SIMILAR PATTERNS OF AMINO ACIDS FOR 1QKU_C_ESTC600_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 5 | ALA A 88GLU A 87LEU A 83LEU A 82ILE A 253 | None | 1.38A | 1qkuC-1csjA:undetectable | 1qkuC-1csjA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 5 | GLU A 87LEU A 83LEU A 82ILE A 253LEU A 285 | None | 1.48A | 1qkuC-1csjA:undetectable | 1qkuC-1csjA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkp | PHYTASE (Escherichiacoli) |
PF00328(His_Phos_2) | 5 | ALA A 214LEU A 249LEU A 247ILE A 237LEU A 170 | None | 1.26A | 1qkuC-1dkpA:0.0 | 1qkuC-1dkpA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dm3 | BIOSYNTHETICTHIOLASE ACETYLATEDAT CYS89 (Zoogloearamigera) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 256LEU A 258MET A 259ILE A 269LEU A 272 | None | 1.37A | 1qkuC-1dm3A:undetectable | 1qkuC-1dm3A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz5 | ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF00982(Glyco_transf_20) | 5 | ALA A 11GLU A 15LEU A 28ILE A 225HIS A 154 | NoneNoneNoneIMD A 902 ( 4.3A)IMD A 902 (-3.9A) | 1.31A | 1qkuC-1gz5A:undetectable | 1qkuC-1gz5A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jzn | GALACTOSE-SPECIFICLECTIN (Crotalus atrox) |
PF00059(Lectin_C) | 5 | ALA A 27GLU A 28LEU A 40ILE A 56HIS A 60 | None | 1.38A | 1qkuC-1jznA:undetectable | 1qkuC-1jznA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nd7 | WW DOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00632(HECT) | 5 | GLU A 798LEU A 680ARG A 855ILE A 699LEU A 691 | None | 1.42A | 1qkuC-1nd7A:undetectable | 1qkuC-1nd7A:21.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | ALA A 350GLU A 353LEU A 387MET A 388LEU A 391ARG A 394MET A 421ILE A 424HIS A 524LEU A 525 | EST A 1 ( 3.7A)EST A 1 (-2.8A)EST A 1 (-4.0A)NoneEST A 1 ( 3.9A)EST A 1 (-3.7A)EST A 1 ( 4.3A)EST A 1 ( 4.5A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 0.43A | 1qkuC-1pcgA:37.4 | 1qkuC-1pcgA:98.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgv | TRNA PSEUDOURIDINESYNTHASE B (Mycobacteriumtuberculosis) |
PF01509(TruB_N)PF09142(TruB_C)PF16198(TruB_C_2) | 5 | ALA A 231GLU A 230LEU A 226LEU A 224LEU A 63 | None | 1.09A | 1qkuC-1sgvA:undetectable | 1qkuC-1sgvA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgv | TRNA PSEUDOURIDINESYNTHASE B (Mycobacteriumtuberculosis) |
PF01509(TruB_N)PF09142(TruB_C)PF16198(TruB_C_2) | 5 | ALA A 231LEU A 226LEU A 224ILE A 51LEU A 63 | None | 1.13A | 1qkuC-1sgvA:undetectable | 1qkuC-1sgvA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ugo | BCL2-ASSOCIATEDATHANOGENE 5 (Mus musculus) |
PF02179(BAG) | 5 | ALA A 79GLU A 83LEU A 57LEU A 53LEU A 20 | None | 1.21A | 1qkuC-1ugoA:undetectable | 1qkuC-1ugoA:15.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xls | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ALA A 272LEU A 309ARG A 316ILE A 345LEU A 436 | 9CR A 801 (-3.5A)9CR A 801 (-4.2A)9CR A 801 (-2.6A)9CR A 801 ( 4.5A)9CR A 801 (-4.7A) | 0.98A | 1qkuC-1xlsA:25.5 | 1qkuC-1xlsA:31.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvp | 60-KDA SS-A/RORIBONUCLEOPROTEIN (Xenopus laevis) |
PF05731(TROVE) | 5 | ALA A 231LEU A 253LEU A 258ILE A 245HIS A 246 | None | 1.41A | 1qkuC-1yvpA:undetectable | 1qkuC-1yvpA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy7 | CYSTEINE PROTEASEAPG4B (Homo sapiens) |
PF03416(Peptidase_C54) | 5 | ALA A 86LEU A 164LEU A 222ILE A 168LEU A 152 | None | 1.21A | 1qkuC-2cy7A:undetectable | 1qkuC-2cy7A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dt8 | DEGV FAMILY PROTEIN (Thermusthermophilus) |
PF02645(DegV) | 5 | ALA A 174LEU A 188LEU A 190ILE A 264HIS A 267 | NoneNoneNonePLM A 701 ( 4.5A)PLM A 701 (-3.7A) | 1.42A | 1qkuC-2dt8A:undetectable | 1qkuC-2dt8A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g7l | TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 5 | ALA A 28LEU A 66ARG A 21HIS A 107LEU A 37 | None | 1.48A | 1qkuC-2g7lA:undetectable | 1qkuC-2g7lA:26.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ALA A 272GLU A 275LEU A 309ARG A 316HIS A 434 | OHT A 500 (-3.5A)OHT A 500 (-2.6A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A)OHT A 500 ( 4.7A) | 0.63A | 1qkuC-2gpvA:26.6 | 1qkuC-2gpvA:36.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4r | EXOPOLYPHOSPHATASE (Aquifexaeolicus) |
PF02541(Ppx-GppA) | 5 | ALA A 96GLU A 97LEU A 100ILE A 64LEU A 45 | None | 1.43A | 1qkuC-2j4rA:undetectable | 1qkuC-2j4rA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mje | ADRENODOXIN HOMOLOG,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00111(Fer2) | 5 | GLU A 2LEU A 4MET A 91ILE A 29HIS A 33 | None | 1.42A | 1qkuC-2mjeA:undetectable | 1qkuC-2mjeA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7p | RIBOFLAVINBIOSYNTHESIS PROTEINRIBD (Escherichiacoli) |
PF00383(dCMP_cyt_deam_1)PF01872(RibD_C) | 5 | GLU A 167LEU A 204ARG A 207ILE A 228LEU A 191 | None | 1.32A | 1qkuC-2o7pA:undetectable | 1qkuC-2o7pA:20.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | ALA A 350GLU A 353LEU A 387MET A 388LEU A 391ARG A 394MET A 421ILE A 424HIS A 524LEU A 525 | EST A 596 ( 3.9A)EST A 596 (-2.7A)EST A 596 ( 4.2A)NoneEST A 596 ( 4.6A)EST A 596 (-4.0A)EST A 596 (-4.5A)EST A 596 ( 4.7A)EST A 596 (-4.2A)EST A 596 (-3.6A) | 0.61A | 1qkuC-2ocfA:36.1 | 1qkuC-2ocfA:99.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjq | UNCHARACTERIZEDPROTEIN LP_2664 (Lactobacillusplantarum) |
PF01966(HD) | 5 | ALA A 37LEU A 52LEU A 50ILE A 97HIS A 58 | None | 0.97A | 1qkuC-2pjqA:undetectable | 1qkuC-2pjqA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgo | PUTATIVE FE-SBIOSYNTHESIS PROTEIN (Lactobacillusacidophilus) |
PF01521(Fe-S_biosyn) | 5 | ALA A 12LEU A 97LEU A 99ILE A 74LEU A 22 | None | 1.38A | 1qkuC-2qgoA:undetectable | 1qkuC-2qgoA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vt2 | REDOX-SENSINGTRANSCRIPTIONALREPRESSOR REX (Bacillussubtilis) |
PF02629(CoA_binding)PF06971(Put_DNA-bind_N) | 5 | GLU A 140LEU A 168ARG A 164ILE A 187HIS A 186 | None | 1.42A | 1qkuC-2vt2A:undetectable | 1qkuC-2vt2A:26.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x1m | METHIONYL-TRNASYNTHETASE (Mycolicibacteriumsmegmatis) |
PF09334(tRNA-synt_1g) | 5 | ALA A 276LEU A 175LEU A 178ILE A 289HIS A 270 | NoneNoneNoneNoneMET A 600 (-4.6A) | 1.16A | 1qkuC-2x1mA:undetectable | 1qkuC-2x1mA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xym | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | ALA A 88LEU A 83LEU A 82ILE A 253LEU A 285 | None | 1.29A | 1qkuC-2xymA:undetectable | 1qkuC-2xymA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbi | SUGAR-BINDINGTRANSCRIPTIONALREGULATOR, LACIFAMILY (Escherichiacoli) |
PF13377(Peripla_BP_3) | 5 | ALA A 172GLU A 175LEU A 327ILE A 295HIS A 165 | None | 1.48A | 1qkuC-3dbiA:undetectable | 1qkuC-3dbiA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dka | DINB-LIKE PROTEIN (Bacillussubtilis) |
PF05163(DinB) | 5 | LEU A 120LEU A 121ILE A 92HIS A 53LEU A 54 | None | 1.33A | 1qkuC-3dkaA:undetectable | 1qkuC-3dkaA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmy | PROTEIN FDRA (Escherichiacoli) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 5 | LEU A 226MET A 171ILE A 180HIS A 222LEU A 247 | None | 1.46A | 1qkuC-3dmyA:undetectable | 1qkuC-3dmyA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dy5 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | GLU A 894LEU A 776ARG A 505ILE A 878LEU A 932 | None | 1.48A | 1qkuC-3dy5A:undetectable | 1qkuC-3dy5A:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e8j | COPROPORPHYRINOGENIII OXIDASE (Leishmanianaiffi) |
PF01218(Coprogen_oxidas) | 5 | ALA A 180GLU A 179LEU A 290ARG A 237HIS A 146 | None | 1.32A | 1qkuC-3e8jA:undetectable | 1qkuC-3e8jA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ego | PROBABLE2-DEHYDROPANTOATE2-REDUCTASE (Bacillussubtilis) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | ALA A 217GLU A 216LEU A 280LEU A 283LEU A 180 | None | 1.32A | 1qkuC-3egoA:undetectable | 1qkuC-3egoA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg4 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | GLU A 894LEU A 776ARG A 505ILE A 878LEU A 932 | None | 1.47A | 1qkuC-3fg4A:undetectable | 1qkuC-3fg4A:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3goa | 3-KETOACYL-COATHIOLASE (Salmonellaenterica) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 246LEU A 34MET A 35LEU A 38ILE A 53 | None | 1.10A | 1qkuC-3goaA:undetectable | 1qkuC-3goaA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib3 | COCE/NOND FAMILYHYDROLASE (Staphylococcusaureus) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 5 | ALA A 143GLU A 144LEU A 181ARG A 49MET A 71 | None | 1.47A | 1qkuC-3ib3A:undetectable | 1qkuC-3ib3A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwp | COPPER HOMEOSTASISPROTEIN CUTC HOMOLOG (Homo sapiens) |
PF03932(CutC) | 5 | ALA A 147LEU A 119LEU A 90MET A 99ILE A 96 | None | 1.44A | 1qkuC-3iwpA:undetectable | 1qkuC-3iwpA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k31 | ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (Anaplasmaphagocytophilum) |
PF13561(adh_short_C2) | 5 | ALA A 71GLU A 72MET A 77ILE A 15HIS A 93 | EDO A 400 (-3.6A)NoneNoneNoneNone | 0.97A | 1qkuC-3k31A:undetectable | 1qkuC-3k31A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kv0 | HET-C2 (Podosporaanserina) |
PF08718(GLTP) | 5 | GLU A 46LEU A 42ARG A 75ILE A 36LEU A 190 | None | 1.07A | 1qkuC-3kv0A:undetectable | 1qkuC-3kv0A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kye | ROADBLOCK/LC7DOMAIN, ROBL_LC7 (Streptomycesavermitilis) |
PF03259(Robl_LC7) | 5 | LEU A 16MET A 17LEU A 20ARG A 23LEU A 128 | None | 1.26A | 1qkuC-3kyeA:undetectable | 1qkuC-3kyeA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3s | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Ruegeriapomeroyi) |
PF00378(ECH_1) | 5 | GLU A 12LEU A 10ARG A 45ILE A 36LEU A 123 | None | 1.32A | 1qkuC-3l3sA:undetectable | 1qkuC-3l3sA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2b | DIAMINOPIMELATEDECARBOXYLASE (Vibrio cholerae) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | ALA A 257LEU A 241ILE A 56HIS A 54LEU A 272 | None | 1.26A | 1qkuC-3n2bA:undetectable | 1qkuC-3n2bA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nc3 | CYTOCHROME P450 CYPX (Bacillussubtilis) |
PF00067(p450) | 5 | ALA A 162LEU A 232LEU A 228ARG A 67ILE A 154 | NoneGOL A 407 ( 4.8A)NoneNoneNone | 1.35A | 1qkuC-3nc3A:2.7 | 1qkuC-3nc3A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzp | ARGININEDECARBOXYLASE (Campylobacterjejuni) |
PF02784(Orn_Arg_deC_N) | 5 | ALA A 251GLU A 250LEU A 186ILE A 238LEU A 271 | None | 1.27A | 1qkuC-3nzpA:undetectable | 1qkuC-3nzpA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o3m | BETA SUBUNIT2-HYDROXYACYL-COADEHYDRATASE (Clostridioidesdifficile) |
PF06050(HGD-D) | 5 | GLU B 41LEU B 281ARG B 171MET B 98LEU B 121 | None | 1.40A | 1qkuC-3o3mB:undetectable | 1qkuC-3o3mB:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o57 | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
PF00233(PDEase_I) | 5 | ALA A 391LEU A 249LEU A 250MET A 196ILE A 199 | None | 1.10A | 1qkuC-3o57A:undetectable | 1qkuC-3o57A:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7j | OHCU DECARBOXYLASE (Klebsiellapneumoniae) |
PF09349(OHCU_decarbox) | 5 | GLU A 161LEU A 158ARG A 49HIS A 80LEU A 83 | None | 1.46A | 1qkuC-3o7jA:undetectable | 1qkuC-3o7jA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ov3 | CURCUMIN SYNTHASE (Curcuma longa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | ALA A 113GLU A 116MET A 20ARG A 350LEU A 187 | None | 1.42A | 1qkuC-3ov3A:undetectable | 1qkuC-3ov3A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pb0 | DIHYDRODIPICOLINATESYNTHASE (Thermotogamaritima) |
PF00701(DHDPS) | 5 | ALA A 276LEU A 261ARG A 285ILE A 265LEU A 269 | None | 1.40A | 1qkuC-3pb0A:undetectable | 1qkuC-3pb0A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pgv | HALOACIDDEHALOGENASE-LIKEHYDROLASE (Klebsiellapneumoniae) |
PF08282(Hydrolase_3) | 5 | ALA A 6LEU A 260MET A 231ILE A 248LEU A 222 | None | 1.25A | 1qkuC-3pgvA:undetectable | 1qkuC-3pgvA:25.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q0g | ENOYL-COA HYDRATASEECHA8 (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 5 | ALA A 170GLU A 169LEU A 158ARG A 163LEU A 119 | None | 1.30A | 1qkuC-3q0gA:undetectable | 1qkuC-3q0gA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgh | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | ALA A 88LEU A 83LEU A 82ILE A 253LEU A 285 | None | 1.27A | 1qkuC-3qghA:undetectable | 1qkuC-3qghA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s8i | PROTEIN DDI1 HOMOLOG1 (Homo sapiens) |
PF09668(Asp_protease) | 5 | ALA A 263LEU A 329MET A 328ILE A 246LEU A 335 | None | 1.46A | 1qkuC-3s8iA:undetectable | 1qkuC-3s8iA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tx8 | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Corynebacteriumglutamicum) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ALA A 42LEU A 43LEU A 48HIS A 113LEU A 18 | None | 1.46A | 1qkuC-3tx8A:undetectable | 1qkuC-3tx8A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tzt | GLYCOSYL TRANSFERASEFAMILY 8 (Anaerococcusprevotii) |
PF01501(Glyco_transf_8) | 5 | ALA A 4LEU A 118ARG A 31ILE A 122LEU A 163 | EDO A 302 (-4.5A)EDO A 302 (-4.3A)NoneNoneNone | 1.24A | 1qkuC-3tztA:undetectable | 1qkuC-3tztA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubr | CYTOCHROME C-552 (Shewanellaoneidensis) |
PF02335(Cytochrom_C552) | 5 | ALA A 347GLU A 346LEU A 409MET A 252LEU A 364 | None | 1.43A | 1qkuC-3ubrA:undetectable | 1qkuC-3ubrA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vh1 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME ATG7 (Saccharomycescerevisiae) |
PF00899(ThiF)PF16420(ATG7_N) | 5 | ALA A 252LEU A 238LEU A 239ILE A 182LEU A 233 | None | 1.40A | 1qkuC-3vh1A:undetectable | 1qkuC-3vh1A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vis | ESTERASE (Thermobifidaalba) |
PF12740(Chlorophyllase2) | 5 | ALA A 160LEU A 147LEU A 143ARG A 182ILE A 81 | None | 1.20A | 1qkuC-3visA:undetectable | 1qkuC-3visA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w36 | NAPH1 (Streptomycessp. CNQ525) |
no annotation | 5 | ALA A 318GLU A 322LEU A 415ILE A 303LEU A 310 | None | 1.21A | 1qkuC-3w36A:1.8 | 1qkuC-3w36A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a73 | L-LACTATEDEHYDROGENASE (Thermusthermophilus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 133LEU A 135LEU A 136ILE A 26LEU A 88 | None | 1.45A | 1qkuC-4a73A:undetectable | 1qkuC-4a73A:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ars | HISTIDINE ACIDPHOSPHATASE (Hafnia alvei) |
PF00328(His_Phos_2) | 5 | ALA A 217LEU A 252LEU A 250ILE A 240LEU A 172 | None | 1.37A | 1qkuC-4arsA:undetectable | 1qkuC-4arsA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfr | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTIC SSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 5 | LEU A1002MET A1001LEU A1000MET A 813LEU A 936 | None | 1.46A | 1qkuC-4bfrA:undetectable | 1qkuC-4bfrA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bju | N-ACETYLGLUCOSAMINE-PHOSPHATE MUTASE (Aspergillusfumigatus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I) | 5 | ALA A 437LEU A 212ARG A 279ILE A 429LEU A 420 | None | 1.40A | 1qkuC-4bjuA:undetectable | 1qkuC-4bjuA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA A 20LEU A 9ILE A 46HIS A 225LEU A 251 | None | 1.43A | 1qkuC-4c30A:undetectable | 1qkuC-4c30A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ce5 | AT-OMEGATA (Aspergillusterreus) |
PF01063(Aminotran_4) | 5 | ALA A 194GLU A 193LEU A 204MET A 272ILE A 219 | None | 1.46A | 1qkuC-4ce5A:undetectable | 1qkuC-4ce5A:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d9i | DIAMINOPROPIONATEAMMONIA-LYASE (Escherichiacoli) |
PF00291(PALP) | 5 | ALA A 213GLU A 212ARG A 70ILE A 334LEU A 63 | None | 1.22A | 1qkuC-4d9iA:undetectable | 1qkuC-4d9iA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ely | DNA GYRASE SUBUNIT A (Shigellaflexneri) |
PF00521(DNA_topoisoIV) | 5 | ALA A 455LEU A 459LEU A 461ILE A 390LEU A 396 | None | 1.40A | 1qkuC-4elyA:undetectable | 1qkuC-4elyA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv5 | ASPARTATECARBAMOYLTRANSFERASE, PUTATIVE (Trypanosomacruzi) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ALA A 123GLU A 122LEU A 96ARG A 116LEU A 110 | None | 1.43A | 1qkuC-4iv5A:undetectable | 1qkuC-4iv5A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1j | NACHT, LRR AND PYDDOMAINS-CONTAININGPROTEIN 14 (Homo sapiens) |
PF02758(PYRIN) | 5 | ALA A 53GLU A 49LEU A 61MET A 62ILE A 78 | None | 1.44A | 1qkuC-4n1jA:undetectable | 1qkuC-4n1jA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1j | NACHT, LRR AND PYDDOMAINS-CONTAININGPROTEIN 14 (Homo sapiens) |
PF02758(PYRIN) | 5 | ALA A 53GLU A 49MET A 62ILE A 78LEU A 27 | None | 1.40A | 1qkuC-4n1jA:undetectable | 1qkuC-4n1jA:18.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 5 | ALA A 287GLU A 290LEU A 324ARG A 331ILE A 361 | None | 0.61A | 1qkuC-4n1yA:30.7 | 1qkuC-4n1yA:38.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 5 | ALA A 287LEU A 324ARG A 331MET A 358ILE A 361 | None | 0.69A | 1qkuC-4n1yA:30.7 | 1qkuC-4n1yA:38.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nl4 | PRIMOSOME ASSEMBLYPROTEIN PRIA (Klebsiellapneumoniae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ALA H 359GLU H 571LEU H 621ARG H 624LEU H 220 | None | 1.35A | 1qkuC-4nl4H:undetectable | 1qkuC-4nl4H:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nt4 | GILGAMESH, ISOFORM I (Drosophilamelanogaster) |
PF00069(Pkinase) | 5 | GLU A 289LEU A 314ARG A 321HIS A 154LEU A 153 | None | 1.37A | 1qkuC-4nt4A:undetectable | 1qkuC-4nt4A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1o | RIBONUCLEASE L (Sus scrofa) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | LEU A 108LEU A 106ILE A 96HIS A 62LEU A 61 | None | 1.20A | 1qkuC-4o1oA:undetectable | 1qkuC-4o1oA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p47 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Ochrobactrumanthropi) |
PF03480(DctP) | 5 | ALA A 267GLU A 266LEU A 54MET A 90ILE A 32 | None | 1.35A | 1qkuC-4p47A:undetectable | 1qkuC-4p47A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmz | XYLANASE (Xanthomonascitri) |
PF00331(Glyco_hydro_10) | 5 | ALA A 313LEU A 25ARG A 318ILE A 285LEU A 257 | None | 1.43A | 1qkuC-4pmzA:undetectable | 1qkuC-4pmzA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4po0 | SERUM ALBUMIN (Oryctolaguscuniculus) |
PF00273(Serum_albumin) | 5 | ALA A 151LEU A 250LEU A 251ILE A 20LEU A 139 | None | 1.43A | 1qkuC-4po0A:undetectable | 1qkuC-4po0A:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzi | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
PF00233(PDEase_I) | 5 | ALA A 563LEU A 421LEU A 422MET A 368ILE A 371 | None | 1.09A | 1qkuC-4wziA:1.9 | 1qkuC-4wziA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zu9 | ELONGATION FACTORSELB (Aquifexaeolicus) |
PF00009(GTP_EFTU)PF09107(SelB-wing_3) | 5 | ALA A 7LEU A 5LEU A 57ILE A 171HIS A 110 | None | 1.39A | 1qkuC-4zu9A:undetectable | 1qkuC-4zu9A:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4y | HOMOSERINEO-ACETYLTRANSFERASE (Pseudomonasveronii) |
PF00561(Abhydrolase_1) | 5 | LEU A 336MET A 332LEU A 333ARG A 72HIS A 322 | None | 1.35A | 1qkuC-5e4yA:undetectable | 1qkuC-5e4yA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fnp | IRON-SULFUR CLUSTERREPAIR PROTEIN YTFE (Escherichiacoli) |
PF01814(Hemerythrin)PF04405(ScdA_N) | 5 | ALA A 216GLU A 220LEU A 72ILE A 79LEU A 137 | NoneNoneNone ZN A1222 ( 4.9A)None | 1.23A | 1qkuC-5fnpA:undetectable | 1qkuC-5fnpA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6g | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | GLU A2173LEU A2213ARG A2206ILE A2184LEU A2244 | None | 1.45A | 1qkuC-5i6gA:undetectable | 1qkuC-5i6gA:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1g | PLECTIN (Homo sapiens) |
no annotation | 5 | ALA A1072GLU A1075LEU A1094ARG A1091ILE A1019 | None | 1.47A | 1qkuC-5j1gA:undetectable | 1qkuC-5j1gA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j90 | RAGB/SUSD DOMAINPROTEIN (Flavobacteriumjohnsoniae) |
PF12741(SusD-like) | 5 | ALA A 229GLU A 243LEU A 183MET A 348LEU A 356 | None | 1.33A | 1qkuC-5j90A:undetectable | 1qkuC-5j90A:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN2NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4L (Bos taurus) |
PF00361(Proton_antipo_M)PF00420(Oxidored_q2)PF06444(NADH_dehy_S2_C) | 5 | ALA N 55GLU N 117LEU K 95LEU K 93HIS N 48 | None | 1.40A | 1qkuC-5lc5N:undetectable | 1qkuC-5lc5N:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 5 | ALA A 277LEU A 316MET A 315ILE A 26LEU A 328 | NoneNoneNoneNone CU A1103 (-4.4A) | 1.31A | 1qkuC-5n4lA:undetectable | 1qkuC-5n4lA:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nkm | PROTEIN SMG-8PROTEIN SMG-9 (Caenorhabditiselegans) |
PF10220(Smg8_Smg9)no annotation | 5 | ALA D 185LEU D 181ILE E 172HIS D 352LEU D 351 | EDO D 402 (-4.0A)NoneNoneNoneNone | 1.23A | 1qkuC-5nkmD:undetectable | 1qkuC-5nkmD:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohj | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
no annotation | 5 | ALA A 563LEU A 421LEU A 422MET A 368ILE A 371 | None | 1.08A | 1qkuC-5ohjA:1.9 | 1qkuC-5ohjA:17.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 9 | ALA A 302GLU A 305LEU A 339MET A 340LEU A 343ARG A 346ILE A 376HIS A 475LEU A 476 | EST A 601 ( 3.9A)EST A 601 (-2.4A)EST A 601 (-3.9A)EST A 601 ( 4.8A)EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 ( 4.4A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 0.54A | 1qkuC-5toaA:30.9 | 1qkuC-5toaA:58.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrd | BIFUNCTIONALCOENZYME PQQSYNTHESIS PROTEINC/D (Methylobacteriumextorquens) |
no annotation | 5 | ALA D 153LEU D 156ARG D 91HIS D 19LEU D 22 | None | 1.19A | 1qkuC-5vrdD:undetectable | 1qkuC-5vrdD:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vws | CYTOCHROME P450 (Thermobisporabispora) |
PF00067(p450) | 5 | ALA A 178GLU A 181LEU A 150HIS A 232LEU A 229 | None | 1.31A | 1qkuC-5vwsA:2.7 | 1qkuC-5vwsA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w3f | TUBULIN ALPHA-1CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | GLU A 27LEU A 23ARG A 244ILE A 16LEU A 231 | None | 1.30A | 1qkuC-5w3fA:undetectable | 1qkuC-5w3fA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x87 | BESTROPHIN (Klebsiellapneumoniae) |
no annotation | 5 | ALA A 82GLU A 81LEU A 85ARG A 201LEU A 272 | None | 1.33A | 1qkuC-5x87A:undetectable | 1qkuC-5x87A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9w | DNA MISMATCH REPAIRPROTEIN MUTS (Neisseriagonorrhoeae) |
no annotation | 5 | GLU A 257LEU A 168ARG A 167ILE A 129LEU A 251 | None | 1.46A | 1qkuC-5x9wA:undetectable | 1qkuC-5x9wA:15.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ze8 | CYTOCHROME C552 (Thermochromatiumtepidum) |
no annotation | 5 | ALA A 353MET A 312LEU A 378ARG A 384ILE A 428 | NoneHEM A 505 ( 3.7A)NoneNoneNone | 1.46A | 1qkuC-5ze8A:undetectable | 1qkuC-5ze8A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6amn | HEAT SHOCK PROTEIN104 (Saccharomycescerevisiae) |
no annotation | 5 | ALA A 38GLU A 41LEU A 21ILE A 76LEU A 30 | None | 1.29A | 1qkuC-6amnA:undetectable | 1qkuC-6amnA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cv9 | SHORT TRANSIENTRECEPTOR POTENTIALCHANNEL 6 (Mus musculus) |
no annotation | 5 | ALA A 105GLU A 106LEU A 138ILE A 175LEU A 151 | None | 1.34A | 1qkuC-6cv9A:undetectable | 1qkuC-6cv9A:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dk2 | - (-) |
no annotation | 5 | ALA A 492GLU A 493ARG A 216ILE A 143LEU A 97 | None | 1.36A | 1qkuC-6dk2A:undetectable | 1qkuC-6dk2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 5 | ALA A 296GLU A 49LEU A 301ARG A 335ILE A 290 | FAD A 401 ( 4.7A) CL A 402 ( 4.6A) CL A 402 (-4.8A) CL A 402 (-3.5A)None | 1.03A | 1qkuC-6dllA:undetectable | 1qkuC-6dllA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhs | RUVB-LIKE HELICASE (Chaetomiumthermophilum) |
no annotation | 5 | ALA A 380GLU A 383LEU A 411LEU A 408ILE A 372 | None | 1.35A | 1qkuC-6fhsA:undetectable | 1qkuC-6fhsA:15.11 |