SIMILAR PATTERNS OF AMINO ACIDS FOR 1QHY_A_CLMA999_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 472
ILE A 421
ILE A 399
VAL A 390
ARG A  20
 None
 0.97A 1qhyA-1a3xA:
undetectable		 1qhyA-1a3xA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ILE A 245
ILE A 257
ASP A 221
VAL A 220
LEU A 218
 None
 1.01A 1qhyA-1e5wA:
undetectable		 1qhyA-1e5wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 SER A   9
VAL A  20
ILE A  73
ILE A  43
GLN A  34
 None
 1.02A 1qhyA-1gytA:
undetectable		 1qhyA-1gytA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		5 ILE A  88
ILE A 105
PHE A  71
ILE A 146
LEU A 167
 None
 0.93A 1qhyA-1hg8A:
undetectable		 1qhyA-1hg8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 VAL A  85
ILE A  87
ILE A 125
ILE A 145
VAL A  59
 None
 1.07A 1qhyA-1i36A:
undetectable		 1qhyA-1i36A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE

(Saccharomyces
cerevisiae) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 ILE A 117
ILE A 147
PHE A 143
VAL A  66
LEU A  64
 None
 1.07A 1qhyA-1ig0A:
undetectable		 1qhyA-1ig0A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 VAL A 247
ILE A 249
ILE A 210
ILE A 190
VAL A 244
 None
 0.93A 1qhyA-1nhcA:
undetectable		 1qhyA-1nhcA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 VAL A 362
ILE A 363
ILE A 375
PHE A 339
VAL A 384
 None
 0.97A 1qhyA-1ny5A:
3.5		 1qhyA-1ny5A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		6 SER A  12
ILE A  54
ASP A  93
VAL A  94
MET A 140
GLN A 144
 ATP  A 501 (-2.6A)
None
None
None
None
None
 1.13A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		11 SER A  12
VAL A  36
ILE A  40
ILE A  54
PHE A  56
ILE A  64
ASP A  93
VAL A  94
LEU A  96
MET A 140
GLN A 144
 ATP  A 501 (-2.6A)
None
None
None
None
None
None
None
None
None
None
 0.41A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		6 SER A  12
VAL A  36
ILE A  64
VAL A  94
MET A 140
GLN A 144
 ATP  A 501 (-2.6A)
None
None
None
None
None
 1.35A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		11 VAL A  36
ILE A  40
ILE A  54
PHE A  56
ILE A  64
ASP A  93
VAL A  94
LEU A  96
ARG A 136
MET A 140
GLN A 144
 None
None
None
None
None
None
None
None
ATP  A 501 (-1.8A)
None
None
 0.67A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		5 VAL A  36
ILE A  54
ASP A  93
VAL A  94
GLN A 144
 None
 0.79A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II

(Sus scrofa) 		PF00431
(CUB) 		5 SER B  83
VAL B  60
ILE B  90
ILE B 105
ILE B  46
 None
 0.81A 1qhyA-1sppB:
undetectable		 1qhyA-1sppB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svi GTP-BINDING PROTEIN
YSXC

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 ILE A 135
ILE A 100
ILE A  96
VAL A  74
LEU A  62
 None
 1.01A 1qhyA-1sviA:
4.4		 1qhyA-1sviA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 VAL A 303
ILE A 338
ILE A 293
ILE A 316
VAL A 323
 None
 0.97A 1qhyA-1vftA:
undetectable		 1qhyA-1vftA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		5 VAL A 346
ILE A 347
ILE A  63
VAL A 279
LEU A 275
 None
 0.95A 1qhyA-1vheA:
2.3		 1qhyA-1vheA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlf PEROXISOME
BIOGENESIS FACTOR 1

(Mus musculus) 		PF09262
(PEX-1N)
PF09263
(PEX-2N) 		6 VAL A 108
ILE A 155
ILE A 145
ILE A 134
VAL A 106
LEU A 169
 None
 1.45A 1qhyA-1wlfA:
undetectable		 1qhyA-1wlfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		5 VAL A 125
ILE A  79
ILE A 140
ILE A 107
VAL A  97
 None
 1.04A 1qhyA-1yloA:
2.4		 1qhyA-1yloA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		5 VAL A 185
ILE A 138
ILE A  22
ILE A  18
VAL A 244
 None
None
None
NAI  A1270 (-3.6A)
None
 1.04A 1qhyA-1zjyA:
3.6		 1qhyA-1zjyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 VAL A 433
ILE A 442
ILE A 186
LEU A 214
GLN A 456
 None
 1.04A 1qhyA-2b0tA:
2.5		 1qhyA-2b0tA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL A 107
ILE A  88
ILE A  90
VAL A 120
LEU A  34
 None
 1.02A 1qhyA-2b39A:
undetectable		 1qhyA-2b39A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 5 ILE P 174
ILE P 159
PHE P 129
ILE P 245
LEU P 186
 None
 0.91A 1qhyA-2btvP:
undetectable		 1qhyA-2btvP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		5 VAL A 360
ILE A 378
ILE A  38
VAL A 353
LEU A 344
 None
 1.00A 1qhyA-2bwmA:
undetectable		 1qhyA-2bwmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		5 VAL A 188
ILE A 125
ILE A 180
PHE A   6
ILE A 155
 None
 0.99A 1qhyA-2csuA:
3.9		 1qhyA-2csuA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A  46
ILE A  53
ILE A  62
VAL A  77
LEU A  59
 None
 1.06A 1qhyA-2cw2A:
undetectable		 1qhyA-2cw2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 VAL A 195
ILE A 222
ILE A 231
ASP A 200
VAL A 201
 None
 0.95A 1qhyA-2e28A:
undetectable		 1qhyA-2e28A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 VAL A 111
ILE A  41
ILE A  52
VAL A 134
LEU A 136
 None
 1.03A 1qhyA-2etvA:
undetectable		 1qhyA-2etvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5j CASPASE-3, P17
SUBUNIT

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 ILE A  50
ILE A  96
ILE A 139
LEU A 136
ARG A  64
 None
 1.07A 1qhyA-2h5jA:
undetectable		 1qhyA-2h5jA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 ILE A 285
ILE A  94
PHE A 144
ASP A 277
LEU A 135
 None
 1.02A 1qhyA-2h98A:
undetectable		 1qhyA-2h98A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj1 HYPOTHETICAL PROTEIN

(Haemophilus
influenzae) 		PF03658
(Ub-RnfH) 		5 ILE A  17
ILE A  47
ILE A  54
LEU A  56
GLN A  39
 None
 0.96A 1qhyA-2hj1A:
undetectable		 1qhyA-2hj1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lui PICK1 PDZ DOMAIN
FUSED TO THE C10 DAT
LIGAND

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ILE A  49
ILE A  35
ILE A  33
VAL A  23
LEU A  25
 None
 1.01A 1qhyA-2luiA:
undetectable		 1qhyA-2luiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		5 ILE A 154
ILE A 157
PHE A 159
ILE A  58
LEU A  41
 None
 0.95A 1qhyA-2o04A:
undetectable		 1qhyA-2o04A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		5 ILE A  82
ILE A   3
PHE A   7
LEU A  74
GLN A  31
 None
 0.95A 1qhyA-2pfrA:
undetectable		 1qhyA-2pfrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 ILE A 234
ILE A 184
ILE A 255
LEU A 245
ARG A 198
 None
 0.93A 1qhyA-2radA:
5.3		 1qhyA-2radA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E2 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus) 		PF00943
(Alpha_E2_glycop) 		5 VAL C  31
ILE C  33
ILE C  47
ILE C 100
LEU C  82
 None
 1.04A 1qhyA-2yewC:
undetectable		 1qhyA-2yewC:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 ILE A 229
ILE A 201
ILE A 112
LEU A  35
ARG A 246
 None
 0.92A 1qhyA-3bf8A:
2.0		 1qhyA-3bf8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e58 PUTATIVE
BETA-PHOSPHOGLUCOMUT
ASE

(Streptococcus
thermophilus) 		PF13419
(HAD_2) 		6 VAL A  94
ILE A   5
ILE A 165
ASP A  90
VAL A  91
LEU A  13
 None
 1.25A 1qhyA-3e58A:
undetectable		 1qhyA-3e58A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erv PUTATIVE C39-LIKE
PEPTIDASE

(Bacillus
anthracis) 		PF13529
(Peptidase_C39_2) 		5 VAL A 167
ILE A 169
PHE A 231
ILE A 154
VAL A 161
 None
 0.95A 1qhyA-3ervA:
undetectable		 1qhyA-3ervA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 SER A 256
VAL A 178
ILE A 175
ILE A 349
ILE A 346
 MYR  A 500 ( 4.1A)
None
None
None
MYR  A 500 (-4.7A)
 0.99A 1qhyA-3fs1A:
undetectable		 1qhyA-3fs1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 ILE A 285
ILE A  94
PHE A 144
ASP A 277
LEU A 135
 None
 1.01A 1qhyA-3glbA:
undetectable		 1qhyA-3glbA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp9 NUCLEOSIDE
DIPHOSPHATE KINASE

(Acanthamoeba
polyphaga
mimivirus) 		PF00334
(NDK) 		5 VAL A   6
ILE A   8
ILE A  21
ILE A  98
LEU A  88
 None
 1.04A 1qhyA-3gp9A:
undetectable		 1qhyA-3gp9A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycolicibacterium
smegmatis) 		PF01648
(ACPS) 		6 VAL A  60
ILE A  61
ILE A  79
ILE A 101
VAL A  95
LEU A  97
 VAL  A  60 ( 0.6A)
ILE  A  61 ( 0.7A)
ILE  A  79 (-0.6A)
ILE  A 101 ( 0.7A)
VAL  A  95 ( 0.6A)
LEU  A  97 ( 0.6A)
 1.46A 1qhyA-3gwmA:
undetectable		 1qhyA-3gwmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		5 SER A  89
ILE A 110
ILE A 214
PHE A 210
GLN A 248
 None
None
None
CA  A 601 ( 4.9A)
CA  A 601 (-3.5A)
 0.97A 1qhyA-3im9A:
undetectable		 1qhyA-3im9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbe SUPEROXIDE DISMUTASE
[CU-ZN]

(Caenorhabditis
elegans) 		PF00080
(Sod_Cu) 		5 ILE A  17
ILE A  96
PHE A  44
VAL A  13
LEU A  37
 None
 0.88A 1qhyA-3kbeA:
undetectable		 1qhyA-3kbeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		5 ILE A 166
ILE A  50
ILE A  66
VAL A  72
LEU A  68
 None
None
None
None
CL  A 208 (-4.3A)
 1.01A 1qhyA-3krvA:
undetectable		 1qhyA-3krvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 SER A 297
VAL A 485
ILE A 481
ILE A 176
ILE A 129
 None
 1.05A 1qhyA-3kzwA:
undetectable		 1qhyA-3kzwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		5 ILE A 127
ILE A  70
VAL A  27
LEU A  28
GLN A  31
 None
 0.97A 1qhyA-3l6dA:
undetectable		 1qhyA-3l6dA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxf FERREDOXIN

(Novosphingobium
aromaticivorans) 		PF00111
(Fer2) 		6 VAL A  99
ILE A   4
ILE A  16
ILE A  33
VAL A  51
LEU A  36
 None
 1.21A 1qhyA-3lxfA:
undetectable		 1qhyA-3lxfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00158
(Sigma54_activat) 		5 VAL A 362
ILE A 363
ILE A 375
PHE A 339
VAL A 384
 None
 1.07A 1qhyA-3m0eA:
2.5		 1qhyA-3m0eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		5 ILE A  45
ILE A  19
ILE A  21
VAL A  37
LEU A  23
 None
 0.94A 1qhyA-3msuA:
undetectable		 1qhyA-3msuA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfg UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF16729
(DUF5067) 		5 SER A  66
VAL A 173
ILE A 114
ILE A  73
ASP A 183
 None
 0.98A 1qhyA-3qfgA:
undetectable		 1qhyA-3qfgA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350

(Pyrococcus
horikoshii) 		PF01881
(Cas_Cas6) 		5 VAL A   5
ILE A   3
ILE A  90
ILE A  28
VAL A 109
 None
 0.93A 1qhyA-3qjpA:
undetectable		 1qhyA-3qjpA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 209
ILE A 205
ILE A 232
PHE A 155
VAL A 218
 None
 1.06A 1qhyA-3qwbA:
undetectable		 1qhyA-3qwbA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 209
ILE A 205
PHE A 155
VAL A 218
LEU A 237
 None
 1.04A 1qhyA-3qwbA:
undetectable		 1qhyA-3qwbA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 SER A 226
ILE A 188
PHE A 206
ILE A 214
LEU A 242
 None
 0.99A 1qhyA-3rg1A:
undetectable		 1qhyA-3rg1A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 ILE A 509
ILE A 393
PHE A 395
ILE A 420
LEU A 411
 None
 1.05A 1qhyA-3tw0A:
undetectable		 1qhyA-3tw0A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ILE A 577
ILE A 581
ILE A 545
VAL A 492
LEU A 488
 None
 0.91A 1qhyA-3vr5A:
2.4		 1qhyA-3vr5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2w CRISPR SYSTEM CMR
SUBUNIT CMR3

(Pyrococcus
furiosus) 		PF09700
(Cas_Cmr3) 		5 SER B 190
VAL B   4
ILE B 178
VAL B 206
LEU B 195
 None
 0.99A 1qhyA-3w2wB:
undetectable		 1qhyA-3w2wB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zig SEPF-LIKE PROTEIN

(Pyrococcus
furiosus) 		PF04472
(SepF) 		5 SER A 103
ILE A 128
ILE A 120
ILE A  76
LEU A  71
 None
 0.99A 1qhyA-3zigA:
undetectable		 1qhyA-3zigA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 399
ILE A 432
PHE A 434
ILE A 477
VAL A 517
 None
 0.91A 1qhyA-3zz1A:
2.2		 1qhyA-3zz1A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 297
ILE A 347
ILE A 341
ILE A 368
LEU A 366
 None
 0.92A 1qhyA-4a2pA:
3.1		 1qhyA-4a2pA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 VAL A 297
ILE A 347
ILE A 341
ILE A 368
LEU A 366
 None
 1.00A 1qhyA-4a2qA:
2.5		 1qhyA-4a2qA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 VAL A 297
ILE A 347
ILE A 341
ILE A 368
LEU A 366
 None
 0.96A 1qhyA-4a2wA:
2.6		 1qhyA-4a2wA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 VAL A 209
ILE A 206
ILE A 220
PHE A 222
ILE A 182
 None
 0.80A 1qhyA-4a9aA:
undetectable		 1qhyA-4a9aA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		6 ILE A2078
ILE A2003
ILE A2164
ASP A2083
VAL A2084
LEU A2085
 None
 1.21A 1qhyA-4d0oA:
undetectable		 1qhyA-4d0oA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00248
(Aldo_ket_red) 		5 VAL A  95
ILE A 129
ILE A 162
LEU A 156
ARG A 119
 None
 1.04A 1qhyA-4exbA:
undetectable		 1qhyA-4exbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 ILE A 244
ILE A 261
ILE A 283
LEU A 272
MET A 253
 None
 0.90A 1qhyA-4fmzA:
undetectable		 1qhyA-4fmzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 ILE A 119
ILE A 142
PHE A 133
VAL A 125
LEU A 148
 None
 1.05A 1qhyA-4fs7A:
undetectable		 1qhyA-4fs7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 ILE A 345
ILE A 368
PHE A 359
VAL A 351
LEU A 374
 None
 1.00A 1qhyA-4fs7A:
undetectable		 1qhyA-4fs7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		5 ILE B 177
ILE B  51
ILE B  50
VAL B  69
LEU B  10
 None
 0.99A 1qhyA-4fwiB:
2.3		 1qhyA-4fwiB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		6 VAL A 239
ILE A 232
ILE A 255
ILE A 278
LEU A 289
MET A 270
 None
 1.32A 1qhyA-4h09A:
undetectable		 1qhyA-4h09A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus) 		PF16396
(DUF5005) 		5 VAL A 420
ILE A 391
ILE A 328
VAL A  55
LEU A 426
 None
 0.83A 1qhyA-4hbsA:
undetectable		 1qhyA-4hbsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htw GAG PROTEIN

(Simian
immunodeficiency
virus) 		PF00607
(Gag_p24) 		5 ILE A  51
ILE A 132
PHE A  39
ILE A  68
VAL A  58
 None
 1.03A 1qhyA-4htwA:
undetectable		 1qhyA-4htwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		5 ILE A 211
ILE A 214
PHE A 216
ILE A  97
LEU A  67
 None
 1.00A 1qhyA-4hwvA:
undetectable		 1qhyA-4hwvA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxi KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 VAL A  96
ILE A  93
ILE A  54
PHE A  75
ILE A  61
 None
 0.92A 1qhyA-4hxiA:
undetectable		 1qhyA-4hxiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 SER A 256
VAL A 178
ILE A 175
ILE A 349
ILE A 346
 MYR  A 401 ( 4.8A)
None
None
None
None
 0.93A 1qhyA-4iqrA:
undetectable		 1qhyA-4iqrA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		5 ILE A 120
ILE A  89
ILE A  92
VAL A  11
LEU A  28
 None
 1.06A 1qhyA-4isaA:
undetectable		 1qhyA-4isaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 VAL A 362
ILE A 363
ILE A 375
PHE A 339
VAL A 384
 None
 1.02A 1qhyA-4l4uA:
2.9		 1qhyA-4l4uA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		5 ILE A 318
ILE A 327
ILE A 325
VAL A 293
LEU A 297
 None
 1.06A 1qhyA-4n7rA:
undetectable		 1qhyA-4n7rA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 VAL A 958
ILE A 892
ILE A 943
PHE A 949
ASP A 957
 None
 1.06A 1qhyA-4o3mA:
5.4		 1qhyA-4o3mA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		5 ILE A  46
ILE A 148
PHE A  19
VAL A 118
LEU A   9
 None
 0.97A 1qhyA-4ojaA:
undetectable		 1qhyA-4ojaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3

(Homo sapiens) 		PF00179
(UQ_con)
PF13923
(zf-C3HC4_2) 		5 VAL L 302
ILE L 299
ILE L 254
PHE L 256
ARG L 205
 None
 0.98A 1qhyA-4r8pL:
undetectable		 1qhyA-4r8pL:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ILE A 245
ILE A 257
ASP A 221
VAL A 220
LEU A 218
 None
 1.01A 1qhyA-4rmaA:
undetectable		 1qhyA-4rmaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 5 VAL A 483
ILE A 480
ILE A 467
ILE A 502
VAL A 444
 None
 0.97A 1qhyA-4xn3A:
undetectable		 1qhyA-4xn3A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y8f TRIOSEPHOSPHATE
ISOMERASE

(Clostridium
perfringens) 		PF00121
(TIM) 		5 VAL A 196
ILE A 149
ILE A 166
ILE A 210
VAL A 204
 None
 1.05A 1qhyA-4y8fA:
undetectable		 1qhyA-4y8fA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 VAL A 108
ILE A  23
PHE A  81
LEU A 122
MET A  86
 None
 1.01A 1qhyA-5ce6A:
undetectable		 1qhyA-5ce6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d88 PREDICTED PROTEASE
OF THE COLLAGENASE
FAMILY

(Methanopyrus
kandleri) 		PF01136
(Peptidase_U32) 		5 VAL A  60
ILE A  24
ILE A  49
VAL A  95
LEU A  93
 None
 1.07A 1qhyA-5d88A:
undetectable		 1qhyA-5d88A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fds PROFILIN-2

(Hevea
brasiliensis) 		PF00235
(Profilin) 		5 VAL A  94
ILE A 103
ILE A  67
PHE A  42
LEU A  60
 None
 0.91A 1qhyA-5fdsA:
undetectable		 1qhyA-5fdsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzs GGDEF FAMILY PROTEIN

(Vibrio cholerae) 		PF00497
(SBP_bac_3) 		5 ILE A 227
ILE A 213
PHE A  66
VAL A 236
LEU A 240
 None
 1.04A 1qhyA-5gzsA:
undetectable		 1qhyA-5gzsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		5 VAL K  86
ILE K  85
ILE K  97
ILE K 123
ASP K 130
 None
 0.99A 1qhyA-5hnzK:
undetectable		 1qhyA-5hnzK:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		5 VAL A  70
ILE A  69
ILE A  81
ILE A 107
ASP A 114
 None
 1.02A 1qhyA-5lt1A:
undetectable		 1qhyA-5lt1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE

(Giardia
intestinalis) 		PF07992
(Pyr_redox_2) 		6 VAL A 278
ILE A  12
PHE A 249
ILE A  96
VAL A  89
GLN A 254
 None
None
FAD  A1001 ( 4.7A)
None
None
None
 1.24A 1qhyA-5m5jA:
undetectable		 1qhyA-5m5jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE

(Giardia
intestinalis) 		PF07992
(Pyr_redox_2) 		6 VAL A 278
ILE A 112
ILE A  12
PHE A 249
ILE A  96
VAL A  89
 None
None
None
FAD  A1001 ( 4.7A)
None
None
 1.11A 1qhyA-5m5jA:
undetectable		 1qhyA-5m5jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxv ISOCHORISMATE LYASE

(Vibrio
anguillarum) 		no annotation 5 VAL A 108
ILE A 107
ILE A  37
ILE A  62
LEU A  58
 None
 0.95A 1qhyA-5wxvA:
undetectable		 1qhyA-5wxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x88 CUTINASE

(Malbranchea
cinnamomea) 		no annotation 6 ILE A 133
ILE A 122
PHE A  94
ILE A 151
VAL A 137
LEU A 138
 None
 1.24A 1qhyA-5x88A:
4.3		 1qhyA-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Enterococcus
faecalis) 		PF01867
(Cas_Cas1) 		5 VAL A   6
ILE A  37
ILE A  62
VAL A   8
LEU A  42
 None
 0.93A 1qhyA-5xvnA:
undetectable		 1qhyA-5xvnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6djw RBR-TYPE E3
UBIQUITIN
TRANSFERASE,RBR-TYPE
E3 UBIQUITIN
TRANSFERASE

(Bactrocera
dorsalis) 		no annotation 5 ILE A  72
ILE A  52
ILE A  85
VAL A  44
LEU A  46
 None
 1.03A 1qhyA-6djwA:
undetectable		 1qhyA-6djwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6djx RBR-TYPE E3
UBIQUITIN
TRANSFERASE,RBR-TYPE
E3 UBIQUITIN
TRANSFERASE

(Bactrocera
dorsalis) 		no annotation 5 ILE A  72
ILE A  52
ILE A  85
VAL A  44
LEU A  46
 None
 1.02A 1qhyA-6djxA:
undetectable		 1qhyA-6djxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 716
ILE A 678
PHE A 648
VAL A 697
LEU A 695
 None
 1.03A 1qhyA-6f91A:
undetectable		 1qhyA-6f91A:
undetectable