SIMILAR PATTERNS OF AMINO ACIDS FOR 1QVU_A_PRLA196_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		4 LEU A 283
THR A 199
TYR A 198
TYR A 244
 None
 1.38A 1qvuA-1d5yA:
0.0		 1qvuA-1d5yA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elw TPR1-DOMAIN OF HOP

(Homo sapiens) 		PF13181
(TPR_8)
PF13414
(TPR_11) 		4 LEU A  99
GLU A 102
TRP A  71
THR A  64
 None
 1.43A 1qvuA-1elwA:
0.0		 1qvuA-1elwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A  43
GLU A 298
THR A  34
TYR A  36
 PG4  A9011 (-4.5A)
None
None
None
 1.07A 1qvuA-1h17A:
3.5		 1qvuA-1h17A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 LEU A 404
GLU A 396
THR A 352
TYR A 349
 None
 1.17A 1qvuA-1lnsA:
0.0		 1qvuA-1lnsA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  83
GLU A 115
TRP A 111
THR A 245
 None
MN  A 502 ( 2.3A)
None
None
 1.40A 1qvuA-1pm2A:
0.1		 1qvuA-1pm2A:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		4 LEU A  54
GLU A  58
TRP A  61
THR A  89
 None
 1.08A 1qvuA-1rpwA:
24.3		 1qvuA-1rpwA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tex STF0
SULFOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF09037
(Sulphotransf) 		4 LEU A 188
GLU A 192
TRP A 195
THR A 106
 None
 1.32A 1qvuA-1texA:
0.3		 1qvuA-1texA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6m ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 LEU A 102
GLU A 105
THR A  51
TYR A  52
 None
 1.11A 1qvuA-1u6mA:
0.0		 1qvuA-1u6mA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 550
GLU A 548
THR A 395
TYR A 565
 None
 1.45A 1qvuA-1v5fA:
1.2		 1qvuA-1v5fA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpr LUCIFERASE

(Lingulodinium
polyedra) 		PF10284
(Luciferase_3H)
PF10285
(Luciferase_cat) 		4 LEU A 882
GLU A 872
THR A1096
TYR A1071
 None
 1.32A 1qvuA-1vprA:
undetectable		 1qvuA-1vprA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		4 LEU A  76
THR A 118
TYR A 115
TYR A 104
 None
 1.18A 1qvuA-1w3iA:
undetectable		 1qvuA-1w3iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		4 LEU A 172
THR A 107
TYR A 142
TYR A 239
 None
 1.25A 1qvuA-1xnfA:
undetectable		 1qvuA-1xnfA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 GLU A 215
THR A  13
TYR A 117
TYR A 178
 CH6  A  63 ( 3.0A)
None
CH6  A  63 ( 4.6A)
None
 1.23A 1qvuA-1xqmA:
undetectable		 1qvuA-1xqmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 220
GLU A 222
TYR A 208
TYR A 184
 None
 1.27A 1qvuA-1ycnA:
2.1		 1qvuA-1ycnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 LEU A  87
GLU A 130
THR A 270
TYR A 268
 None
 1.42A 1qvuA-1z7mA:
undetectable		 1qvuA-1z7mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)

(Mycobacterium
tuberculosis) 		PF03405
(FA_desaturase_2) 		4 LEU A  14
GLU A  15
TRP A  95
THR A  23
 None
 0.99A 1qvuA-1za0A:
1.3		 1qvuA-1za0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU B 374
GLU B 375
THR B 451
TYR B 454
 None
 1.43A 1qvuA-2a1aB:
undetectable		 1qvuA-2a1aB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 LEU A 170
GLU A 171
THR A 223
TYR A 131
 None
 1.48A 1qvuA-2a30A:
1.8		 1qvuA-2a30A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU A 175
TRP A 159
THR A  87
TYR A 244
 None
 1.37A 1qvuA-2aeyA:
undetectable		 1qvuA-2aeyA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		4 LEU A  95
TRP A  47
THR A  13
TYR A 356
 None
 1.44A 1qvuA-2fv0A:
undetectable		 1qvuA-2fv0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 LEU A 652
GLU A 646
THR A 624
TYR A 548
 None
 1.48A 1qvuA-2gj4A:
undetectable		 1qvuA-2gj4A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 GLU A  16
TRP A 246
TYR A  65
TYR A 311
 None
 1.28A 1qvuA-2i58A:
undetectable		 1qvuA-2i58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		4 LEU A 176
GLU A 172
TRP A 169
THR A 105
 None
 1.47A 1qvuA-2igtA:
undetectable		 1qvuA-2igtA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 LEU A 337
GLU A 346
THR A 212
TYR A 242
 None
 1.43A 1qvuA-2p50A:
undetectable		 1qvuA-2p50A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		4 LEU A 202
GLU A 253
TYR A 174
TYR A 261
 None
 1.40A 1qvuA-2pfvA:
1.9		 1qvuA-2pfvA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyf MAD2L1-BINDING
PROTEIN

(Homo sapiens) 		PF06581
(p31comet) 		4 LEU B 135
GLU B 139
THR B 183
TYR B  91
 None
 1.27A 1qvuA-2qyfB:
undetectable		 1qvuA-2qyfB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 GLU A 108
TRP A 139
THR A 117
TYR A 208
 MN  A1005 (-2.5A)
None
None
None
 1.36A 1qvuA-2vqaA:
undetectable		 1qvuA-2vqaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A 126
THR A 132
TYR A 163
TYR A 139
 None
 1.33A 1qvuA-2wvgA:
undetectable		 1qvuA-2wvgA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		4 LEU A 289
GLU A 293
THR A 196
TYR A 277
 None
 1.38A 1qvuA-2yzsA:
0.9		 1qvuA-2yzsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 LEU A 573
THR A 548
TYR A 546
TYR A 606
 None
 0.85A 1qvuA-2z87A:
undetectable		 1qvuA-2z87A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 621
GLU A 620
TRP A 628
THR A 652
 None
 1.25A 1qvuA-3ahiA:
undetectable		 1qvuA-3ahiA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 LEU B 255
THR B 217
TYR B 216
TYR B 273
 None
 1.32A 1qvuA-3aqcB:
undetectable		 1qvuA-3aqcB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvz S-LAYER PROTEIN

(Clostridioides
difficile) 		PF12211
(LMWSLP_N) 		4 LEU A 237
THR A   9
TYR A   8
TYR A  87
 None
None
PO4  A 274 (-4.5A)
None
 1.16A 1qvuA-3cvzA:
undetectable		 1qvuA-3cvzA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 LEU A 120
THR A  13
TYR A 155
TYR A 141
 None
 1.49A 1qvuA-3e23A:
undetectable		 1qvuA-3e23A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		4 LEU A  92
THR A 218
TYR A 132
TYR A 114
 None
 1.40A 1qvuA-3eslA:
undetectable		 1qvuA-3eslA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5o UNCHARACTERIZED
PROTEIN RV2866

(Mycobacterium
tuberculosis) 		PF05016
(ParE_toxin) 		4 LEU B  49
THR B  74
TYR B  75
TYR B  79
 None
 1.50A 1qvuA-3g5oB:
undetectable		 1qvuA-3g5oB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis) 		PF00923
(TAL_FSA) 		4 LEU A  81
THR A 111
TYR A 114
TYR A 122
 None
 1.28A 1qvuA-3igxA:
undetectable		 1qvuA-3igxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 266
THR A 380
TYR A 381
TYR A 239
 None
 1.15A 1qvuA-3iuyA:
undetectable		 1qvuA-3iuyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 160
THR A 192
TYR A 191
TYR A 233
 None
 1.43A 1qvuA-3kezA:
undetectable		 1qvuA-3kezA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 LEU A 167
THR A 221
TYR A 223
TYR A 447
 None
 1.49A 1qvuA-3ombA:
1.2		 1qvuA-3ombA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soy NTF2-LIKE
SUPERFAMILY PROTEIN

(Salmonella
enterica) 		PF14534
(DUF4440) 		4 GLU A 149
TRP A 130
THR A 145
TYR A  96
 IMD  A 182 (-3.2A)
IMD  A 182 ( 3.8A)
None
None
 1.43A 1qvuA-3soyA:
undetectable		 1qvuA-3soyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 LEU A 726
TRP A 624
TYR A 470
TYR A 579
 None
 1.48A 1qvuA-3vmnA:
undetectable		 1qvuA-3vmnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 GLU A 246
THR A 190
TYR A 117
TYR A 110
 None
 1.24A 1qvuA-3vw5A:
undetectable		 1qvuA-3vw5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 294
GLU A 291
THR A 262
TYR A 192
 None
 1.33A 1qvuA-3zh2A:
undetectable		 1qvuA-3zh2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by2 ANASTRAL SPINDLE 2,
SAS 4

(Drosophila
melanogaster) 		PF07202
(Tcp10_C) 		4 LEU A 135
GLU A 136
THR A 113
TYR A 118
 None
 1.40A 1qvuA-4by2A:
undetectable		 1qvuA-4by2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 TRP A 342
THR A 354
TYR A 358
TYR A 305
 None
 1.45A 1qvuA-4i5jA:
undetectable		 1qvuA-4i5jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilo CT398

(Chlamydia
trachomatis) 		PF02591
(zf-RING_7) 		4 LEU A   9
GLU A  13
TYR A 179
TYR A 231
 None
 1.40A 1qvuA-4iloA:
undetectable		 1qvuA-4iloA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		4 LEU A  37
THR A  79
TYR A 196
TYR A  35
 None
 1.41A 1qvuA-4in9A:
undetectable		 1qvuA-4in9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1x NADPH:FERREDOXIN
REDUCTASE

(Rhodobacter
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 163
GLU A 164
TYR A  80
TYR A 189
 None
 1.34A 1qvuA-4k1xA:
undetectable		 1qvuA-4k1xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 4 LEU A 231
GLU A 202
TRP A 117
THR A 149
 None
GAI  A 501 ( 2.7A)
GAI  A 501 (-3.9A)
None
 1.13A 1qvuA-4lypA:
undetectable		 1qvuA-4lypA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 488
GLU A 490
THR A 316
TYR A 485
 None
 1.12A 1qvuA-4m8uA:
undetectable		 1qvuA-4m8uA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 LEU A 443
THR A 482
TYR A 458
TYR A 465
 None
 1.49A 1qvuA-4oe1A:
undetectable		 1qvuA-4oe1A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		4 LEU A 283
GLU A 272
THR A 321
TYR A 322
 None
 1.41A 1qvuA-4u0tA:
undetectable		 1qvuA-4u0tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyr FLOCCULATION PROTEIN
FLO11

(Saccharomyces
cerevisiae) 		PF10182
(Flo11) 		4 LEU A  90
THR A 171
TYR A 154
TYR A 113
 None
 1.34A 1qvuA-4uyrA:
undetectable		 1qvuA-4uyrA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uys FLOCCULATION PROTEIN
FLO11

(Saccharomyces
cerevisiae) 		PF10182
(Flo11) 		4 LEU A  90
THR A 171
TYR A 154
TYR A 113
 None
 1.42A 1qvuA-4uysA:
undetectable		 1qvuA-4uysA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 4 LEU A 616
GLU A 620
THR A  55
TYR A  68
 None
 1.32A 1qvuA-4zuzA:
undetectable		 1qvuA-4zuzA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnc HEME BINDING PROTEIN
MSMEG_6519

(Mycolicibacterium
smegmatis) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		4 LEU A  64
THR A 167
TYR A 172
TYR A  62
 None
 1.48A 1qvuA-5bncA:
undetectable		 1qvuA-5bncA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 207
TRP A 455
THR A 114
TYR A 116
 None
 1.39A 1qvuA-5ehfA:
undetectable		 1qvuA-5ehfA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjv NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-2

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 LEU A  85
THR A 213
TYR A 231
TYR A 153
 None
 1.40A 1qvuA-5fjvA:
undetectable		 1qvuA-5fjvA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU A  70
GLU A  71
THR A 120
TYR A 116
 None
 1.37A 1qvuA-5flzA:
2.5		 1qvuA-5flzA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		5 LEU A  86
GLU A 110
THR A 211
TYR A 212
TYR A 192
 None
None
MAN  A1224 (-3.3A)
None
None
 1.45A 1qvuA-5fohA:
undetectable		 1qvuA-5fohA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 4 LEU A 282
GLU A 281
THR A 313
TYR A 310
 None
 1.29A 1qvuA-5h4vA:
undetectable		 1qvuA-5h4vA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 LEU A  12
GLU A  19
THR A 239
TYR A 329
 None
 1.50A 1qvuA-5i33A:
undetectable		 1qvuA-5i33A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 LEU A 855
TRP A 789
THR A 868
TYR A 887
 None
 1.32A 1qvuA-5kdxA:
undetectable		 1qvuA-5kdxA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		4 GLU A 611
THR A 553
TYR A 556
TYR A 420
 MAN  A 709 ( 2.8A)
None
None
None
 1.25A 1qvuA-5kkbA:
undetectable		 1qvuA-5kkbA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 336
GLU A 335
THR A 321
TYR A 310
 None
 1.11A 1qvuA-5kzsA:
undetectable		 1qvuA-5kzsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 LEU A  49
GLU A  51
TYR A 531
TYR A 551
 None
 1.18A 1qvuA-5kztA:
undetectable		 1qvuA-5kztA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 279
GLU A 294
TRP A 384
THR A 197
 LEU  A 279 ( 0.5A)
GLU  A 294 ( 0.5A)
TRP  A 384 ( 0.5A)
THR  A 197 ( 0.8A)
 1.29A 1qvuA-5l5nA:
undetectable		 1qvuA-5l5nA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 4 LEU A 129
GLU A  97
THR A 219
TYR A 225
 None
 1.34A 1qvuA-5lfdA:
undetectable		 1qvuA-5lfdA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A  87
THR A 294
TYR A 307
TYR A 135
 None
 1.42A 1qvuA-5mzsA:
undetectable		 1qvuA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o77 OMPK35

(Klebsiella
pneumoniae) 		no annotation 4 GLU A 247
TRP A 116
THR A 124
TYR A  99
 None
 1.45A 1qvuA-5o77A:
undetectable		 1qvuA-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o77 OMPK35

(Klebsiella
pneumoniae) 		no annotation 4 LEU A 285
TRP A 116
THR A 124
TYR A 118
 None
 1.28A 1qvuA-5o77A:
undetectable		 1qvuA-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A  45
GLU A 182
TRP A 181
THR A 191
 None
 1.41A 1qvuA-5tc4A:
undetectable		 1qvuA-5tc4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 LEU A 594
TRP A  26
THR A 515
TYR A 587
 None
 1.38A 1qvuA-5ubkA:
undetectable		 1qvuA-5ubkA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 4 LEU A 351
GLU A 152
THR A 300
TYR A 317
 None
 1.41A 1qvuA-5wmlA:
undetectable		 1qvuA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9j PRHC

(Penicillium
brasilianum) 		no annotation 4 GLU A 126
THR A  56
TYR A  59
TYR A 104
 None
 1.20A 1qvuA-5x9jA:
undetectable		 1qvuA-5x9jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 351
TRP A 354
THR A  36
TYR A  50
 None
 1.24A 1qvuA-5xd7A:
undetectable		 1qvuA-5xd7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1z GLUTAMATE--TRNA
LIGASE

(Elizabethkingia
anophelis) 		PF00749
(tRNA-synt_1c) 		4 LEU A 114
GLU A 113
THR A 157
TYR A 130
 None
 1.17A 1qvuA-6b1zA:
undetectable		 1qvuA-6b1zA:
16.44