SIMILAR PATTERNS OF AMINO ACIDS FOR 1QHS_A_CLMA888

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		5 PRO A  44
LYS A  46
MET A  47
ALA A  50
GLU A  67
 None
 0.83A 1qhsA-1qhxA:
33.8		 1qhsA-1qhxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 PRO A 376
LYS A  60
MET A  61
ALA A  64
 None
 1.46A 1qhsA-1zfjA:
0.0		 1qhsA-1zfjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME C1

(Rhodobacter
capsulatus) 		PF02167
(Cytochrom_C1) 		4 PRO D 128
MET D 214
ALA D 217
GLU D 218
 None
 1.22A 1qhsA-1zrtD:
0.0		 1qhsA-1zrtD:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcm COLD SHOCK DOMAIN
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF00313
(CSD) 		4 PRO A  55
LYS A  56
ALA A  59
GLU A  31
 None
 1.48A 1qhsA-2kcmA:
0.0		 1qhsA-2kcmA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 PRO A 158
MET A 159
ALA A 160
GLU A 275
 None
 1.44A 1qhsA-3c8tA:
0.0		 1qhsA-3c8tA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		4 PRO A 251
LYS A 253
MET A 252
ALA A 286
 None
 1.45A 1qhsA-3fbsA:
0.0		 1qhsA-3fbsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		4 PRO A  63
MET A  70
ALA A  60
GLU A  76
 None
 1.38A 1qhsA-3fcjA:
0.0		 1qhsA-3fcjA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PRO A 175
LYS A 178
ALA A 181
GLU A 128
 None
 1.02A 1qhsA-3vabA:
0.3		 1qhsA-3vabA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PRO A 175
LYS A 178
ALA A 182
GLU A 128
 None
 1.41A 1qhsA-3vabA:
0.3		 1qhsA-3vabA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 LYS B2733
MET B2732
ALA B2731
GLU B2728
 None
 1.16A 1qhsA-4bedB:
0.0		 1qhsA-4bedB:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7q NUDF PROTEIN

(Bdellovibrio
bacteriovorus) 		PF00293
(NUDIX) 		4 PRO A  50
MET A  48
ALA A  76
GLU A  96
 None
None
GOL  A 207 ( 3.9A)
None
 1.18A 1qhsA-5c7qA:
undetectable		 1qhsA-5c7qA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		4 PRO A 143
LYS A 146
ALA A 150
GLU A 124
 None
 1.18A 1qhsA-5ht0A:
undetectable		 1qhsA-5ht0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t86 CDIA TOXIN
CDII IMMUNITY
PROTEIN

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		4 PRO A 212
LYS I  37
ALA A 189
GLU A 247
 None
 1.22A 1qhsA-5t86A:
undetectable		 1qhsA-5t86A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpi PUTATIVE
TRANSCRIPTIONAL
REGULATOR (LYSR
FAMILY)

(Klebsiella
pneumoniae) 		PF03466
(LysR_substrate) 		4 PRO A 235
MET A 238
ALA A 101
GLU A  97
 None
 1.25A 1qhsA-5tpiA:
undetectable		 1qhsA-5tpiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		4 PRO A 374
LYS A  58
MET A  59
ALA A  62
 None
 1.29A 1qhsA-5upyA:
undetectable		 1qhsA-5upyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 PRO h  26
LYS h  28
MET h  29
ALA a 185
 None
 1.46A 1qhsA-5xtch:
undetectable		 1qhsA-5xtch:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckv BCL-2-RELATED
OVARIAN KILLER
PROTEIN

(Homo sapiens) 		no annotation 4 PRO A 143
MET A 145
ALA A 148
GLU A  99
 None
 1.31A 1qhsA-6ckvA:
undetectable		 1qhsA-6ckvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d79 SULFATE TRANSPORTER
CYSZ

(Pseudomonas
fragi) 		no annotation 4 PRO A  98
MET A 128
ALA A 127
GLU A 124
 None
 1.44A 1qhsA-6d79A:
undetectable		 1qhsA-6d79A:
undetectable