SIMILAR PATTERNS OF AMINO ACIDS FOR 1QVT_A_PRLA311_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c5d MONOCLONAL ANTIBODY
AGAINST THE MAIN
IMMUNOGENIC REGION
OF THE HUMAN MUSCLE
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		no annotation 4 LEU H  67
THR H 111
TYR H  93
ILE H  48
 None
 1.12A 1qvtA-1c5dH:
undetectable		 1qvtA-1c5dH:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		4 LEU A 215
GLU A 216
GLU A 217
ILE A 211
 None
 0.99A 1qvtA-1e0cA:
undetectable		 1qvtA-1e0cA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		4 LEU A 227
GLU A 224
GLU A 226
ILE A 278
 None
 1.07A 1qvtA-1f76A:
0.6		 1qvtA-1f76A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 GLU A 135
THR A 115
TYR A 116
TYR A 121
 None
 1.15A 1qvtA-1fblA:
undetectable		 1qvtA-1fblA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		4 LEU A 392
GLU A 389
THR A 344
TYR A 351
 None
 0.69A 1qvtA-1fkmA:
0.0		 1qvtA-1fkmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		4 GLU A 150
TYR A 154
ILE A 139
TYR A 324
 None
 0.99A 1qvtA-1kobA:
0.1		 1qvtA-1kobA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5i APC PROTEIN

(Homo sapiens) 		PF11414
(Suppressor_APC) 		4 LEU A 137
GLU A 138
GLU A 136
ILE A 231
 None
 1.07A 1qvtA-1m5iA:
undetectable		 1qvtA-1m5iA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG

(Staphylococcus
aureus) 		PF02898
(NO_synthase) 		4 LEU A  48
GLU A  45
ILE A 108
TYR A 217
 None
 1.13A 1qvtA-1mjtA:
1.0		 1qvtA-1mjtA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 349
GLU A 350
ILE A 345
TYR A 170
 None
 1.15A 1qvtA-1qdlA:
undetectable		 1qvtA-1qdlA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 301
GLU A 300
ILE A 334
TYR A 344
 None
 0.94A 1qvtA-1r5mA:
undetectable		 1qvtA-1r5mA:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		4 LEU A  54
GLU A  57
GLU A  58
TRP A  61
 None
 0.90A 1qvtA-1rpwA:
24.1		 1qvtA-1rpwA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		4 LEU A 119
GLU A 121
ILE A 182
TYR A 374
 None
 1.06A 1qvtA-1u7gA:
1.1		 1qvtA-1u7gA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 LEU A 299
GLU A 296
TYR A 259
ILE A 251
 None
 0.82A 1qvtA-1v4gA:
0.0		 1qvtA-1v4gA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 GLU A 299
GLU A 295
ILE A 248
TYR A 252
 None
 1.02A 1qvtA-1z9aA:
0.0		 1qvtA-1z9aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus) 		PF02073
(Peptidase_M29) 		4 LEU A 349
GLU A 319
ILE A 386
TYR A 214
 None
CO  A 501 ( 2.6A)
None
None
 1.15A 1qvtA-1zjcA:
undetectable		 1qvtA-1zjcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bep UBIQUITIN-CONJUGATIN
G ENZYME E2-25 KDA

(Bos taurus) 		PF00179
(UQ_con) 		4 LEU A 106
GLU A  15
ILE A   9
TYR A  66
 None
 0.97A 1qvtA-2bepA:
undetectable		 1qvtA-2bepA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 LEU A  79
GLU A  82
TYR A  34
ILE A  52
 None
 0.99A 1qvtA-2bvmA:
undetectable		 1qvtA-2bvmA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLU A 168
GLU A 187
THR A 541
TYR A 454
 None
 0.92A 1qvtA-2cfmA:
undetectable		 1qvtA-2cfmA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 GLU A 271
GLU A 229
TYR A 191
TYR A 257
 None
 0.78A 1qvtA-2chqA:
3.0		 1qvtA-2chqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 LEU A 113
GLU A 110
GLU A 109
ILE A  94
 None
 0.97A 1qvtA-2csuA:
undetectable		 1qvtA-2csuA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwp METRS RELATED
PROTEIN

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		4 LEU A  61
GLU A  62
GLU A  59
ILE A  35
 None
 0.92A 1qvtA-2cwpA:
undetectable		 1qvtA-2cwpA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 LEU A 278
GLU A 281
THR A 370
ILE A 365
 None
 1.05A 1qvtA-2d62A:
undetectable		 1qvtA-2d62A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE

(Sulfurisphaera
tokodaii) 		no annotation 4 LEU A  56
GLU A  53
ILE A  85
TYR A  72
 None
 0.77A 1qvtA-2dgdA:
undetectable		 1qvtA-2dgdA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 LEU A 850
GLU A 849
THR A 868
ILE A 875
 None
 0.87A 1qvtA-2eyqA:
undetectable		 1qvtA-2eyqA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8n HISTONE H2A TYPE 1

(Mus musculus) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 LEU K  93
GLU K  61
GLU K  92
TYR K  57
 None
 1.12A 1qvtA-2f8nK:
2.0		 1qvtA-2f8nK:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		4 LEU A 422
GLU A 427
ILE A 476
TYR A 456
 None
 0.97A 1qvtA-2fgyA:
undetectable		 1qvtA-2fgyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzl DNA REPAIR PROTEIN
RAD25, XPB

(Archaeoglobus
fulgidus) 		PF16203
(ERCC3_RAD25_C) 		4 LEU A 387
GLU A 384
GLU A 385
ILE A 374
 None
 1.05A 1qvtA-2fzlA:
undetectable		 1qvtA-2fzlA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A 258
GLU A 265
THR A 210
ILE A 205
 None
 1.12A 1qvtA-2hunA:
undetectable		 1qvtA-2hunA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 LEU A 228
GLU A 227
THR A 399
TYR A 402
 None
 1.14A 1qvtA-2iyoA:
undetectable		 1qvtA-2iyoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		4 LEU A 117
GLU A  26
GLU A 119
ILE A  24
 None
 0.76A 1qvtA-2k4wA:
undetectable		 1qvtA-2k4wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7a UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		no annotation 4 GLU A  17
TRP A  19
TYR A  58
ILE A  77
 None
 1.09A 1qvtA-2m7aA:
undetectable		 1qvtA-2m7aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 LEU A 460
TRP A 335
THR A 469
ILE A 476
 None
 1.05A 1qvtA-2o1xA:
undetectable		 1qvtA-2o1xA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 218
THR A 322
ILE A  21
TYR A  23
 MG  A 501 (-3.1A)
None
None
None
 1.13A 1qvtA-2p88A:
undetectable		 1qvtA-2p88A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 761
GLU A 756
THR A1371
ILE A 733
 None
 0.91A 1qvtA-2pffA:
undetectable		 1qvtA-2pffA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 933
GLU A 934
ILE A 929
TYR A 921
 None
 1.13A 1qvtA-2r4bA:
undetectable		 1qvtA-2r4bA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 LEU A  79
GLU A  82
TYR A  34
ILE A  52
 None
 1.03A 1qvtA-2vl8A:
undetectable		 1qvtA-2vl8A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bho CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 5

(Homo sapiens) 		PF13869
(NUDIX_2) 		4 LEU A  53
GLU A  55
THR A  79
ILE A 128
 None
 0.80A 1qvtA-3bhoA:
undetectable		 1qvtA-3bhoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f92 UBIQUITIN-CONJUGATIN
G ENZYME E2 K

(Homo sapiens) 		PF00179
(UQ_con)
PF00627
(UBA) 		4 LEU A 106
GLU A  15
ILE A   9
TYR A  66
 None
 1.03A 1qvtA-3f92A:
undetectable		 1qvtA-3f92A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 761
GLU A 756
THR A1371
ILE A 733
 None
 0.90A 1qvtA-3hmjA:
undetectable		 1qvtA-3hmjA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		4 LEU A  65
GLU A  61
THR A 196
TYR A 152
 None
 0.84A 1qvtA-3hxkA:
undetectable		 1qvtA-3hxkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 266
THR A 380
ILE A 291
TYR A 239
 None
 1.04A 1qvtA-3iuyA:
undetectable		 1qvtA-3iuyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 LEU A 553
THR A 405
ILE A 395
TYR A 440
 None
 1.04A 1qvtA-3ixwA:
undetectable		 1qvtA-3ixwA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF3

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		4 THR r 499
TYR r 503
ILE r 536
TYR r 537
 None
 1.15A 1qvtA-3jb9r:
undetectable		 1qvtA-3jb9r:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU A 463
GLU A 451
ILE A 475
TYR A 489
 None
 0.87A 1qvtA-3k0sA:
undetectable		 1qvtA-3k0sA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 LEU A  49
GLU A 334
THR A 383
ILE A 345
 None
 1.07A 1qvtA-3k1tA:
undetectable		 1qvtA-3k1tA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU A 357
THR A 388
ILE A 480
TYR A 478
 None
None
None
NAG  A5001 (-3.6A)
 0.82A 1qvtA-3kf3A:
undetectable		 1qvtA-3kf3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 LEU A 274
GLU A 278
ILE A 256
TYR A 286
 None
 0.97A 1qvtA-3kl9A:
undetectable		 1qvtA-3kl9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		4 LEU A  26
GLU A  32
THR A  38
ILE A  10
 None
 1.06A 1qvtA-3lahA:
undetectable		 1qvtA-3lahA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 LEU A 221
GLU A 212
THR A 400
ILE A 315
 None
 1.15A 1qvtA-3m62A:
2.0		 1qvtA-3m62A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlp TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF01833
(TIG)
PF16422
(COE1_DBD)
PF16423
(COE1_HLH) 		4 LEU A 192
THR A 104
ILE A 108
TYR A 110
 None
 1.06A 1qvtA-3mlpA:
undetectable		 1qvtA-3mlpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 LEU A 548
GLU A 547
THR A 553
ILE A 566
 None
 1.03A 1qvtA-3opbA:
2.1		 1qvtA-3opbA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqm MLR3007 PROTEIN

(Mesorhizobium
loti) 		PF01063
(Aminotran_4) 		4 GLU A 150
GLU A 138
THR A 105
ILE A 148
 LLP  A 117 ( 3.4A)
EDO  A 275 (-3.6A)
None
None
 1.02A 1qvtA-3qqmA:
undetectable		 1qvtA-3qqmA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 216
GLU A 215
GLU A 217
ILE A 283
 None
 1.11A 1qvtA-3qtyA:
undetectable		 1qvtA-3qtyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		4 GLU A 169
GLU A 178
TYR A 197
ILE A 186
 None
 0.88A 1qvtA-3re2A:
2.2		 1qvtA-3re2A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 LEU A 151
GLU A 152
ILE A 184
TYR A 188
 None
 0.70A 1qvtA-3s5kA:
undetectable		 1qvtA-3s5kA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 LEU A  83
GLU A  82
ILE A  24
TYR A  20
 None
 1.12A 1qvtA-3u02A:
undetectable		 1qvtA-3u02A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2i NADH-CYTOCHROME B5
REDUCTASE 3

(Sus scrofa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 102
GLU A 103
ILE A  81
TYR A  65
 None
None
FAD  A 301 (-3.7A)
FAD  A 301 (-4.2A)
 1.11A 1qvtA-3w2iA:
undetectable		 1qvtA-3w2iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk6 BCL-2-LIKE PROTEIN 1

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 LEU A 178
GLU A 179
THR A 190
ILE A 140
 None
 1.03A 1qvtA-3zk6A:
3.1		 1qvtA-3zk6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 286
GLU A  10
ILE A 296
TYR A 298
 None
 1.08A 1qvtA-4a14A:
undetectable		 1qvtA-4a14A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		4 LEU A 416
GLU A 413
THR A 213
ILE A 208
 None
 1.02A 1qvtA-4b67A:
undetectable		 1qvtA-4b67A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A  68
THR A  24
TYR A   4
ILE A  32
 None
 1.00A 1qvtA-4b9dA:
undetectable		 1qvtA-4b9dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		4 GLU A 149
THR A 359
ILE A 269
TYR A 274
 None
 1.07A 1qvtA-4f7aA:
undetectable		 1qvtA-4f7aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		4 LEU A 104
TYR A 259
ILE A 261
TYR A 263
 None
 1.05A 1qvtA-4gu7A:
undetectable		 1qvtA-4gu7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 321
GLU A 322
GLU A 319
ILE A 361
 None
 1.12A 1qvtA-4gv1A:
undetectable		 1qvtA-4gv1A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3e SUPEROXIDE DISMUTASE

(Trypanosoma
cruzi) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A 100
THR A 184
ILE A  87
TYR A  79
 None
 1.15A 1qvtA-4h3eA:
undetectable		 1qvtA-4h3eA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 LEU A  99
THR A 162
TYR A 160
ILE A  52
 None
 1.11A 1qvtA-4hvfA:
undetectable		 1qvtA-4hvfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 LEU A 349
GLU A 319
ILE A 386
TYR A 215
 None
ZN  A 502 ( 2.5A)
None
None
 1.10A 1qvtA-4icqA:
undetectable		 1qvtA-4icqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqf CST COMPLEX SUBUNIT
STN1

(Homo sapiens) 		PF09170
(STN1_2) 		4 LEU A 229
GLU A 230
GLU A 228
ILE A 271
 None
 1.10A 1qvtA-4jqfA:
1.8		 1qvtA-4jqfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n68 CONTACTIN-5

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A 940
TRP A 914
THR A 949
ILE A 892
 None
 1.03A 1qvtA-4n68A:
undetectable		 1qvtA-4n68A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 LEU A 285
THR A 224
ILE A 241
TYR A 242
 None
 1.02A 1qvtA-4qxdA:
undetectable		 1qvtA-4qxdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 GLU A 354
GLU A 350
TYR A 325
ILE A 358
 None
 1.13A 1qvtA-4r04A:
undetectable		 1qvtA-4r04A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 LEU A1960
GLU A1957
TYR A1897
ILE A1920
 None
 0.98A 1qvtA-4r7yA:
undetectable		 1qvtA-4r7yA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 LEU A 200
TRP A 209
ILE A 183
TYR A 129
 None
 0.73A 1qvtA-4rwaA:
undetectable		 1qvtA-4rwaA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 GLU A 282
THR A 144
ILE A 168
TYR A 248
 None
 0.81A 1qvtA-4ufcA:
undetectable		 1qvtA-4ufcA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyb SEC14-LIKE PROTEIN 3

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 LEU A 209
GLU A 211
ILE A 217
TYR A 202
 None
 1.10A 1qvtA-4uybA:
undetectable		 1qvtA-4uybA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 LEU A 357
GLU A 356
ILE A 364
TYR A 338
 None
 1.03A 1qvtA-4wd9A:
undetectable		 1qvtA-4wd9A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlh LIPOPOLYSACCHARIDE
ASSEMBLY PROTEIN B

(Escherichia
coli) 		PF14559
(TPR_19) 		4 LEU A 133
GLU A 136
THR A 102
ILE A 110
 None
 1.03A 1qvtA-4zlhA:
undetectable		 1qvtA-4zlhA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 LEU A1397
GLU A1393
ILE A1570
TYR A1574
 None
 0.97A 1qvtA-5amqA:
undetectable		 1qvtA-5amqA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 349
GLU A 348
ILE A 408
TYR A 421
 None
 1.07A 1qvtA-5c78A:
1.2		 1qvtA-5c78A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1x D4-30 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B  67
THR B 107
TYR B  90
ILE B  48
 None
 1.08A 1qvtA-5d1xB:
undetectable		 1qvtA-5d1xB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e52 CONTACTIN-5

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A 940
TRP A 914
THR A 949
ILE A 892
 None
 0.96A 1qvtA-5e52A:
undetectable		 1qvtA-5e52A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A 810
GLU A 808
TYR A 441
ILE A 596
 None
 0.74A 1qvtA-5eawA:
undetectable		 1qvtA-5eawA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 927
GLU A 928
ILE A 923
TYR A 915
 None
 1.00A 1qvtA-5j9zA:
undetectable		 1qvtA-5j9zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 LEU A 336
GLU A 334
ILE A 175
TYR A 122
 None
 1.04A 1qvtA-5ngkA:
undetectable		 1qvtA-5ngkA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 LEU A 177
TRP A  40
ILE A 118
TYR A 123
 None
 1.05A 1qvtA-5thhA:
undetectable		 1qvtA-5thhA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LEU A 250
GLU A 254
ILE A 103
TYR A 108
 None
 1.11A 1qvtA-5u47A:
undetectable		 1qvtA-5u47A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A1452
THR A1494
TYR A1493
ILE A1471
 None
 1.09A 1qvtA-5ujaA:
3.6		 1qvtA-5ujaA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A 187
GLU A 190
GLU A 152
ILE A 144
 None
 0.88A 1qvtA-5utuA:
undetectable		 1qvtA-5utuA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 237
GLU A 241
TRP A 263
ILE A 136
 None
None
PEP  A 504 ( 4.8A)
None
 1.05A 1qvtA-5uxnA:
0.7		 1qvtA-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		4 LEU A  38
GLU A  34
ILE A  70
TYR A  71
 None
 0.84A 1qvtA-5v1sA:
undetectable		 1qvtA-5v1sA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		4 LEU A 265
GLU A 262
THR A 294
ILE A 301
 None
 0.91A 1qvtA-5vn5A:
undetectable		 1qvtA-5vn5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 LEU A  79
THR A 319
ILE A  42
TYR A  64
 None
 1.07A 1qvtA-5vqdA:
undetectable		 1qvtA-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 GLU A 381
TYR A 413
ILE A 569
TYR A 149
 GLC  A 810 ( 2.4A)
None
None
None
 1.11A 1qvtA-5x7hA:
undetectable		 1qvtA-5x7hA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 304
THR A  36
TYR A  50
ILE A 348
 None
 0.81A 1qvtA-5xd7A:
undetectable		 1qvtA-5xd7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xni MCYF

(Microcystis
aeruginosa) 		no annotation 4 GLU A  62
THR A  89
TYR A  92
ILE A  66
 None
DGL  A 301 (-4.0A)
None
None
 1.13A 1qvtA-5xniA:
undetectable		 1qvtA-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 LEU A 219
GLU A 220
ILE A 582
TYR A 543
 None
 1.15A 1qvtA-5zalA:
undetectable		 1qvtA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 LEU A 348
THR A 266
ILE A 271
TYR A 287
 None
 1.01A 1qvtA-6begA:
undetectable		 1qvtA-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f39 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 4 GLU A 179
THR A 182
TYR A 181
ILE A 188
 None
 0.90A 1qvtA-6f39A:
undetectable		 1qvtA-6f39A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 LEU D 231
THR D 202
ILE D 162
TYR D 171
 None
 0.94A 1qvtA-6fmlD:
undetectable		 1qvtA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 LEU L 558
THR M 153
TYR M 152
ILE L 562
 None
None
3PE  M 501 ( 4.4A)
3PE  M 501 (-4.0A)
 1.11A 1qvtA-6g2jL:
undetectable		 1qvtA-6g2jL:
undetectable