SIMILAR PATTERNS OF AMINO ACIDS FOR 1QU3_A_MRCA993_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		4 TRP A 562
SER A 597
LYS A 598
VAL A 603
 MRC  A1993 (-4.8A)
MRC  A1993 (-4.5A)
None
None
 0.67A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp9 ICE-BINDING PROTEIN

(Colwellia sp.
SLW05) 		PF11999
(DUF3494) 		4 TRP A 136
SER A  18
LYS A  19
VAL A  78
 None
 1.34A 1qu3A-3wp9A:
0.0		 1qu3A-3wp9A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu3 ICE-BINDING PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		4 TRP A 174
SER A  50
LYS A  51
VAL A 116
 None
 1.36A 1qu3A-4nu3A:
0.0		 1qu3A-4nu3A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzg CAPSID PROTEIN VP0

(Rhinovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 TRP C 145
SER C  69
LYS C  94
VAL C  70
 None
 1.47A 1qu3A-5jzgC:
0.0		 1qu3A-5jzgC:
17.34