SIMILAR PATTERNS OF AMINO ACIDS FOR 1QKU_A_ESTA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)


(Hepacivirus C)
PF00998
(RdRP_3)
5 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
None
1.38A 1qkuA-1csjA:
undetectable
1qkuA-1csjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)


(Hepacivirus C)
PF00998
(RdRP_3)
5 GLU A  87
LEU A  83
LEU A  82
ILE A 253
LEU A 285
None
1.49A 1qkuA-1csjA:
undetectable
1qkuA-1csjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli)
PF00328
(His_Phos_2)
5 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
None
1.26A 1qkuA-1dkpA:
0.0
1qkuA-1dkpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89


(Zoogloea
ramigera)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A 256
LEU A 258
MET A 259
ILE A 269
LEU A 272
None
1.37A 1qkuA-1dm3A:
undetectable
1qkuA-1dm3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE


(Escherichia
coli)
PF00982
(Glyco_transf_20)
5 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
1.31A 1qkuA-1gz5A:
0.0
1qkuA-1gz5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzn GALACTOSE-SPECIFIC
LECTIN


(Crotalus atrox)
PF00059
(Lectin_C)
5 ALA A  27
GLU A  28
LEU A  40
ILE A  56
HIS A  60
None
1.38A 1qkuA-1jznA:
undetectable
1qkuA-1jznA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00632
(HECT)
5 GLU A 798
LEU A 680
ARG A 855
ILE A 699
LEU A 691
None
1.41A 1qkuA-1nd7A:
undetectable
1qkuA-1nd7A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
MET A 421
ILE A 424
HIS A 524
LEU A 525
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.43A 1qkuA-1pcgA:
37.4
1qkuA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B


(Mycobacterium
tuberculosis)
PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2)
5 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
None
1.09A 1qkuA-1sgvA:
undetectable
1qkuA-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B


(Mycobacterium
tuberculosis)
PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2)
5 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
None
1.13A 1qkuA-1sgvA:
undetectable
1qkuA-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugo BCL2-ASSOCIATED
ATHANOGENE 5


(Mus musculus)
PF02179
(BAG)
5 ALA A  79
GLU A  83
LEU A  57
LEU A  53
LEU A  20
None
1.20A 1qkuA-1ugoA:
undetectable
1qkuA-1ugoA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlm PROTEIN CGI-38

(Mus musculus)
PF05517
(p25-alpha)
5 ALA A  52
LEU A  89
LEU A  86
MET A  37
ILE A  77
None
1.26A 1qkuA-1wlmA:
undetectable
1qkuA-1wlmA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 272
LEU A 309
ARG A 316
ILE A 345
LEU A 436
9CR  A 801 (-3.5A)
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-4.7A)
0.98A 1qkuA-1xlsA:
25.4
1qkuA-1xlsA:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN


(Xenopus laevis)
PF05731
(TROVE)
5 ALA A 231
LEU A 253
LEU A 258
ILE A 245
HIS A 246
None
1.40A 1qkuA-1yvpA:
undetectable
1qkuA-1yvpA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B


(Homo sapiens)
PF03416
(Peptidase_C54)
5 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
None
1.22A 1qkuA-2cy7A:
undetectable
1qkuA-2cy7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus)
PF02645
(DegV)
5 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
1.42A 1qkuA-2dt8A:
undetectable
1qkuA-2dt8A:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
0.61A 1qkuA-2gpvA:
26.6
1qkuA-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus)
PF02541
(Ppx-GppA)
5 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
None
1.42A 1qkuA-2j4rA:
undetectable
1qkuA-2j4rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mje ADRENODOXIN HOMOLOG,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00111
(Fer2)
5 GLU A   2
LEU A   4
MET A  91
ILE A  29
HIS A  33
None
1.42A 1qkuA-2mjeA:
undetectable
1qkuA-2mjeA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD


(Escherichia
coli)
PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C)
5 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
None
1.32A 1qkuA-2o7pA:
undetectable
1qkuA-2o7pA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
MET A 421
ILE A 424
HIS A 524
LEU A 525
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.60A 1qkuA-2ocfA:
36.1
1qkuA-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664


(Lactobacillus
plantarum)
PF01966
(HD)
5 ALA A  37
LEU A  52
LEU A  50
ILE A  97
HIS A  58
None
0.96A 1qkuA-2pjqA:
undetectable
1qkuA-2pjqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgo PUTATIVE FE-S
BIOSYNTHESIS PROTEIN


(Lactobacillus
acidophilus)
PF01521
(Fe-S_biosyn)
5 ALA A  12
LEU A  97
LEU A  99
ILE A  74
LEU A  22
None
1.38A 1qkuA-2qgoA:
undetectable
1qkuA-2qgoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX


(Bacillus
subtilis)
PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N)
5 GLU A 140
LEU A 168
ARG A 164
ILE A 187
HIS A 186
None
1.42A 1qkuA-2vt2A:
undetectable
1qkuA-2vt2A:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE


(Mycolicibacterium
smegmatis)
PF09334
(tRNA-synt_1g)
5 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 270
None
None
None
None
MET  A 600 (-4.6A)
1.16A 1qkuA-2x1mA:
undetectable
1qkuA-2x1mA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
5 ALA A  88
LEU A  83
LEU A  82
ILE A 253
LEU A 285
None
1.29A 1qkuA-2xymA:
undetectable
1qkuA-2xymA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1


(Homo sapiens)
PF01287
(eIF-5a)
5 ALA A 145
GLU A 144
LEU A 101
ARG A 109
ILE A 123
UNX  A   6 ( 3.9A)
UNX  A   5 (-3.9A)
UNX  A   1 (-3.8A)
None
None
1.48A 1qkuA-3cpfA:
undetectable
1qkuA-3cpfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Escherichia
coli)
PF13377
(Peripla_BP_3)
5 ALA A 172
GLU A 175
LEU A 327
ILE A 295
HIS A 165
None
1.48A 1qkuA-3dbiA:
undetectable
1qkuA-3dbiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis)
PF05163
(DinB)
5 LEU A 120
LEU A 121
ILE A  92
HIS A  53
LEU A  54
None
1.33A 1qkuA-3dkaA:
undetectable
1qkuA-3dkaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
5 LEU A 226
MET A 171
ILE A 180
HIS A 222
LEU A 247
None
1.46A 1qkuA-3dmyA:
undetectable
1qkuA-3dmyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
None
1.48A 1qkuA-3dy5A:
undetectable
1qkuA-3dy5A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE


(Leishmania
naiffi)
PF01218
(Coprogen_oxidas)
5 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
None
1.32A 1qkuA-3e8jA:
undetectable
1qkuA-3e8jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE


(Bacillus
subtilis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
None
1.31A 1qkuA-3egoA:
undetectable
1qkuA-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
None
1.47A 1qkuA-3fg4A:
undetectable
1qkuA-3fg4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE


(Salmonella
enterica)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A 246
LEU A  34
MET A  35
LEU A  38
ILE A  53
None
1.11A 1qkuA-3goaA:
undetectable
1qkuA-3goaA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE


(Staphylococcus
aureus)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
5 ALA A 143
GLU A 144
LEU A 181
ARG A  49
MET A  71
None
1.45A 1qkuA-3ib3A:
undetectable
1qkuA-3ib3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE


(Anaplasma
phagocytophilum)
PF13561
(adh_short_C2)
5 ALA A  71
GLU A  72
MET A  77
ILE A  15
HIS A  93
EDO  A 400 (-3.6A)
None
None
None
None
0.96A 1qkuA-3k31A:
undetectable
1qkuA-3k31A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina)
PF08718
(GLTP)
5 GLU A  46
LEU A  42
ARG A  75
ILE A  36
LEU A 190
None
1.08A 1qkuA-3kv0A:
undetectable
1qkuA-3kv0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7


(Streptomyces
avermitilis)
PF03259
(Robl_LC7)
5 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
None
1.26A 1qkuA-3kyeA:
undetectable
1qkuA-3kyeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3s ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Ruegeria
pomeroyi)
PF00378
(ECH_1)
5 GLU A  12
LEU A  10
ARG A  45
ILE A  36
LEU A 123
None
1.32A 1qkuA-3l3sA:
undetectable
1qkuA-3l3sA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2b DIAMINOPIMELATE
DECARBOXYLASE


(Vibrio cholerae)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 ALA A 257
LEU A 241
ILE A  56
HIS A  54
LEU A 272
None
1.28A 1qkuA-3n2bA:
undetectable
1qkuA-3n2bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis)
PF00067
(p450)
5 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
None
GOL  A 407 ( 4.8A)
None
None
None
1.34A 1qkuA-3nc3A:
2.6
1qkuA-3nc3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE


(Campylobacter
jejuni)
PF02784
(Orn_Arg_deC_N)
5 ALA A 251
GLU A 250
LEU A 186
ILE A 238
LEU A 271
None
1.26A 1qkuA-3nzpA:
undetectable
1qkuA-3nzpA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE


(Clostridioides
difficile)
PF06050
(HGD-D)
5 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
None
1.39A 1qkuA-3o3mB:
undetectable
1qkuA-3o3mB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B


(Homo sapiens)
PF00233
(PDEase_I)
5 ALA A 391
LEU A 249
LEU A 250
MET A 196
ILE A 199
None
1.10A 1qkuA-3o57A:
undetectable
1qkuA-3o57A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae)
PF09349
(OHCU_decarbox)
5 GLU A 161
LEU A 158
ARG A  49
HIS A  80
LEU A  83
None
1.46A 1qkuA-3o7jA:
undetectable
1qkuA-3o7jA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 ALA A 113
GLU A 116
MET A  20
ARG A 350
LEU A 187
None
1.41A 1qkuA-3ov3A:
undetectable
1qkuA-3ov3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE


(Thermotoga
maritima)
PF00701
(DHDPS)
5 ALA A 276
LEU A 261
ARG A 285
ILE A 265
LEU A 269
None
1.41A 1qkuA-3pb0A:
undetectable
1qkuA-3pb0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Klebsiella
pneumoniae)
PF08282
(Hydrolase_3)
5 ALA A   6
LEU A 260
MET A 231
ILE A 248
LEU A 222
None
1.25A 1qkuA-3pgvA:
undetectable
1qkuA-3pgvA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
5 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
None
1.30A 1qkuA-3q0gA:
undetectable
1qkuA-3q0gA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
5 ALA A  88
LEU A  83
LEU A  82
ILE A 253
LEU A 285
None
1.26A 1qkuA-3qghA:
undetectable
1qkuA-3qghA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8i PROTEIN DDI1 HOMOLOG
1


(Homo sapiens)
PF09668
(Asp_protease)
5 ALA A 263
LEU A 329
MET A 328
ILE A 246
LEU A 335
None
1.45A 1qkuA-3s8iA:
undetectable
1qkuA-3s8iA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Corynebacterium
glutamicum)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ALA A  42
LEU A  43
LEU A  48
HIS A 113
LEU A  18
None
1.45A 1qkuA-3tx8A:
undetectable
1qkuA-3tx8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzt GLYCOSYL TRANSFERASE
FAMILY 8


(Anaerococcus
prevotii)
PF01501
(Glyco_transf_8)
5 ALA A   4
LEU A 118
ARG A  31
ILE A 122
LEU A 163
EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
None
1.26A 1qkuA-3tztA:
undetectable
1qkuA-3tztA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis)
PF02335
(Cytochrom_C552)
5 ALA A 347
GLU A 346
LEU A 409
MET A 252
LEU A 364
None
1.43A 1qkuA-3ubrA:
undetectable
1qkuA-3ubrA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7


(Saccharomyces
cerevisiae)
PF00899
(ThiF)
PF16420
(ATG7_N)
5 ALA A 252
LEU A 238
LEU A 239
ILE A 182
LEU A 233
None
1.39A 1qkuA-3vh1A:
undetectable
1qkuA-3vh1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba)
PF12740
(Chlorophyllase2)
5 ALA A 160
LEU A 147
LEU A 143
ARG A 182
ILE A  81
None
1.20A 1qkuA-3visA:
undetectable
1qkuA-3visA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525)
no annotation 5 ALA A 318
GLU A 322
LEU A 415
ILE A 303
LEU A 310
None
1.21A 1qkuA-3w36A:
1.7
1qkuA-3w36A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ALA A 133
LEU A 135
LEU A 136
ILE A  26
LEU A  88
None
1.45A 1qkuA-4a73A:
undetectable
1qkuA-4a73A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE


(Hafnia alvei)
PF00328
(His_Phos_2)
5 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
None
1.37A 1qkuA-4arsA:
undetectable
1qkuA-4arsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE


(Aspergillus
fumigatus)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
5 ALA A 437
LEU A 212
ARG A 279
ILE A 429
LEU A 420
None
1.39A 1qkuA-4bjuA:
undetectable
1qkuA-4bjuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA A  20
LEU A   9
ILE A  46
HIS A 225
LEU A 251
None
1.43A 1qkuA-4c30A:
undetectable
1qkuA-4c30A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus)
PF01063
(Aminotran_4)
5 ALA A 194
GLU A 193
LEU A 204
MET A 272
ILE A 219
None
1.46A 1qkuA-4ce5A:
undetectable
1qkuA-4ce5A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE


(Escherichia
coli)
PF00291
(PALP)
5 ALA A 213
GLU A 212
ARG A  70
ILE A 334
LEU A  63
None
1.22A 1qkuA-4d9iA:
undetectable
1qkuA-4d9iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ely DNA GYRASE SUBUNIT A

(Shigella
flexneri)
PF00521
(DNA_topoisoIV)
5 ALA A 455
LEU A 459
LEU A 461
ILE A 390
LEU A 396
None
1.40A 1qkuA-4elyA:
undetectable
1qkuA-4elyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE


(Trypanosoma
cruzi)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ALA A 123
GLU A 122
LEU A  96
ARG A 116
LEU A 110
None
1.42A 1qkuA-4iv5A:
undetectable
1qkuA-4iv5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14


(Homo sapiens)
PF02758
(PYRIN)
5 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
None
1.43A 1qkuA-4n1jA:
undetectable
1qkuA-4n1jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14


(Homo sapiens)
PF02758
(PYRIN)
5 ALA A  53
GLU A  49
MET A  62
ILE A  78
LEU A  27
None
1.39A 1qkuA-4n1jA:
undetectable
1qkuA-4n1jA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 ALA A 287
GLU A 290
LEU A 324
ARG A 331
ILE A 361
None
0.60A 1qkuA-4n1yA:
30.6
1qkuA-4n1yA:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 ALA A 287
LEU A 324
ARG A 331
MET A 358
ILE A 361
None
0.69A 1qkuA-4n1yA:
30.6
1qkuA-4n1yA:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA


(Klebsiella
pneumoniae)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ALA H 359
GLU H 571
LEU H 621
ARG H 624
LEU H 220
None
1.34A 1qkuA-4nl4H:
undetectable
1qkuA-4nl4H:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt4 GILGAMESH, ISOFORM I

(Drosophila
melanogaster)
PF00069
(Pkinase)
5 GLU A 289
LEU A 314
ARG A 321
HIS A 154
LEU A 153
None
1.37A 1qkuA-4nt4A:
undetectable
1qkuA-4nt4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
None
1.20A 1qkuA-4o1oA:
undetectable
1qkuA-4o1oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Ochrobactrum
anthropi)
PF03480
(DctP)
5 ALA A 267
GLU A 266
LEU A  54
MET A  90
ILE A  32
None
1.35A 1qkuA-4p47A:
undetectable
1qkuA-4p47A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri)
PF00331
(Glyco_hydro_10)
5 ALA A 313
LEU A  25
ARG A 318
ILE A 285
LEU A 257
None
1.43A 1qkuA-4pmzA:
undetectable
1qkuA-4pmzA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
5 ALA A 151
LEU A 250
LEU A 251
ILE A  20
LEU A 139
None
1.43A 1qkuA-4po0A:
undetectable
1qkuA-4po0A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B


(Homo sapiens)
PF00233
(PDEase_I)
5 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
None
1.09A 1qkuA-4wziA:
1.9
1qkuA-4wziA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB


(Aquifex
aeolicus)
PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3)
5 ALA A   7
LEU A   5
LEU A  57
ILE A 171
HIS A 110
None
1.39A 1qkuA-4zu9A:
undetectable
1qkuA-4zu9A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE


(Pseudomonas
veronii)
PF00561
(Abhydrolase_1)
5 LEU A 336
MET A 332
LEU A 333
ARG A  72
HIS A 322
None
1.34A 1qkuA-5e4yA:
undetectable
1qkuA-5e4yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE


(Escherichia
coli)
PF01814
(Hemerythrin)
PF04405
(ScdA_N)
5 ALA A 216
GLU A 220
LEU A  72
ILE A  79
LEU A 137
None
None
None
ZN  A1222 ( 4.9A)
None
1.23A 1qkuA-5fnpA:
undetectable
1qkuA-5fnpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 GLU A2173
LEU A2213
ARG A2206
ILE A2184
LEU A2244
None
1.44A 1qkuA-5i6gA:
undetectable
1qkuA-5i6gA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1g PLECTIN

(Homo sapiens)
no annotation 5 ALA A1072
GLU A1075
LEU A1094
ARG A1091
ILE A1019
None
1.46A 1qkuA-5j1gA:
undetectable
1qkuA-5j1gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN


(Flavobacterium
johnsoniae)
PF12741
(SusD-like)
5 ALA A 229
GLU A 243
LEU A 183
MET A 348
LEU A 356
None
1.34A 1qkuA-5j90A:
undetectable
1qkuA-5j90A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L


(Bos taurus)
PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF06444
(NADH_dehy_S2_C)
5 ALA N  55
GLU N 117
LEU K  95
LEU K  93
HIS N  48
None
1.41A 1qkuA-5lc5N:
undetectable
1qkuA-5lc5N:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus)
no annotation 5 ALA A 277
LEU A 316
MET A 315
ILE A  26
LEU A 328
None
None
None
None
CU  A1103 (-4.4A)
1.32A 1qkuA-5n4lA:
undetectable
1qkuA-5n4lA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8
PROTEIN SMG-9


(Caenorhabditis
elegans)
PF10220
(Smg8_Smg9)
no annotation
5 ALA D 185
LEU D 181
ILE E 172
HIS D 352
LEU D 351
EDO  D 402 (-4.0A)
None
None
None
None
1.22A 1qkuA-5nkmD:
undetectable
1qkuA-5nkmD:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B


(Homo sapiens)
no annotation 5 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
None
1.08A 1qkuA-5ohjA:
undetectable
1qkuA-5ohjA:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
9 ALA A 302
GLU A 305
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 376
HIS A 475
LEU A 476
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
0.54A 1qkuA-5toaA:
30.8
1qkuA-5toaA:
58.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 ALA A 297
GLU A 296
ARG A 192
MET A 470
LEU A 476
None
1.36A 1qkuA-5vl1A:
undetectable
1qkuA-5vl1A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D


(Methylobacterium
extorquens)
no annotation 5 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
None
1.19A 1qkuA-5vrdD:
undetectable
1qkuA-5vrdD:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora)
PF00067
(p450)
5 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
None
1.31A 1qkuA-5vwsA:
2.7
1qkuA-5vwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN


(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 GLU A  27
LEU A  23
ARG A 244
ILE A  16
LEU A 231
None
1.29A 1qkuA-5w3fA:
undetectable
1qkuA-5w3fA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae)
no annotation 5 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
None
1.33A 1qkuA-5x87A:
undetectable
1qkuA-5x87A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS


(Neisseria
gonorrhoeae)
no annotation 5 GLU A 257
LEU A 168
ARG A 167
ILE A 129
LEU A 251
None
1.47A 1qkuA-5x9wA:
undetectable
1qkuA-5x9wA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum)
no annotation 5 ALA A 353
MET A 312
LEU A 378
ARG A 384
ILE A 428
None
HEM  A 505 ( 3.7A)
None
None
None
1.45A 1qkuA-5ze8A:
undetectable
1qkuA-5ze8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104


(Saccharomyces
cerevisiae)
no annotation 5 ALA A  38
GLU A  41
LEU A  21
ILE A  76
LEU A  30
None
1.29A 1qkuA-6amnA:
undetectable
1qkuA-6amnA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6


(Mus musculus)
no annotation 5 ALA A 105
GLU A 106
LEU A 138
ILE A 175
LEU A 151
None
1.35A 1qkuA-6cv9A:
undetectable
1qkuA-6cv9A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-)
no annotation 5 ALA A 492
GLU A 493
ARG A 216
ILE A 143
LEU A  97
None
1.36A 1qkuA-6dk2A:
undetectable
1qkuA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE


(Pseudomonas
putida)
no annotation 5 ALA A 296
GLU A  49
LEU A 301
ARG A 335
ILE A 290
FAD  A 401 ( 4.7A)
CL  A 402 ( 4.6A)
CL  A 402 (-4.8A)
CL  A 402 (-3.5A)
None
1.02A 1qkuA-6dllA:
undetectable
1qkuA-6dllA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum)
no annotation 5 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
None
1.35A 1qkuA-6fhsA:
undetectable
1qkuA-6fhsA:
15.11