SIMILAR PATTERNS OF AMINO ACIDS FOR 1QOM_A_H4BA902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A


(Corynebacterium
sp.)
PF00248
(Aldo_ket_red)
3 ARG A 171
ILE A 255
TRP A 221
None
0.99A 1qomA-1a80A:
undetectable
1qomA-1a80A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE


(Escherichia
virus Lambda)
PF00149
(Metallophos)
3 ARG A 162
ILE A 159
TRP A 160
SO4  A3001 (-3.3A)
None
None
0.90A 1qomA-1g5bA:
undetectable
1qomA-1g5bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ


(Escherichia
virus G4)
PF02305
(Phage_F)
3 ARG 1 382
ILE 1 168
TRP 1 169
None
1.09A 1qomA-1gff1:
0.0
1qomA-1gff1:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus)
PF00151
(Lipase)
PF01477
(PLAT)
3 ARG A 439
ILE A 401
TRP A 402
None
1.12A 1qomA-1hplA:
0.2
1qomA-1hplA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB


(Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
3 ARG A 157
ILE A 151
TRP A 155
None
1.15A 1qomA-1iirA:
0.0
1qomA-1iirA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803)
PF00497
(SBP_bac_3)
3 ARG A  36
ILE A  30
TRP A 224
None
1.12A 1qomA-1iiwA:
0.0
1qomA-1iiwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
3 ARG A 302
ILE A 100
TRP A 105
None
1.01A 1qomA-1jqgA:
undetectable
1qomA-1jqgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Comamonas
testosteroni)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
3 ARG A  67
ILE A 107
TRP A 136
HEC  A 802 (-4.2A)
None
None
1.17A 1qomA-1kb0A:
undetectable
1qomA-1kb0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE


(Escherichia
coli)
PF13406
(SLT_2)
3 ARG A 167
ILE A 159
TRP A 165
None
1.19A 1qomA-1ltmA:
0.0
1qomA-1ltmA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Mus musculus)
PF02898
(NO_synthase)
3 ARG A 375
ILE A 456
TRP A 457
H4B  A 901 (-3.4A)
H4B  A 901 (-4.7A)
H4B  A 901 ( 3.7A)
0.47A 1qomA-1qw5A:
60.1
1qomA-1qw5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 ARG A 121
ILE A 454
TRP A 456
None
CU  A1503 (-3.4A)
None
1.06A 1qomA-1v10A:
undetectable
1qomA-1v10A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE


(Sulfurisphaera
tokodaii)
PF00908
(dTDP_sugar_isom)
3 ARG A  40
ILE A  13
TRP A 111
None
0.98A 1qomA-1wltA:
undetectable
1qomA-1wltA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wms RAS-RELATED PROTEIN
RAB-9A


(Homo sapiens)
PF00071
(Ras)
3 ARG A  78
ILE A  11
TRP A  61
None
1.15A 1qomA-1wmsA:
undetectable
1qomA-1wmsA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z06 RAS-RELATED PROTEIN
RAB-33B


(Mus musculus)
PF00071
(Ras)
3 ARG A 105
ILE A  37
TRP A  87
None
1.04A 1qomA-1z06A:
undetectable
1qomA-1z06A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a46 GFP-LIKE FLUORESCENT
CHROMOPROTEIN
AMFP486


(Anemonia majano)
PF01353
(GFP)
3 ARG A  72
ILE A 113
TRP A 111
CR7  A  68 ( 4.4A)
None
CR7  A  68 ( 4.1A)
0.93A 1qomA-2a46A:
undetectable
1qomA-2a46A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayu NUCLEOSOME ASSEMBLY
PROTEIN


(Saccharomyces
cerevisiae)
PF00956
(NAP)
3 ARG A 355
ILE A 131
TRP A 132
None
0.90A 1qomA-2ayuA:
undetectable
1qomA-2ayuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT


(Rhodococcus sp.
NCIMB 12038)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 ARG A 324
ILE A 199
TRP A 197
None
1.03A 1qomA-2b24A:
undetectable
1qomA-2b24A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE


(Perkinsus
marinus)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
3 ARG A 101
ILE A 163
TRP A 137
None
1.18A 1qomA-2cw3A:
undetectable
1qomA-2cw3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa8 HYPOTHETICAL PROTEIN
ATU0228


(Agrobacterium
fabrum)
PF10262
(Rdx)
3 ARG A  64
ILE A  52
TRP A  60
None
1.13A 1qomA-2fa8A:
undetectable
1qomA-2fa8A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
3 ARG A 414
ILE A 406
TRP A 408
None
0.98A 1qomA-2fknA:
undetectable
1qomA-2fknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
3 ARG A 833
ILE A 822
TRP A 800
None
1.14A 1qomA-2henA:
undetectable
1qomA-2henA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
PF04945
(YHS)
3 ARG A 116
ILE B 145
TRP B  57
None
1.21A 1qomA-2incA:
undetectable
1qomA-2incA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE


(Mycoplasma
mycoides)
PF01712
(dNK)
3 ARG A 145
ILE A 139
TRP A 158
DCP  A1202 (-2.8A)
None
None
1.02A 1qomA-2jaqA:
undetectable
1qomA-2jaqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljr GLUTATHIONE
S-TRANSFERASE


(Homo sapiens)
PF00043
(GST_C)
PF02798
(GST_N)
3 ARG A 107
ILE A 112
TRP A 115
None
1.13A 1qomA-2ljrA:
undetectable
1qomA-2ljrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nba PREPILIN-TYPE
CLEAVAGE/METHYLATION
N-TERMINAL DOMAIN
PROTEIN


(Neisseria
subflava)
PF16732
(ComP_DUS)
3 ARG A 113
ILE A  64
TRP A  42
None
1.12A 1qomA-2nbaA:
undetectable
1qomA-2nbaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pes URICASE

(Aspergillus
flavus)
PF01014
(Uricase)
3 ARG A 128
ILE A 142
TRP A 188
None
0.87A 1qomA-2pesA:
undetectable
1qomA-2pesA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN


(Thermoplasma
acidophilum)
PF03463
(eRF1_1)
PF03465
(eRF1_3)
3 ARG A 293
ILE A  70
TRP A  24
None
1.04A 1qomA-2qi2A:
undetectable
1qomA-2qi2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
3 ARG A 418
ILE A 410
TRP A 412
None
0.94A 1qomA-2v7gA:
undetectable
1qomA-2v7gA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2r NUCLEOSOME ASSEMBLY
PROTEIN


(Saccharomyces
cerevisiae)
PF00956
(NAP)
3 ARG A 355
ILE A 131
TRP A 132
None
1.04A 1qomA-2z2rA:
undetectable
1qomA-2z2rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A)
no annotation 3 ARG A 169
ILE A 217
TRP A 140
None
1.16A 1qomA-3cjiA:
undetectable
1qomA-3cjiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE


(Lactobacillus
casei)
PF00186
(DHFR_1)
3 ARG A 117
ILE A  13
TRP A   5
None
NDP  A 163 (-3.8A)
None
0.97A 1qomA-3dfrA:
undetectable
1qomA-3dfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 ARG A 835
ILE A 824
TRP A 802
None
1.02A 1qomA-3dkoA:
undetectable
1qomA-3dkoA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Homo sapiens)
PF02898
(NO_synthase)
3 ARG A 381
ILE A 462
TRP A 463
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
0.39A 1qomA-3e7gA:
58.3
1qomA-3e7gA:
87.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2)
PF00665
(rve)
PF02022
(Integrase_Zn)
3 ARG A 107
ILE A 110
TRP A  61
None
0.95A 1qomA-3f9kA:
undetectable
1qomA-3f9kA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE


(Solanum
lycopersicum)
PF00082
(Peptidase_S8)
3 ARG A 165
ILE A 162
TRP A 166
None
1.12A 1qomA-3i6sA:
undetectable
1qomA-3i6sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)


(Rattus
norvegicus)
PF07686
(V-set)
3 ARG B 164
ILE B 148
TRP B 147
None
1.09A 1qomA-3iy7B:
undetectable
1qomA-3iy7B:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 US2

(Kluyveromyces
lactis)
PF00318
(Ribosomal_S2)
3 ARG A 183
ILE A  57
TRP A  54
None
1.20A 1qomA-3j81A:
undetectable
1qomA-3j81A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42


(Schizosaccharomyces
pombe)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
3 ARG A1055
ILE A1115
TRP A1064
None
1.18A 1qomA-3jb9A:
undetectable
1qomA-3jb9A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
3 ARG A 117
ILE A 214
TRP A 215
ADP  A 400 (-2.6A)
None
None
0.91A 1qomA-3jq3A:
undetectable
1qomA-3jq3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE


(Pimelobacter
simplex)
PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2)
3 ARG A 429
ILE A 349
TRP A 442
None
SF4  A 801 (-4.1A)
None
1.19A 1qomA-3k30A:
undetectable
1qomA-3k30A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwd 6-PHOSPHOGLUCONOLACT
ONASE


(Chromohalobacter
salexigens)
PF01182
(Glucosamine_iso)
3 ARG A   9
ILE A 188
TRP A 223
None
0.90A 1qomA-3lwdA:
undetectable
1qomA-3lwdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris)
PF00378
(ECH_1)
3 ARG A  24
ILE A  19
TRP A  28
None
1.13A 1qomA-3m6mA:
undetectable
1qomA-3m6mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT


(Komagataella
pastoris)
PF00365
(PFK)
3 ARG A 230
ILE A 237
TRP A 265
SO4  A 996 (-4.3A)
None
None
1.09A 1qomA-3opyA:
undetectable
1qomA-3opyA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN


(Actinobacillus
pleuropneumoniae)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
3 ARG A 221
ILE A 193
TRP A 152
GOL  A3968 (-3.5A)
None
None
1.21A 1qomA-3pqsA:
undetectable
1qomA-3pqsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ARG A 422
ILE A 537
TRP A 515
TRS  A 640 (-3.9A)
None
None
1.12A 1qomA-3s95A:
undetectable
1qomA-3s95A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC


(Abies grandis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 ARG A 749
ILE A 685
TRP A 689
None
1.05A 1qomA-3s9vA:
undetectable
1qomA-3s9vA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 ARG A 122
ILE A 455
TRP A 457
None
CU  A 501 (-3.8A)
None
0.94A 1qomA-3t6wA:
undetectable
1qomA-3t6wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR


(Phytophthora
sojae)
PF16683
(TGase_elicitor)
3 ARG A 438
ILE A 442
TRP A 441
None
1.07A 1qomA-3tw5A:
undetectable
1qomA-3tw5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525)
no annotation 3 ARG A 385
ILE A 406
TRP A 411
None
0.71A 1qomA-3w36A:
undetectable
1qomA-3w36A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhc PHYTASE

(Citrobacter
braakii)
PF00328
(His_Phos_2)
3 ARG A 158
ILE A 152
TRP A 210
None
1.03A 1qomA-3zhcA:
undetectable
1qomA-3zhcA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans)
PF10140
(YukC)
3 ARG A 102
ILE A 104
TRP A 136
None
0.91A 1qomA-4anoA:
undetectable
1qomA-4anoA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT


(Pseudonaja
textilis)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
3 ARG V 926
ILE V 961
TRP V 939
None
0.95A 1qomA-4bxsV:
undetectable
1qomA-4bxsV:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3


(Neurospora
crassa)
no annotation 3 ARG A 104
ILE A  64
TRP B 566
PO4  A 401 (-4.0A)
None
None
0.95A 1qomA-4czxA:
undetectable
1qomA-4czxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima)
PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
3 ARG A 931
ILE A 859
TRP A 885
None
1.07A 1qomA-4ddwA:
undetectable
1qomA-4ddwA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0j NON-STRUCTURAL
PROTEIN 2


(Rotavirus A)
PF02509
(Rota_NS35)
3 ARG A 227
ILE A 265
TRP A 269
None
0.90A 1qomA-4g0jA:
undetectable
1qomA-4g0jA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
3 ARG A 521
ILE A 548
TRP A 570
None
1.20A 1qomA-4iigA:
undetectable
1qomA-4iigA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis)
PF16103
(DUF4822)
3 ARG A 190
ILE A  89
TRP A  65
None
1.20A 1qomA-4kh8A:
undetectable
1qomA-4kh8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwf FAB AR3C HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 ARG A  94
ILE A  69
TRP A  36
None
1.14A 1qomA-4mwfA:
undetectable
1qomA-4mwfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okj 3'-5'
EXORIBONUCLEASE
RV2179C/MT2234.1


(Mycobacterium
tuberculosis)
PF16473
(DUF5051)
3 ARG A 135
ILE A 156
TRP A 124
None
1.02A 1qomA-4okjA:
undetectable
1qomA-4okjA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 ARG A 816
ILE A 805
TRP A 783
None
1.17A 1qomA-4p2kA:
undetectable
1qomA-4p2kA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsk KETOL-ACID
REDUCTOISOMERASE


(Alicyclobacillus
acidocaldarius)
PF01450
(IlvC)
PF07991
(IlvN)
3 ARG A  84
ILE A 291
TRP A 290
None
1.10A 1qomA-4tskA:
undetectable
1qomA-4tskA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ


(Robinia
pseudoacacia)
PF00704
(Glyco_hydro_18)
3 ARG A 135
ILE A 100
TRP A 134
NA  A 502 ( 4.4A)
None
None
1.20A 1qomA-4uriA:
undetectable
1qomA-4uriA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb3 NUDIX HYDROLASE 7

(Arabidopsis
thaliana)
PF00293
(NUDIX)
3 ARG A  74
ILE A  53
TRP A  54
None
1.05A 1qomA-4zb3A:
undetectable
1qomA-4zb3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
3 ARG B  24
ILE B 168
TRP B 169
None
1.19A 1qomA-4zktB:
undetectable
1qomA-4zktB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
3 ARG A1164
ILE A1161
TRP A1134
None
0.88A 1qomA-4zxiA:
undetectable
1qomA-4zxiA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
3 ARG A1164
ILE A1298
TRP A1134
None
0.99A 1qomA-4zxiA:
undetectable
1qomA-4zxiA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E


(Drosophila
melanogaster)
PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41)
3 ARG A 852
ILE A 921
TRP A 894
None
1.16A 1qomA-5a01A:
undetectable
1qomA-5a01A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L24


(Dictyostelium
discoideum)
PF01246
(Ribosomal_L24e)
3 ARG G  56
ILE G  49
TRP G  51
None
1.04A 1qomA-5an9G:
undetectable
1qomA-5an9G:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT


(Candidatus
Kuenenia
stuttgartiensis)
no annotation 3 ARG A 227
ILE A 163
TRP A 423
None
1.09A 1qomA-5c2vA:
undetectable
1qomA-5c2vA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF08326
(ACC_central)
3 ARG A1173
ILE A1115
TRP A1131
None
1.04A 1qomA-5cs4A:
1.3
1qomA-5cs4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00364
(Biotin_lipoyl)
PF08326
(ACC_central)
3 ARG A1173
ILE A1115
TRP A1131
None
1.20A 1qomA-5csaA:
1.7
1qomA-5csaA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 ARG A 121
ILE A 453
TRP A 455
None
CU  A 510 (-3.7A)
None
0.98A 1qomA-5ehfA:
undetectable
1qomA-5ehfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM


(Bacillus
subtilis)
no annotation 3 ARG V 143
ILE V 153
TRP V 150
APC  V 301 ( 4.9A)
None
None
0.93A 1qomA-5f2vV:
undetectable
1qomA-5f2vV:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
3 ARG C 114
ILE C 119
TRP C  93
None
1.09A 1qomA-5flzC:
undetectable
1qomA-5flzC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A


(Homo sapiens)
PF06105
(Aph-1)
3 ARG C 186
ILE C 230
TRP C 227
None
1.15A 1qomA-5fn4C:
undetectable
1qomA-5fn4C:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsy MACRODOMAIN

(Trypanosoma
brucei)
PF01661
(Macro)
3 ARG A 169
ILE A  57
TRP A  76
None
1.04A 1qomA-5fsyA:
undetectable
1qomA-5fsyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
3 ARG A1190
ILE A1187
TRP A1176
None
1.01A 1qomA-5gzuA:
undetectable
1qomA-5gzuA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5


(Homo sapiens)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
3 ARG A 260
ILE A 253
TRP A 254
None
1.11A 1qomA-5h1kA:
undetectable
1qomA-5h1kA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibv CAPSID POLYPROTEIN
VP90


(Mamastrovirus 1)
PF03115
(Astro_capsid_N)
3 ARG A 179
ILE A 102
TRP A 350
None
1.18A 1qomA-5ibvA:
undetectable
1qomA-5ibvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
3 ARG A 623
ILE A 659
TRP A 656
None
1.19A 1qomA-5ja1A:
undetectable
1qomA-5ja1A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3z POLYKETIDE
KETOREDUCTASE SIMC7


(Streptomyces
antibioticus)
PF13460
(NAD_binding_10)
3 ARG A 130
ILE A 119
TRP A 126
None
1.17A 1qomA-5l3zA:
undetectable
1qomA-5l3zA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
3 ARG A 605
ILE A 607
TRP A 606
None
1.19A 1qomA-5l46A:
undetectable
1qomA-5l46A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 ARG A 122
ILE A 455
TRP A 457
None
CU  A 504 (-3.8A)
None
0.99A 1qomA-5mewA:
undetectable
1qomA-5mewA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n77 MAGNESIUM TRANSPORT
PROTEIN CORA


(Escherichia
coli)
PF01544
(CorA)
3 ARG A  14
ILE A  29
TRP A  28
None
1.05A 1qomA-5n77A:
undetectable
1qomA-5n77A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT


(Homo sapiens)
no annotation 3 ARG A 822
ILE A 891
TRP A 864
None
1.15A 1qomA-5nprA:
undetectable
1qomA-5nprA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-)
no annotation 3 ARG A  82
ILE A  64
TRP A  70
None
1.08A 1qomA-5ojrA:
undetectable
1qomA-5ojrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 1


(Saccharomyces
cerevisiae)
no annotation 3 ARG 1  30
ILE 1  16
TRP 1  29
None
0.91A 1qomA-5oqj1:
undetectable
1qomA-5oqj1:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH SUBUNIT TFB1


(Saccharomyces
cerevisiae)
no annotation 3 ARG 1  30
ILE 1  16
TRP 1  29
None
0.90A 1qomA-5oqm1:
undetectable
1qomA-5oqm1:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t89 VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF00047
(ig)
PF07679
(I-set)
PF13927
(Ig_3)
3 ARG X 546
ILE X 464
TRP X 466
None
1.17A 1qomA-5t89X:
undetectable
1qomA-5t89X:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT


(Homo sapiens)
PF05063
(MT-A70)
3 ARG A 508
ILE A 503
TRP A 457
None
0.83A 1qomA-5teyA:
undetectable
1qomA-5teyA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1


(Homo sapiens)
PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N)
3 ARG A 267
ILE A 176
TRP A 175
None
1.20A 1qomA-5u6oA:
undetectable
1qomA-5u6oA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'


(Mycobacterium
tuberculosis)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
3 ARG D 113
ILE D 104
TRP D 105
None
0.98A 1qomA-5uheD:
undetectable
1qomA-5uheD:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX


(Lassa
mammarenavirus)
PF00798
(Arena_glycoprot)
3 ARG A 193
ILE A 239
TRP A 196
None
1.10A 1qomA-5vk2A:
undetectable
1qomA-5vk2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygh CAPSID PROTEIN

(Zika virus)
no annotation 3 ARG A  55
ILE A  66
TRP A  69
None
1.03A 1qomA-5yghA:
undetectable
1qomA-5yghA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN


(Vibrio harveyi)
no annotation 3 ARG A 509
ILE A 512
TRP A 513
None
None
CBS  A 604 (-3.8A)
1.15A 1qomA-5yqwA:
undetectable
1qomA-5yqwA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans)
no annotation 3 ARG A 142
ILE A 114
TRP A 117
None
1.16A 1qomA-5z5dA:
undetectable
1qomA-5z5dA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byk 14-3-3 PROTEIN
BETA/ALPHA


(Homo sapiens)
no annotation 3 ARG A  58
ILE A  88
TRP A  61
None
1.13A 1qomA-6bykA:
undetectable
1qomA-6bykA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-)
no annotation 3 ARG A 202
ILE A  11
TRP A  50
None
1.19A 1qomA-6c7vA:
undetectable
1qomA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz ASK1
DAD4


(Chaetomium
thermophilum)
no annotation 3 ARG A  59
ILE E  44
TRP A  62
None
1.00A 1qomA-6cfzA:
undetectable
1qomA-6cfzA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN


(Homo sapiens)
no annotation 3 ARG A 338
ILE A 498
TRP A 341
None
1.01A 1qomA-6ei1A:
undetectable
1qomA-6ei1A:
11.43