SIMILAR PATTERNS OF AMINO ACIDS FOR 1QFT_B_HSMB176_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 SER A 451
TYR A 453
VAL A 472
PHE A 510
ASP A 536
 None
 1.49A 1qftB-1gq1A:
0.1		 1qftB-1gq1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x46 ALLERGEN ARG R 1

(Argas reflexus) 		PF02098
(His_binding) 		5 SER A  28
TYR A  37
VAL A  53
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.53A 1qftB-2x46A:
17.6		 1qftB-2x46A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brn LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		5 SER A  18
TYR A  27
VAL A  43
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.33A 1qftB-3brnA:
8.5		 1qftB-3brnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu1 LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		5 SER A  12
TYR A  21
VAL A  37
ASP A  94
TRP A 105
 HSM  A 301 (-3.6A)
HSM  A 301 (-3.2A)
None
HSM  A 301 (-2.9A)
HSM  A 301 (-3.3A)
 0.45A 1qftB-3bu1A:
17.5		 1qftB-3bu1A:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		7 SER A  20
TYR A  29
PHE A  98
TYR A 100
ASP A 120
ILE A 122
TRP A 137
 None
None
None
HSM  A 174 (-3.6A)
None
None
None
 0.54A 1qftB-3g7xA:
33.4		 1qftB-3g7xA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		7 TYR A  29
VAL A  51
PHE A  98
TYR A 100
ASP A 120
ILE A 122
TRP A 137
 None
None
None
HSM  A 174 (-3.6A)
None
None
None
 0.24A 1qftB-3g7xA:
33.4		 1qftB-3g7xA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-2
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS)
PF04739
(AMPKBI)
PF16561
(AMPK1_CBM) 		5 SER G 160
TYR B 259
VAL B 264
ASP G 157
ILE G 156
 None
 1.38A 1qftB-4rerG:
0.0		 1qftB-4rerG:
19.42