THR A  58
TYR A  57
TYR A  36
LEU A  34
 None
 1.07A 1qzrB-2ck2A:
undetectable		 1qzrB-2ck2A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 THR A 305
TYR A 302
LEU A 299
GLN A 303
 None
 1.08A 1qzrB-2dw6A:
undetectable		 1qzrB-2dw6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 THR A 459
ASN A 434
TYR A 438
LEU A 456
 None
DU  A 611 (-3.0A)
None
None
 0.98A 1qzrB-2h2qA:
undetectable		 1qzrB-2h2qA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib5 CHROMO PROTEIN

(Epiactis
japonica) 		PF01353
(GFP) 		4 THR A 108
TYR A 117
ASN A  61
LEU A  13
 None
CRQ  A  65 ( 4.1A)
None
None
 1.12A 1qzrB-2ib5A:
undetectable		 1qzrB-2ib5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgy TRANSLOCATOR PROTEIN

(Mus musculus) 		PF03073
(TspO_MBR) 		4 THR A 122
TYR A  85
ASN A  92
GLN A  88
 None
 1.02A 1qzrB-2mgyA:
undetectable		 1qzrB-2mgyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		4 THR A 108
ASN A 102
TYR A 101
LEU A  75
 None
 0.99A 1qzrB-2nygA:
undetectable		 1qzrB-2nygA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 THR A 373
TYR A 316
TYR A 201
LEU A 204
 None
LLP  A 232 ( 4.6A)
LLP  A 232 ( 4.3A)
None
 1.04A 1qzrB-2o0rA:
undetectable		 1qzrB-2o0rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2

(Plasmodium
vivax) 		PF00268
(Ribonuc_red_sm) 		4 THR A 135
ASN A 142
TYR A 143
LEU A  91
 None
 1.01A 1qzrB-2o1zA:
undetectable		 1qzrB-2o1zA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN

(Plasmodium
yoelii) 		PF00268
(Ribonuc_red_sm) 		4 THR A 136
ASN A 143
TYR A 144
LEU A  92
 None
 1.09A 1qzrB-2p1iA:
undetectable		 1qzrB-2p1iA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p31 GLUTATHIONE
PEROXIDASE 7

(Homo sapiens) 		PF00255
(GSHPx) 		4 THR A  60
TYR A  64
ASN A  52
LEU A  67
 None
 1.06A 1qzrB-2p31A:
undetectable		 1qzrB-2p31A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3j VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 THR A 186
TYR A 177
ASN A 183
LEU A 158
 None
 1.03A 1qzrB-2p3jA:
undetectable		 1qzrB-2p3jA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqf POLY [ADP-RIBOSE]
POLYMERASE 12

(Homo sapiens) 		PF00644
(PARP) 		4 HIS A 605
THR A 679
TYR A 677
GLN A 527
 None
 1.06A 1qzrB-2pqfA:
undetectable		 1qzrB-2pqfA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 HIS A 472
TYR A 522
TYR A 271
LEU A 261
 None
 0.99A 1qzrB-2qr4A:
undetectable		 1qzrB-2qr4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 THR A 268
TYR A 269
TYR A 273
LEU A 242
 EDO  A 295 ( 4.5A)
EDO  A 295 (-3.8A)
None
None
 1.02A 1qzrB-2r3bA:
undetectable		 1qzrB-2r3bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 289
TYR A 491
LEU A 499
GLN A 495
 None
None
None
NAG  A 557 (-3.4A)
 1.04A 1qzrB-2rjqA:
undetectable		 1qzrB-2rjqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 HIS A 303
THR A 334
TYR A 330
TYR A 327
 None
 1.01A 1qzrB-2v1uA:
undetectable		 1qzrB-2v1uA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 THR A 280
TYR A 279
TYR A 287
LEU A 242
 None
 1.13A 1qzrB-2vmjA:
undetectable		 1qzrB-2vmjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 THR A 411
TYR A 410
LEU A 244
GLN A 409
 None
 1.07A 1qzrB-2vobA:
undetectable		 1qzrB-2vobA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		4 HIS A 474
TYR A 476
TYR A 540
LEU A 522
 None
 1.11A 1qzrB-2vpjA:
undetectable		 1qzrB-2vpjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aad HISTONE CHAPERONE
ASF1A

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		4 TYR B  44
ASN B  80
LEU B  57
GLN B  55
 None
 0.93A 1qzrB-3aadB:
undetectable		 1qzrB-3aadB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 HIS A 483
TYR A 443
ASN A 635
LEU A 452
 None
 1.11A 1qzrB-3biwA:
undetectable		 1qzrB-3biwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 TYR A 180
ASN A 147
TYR A 148
LEU A 166
 None
 0.81A 1qzrB-3dmkA:
undetectable		 1qzrB-3dmkA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejv UNCHARACTERIZED
PROTEIN WITH
CYSTATIN-LIKE FOLD

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 THR A  17
ASN A  11
LEU A  31
GLN A  15
 None
 0.96A 1qzrB-3ejvA:
undetectable		 1qzrB-3ejvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdq MOTILITY GENE
REPRESSOR MOGR

(Listeria
monocytogenes) 		PF12181
(MogR_DNAbind) 		4 HIS A  47
THR A  25
ASN A  19
GLN A  16
 None
 1.03A 1qzrB-3fdqA:
undetectable		 1qzrB-3fdqA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 TYR A4078
ASN A4102
TYR A4106
LEU A4080
 None
 0.79A 1qzrB-3g1nA:
undetectable		 1qzrB-3g1nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6

(Saccharomyces
cerevisiae) 		PF04756
(OST3_OST6) 		4 HIS A  66
THR A  85
ASN A  39
LEU A 106
 None
 0.91A 1qzrB-3ga4A:
undetectable		 1qzrB-3ga4A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  54
TYR H  52
ASN H  58
TYR H  33
 None
None
SO4  H 214 (-4.4A)
None
 1.12A 1qzrB-3go1H:
undetectable		 1qzrB-3go1H:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		4 TYR A  22
ASN A 230
TYR A 231
LEU A  59
 None
 1.12A 1qzrB-3godA:
undetectable		 1qzrB-3godA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN

(Gallus gallus) 		PF02167
(Cytochrom_C1) 		4 THR D 175
TYR D 171
ASN D 166
LEU D 169
 None
 1.04A 1qzrB-3h1lD:
undetectable		 1qzrB-3h1lD:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE

(Klebsiella
pneumoniae) 		PF00571
(CBS) 		4 HIS A 326
THR A 309
LEU A 300
GLN A 304
 None
 1.05A 1qzrB-3k2vA:
undetectable		 1qzrB-3k2vA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kij PROBABLE GLUTATHIONE
PEROXIDASE 8

(Homo sapiens) 		PF00255
(GSHPx) 		4 THR A  82
TYR A  86
ASN A  74
LEU A  89
 None
 1.10A 1qzrB-3kijA:
undetectable		 1qzrB-3kijA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 HIS A 230
THR A 382
TYR A 384
LEU A 330
 None
 1.09A 1qzrB-3ouhA:
undetectable		 1qzrB-3ouhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozq SERPIN48

(Tenebrio
molitor) 		PF00079
(Serpin) 		4 HIS A 229
ASN A 271
TYR A 225
LEU A 234
 None
 1.07A 1qzrB-3ozqA:
undetectable		 1qzrB-3ozqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd8 PROBABLE
BACTERIOFERRITIN
BFRB

(Mycobacterium
tuberculosis) 		PF00210
(Ferritin) 		4 HIS A  12
ASN A  21
LEU A 109
GLN A  18
 None
 1.13A 1qzrB-3qd8A:
undetectable		 1qzrB-3qd8A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		4 HIS A 314
THR A 320
TYR A 253
LEU A 368
 None
 1.07A 1qzrB-3s30A:
undetectable		 1qzrB-3s30A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 HIS B 395
THR B 342
TYR B 343
LEU B 407
 None
 1.01A 1qzrB-3t5vB:
undetectable		 1qzrB-3t5vB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 TYR B 222
ASN B 212
LEU B 176
GLN B 219
 None
 1.00A 1qzrB-3t5vB:
undetectable		 1qzrB-3t5vB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		4 THR A 179
ASN A 152
TYR A 150
LEU A  92
 None
 0.79A 1qzrB-3v10A:
undetectable		 1qzrB-3v10A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 HIS A 201
TYR A 247
LEU A 207
GLN A 232
 None
 1.02A 1qzrB-3vm5A:
undetectable		 1qzrB-3vm5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1

(Homo sapiens) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N)
PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 THR A 128
ASN B  90
LEU A  80
GLN A 106
 None
 1.02A 1qzrB-3zyjA:
undetectable		 1qzrB-3zyjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16543
(DFRP_C)
PF16897
(MMR_HSR1_Xtn) 		4 THR C 221
ASN A 268
TYR A 247
LEU A 249
 None
 0.98A 1qzrB-4a9aC:
undetectable		 1qzrB-4a9aC:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akd MANNOSE-SPECIFIC
LECTIN KM+

(Artocarpus
integer) 		PF01419
(Jacalin) 		4 THR A 101
TYR A 113
TYR A  34
LEU A  32
 None
 1.07A 1qzrB-4akdA:
undetectable		 1qzrB-4akdA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae) 		PF07571
(TAF6_C) 		4 THR A 279
TYR A 280
TYR A 284
LEU A 287
 None
None
NHE  A 400 (-4.7A)
None
 1.02A 1qzrB-4atgA:
undetectable		 1qzrB-4atgA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		4 HIS A 250
THR A 256
TYR A 210
LEU A 214
 None
 1.12A 1qzrB-4b2gA:
undetectable		 1qzrB-4b2gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 THR A  13
TYR A  14
ASN A 113
LEU A  40
 None
 0.61A 1qzrB-4ckbA:
undetectable		 1qzrB-4ckbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 HIS A 307
THR A 175
TYR A 176
TYR A 359
 None
 0.88A 1qzrB-4fozA:
undetectable		 1qzrB-4fozA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A1202 (-4.6A)
None
None
ANP  A1202 (-3.0A)
 0.41A 1qzrB-4gfhA:
59.7		 1qzrB-4gfhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		4 THR A 126
TYR A 125
ASN A  41
LEU A  29
 None
 0.98A 1qzrB-4gouA:
undetectable		 1qzrB-4gouA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 HIS M 292
THR M 322
TYR M 321
LEU M 440
 None
 1.09A 1qzrB-4heaM:
undetectable		 1qzrB-4heaM:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 THR B 536
ASN B 446
TYR B 445
LEU B 547
 None
 1.10A 1qzrB-4i0wB:
0.8		 1qzrB-4i0wB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		4 THR A 253
ASN A 228
TYR A 232
LEU A 250
 None
UMP  A 401 (-3.3A)
None
None
 1.10A 1qzrB-4iqqA:
undetectable		 1qzrB-4iqqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 HIS A  83
THR A 308
TYR A 129
LEU A  98
 None
 1.07A 1qzrB-4irqA:
undetectable		 1qzrB-4irqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 HIS A 357
THR A  10
ASN A   4
LEU A  75
 None
 1.12A 1qzrB-4kdsA:
undetectable		 1qzrB-4kdsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		4 HIS A 223
THR A  32
TYR A  33
LEU A 230
 EDO  A 304 (-3.9A)
None
EDO  A 304 (-4.3A)
None
 0.97A 1qzrB-4ldnA:
undetectable		 1qzrB-4ldnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 4 ASN A 282
TYR A 281
LEU A 289
GLN A 284
 None
 0.91A 1qzrB-4mfzA:
undetectable		 1qzrB-4mfzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 THR E 485
TYR E 484
TYR E 415
LEU E 428
 None
 1.10A 1qzrB-4obuE:
undetectable		 1qzrB-4obuE:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 ASN A 286
TYR A 285
LEU A 293
GLN A 288
 None
 0.90A 1qzrB-4q38A:
undetectable		 1qzrB-4q38A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 HIS B 395
THR B 342
TYR B 343
LEU B 407
 None
 1.02A 1qzrB-4trqB:
undetectable		 1qzrB-4trqB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 TYR B 222
ASN B 212
LEU B 176
GLN B 219
 None
 1.09A 1qzrB-4trqB:
undetectable		 1qzrB-4trqB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 ASN C 130
TYR C 129
LEU C 126
GLN C  16
 None
 0.90A 1qzrB-4u8uC:
undetectable		 1qzrB-4u8uC:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		4 THR A 239
ASN A 214
TYR A 218
LEU A 236
 None
BVP  A1001 (-2.8A)
None
None
 1.03A 1qzrB-4xscA:
undetectable		 1qzrB-4xscA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		4 THR A  26
ASN A  20
LEU A  50
GLN A  24
 None
 0.96A 1qzrB-4z8sA:
undetectable		 1qzrB-4z8sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 THR A  47
TYR A  48
TYR A  52
LEU A  37
 None
 0.92A 1qzrB-5a05A:
undetectable		 1qzrB-5a05A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2

(Mus musculus) 		PF06046
(Sec6) 		4 THR A 244
TYR A 245
TYR A 249
LEU A 224
 None
 1.07A 1qzrB-5b86A:
1.8		 1qzrB-5b86A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 HIS A 122
THR A 107
ASN A 147
LEU A 153
 None
 1.05A 1qzrB-5c54A:
undetectable		 1qzrB-5c54A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ca6 PORCINE ROTAVIRUS
TFR-41 VP8*

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 THR A 186
TYR A 177
ASN A 183
LEU A 158
 GOL  A 301 (-3.6A)
None
None
None
 0.98A 1qzrB-5ca6A:
undetectable		 1qzrB-5ca6A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		4 THR A 262
TYR A 263
LEU A 315
GLN A 266
 None
 1.00A 1qzrB-5czyA:
undetectable		 1qzrB-5czyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn8 GTPASE DER

(Coxiella
burnetii) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 HIS A 389
ASN A 420
LEU A 352
GLN A 350
 None
 0.93A 1qzrB-5dn8A:
undetectable		 1qzrB-5dn8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 TYR A 658
ASN A 747
LEU A 662
GLN A 659
 None
None
NAG  A 909 (-4.1A)
None
 0.82A 1qzrB-5gz4A:
undetectable		 1qzrB-5gz4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 THR A   9
ASN A  29
TYR A  32
LEU A  17
 None
 1.08A 1qzrB-5ikbA:
undetectable		 1qzrB-5ikbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juh ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		PF08548
(Peptidase_M10_C) 		4 THR A  78
TYR A 146
TYR A 151
LEU A 101
 None
 1.01A 1qzrB-5juhA:
undetectable		 1qzrB-5juhA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		4 ASN A  34
TYR A  35
LEU A 297
GLN A 295
 None
 1.09A 1qzrB-5m23A:
undetectable		 1qzrB-5m23A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugw TELOMERASE REVERSE
TRANSCRIPTASE

(Homo sapiens) 		no annotation 4 HIS A1013
THR A1088
TYR A1089
LEU A1092
 None
 0.78A 1qzrB-5ugwA:
undetectable		 1qzrB-5ugwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 4 THR A  23
ASN A  60
TYR A  59
GLN A  26
 None
 0.87A 1qzrB-5ux4A:
undetectable		 1qzrB-5ux4A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		4 THR A  43
ASN A 148
LEU A  22
GLN A  41
 None
 1.05A 1qzrB-5xtoA:
undetectable		 1qzrB-5xtoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ymt OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 4 THR A 122
TYR A 113
ASN A 119
LEU A  94
 None
 0.94A 1qzrB-5ymtA:
undetectable		 1qzrB-5ymtA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 ASN W  34
TYR W  35
LEU W 297
GLN W 295
 None
 1.10A 1qzrB-6bynW:
undetectable		 1qzrB-6bynW:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 4 THR A  61
TYR A  37
ASN A 138
LEU A  40
 None
 1.00A 1qzrB-6d6vA:
undetectable		 1qzrB-6d6vA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e12 -

(-) 		no annotation 4 HIS A 120
TYR A 143
LEU A 147
GLN A 146
 OLA  A 301 (-3.8A)
None
OLA  A 301 ( 4.2A)
None
 0.88A 1qzrB-6e12A:
undetectable		 1qzrB-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 THR P 339
TYR P 236
TYR P 244
LEU P 241
 None
 1.08A 1qzrB-6g2jP:
undetectable		 1qzrB-6g2jP:
10.61